Best TWAS P=3.61e-13 · Best GWAS P=2.28e-13 conditioned to 0.233
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SLC35E2 | 0.35 | 0.15 | enet | 24 | 0.17 | 1.0e-20 | 6.1 | -5.6 | 1.9e-08 | -0.71 | 0.93 | 0.07 | FALSE |
2 | GTEx | Adipose Visceral Omentum | RP1-283E3.4 | 0.26 | 0.05 | enet | 25 | 0.16 | 1.5e-08 | 1.8 | 5.6 | 1.8e-08 | 0.21 | 0.15 | 0.07 | TRUE |
3 | GTEx | Brain Cerebellar Hemisphere | NADK | 0.18 | 0.11 | lasso | 7 | 0.09 | 3.1e-03 | 6.4 | 6.5 | 5.8e-11 | 0.85 | 0.02 | 0.70 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | RP5-890O3.9 | 0.24 | 0.02 | lasso | 9 | 0.02 | 1.3e-01 | 7.2 | -7.3 | 3.6e-13 | -0.91 | 0.01 | 0.75 | TRUE |
5 | GTEx | Cells Transformed fibroblasts | CDK11B | 0.10 | 0.06 | lasso | 4 | 0.05 | 2.1e-04 | -2.0 | 5.6 | 2.4e-08 | 0.85 | 0.03 | 0.90 | FALSE |
6 | GTEx | Esophagus Mucosa | TMEM52 | 0.17 | 0.18 | lasso | 2 | 0.20 | 2.9e-13 | 6.4 | -6.4 | 1.3e-10 | -0.83 | 0.65 | 0.35 | FALSE |
7 | GTEx | Lung | NADK | 0.07 | 0.03 | lasso | 3 | 0.02 | 8.5e-03 | -5.9 | 6.7 | 2.8e-11 | 0.94 | 0.02 | 0.93 | FALSE |
8 | GTEx | Muscle Skeletal | NADK | 0.06 | 0.00 | enet | 9 | 0.00 | 1.3e-01 | 6.4 | 6.6 | 5.3e-11 | 0.79 | 0.05 | 0.85 | FALSE |
9 | GTEx | Muscle Skeletal | TMEM52 | 0.11 | 0.08 | lasso | 6 | 0.10 | 7.2e-10 | 6.7 | -6.4 | 1.2e-10 | -0.84 | 0.39 | 0.61 | FALSE |
10 | GTEx | Pituitary | NADK | 0.21 | 0.09 | enet | 15 | 0.07 | 9.5e-03 | 6.7 | 5.5 | 3.2e-08 | 0.67 | 0.03 | 0.55 | FALSE |
11 | GTEx | Skin Not Sun Exposed Suprapubic | TMEM52 | 0.19 | 0.18 | lasso | 4 | 0.14 | 2.6e-08 | -5.9 | -6.3 | 2.4e-10 | -0.92 | 0.03 | 0.97 | FALSE |
12 | GTEx | Skin Sun Exposed Lower leg | TMEM52 | 0.17 | 0.14 | lasso | 7 | 0.15 | 2.0e-12 | -6.8 | -6.8 | 7.3e-12 | -0.92 | 0.04 | 0.96 | FALSE |
13 | ROSMAP | Brain Pre-frontal Cortex | C1orf222 | 0.11 | 0.14 | enet | 18 | 0.14 | 1.8e-17 | 4.0 | -5.7 | 1.2e-08 | -0.70 | 0.99 | 0.01 | FALSE |
14 | ROSMAP | Brain Pre-frontal Cortex | MMP23B | 0.05 | 0.04 | lasso | 2 | 0.03 | 1.9e-04 | 5.7 | 5.7 | 1.6e-08 | 0.80 | 0.06 | 0.92 | FALSE |
15 | ROSMAP | Brain Pre-frontal Cortex | SLC35E2 | 0.03 | 0.00 | blup | 291 | 0.01 | 1.4e-02 | 1.4 | -5.3 | 1.4e-07 | -0.73 | 0.03 | 0.68 | FALSE |
16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC35E2 | 0.03 | 0.03 | blup | 35 | 0.01 | 7.0e-02 | 7.1 | 6.2 | 5.7e-10 | 0.95 | 0.00 | 0.99 | FALSE |
17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM52 | 0.02 | 0.01 | blup | 37 | 0.02 | 6.6e-03 | 6.5 | -6.6 | 3.9e-11 | -0.91 | 0.01 | 0.80 | FALSE |
18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC35E2 | 0.03 | 0.00 | blup | 34 | 0.01 | 5.3e-02 | 6.0 | -5.8 | 8.1e-09 | -0.82 | 0.02 | 0.48 | FALSE |
19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC35E2 | 0.04 | 0.03 | lasso | 5 | 0.05 | 1.4e-06 | 6.0 | -5.4 | 6.7e-08 | -0.79 | 0.01 | 0.98 | FALSE |