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chr7:98,774,738-101,482,413

Best TWAS P=2.24e-09 · Best GWAS P=6.96e-09 conditioned to 0.447

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	TRIM4	0.40	0.39	lasso	5	0.40	4.5e-22	-5.4	5.7	1.2e-08	-0.73	0.03	0.97	FALSE
2	GTEx	Adrenal Gland	TRIM4	0.51	0.37	lasso	7	0.48	1.6e-19	-5.4	5.3	9.8e-08	-0.71	0.04	0.96	FALSE
3	GTEx	Adrenal Gland	STAG3L5P-PVRIG2P-PILRB	0.32	0.25	enet	43	0.20	7.0e-08	-2.9	-5.2	2.5e-07	0.43	0.96	0.01	FALSE
4	GTEx	Artery Aorta	TRIM4	0.33	0.42	lasso	9	0.40	2.4e-23	-5.4	5.4	7.4e-08	-0.72	0.03	0.97	FALSE
5	GTEx	Artery Coronary	TRIM4	0.49	0.33	lasso	9	0.27	9.2e-10	-5.4	5.5	4.5e-08	-0.73	0.03	0.97	FALSE
6	GTEx	Artery Tibial	TRIM4	0.39	0.37	lasso	10	0.37	3.7e-30	-5.4	5.4	8.5e-08	-0.72	0.03	0.97	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	TRIM4	0.14	0.11	lasso	7	0.06	1.1e-02	-5.4	5.6	2.8e-08	-0.74	0.03	0.77	FALSE
8	GTEx	Breast Mammary Tissue	TRIM4	0.35	0.35	enet	22	0.37	6.1e-20	-5.4	5.5	3.7e-08	-0.76	0.03	0.97	FALSE
9	GTEx	Breast Mammary Tissue (Female)	TRIM4	0.35	0.29	lasso	10	0.28	7.7e-09	-5.2	5.4	5.4e-08	-0.76	0.03	0.96	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	TRIM4	0.49	0.47	lasso	7	0.47	4.3e-17	-5.4	5.5	4.9e-08	-0.73	0.03	0.97	FALSE
11	GTEx	Cells Transformed fibroblasts	ZKSCAN1	0.23	0.18	lasso	5	0.19	4.9e-14	-5.4	5.4	6.3e-08	-0.54	0.03	0.97	FALSE
12	GTEx	Cells Transformed fibroblasts	TRIM4	0.41	0.39	lasso	8	0.39	4.6e-31	-5.4	5.5	3.8e-08	-0.73	0.03	0.97	FALSE
13	GTEx	Colon Transverse	AP1S1	0.44	0.26	enet	28	0.26	1.4e-12	-4.0	-5.1	3.0e-07	0.19	0.01	0.71	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	TRIM4	0.35	0.24	lasso	10	0.23	7.6e-09	-5.2	5.6	1.8e-08	-0.73	0.03	0.96	FALSE
15	GTEx	Esophagus Mucosa	TRIM4	0.38	0.40	enet	21	0.39	1.6e-27	-5.4	5.2	1.6e-07	-0.75	0.03	0.97	FALSE
16	GTEx	Esophagus Muscularis	TRIM4	0.30	0.30	lasso	9	0.29	6.8e-18	-5.4	5.5	3.4e-08	-0.72	0.03	0.97	FALSE
17	GTEx	Heart Atrial Appendage	TRIM4	0.23	0.25	lasso	7	0.23	9.8e-11	-5.4	5.4	6.1e-08	-0.72	0.03	0.97	FALSE
18	GTEx	Liver	TRIM4	0.33	0.30	lasso	10	0.28	1.6e-08	-5.4	5.3	1.2e-07	-0.72	0.03	0.97	FALSE
19	GTEx	Lung	TRIM4	0.35	0.35	lasso	3	0.35	5.4e-28	-5.4	5.4	6.8e-08	-0.73	0.03	0.97	FALSE
20	GTEx	Muscle Skeletal	TRIM4	0.19	0.18	lasso	4	0.18	1.3e-17	-5.4	5.4	8.3e-08	-0.72	0.03	0.97	FALSE
21	GTEx	Nerve Tibial	TRIM4	0.44	0.43	lasso	4	0.46	3.1e-36	-5.4	5.2	2.3e-07	-0.73	0.03	0.97	FALSE
22	GTEx	Ovary	TRIM4	0.20	0.04	enet	11	0.07	1.1e-02	4.7	5.2	1.6e-07	-0.72	0.04	0.82	FALSE
23	GTEx	Pancreas	TRIM4	0.48	0.31	lasso	12	0.34	3.2e-15	-5.3	5.1	3.1e-07	-0.71	0.04	0.96	FALSE
