Best TWAS P=9.83e-09 · Best GWAS P=5.3e-10 conditioned to 0.000341
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | GHR | 0.14 | 0.02 | lasso | 9 | 0.06 | 9.9e-03 | -5.8 | 5.7 | 9.8e-09 | -0.31 | 0.08 | 0.42 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | C5orf34 | 0.10 | 0.01 | enet | 20 | 0.01 | 3.0e-02 | -1.7 | -5.6 | 2.5e-08 | -0.04 | 0.05 | 0.16 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | SEPP1 | 0.18 | 0.19 | lasso | 11 | 0.21 | 1.3e-26 | -5.0 | 5.2 | 2.5e-07 | -0.48 | 0.62 | 0.38 | TRUE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GHR | 0.12 | 0.11 | enet | 6 | 0.13 | 2.5e-13 | 4.7 | 5.5 | 4.0e-08 | -0.26 | 0.19 | 0.81 | FALSE |