Best TWAS P=1.74e-09 · Best GWAS P=2.76e-09 conditioned to 0.107
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Caudate basal ganglia | STEAP2 | 0.30 | 0.08 | lasso | 4 | 0.15 | 4.1e-05 | -4.8 | 6.0 | 1.7e-09 | -0.84 | 0.02 | 0.94 | TRUE |
2 | GTEx | Cells Transformed fibroblasts | GTPBP10 | 0.13 | 0.13 | lasso | 3 | 0.11 | 7.8e-09 | -5.1 | 5.2 | 2.1e-07 | -0.83 | 0.05 | 0.95 | FALSE |
3 | ROSMAP | Brain Pre-frontal Cortex | GTPBP10 | 0.07 | 0.07 | enet | 21 | 0.07 | 1.9e-09 | -5.5 | 5.6 | 1.9e-08 | -0.89 | 0.00 | 1.00 | FALSE |
4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GTPBP10 | 0.08 | 0.01 | blup | 61 | 0.03 | 7.8e-03 | -5.9 | 5.8 | 8.6e-09 | -0.83 | 0.00 | 0.97 | FALSE |
5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GTPBP10 | 0.05 | 0.04 | lasso | 2 | 0.02 | 1.5e-03 | -5.1 | 5.1 | 2.7e-07 | -0.83 | 0.05 | 0.90 | FALSE |
6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GTPBP10 | 0.03 | 0.03 | lasso | 2 | 0.02 | 5.2e-03 | -5.2 | 5.2 | 1.6e-07 | -0.84 | 0.05 | 0.94 | FALSE |
7 | The Cancer Genome Atlas | Thyroid Carcinoma | GTPBP10 | 0.08 | 0.10 | lasso | 4 | 0.10 | 1.0e-09 | -4.7 | 5.6 | 2.2e-08 | -0.86 | 0.02 | 0.98 | FALSE |