24	GTEx	Prostate	TRIM4	0.30	0.30	lasso	5	0.20	8.2e-06	-5.4	5.4	8.1e-08	-0.72	0.04	0.95	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	TRIM4	0.18	0.09	enet	17	0.13	1.8e-07	-5.4	6.0	2.4e-09	-0.87	0.03	0.97	FALSE
26	GTEx	Skin Sun Exposed Lower leg	TRIM4	0.39	0.26	lasso	11	0.25	5.5e-21	-5.4	5.7	1.0e-08	-0.83	0.03	0.97	FALSE
27	GTEx	Skin Sun Exposed Lower leg	ZNF3	0.05	0.01	lasso	4	0.01	7.9e-02	5.5	5.5	3.0e-08	-0.67	0.04	0.82	FALSE
28	GTEx	Small Intestine Terminal Ileum	TRIM4	0.40	0.37	lasso	4	0.34	1.5e-08	-5.3	5.3	1.1e-07	-0.73	0.04	0.96	FALSE
29	GTEx	Spleen	TRIM4	0.55	0.55	lasso	10	0.53	5.8e-16	-5.2	5.2	2.5e-07	-0.72	0.04	0.96	FALSE
30	GTEx	Stomach	TRIM4	0.34	0.27	enet	35	0.28	6.1e-14	-5.4	6.0	2.2e-09	-0.69	0.03	0.97	TRUE
31	GTEx	Testis	TRIM4	0.42	0.35	lasso	17	0.36	8.6e-17	-5.4	5.4	5.3e-08	-0.81	0.03	0.97	FALSE
32	GTEx	Thyroid	TRIM4	0.47	0.47	lasso	5	0.50	6.1e-43	-5.4	5.2	2.3e-07	-0.73	0.03	0.97	FALSE
33	GTEx	Vagina	TRIM4	0.32	0.19	lasso	7	0.27	6.0e-07	-5.4	5.5	5.0e-08	-0.68	0.04	0.91	FALSE
34	GTEx	Whole Blood	TRIM4	0.12	0.05	lasso	5	0.06	5.9e-06	-5.3	5.9	4.8e-09	-0.81	0.03	0.96	FALSE
35	METSIM	Adipose	TRIM4	0.17	0.22	lasso	13	0.22	3.9e-32	-5.3	5.5	3.1e-08	-0.76	0.04	0.96	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	TRIM4	0.08	0.09	lasso	4	0.09	2.5e-11	-5.4	5.2	2.0e-07	-0.70	0.04	0.96	FALSE
37	YFS	Blood	TRIM4	0.16	0.24	enet	17	0.24	9.7e-78	-5.4	5.4	5.7e-08	-0.74	0.04	0.96	FALSE
38	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM4	0.08	0.18	lasso	6	0.16	8.3e-14	-5.3	5.4	6.0e-08	-0.76	0.03	0.97	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	OR2AE1	0.16	0.22	enet	16	0.22	3.7e-45	-5.4	-5.3	1.1e-07	0.72	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM4	0.09	0.15	lasso	7	0.15	6.3e-30	-5.4	5.6	2.4e-08	-0.79	0.03	0.97	FALSE
41	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRIM4	0.12	0.10	blup	52	0.09	3.7e-05	-5.2	5.2	2.4e-07	-0.82	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Colon Adenocarcinoma	AP1S1	0.10	0.05	blup	52	0.05	1.1e-03	-4.0	-5.2	2.4e-07	0.14	0.01	0.51	FALSE
43	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIM4	0.22	0.28	lasso	10	0.29	5.5e-17	-5.4	5.6	2.7e-08	-0.83	0.03	0.97	FALSE
44	The Cancer Genome Atlas	Glioblastoma Multiforme	OR2AE1	0.10	0.04	blup	42	0.07	3.5e-03	-5.2	-5.3	1.0e-07	0.72	0.01	0.75	FALSE
45	The Cancer Genome Atlas	Glioblastoma Multiforme	TRIM4	0.23	0.13	blup	52	0.20	1.4e-06	-5.4	5.7	1.6e-08	-0.78	0.02	0.97	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TRIM4	0.10	0.12	enet	12	0.13	1.5e-14	-5.4	5.3	1.1e-07	-0.81	0.02	0.98	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AP1S1	0.16	0.05	lasso	3	0.09	7.7e-10	-4.0	-5.3	1.1e-07	0.18	0.01	0.81	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM4	0.21	0.17	lasso	6	0.18	1.1e-19	-5.4	5.3	1.2e-07	-0.73	0.03	0.97	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VGF	0.09	0.03	enet	13	0.04	7.1e-05	-4.0	-5.8	5.1e-09	0.20	0.00	0.12	TRUE
