Best TWAS P=2.57e-14 · Best GWAS P=1.56e-24 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HELLS | 0.04 | 0.04 | enet | 12 | 0.04 | 5.1e-06 | -4.9 | -6.9 | 5.5e-12 | 0.23 | 0.97 | 0.00 | FALSE |
| 2 | GTEx | Nerve Tibial | PLCE1 | 0.35 | 0.11 | enet | 25 | 0.23 | 2.1e-16 | 1.6 | -7.6 | 2.6e-14 | 0.29 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Pituitary | CYP2C8 | 0.20 | 0.05 | lasso | 7 | 0.04 | 4.1e-02 | -5.4 | -5.4 | 7.8e-08 | 0.48 | 0.09 | 0.48 | TRUE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | PLCE1 | 0.11 | 0.09 | lasso | 2 | 0.07 | 7.1e-05 | 3.8 | -6.1 | 1.1e-09 | 0.23 | 0.18 | 0.08 | TRUE |
| 5 | GTEx | Testis | PIPSL | 0.14 | 0.00 | enet | 21 | 0.00 | 3.0e-01 | -2.0 | 6.5 | 6.3e-11 | -0.20 | 0.06 | 0.12 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HELLS | 0.04 | 0.01 | blup | 47 | 0.03 | 1.3e-06 | -4.9 | -5.5 | 3.9e-08 | 0.20 | 0.04 | 0.95 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLCE1 | 0.11 | 0.09 | blup | 166 | 0.10 | 1.1e-19 | -3.4 | -6.7 | 1.6e-11 | 0.20 | 1.00 | 0.00 | TRUE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NOC3L | 0.05 | 0.01 | enet | 5 | 0.03 | 6.3e-04 | 7.7 | -6.1 | 1.2e-09 | 0.70 | 0.13 | 0.56 | TRUE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLCE1 | 0.11 | 0.01 | blup | 167 | 0.05 | 3.9e-06 | 2.9 | -5.8 | 5.6e-09 | 0.22 | 0.35 | 0.04 | TRUE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBC1D12 | 0.04 | 0.04 | blup | 63 | 0.03 | 3.9e-04 | -5.0 | -5.8 | 7.1e-09 | 0.12 | 0.24 | 0.50 | TRUE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | HELLS | 0.05 | 0.02 | blup | 47 | 0.03 | 9.6e-04 | -3.9 | -5.7 | 1.3e-08 | 0.24 | 0.08 | 0.80 | TRUE |