Best TWAS P=1.21e-19 · Best GWAS P=4.35e-20 conditioned to 0.00404
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | C10orf11 | 0.24 | 0.21 | lasso | 9 | 0.20 | 3.3e-16 | -7.8 | 8.6 | 1.0e-17 | -0.87 | 0.16 | 0.84 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | C10orf11 | 0.40 | 0.32 | enet | 11 | 0.27 | 2.2e-14 | -7.8 | 9.0 | 2.9e-19 | -0.89 | 0.05 | 0.95 | FALSE |
| 3 | GTEx | Adrenal Gland | C10orf11 | 0.24 | 0.22 | enet | 21 | 0.18 | 5.8e-07 | -7.8 | 8.1 | 4.9e-16 | -0.83 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Esophagus Muscularis | C10orf11 | 0.45 | 0.39 | enet | 42 | 0.38 | 5.1e-24 | -7.8 | 9.1 | 1.2e-19 | -0.84 | 0.43 | 0.57 | TRUE |
| 5 | GTEx | Lung | C10orf11 | 0.30 | 0.26 | lasso | 5 | 0.24 | 2.0e-18 | -7.8 | 8.5 | 1.5e-17 | -0.87 | 0.14 | 0.86 | FALSE |
| 6 | GTEx | Testis | ZNF503-AS2 | 0.16 | 0.02 | lasso | 4 | 0.06 | 1.3e-03 | -5.8 | -5.3 | 1.1e-07 | 0.50 | 0.09 | 0.33 | FALSE |
| 7 | GTEx | Thyroid | C10orf11 | 0.38 | 0.21 | lasso | 9 | 0.25 | 6.7e-19 | -7.4 | 8.6 | 1.0e-17 | -0.80 | 0.28 | 0.72 | FALSE |
| 8 | METSIM | Adipose | C10orf11 | 0.11 | 0.10 | enet | 14 | 0.10 | 1.1e-14 | -7.4 | 7.4 | 1.2e-13 | -0.78 | 0.73 | 0.27 | FALSE |