50	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TRIM4	0.12	0.16	blup	52	0.20	2.0e-11	-5.3	5.6	1.7e-08	-0.78	0.03	0.97	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	OR2AE1	0.11	0.15	lasso	4	0.14	1.2e-15	-5.4	-5.4	7.4e-08	0.72	0.01	0.99	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIM4	0.09	0.18	lasso	5	0.18	2.0e-19	-5.3	5.2	1.9e-07	-0.75	0.04	0.96	FALSE
53	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TRIM4	0.12	0.14	blup	52	0.16	7.2e-08	5.5	5.7	1.1e-08	-0.76	0.04	0.96	FALSE
54	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIM4	0.08	0.14	lasso	7	0.13	3.6e-15	-5.4	5.4	6.6e-08	-0.72	0.03	0.97	FALSE
55	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRIM4	0.09	0.20	lasso	4	0.19	1.7e-21	-5.4	5.6	2.9e-08	-0.78	0.03	0.97	FALSE
56	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM4	0.05	0.04	blup	52	0.03	2.5e-03	-5.4	5.4	5.1e-08	-0.70	0.03	0.91	FALSE
57	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TRIM4	0.22	0.07	blup	52	0.13	3.4e-06	-5.4	5.2	1.8e-07	-0.66	0.03	0.97	FALSE
58	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	OR2AE1	0.18	0.12	lasso	4	0.11	2.7e-05	-5.4	-5.6	2.3e-08	0.73	0.01	0.98	FALSE
59	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TRIM4	0.16	0.19	lasso	1	0.17	3.5e-07	-5.3	5.3	1.3e-07	-0.73	0.03	0.97	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	GJC3	0.03	0.05	lasso	6	0.05	1.5e-05	-5.4	-5.5	4.5e-08	0.88	0.03	0.96	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRIM4	0.18	0.22	lasso	5	0.22	8.0e-23	-5.4	5.4	7.4e-08	-0.72	0.03	0.97	FALSE
62	The Cancer Genome Atlas	Rectum Adenocarcinoma	TRIM4	0.17	0.04	blup	52	0.08	6.6e-03	-5.4	5.2	2.2e-07	-0.71	0.02	0.46	FALSE
63	The Cancer Genome Atlas	Soft Tissue Sarcoma	TRIM4	0.09	0.09	lasso	1	0.07	3.2e-05	-5.4	5.4	7.7e-08	-0.72	0.03	0.96	FALSE
64	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TRIM4	0.16	0.04	enet	12	0.02	9.1e-02	5.5	5.6	2.1e-08	-0.73	0.02	0.60	FALSE
65	The Cancer Genome Atlas	Stomach Adenocarcinoma	OR2AE1	0.05	0.04	enet	10	0.05	1.9e-04	-5.4	-5.7	9.3e-09	0.62	0.01	0.89	FALSE
66	The Cancer Genome Atlas	Stomach Adenocarcinoma	TRIM4	0.12	0.06	blup	52	0.09	5.6e-07	-5.4	5.4	7.7e-08	-0.86	0.01	0.99	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM4	0.16	0.30	lasso	9	0.30	9.9e-30	-5.4	5.6	2.4e-08	-0.73	0.03	0.97	FALSE