Best TWAS P=2.72e-17 · Best GWAS P=6.32e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | EXOSC10 | 0.09 | 0.02 | lasso | 5 | 0.01 | 6.6e-02 | -5.9 | 5.5 | 4.7e-08 | -0.07 | 0.02 | 0.88 | TRUE |
| 2 | GTEx | Brain Caudate basal ganglia | KIF1B | 0.25 | 0.00 | lasso | 5 | 0.02 | 1.1e-01 | -4.7 | -6.8 | 1.1e-11 | -0.08 | 0.04 | 0.44 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | UBE4B | 0.09 | 0.00 | enet | 21 | 0.00 | 1.4e-01 | -5.1 | -5.9 | 3.2e-09 | -0.10 | 0.04 | 0.34 | FALSE |
| 4 | GTEx | Esophagus Mucosa | KIF1B | 0.10 | 0.00 | enet | 17 | 0.01 | 1.2e-01 | -5.2 | -8.5 | 2.7e-17 | -0.13 | 0.08 | 0.64 | TRUE |
| 5 | GTEx | Muscle Skeletal | KIF1B | 0.04 | 0.08 | lasso | 1 | 0.07 | 3.1e-07 | -6.3 | -6.3 | 3.5e-10 | -0.13 | 0.93 | 0.05 | FALSE |
| 6 | GTEx | Nerve Tibial | KIF1B | 0.10 | 0.07 | lasso | 6 | 0.04 | 8.5e-04 | -5.1 | -5.6 | 2.7e-08 | -0.12 | 0.86 | 0.09 | FALSE |
| 7 | GTEx | Thyroid | KIF1B | 0.13 | 0.14 | lasso | 5 | 0.16 | 5.3e-12 | -6.3 | -6.0 | 2.5e-09 | -0.12 | 1.00 | 0.00 | FALSE |
| 8 | NTR | Blood | KIF1B | 0.11 | 0.08 | enet | 11 | 0.09 | 3.7e-28 | 7.9 | 7.2 | 6.2e-13 | 0.02 | 0.00 | 1.00 | FALSE |
| 9 | YFS | Blood | KIF1B | 0.30 | 0.26 | enet | 49 | 0.29 | 7.8e-97 | 7.9 | 6.9 | 4.4e-12 | 0.03 | 0.01 | 0.99 | FALSE |
| 10 | YFS | Blood | SPSB1 | 0.03 | 0.03 | bslmm | 425 | 0.03 | 1.5e-09 | 8.1 | 7.8 | 4.6e-15 | 0.96 | 0.00 | 1.00 | TRUE |
| 11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | H6PD | 0.31 | 0.06 | blup | 64 | 0.14 | 3.8e-06 | 2.8 | -5.8 | 7.6e-09 | -0.49 | 0.04 | 0.52 | FALSE |