Best TWAS P=3.13e-11 · Best GWAS P=4.36e-12 conditioned to 1.29e-11
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP11-179B2.2 | 0.15 | 0.08 | lasso | 6 | 0.08 | 3.2e-07 | -4.8 | -5.5 | 3.6e-08 | 0.02 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Visceral Omentum | RP11-179B2.2 | 0.13 | 0.02 | lasso | 3 | 0.03 | 6.5e-03 | -6.6 | -6.3 | 2.7e-10 | 0.02 | 0.01 | 0.99 | FALSE |
3 | GTEx | Artery Aorta | RP11-179B2.2 | 0.16 | 0.11 | lasso | 2 | 0.09 | 7.6e-06 | -6.6 | -6.3 | 3.6e-10 | 0.02 | 0.00 | 0.99 | FALSE |
4 | GTEx | Artery Tibial | RP11-179B2.2 | 0.11 | 0.09 | lasso | 4 | 0.08 | 8.8e-07 | -6.6 | -6.6 | 4.1e-11 | 0.03 | 0.00 | 1.00 | FALSE |
5 | GTEx | Brain Cerebellum | RP11-179B2.2 | 0.37 | 0.21 | lasso | 4 | 0.20 | 1.4e-06 | -6.7 | -6.5 | 9.8e-11 | 0.02 | 0.00 | 0.99 | FALSE |
6 | GTEx | Brain Frontal Cortex BA9 | RP11-179B2.2 | 0.22 | 0.15 | lasso | 2 | 0.11 | 7.2e-04 | -6.7 | -6.3 | 2.6e-10 | 0.01 | 0.01 | 0.96 | FALSE |
7 | GTEx | Breast Mammary Tissue | RP11-179B2.2 | 0.11 | 0.09 | lasso | 2 | 0.07 | 1.8e-04 | -6.6 | -5.9 | 3.8e-09 | 0.02 | 0.01 | 0.99 | FALSE |
8 | GTEx | Breast Mammary Tissue (Male) | RP11-179B2.2 | 0.16 | -0.01 | enet | 4 | -0.01 | 7.1e-01 | 5.4 | -5.4 | 7.0e-08 | 0.07 | 0.03 | 0.48 | FALSE |
9 | GTEx | Esophagus Muscularis | RP11-179B2.2 | 0.15 | 0.16 | lasso | 3 | 0.16 | 8.1e-10 | -6.6 | -6.6 | 3.4e-11 | 0.03 | 0.01 | 0.99 | FALSE |
10 | GTEx | Heart Left Ventricle | RP11-179B2.2 | 0.15 | 0.18 | enet | 2 | 0.14 | 4.8e-08 | -6.7 | -6.6 | 3.1e-11 | 0.02 | 0.00 | 1.00 | TRUE |
11 | GTEx | Lung | RP11-179B2.2 | 0.18 | 0.12 | lasso | 3 | 0.12 | 1.7e-09 | -6.7 | -6.3 | 3.1e-10 | 0.02 | 0.00 | 1.00 | FALSE |
12 | GTEx | Nerve Tibial | RP11-179B2.2 | 0.15 | 0.08 | lasso | 2 | 0.12 | 6.4e-09 | -6.6 | -5.4 | 7.3e-08 | 0.01 | 0.01 | 0.99 | FALSE |
13 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-179B2.2 | 0.27 | 0.15 | enet | 36 | 0.15 | 2.0e-08 | -6.7 | -6.1 | 9.5e-10 | 0.00 | 0.00 | 1.00 | FALSE |
14 | GTEx | Thyroid | RP11-179B2.2 | 0.18 | 0.12 | lasso | 7 | 0.11 | 8.3e-09 | -4.8 | -5.3 | 1.4e-07 | 0.02 | 0.03 | 0.97 | FALSE |
15 | The Cancer Genome Atlas | Colon Adenocarcinoma | MRPL43 | 0.07 | 0.02 | blup | 52 | 0.00 | 1.7e-01 | -6.4 | 5.9 | 3.8e-09 | -0.03 | 0.01 | 0.86 | FALSE |