Best TWAS P=1.65e-18 · Best GWAS P=7e-17 conditioned to 0.717
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RMI1 | 0.07 | 0.06 | lasso | 3 | 0.06 | 1.4e-07 | 7.6 | -7.9 | 2.6e-15 | -0.98 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RMI1 | 0.11 | 0.03 | lasso | 3 | 0.04 | 3.8e-04 | -7.3 | -7.0 | 1.9e-12 | -0.52 | 0.14 | 0.78 | FALSE |
| 3 | GTEx | Artery Aorta | GKAP1 | 0.15 | 0.02 | enet | 24 | 0.03 | 6.0e-03 | 4.0 | -7.9 | 3.6e-15 | -0.44 | 0.14 | 0.42 | FALSE |
| 4 | GTEx | Testis | UBQLN1 | 0.10 | 0.02 | enet | 20 | 0.04 | 1.1e-02 | 2.6 | -5.4 | 5.2e-08 | -0.30 | 0.15 | 0.36 | FALSE |
| 5 | GTEx | Testis | RMI1 | 0.12 | 0.11 | enet | 15 | 0.14 | 1.3e-06 | -7.3 | -8.3 | 7.2e-17 | -0.82 | 0.03 | 0.95 | FALSE |
| 6 | METSIM | Adipose | RMI1 | 0.04 | 0.02 | lasso | 7 | 0.01 | 4.9e-03 | -7.1 | -6.6 | 3.9e-11 | -0.53 | 0.60 | 0.20 | FALSE |
| 7 | YFS | Blood | GKAP1 | 0.02 | 0.01 | blup | 614 | 0.01 | 3.2e-04 | 7.4 | -5.8 | 5.9e-09 | -0.70 | 0.02 | 0.97 | FALSE |
| 8 | YFS | Blood | RMI1 | 0.07 | 0.09 | bslmm | 528 | 0.09 | 1.5e-27 | 8.0 | 7.3 | 3.3e-13 | 0.95 | 0.02 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | UBQLN1 | 0.03 | 0.02 | lasso | 2 | 0.01 | 2.3e-02 | 7.5 | -6.1 | 1.0e-09 | -0.55 | 0.04 | 0.51 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RMI1 | 0.02 | 0.02 | blup | 31 | 0.01 | 8.8e-04 | 8.1 | -8.6 | 7.0e-18 | -0.93 | 0.01 | 0.89 | FALSE |
| 11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RMI1 | 0.05 | 0.04 | lasso | 2 | 0.00 | 1.8e-01 | -7.3 | -7.3 | 4.0e-13 | -0.57 | 0.02 | 0.20 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | RMI1 | 0.40 | 0.03 | lasso | 2 | 0.06 | 1.9e-04 | -7.3 | -7.0 | 2.0e-12 | -0.53 | 0.20 | 0.13 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RMI1 | 0.03 | 0.03 | lasso | 4 | 0.04 | 4.1e-05 | 8.1 | -8.8 | 1.7e-18 | -0.92 | 0.02 | 0.94 | TRUE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RMI1 | 0.03 | 0.03 | blup | 31 | 0.01 | 1.2e-02 | 8.1 | -8.4 | 3.8e-17 | -0.97 | 0.02 | 0.94 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C9orf64 | 0.07 | 0.03 | enet | 14 | 0.03 | 3.3e-04 | -7.1 | 5.9 | 4.7e-09 | 0.60 | 0.03 | 0.50 | FALSE |
| 16 | The Cancer Genome Atlas | Rectum Adenocarcinoma | UBQLN1 | 0.22 | 0.02 | lasso | 3 | 0.09 | 3.5e-03 | 7.6 | -8.5 | 2.3e-17 | -0.42 | 0.02 | 0.39 | TRUE |
| 17 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RMI1 | 0.05 | 0.06 | enet | 5 | 0.06 | 2.2e-05 | -7.1 | -8.4 | 4.6e-17 | -0.71 | 0.08 | 0.63 | FALSE |
| 18 | The Cancer Genome Atlas | Stomach Adenocarcinoma | UBQLN1 | 0.06 | 0.00 | blup | 62 | 0.02 | 1.3e-02 | -3.3 | -7.5 | 4.7e-14 | -0.45 | 0.04 | 0.18 | FALSE |
| 19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C9orf64 | 0.17 | 0.05 | enet | 8 | 0.09 | 4.5e-04 | -7.5 | 6.8 | 7.5e-12 | 0.75 | 0.03 | 0.66 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | C9orf64 | 0.04 | 0.00 | blup | 34 | 0.02 | 6.1e-03 | -7.1 | 5.3 | 1.4e-07 | 0.24 | 0.03 | 0.04 | FALSE |