Hub : Genes

MRPL43

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1334 0.0485 3.1e-04 0.046 NA 0.049 NA 0.060 1.5e-04 NA 1.1e-04 NA 1.8e-05
2 GTEx Heart Atrial Appendage 0.1560 0.0570 2.2e-03 0.074 NA 0.085 NA 0.093 3.1e-04 NA 1.2e-04 NA 5.8e-05
3 METSIM Adipose 0.0483 0.0167 1.0e-04 0.035 0.034 0.025 0.038 0.027 4.5e-06 6.0e-06 8.5e-05 1.9e-06 4.9e-05
4 NTR Blood 0.0380 0.0107 3.6e-07 0.018 0.029 0.022 0.029 0.021 1.3e-06 8.1e-10 1.2e-07 9.0e-10 1.4e-07
5 ROSMAP Brain Pre-frontal Cortex 0.0964 0.0235 7.5e-10 0.085 0.080 0.086 0.090 0.088 5.2e-11 2.0e-10 3.7e-11 1.2e-11 1.8e-11
6 YFS Blood 0.2127 0.0281 0.0e+00 0.281 0.261 0.277 0.284 0.283 1.1e-92 3.5e-85 3.1e-91 1.1e-93 2.2e-93
7 TCGA Breast Invasive Carcinoma 0.0220 0.0102 7.2e-05 0.024 0.023 0.028 NA 0.027 6.8e-06 1.1e-05 1.5e-06 NA 2.7e-06
8 TCGA Colon Adenocarcinoma 0.0740 0.0490 8.4e-03 0.018 0.004 0.002 NA 0.001 3.1e-02 1.7e-01 2.4e-01 NA 2.8e-01
9 TCGA Glioblastoma Multiforme 0.3110 0.1180 1.1e-04 -0.007 0.101 0.151 NA 0.065 6.1e-01 5.7e-04 2.4e-05 NA 4.9e-03
10 TCGA Head and Neck Squamous Cell Carcinoma 0.0282 0.0139 8.7e-04 0.020 0.029 0.004 NA 0.008 2.4e-03 3.0e-04 1.0e-01 NA 3.4e-02
11 TCGA Kidney Renal Clear Cell Carcinoma 0.0223 0.0114 5.6e-03 0.020 0.018 0.016 NA 0.017 2.1e-03 3.5e-03 6.1e-03 NA 4.6e-03
12 TCGA Brain Lower Grade Glioma 0.0792 0.0281 5.6e-10 0.117 0.087 0.097 NA 0.116 3.4e-13 4.5e-10 4.4e-11 NA 3.9e-13
13 TCGA Liver Hepatocellular Carcinoma 0.0550 0.0290 8.3e-03 0.046 0.031 0.047 NA 0.046 3.2e-03 1.3e-02 3.0e-03 NA 3.2e-03
14 TCGA Ovarian Serous Cystadenocarcinoma 0.0610 0.0300 2.1e-04 0.039 0.042 0.040 NA 0.032 1.2e-03 7.4e-04 1.1e-03 NA 3.0e-03
15 TCGA Pheochromocytoma and Paraganglioma 0.2740 0.0780 1.6e-08 0.236 0.176 0.213 NA 0.211 8.1e-10 1.6e-07 6.4e-09 NA 7.8e-09
16 TCGA Prostate Adenocarcinoma 0.1326 0.0426 2.7e-14 0.155 0.143 0.148 NA 0.149 6.5e-16 1.0e-14 3.1e-15 NA 2.4e-15
17 TCGA Stomach Adenocarcinoma 0.1040 0.0400 1.2e-07 0.071 0.092 0.078 NA 0.067 7.9e-06 3.3e-07 2.9e-06 NA 1.3e-05
18 TCGA Thyroid Carcinoma 0.1970 0.0500 0.0e+00 0.228 0.256 0.245 NA 0.242 5.4e-22 8.0e-25 1.2e-23 NA 2.4e-23

