Best TWAS P=2.39e-17 · Best GWAS P=8.58e-17 conditioned to 0.0794
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cortex | NRBF2 | 0.30 | 0.26 | enet | 24 | 0.21 | 1.4e-06 | -7.6 | -7.5 | 5.6e-14 | -0.95 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | NRBF2 | 0.25 | 0.17 | lasso | 6 | 0.16 | 6.1e-05 | 8.3 | -8.1 | 4.9e-16 | -0.98 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | JMJD1C | 0.09 | 0.01 | enet | 18 | 0.07 | 8.6e-06 | -6.7 | -7.6 | 4.1e-14 | -0.62 | 0.12 | 0.71 | FALSE |
| 4 | GTEx | Esophagus Mucosa | NRBF2 | 0.14 | 0.11 | lasso | 10 | 0.11 | 6.4e-08 | 8.0 | -8.1 | 6.0e-16 | -0.95 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Nerve Tibial | NRBF2 | 0.08 | 0.09 | enet | 11 | 0.06 | 5.0e-05 | 8.0 | -7.8 | 4.0e-15 | -0.91 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Stomach | NRBF2 | 0.09 | 0.04 | lasso | 6 | 0.03 | 1.6e-02 | -3.3 | -5.7 | 1.1e-08 | -0.73 | 0.08 | 0.42 | FALSE |
| 7 | GTEx | Testis | NRBF2 | 0.14 | 0.08 | lasso | 12 | 0.09 | 6.7e-05 | 8.0 | -7.6 | 2.5e-14 | -0.96 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Testis | JMJD1C-AS1 | 0.22 | 0.08 | enet | 23 | 0.10 | 3.7e-05 | -6.3 | -6.5 | 1.0e-10 | -0.41 | 0.67 | 0.04 | FALSE |
| 9 | GTEx | Thyroid | NRBF2 | 0.11 | 0.05 | lasso | 3 | 0.07 | 2.5e-06 | -4.8 | -7.0 | 2.8e-12 | -0.72 | 0.03 | 0.97 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | NRBF2 | 0.34 | 0.46 | lasso | 5 | 0.46 | 3.1e-66 | 8.3 | -8.1 | 6.5e-16 | -0.99 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NRBF2 | 0.07 | 0.04 | blup | 42 | 0.02 | 7.3e-03 | 8.2 | -6.0 | 2.0e-09 | -0.84 | 0.00 | 0.98 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NRBF2 | 0.05 | 0.06 | lasso | 2 | 0.06 | 5.5e-12 | 8.3 | -8.2 | 2.3e-16 | -1.00 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | NRBF2 | 0.13 | 0.10 | enet | 11 | 0.09 | 4.9e-06 | 8.3 | -7.5 | 5.5e-14 | -0.85 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Glioblastoma Multiforme | JMJD1C | 0.11 | 0.02 | blup | 87 | 0.05 | 1.4e-02 | 8.2 | -8.0 | 1.0e-15 | -0.87 | 0.01 | 0.74 | FALSE |
| 15 | The Cancer Genome Atlas | Glioblastoma Multiforme | NRBF2 | 0.17 | 0.09 | enet | 10 | 0.13 | 1.1e-04 | 8.3 | -8.2 | 3.6e-16 | -0.88 | 0.00 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NRBF2 | 0.04 | 0.04 | enet | 5 | 0.03 | 1.3e-04 | 8.2 | -7.6 | 3.5e-14 | -0.97 | 0.00 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NRBF2 | 0.10 | 0.06 | lasso | 7 | 0.08 | 3.5e-09 | -3.8 | -6.5 | 9.6e-11 | -0.88 | 0.01 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NRBF2 | 0.08 | 0.08 | enet | 6 | 0.08 | 4.3e-09 | 8.3 | -7.6 | 2.6e-14 | -0.98 | 0.00 | 1.00 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | REEP3 | 0.04 | 0.04 | blup | 59 | 0.05 | 1.8e-06 | -3.8 | 5.7 | 1.5e-08 | 0.80 | 0.03 | 0.97 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Adenocarcinoma | NRBF2 | 0.09 | 0.06 | enet | 8 | 0.07 | 2.7e-08 | 8.2 | -6.8 | 1.3e-11 | -0.94 | 0.00 | 1.00 | FALSE |
| 21 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LOC84989 | 0.10 | 0.05 | blup | 19 | 0.04 | 7.7e-03 | -6.2 | -7.8 | 5.0e-15 | -0.69 | 0.01 | 0.36 | FALSE |
| 22 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NRBF2 | 0.18 | 0.13 | enet | 11 | 0.08 | 2.5e-04 | 8.2 | -7.5 | 4.6e-14 | -0.89 | 0.00 | 0.99 | FALSE |
| 23 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NRBF2 | 0.08 | 0.02 | blup | 40 | 0.04 | 8.6e-03 | 8.3 | -8.5 | 2.4e-17 | -0.89 | 0.00 | 0.90 | TRUE |
| 24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | JMJD1C | 0.04 | 0.01 | blup | 88 | 0.01 | 9.7e-03 | 8.2 | -6.1 | 1.1e-09 | -0.87 | 0.01 | 0.91 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NRBF2 | 0.08 | 0.09 | lasso | 6 | 0.08 | 9.7e-09 | 8.2 | -7.8 | 8.1e-15 | -0.98 | 0.00 | 1.00 | FALSE |
| 26 | The Cancer Genome Atlas | Thyroid Carcinoma | NRBF2 | 0.14 | 0.10 | enet | 16 | 0.09 | 8.1e-09 | 8.2 | -7.6 | 3.4e-14 | -0.91 | 0.00 | 1.00 | FALSE |