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Bipolar Disorder (2018) 0.0 0.1 0.6 0.7 -0.5 -0.0 0.3 -0.0 -0.2 -0.3 -0.4 0.0 -0.2 -0.0 -0.1 -0.3 -0.1 -0.1 -0.0 -0.1 -0.0
Bipolar Disorder or Schizophrenia 0.3 0.7 2.2 1.1 -0.4 -0.2 0.1 0.5 1.0 0.4 -1.5 1.3 -0.1 1.2 0.8 0.7 0.5 1.0 0.9 0.7 0.9
Depressed Affect (Nagel 2018) 0.6 1.2 8.6 -1.0 -0.9 1.6 -1.0 -1.0 -0.0 -0.4 -2.9 0.3 -1.7 -0.4 -0.3 -0.8 -0.8 -0.2 -0.5 -1.2 -0.5
Depression (Nagel 2018) 0.5 0.7 2.2 -0.1 1.1 0.3 -0.6 0.8 1.5 1.3 -0.5 0.5 0.2 0.8 1.3 0.8 0.5 1.3 1.0 0.3 1.0
Intelligence (Savage-Jansen 2018) 0.1 0.2 1.0 0.5 1.0 0.8 0.2 0.2 0.1 0.6 0.8 -0.8 0.0 -0.2 0.2 0.1 0.7 -0.2 0.2 -0.1 0.4
Neuroticism (Nagel 2018) 0.2 0.4 4.4 -0.4 -0.2 1.1 -0.1 -0.6 0.1 0.2 -2.1 0.2 -0.9 0.1 -0.0 0.0 -0.1 0.2 -0.1 -0.7 -0.2
Schizophrenia (2018) 0.6 1.2 3.3 0.8 -0.0 -0.3 -0.2 0.6 1.5 0.7 -1.8 1.7 0.1 1.5 1.2 1.1 0.7 1.3 1.2 1.0 1.2
Schizophrenia vs Biploar Disorder 0.5 0.6 4.5 -1.1 -1.1 0.1 -1.0 -0.5 0.1 -0.7 -2.1 0.7 -1.4 0.0 -0.3 -0.3 -0.3 -0.1 -0.3 -0.2 0.0
Worry (Nagel 2018) 0.3 0.7 1.6 -0.2 1.3 -0.6 1.2 0.7 0.5 1.3 0.5 0.3 1.2 1.0 0.7 1.0 1.0 0.8 0.7 0.5 0.1
Alzheimer’s Disease (in mother) 2.1 2.5 4.4 0.2 1.1 -1.7 0.7 2.0 1.9 1.7 1.5 1.6 0.7 1.2 1.9 2.0 1.6 1.5 1.6 1.7 2.1
Alzheimer’s Disease (in father) 0.6 0.6 2.2 0.6 1.5 -0.5 0.0 0.9 0.5 0.9 1.3 0.4 1.0 0.8 0.6 0.5 0.8 0.6 0.7 0.6 0.4
Alzheimer’s Disease (including proxy) 3.5 5.1 9.5 0.8 1.8 -2.6 1.1 2.9 2.5 2.3 3.1 1.4 1.9 2.1 2.6 2.5 2.4 2.3 2.4 2.3 2.4
Crohns Disease (2017) 0.8 1.7 3.6 -0.7 -1.0 1.0 -1.9 -1.1 -1.7 -1.4 -0.5 -1.6 -0.6 -1.1 -1.5 -1.6 -1.2 -1.1 -1.2 -1.6 -1.6
Irritable Bowel Disease (IBD) 0.2 0.6 1.3 0.0 -0.6 0.6 -0.5 -0.7 -1.1 -0.8 0.2 -1.0 -0.2 -0.5 -0.9 -1.1 -0.5 -0.5 -0.7 -1.0 -1.2
Ulcerative Colitis (UC) 0.1 0.1 0.7 0.4 -0.0 0.1 0.8 0.0 -0.1 0.2 0.7 -0.1 0.4 0.4 -0.0 -0.2 0.5 0.3 0.1 -0.1 -0.3
Major Depression (MDD) 0.2 0.2 1.8 -0.1 -0.3 0.0 0.2 -0.7 -0.3 -0.2 -1.4 0.0 -0.7 -0.0 -0.3 -0.3 -0.3 -0.5 -0.3 -0.2 -0.3
Reaction Time 0.8 1.6 3.9 -1.4 -0.9 0.5 -1.7 -1.3 -1.0 -1.4 -2.0 -0.9 -1.6 -1.1 -1.2 -1.4 -1.3 -1.1 -1.2 -0.9 -0.5
Verbal and Numeric Reasoning (VNR) 0.4 1.1 4.4 -1.2 -0.7 1.2 -1.1 -0.8 -0.5 -0.6 -0.7 -2.1 -1.2 -1.3 -0.7 -0.9 -1.2 -1.0 -0.8 -0.8 -0.4
Breast Cancer 0.5 1.1 5.0 -2.2 -1.6 1.0 -0.6 -1.0 -0.4 -1.0 -1.6 -0.1 -1.5 -0.8 -0.7 -0.9 -1.2 -0.3 -0.6 -0.9 -0.2
Ovarian Cancer 1.2 1.6 3.4 0.3 1.1 -0.6 0.3 0.9 1.6 1.6 0.5 1.2 0.6 1.5 1.4 1.4 1.8 1.7 1.5 0.9 1.9
Prostate Cancer 0.1 0.1 0.6 0.3 -0.4 -0.8 0.6 -0.1 0.3 -0.2 -0.1 -0.2 -0.1 0.0 0.2 0.1 -0.4 0.1 0.2 0.2 0.2
Age at First Birth 6.7 9.8 13.8 2.1 3.7 -2.4 1.5 3.7 2.8 3.5 3.6 2.2 3.7 3.4 3.1 3.4 3.4 3.0 3.0 3.6 3.0
Bipolar Disorder (2011) 0.1 0.1 0.5 -0.5 -0.4 0.6 0.3 -0.3 -0.4 -0.3 -0.5 0.0 -0.4 -0.3 -0.3 -0.5 -0.2 -0.1 -0.1 -0.7 -0.1
Body Mass Index (BMI) (2010) 3.4 4.7 8.1 2.9 1.3 -2.4 2.1 2.2 2.7 1.7 0.4 2.5 0.3 2.3 2.2 2.5 2.4 2.1 2.0 2.3 2.8
Coronary Artery Disease (CAD) 2.2 2.6 4.3 1.6 1.2 -1.0 0.0 1.5 2.0 1.5 1.3 -0.7 1.3 1.8 1.9 2.1 1.9 1.8 1.8 2.0 1.9
Crohns Disease (2012) 0.4 0.6 2.0 0.6 0.7 0.4 -1.3 0.0 -0.9 0.1 0.3 -1.2 0.6 -0.2 -0.6 -0.8 0.2 -0.3 -0.4 -1.4 -1.4
Mean Putamen Volume 2.6 3.0 5.5 1.8 1.6 -0.0 1.4 1.6 2.3 2.0 0.7 1.5 1.3 2.0 2.2 1.8 1.7 2.1 2.1 1.4 2.0
Fasting Glucose 0.2 0.2 1.1 0.3 0.1 -1.0 0.7 0.2 0.4 0.2 -0.2 0.7 0.6 0.8 0.1 0.2 0.3 0.7 0.2 0.5 0.5
HbA1C 0.3 0.3 1.2 -0.8 -0.6 0.7 -0.6 -0.2 -0.3 -0.5 0.1 -1.1 -0.6 -0.7 -0.3 -0.4 -0.3 -0.6 -0.2 -0.3 -0.3
HDL Cholesterol 1.6 2.7 4.6 -1.0 -1.6 1.3 -1.5 -1.8 -2.1 -1.9 -0.6 -0.7 -1.3 -1.8 -2.0 -1.8 -1.9 -1.7 -2.1 -1.5 -1.9
LDL Cholesterol 0.2 0.3 1.8 1.3 0.3 -0.5 -0.2 -0.5 -0.6 -0.2 -0.2 0.6 0.3 -0.2 -0.7 -0.5 -0.3 -0.4 -0.7 -0.4 -0.6
Lupus 1.4 2.1 3.3 -1.0 -1.8 1.0 -1.7 -1.6 -1.4 -1.8 -1.5 -1.3 -1.7 -1.7 -1.4 -1.3 -1.3 -1.6 -1.5 -1.2 -1.3
Neuroticism (2016) 1.3 1.9 3.3 1.2 0.8 -0.8 1.8 1.2 1.4 1.4 1.1 1.5 1.1 1.7 1.4 1.7 1.7 1.6 1.3 1.4 1.2
Primary Biliary Cirrhosis 1.2 1.7 2.9 1.7 0.0 -1.7 0.9 1.1 1.7 1.1 0.8 1.0 0.8 1.4 1.5 1.6 1.7 1.2 1.4 1.6 1.5
Rheumatoid Arthritis 0.2 0.2 0.7 0.4 -0.7 0.3 -0.5 -0.5 -0.2 -0.6 -0.9 0.5 -0.8 -0.2 -0.3 -0.3 -0.0 -0.1 -0.3 -0.4 -0.4
Schizophrenia (2014) 0.5 1.2 11.0 -0.5 -1.6 0.9 -1.3 -0.8 0.2 -0.7 -3.3 0.7 -1.5 -0.1 -0.2 -0.4 -0.8 0.3 -0.2 -0.9 -0.1
Triglycerides 0.7 1.2 2.5 1.5 0.5 -1.3 1.3 1.1 1.2 0.8 0.1 0.7 0.5 1.1 1.0 1.2 1.0 1.3 1.1 0.9 1.6
Type 2 Diabetes (T2D) (2012) 1.5 1.7 7.4 -0.1 -1.2 1.4 -1.0 -1.1 -1.3 -1.4 0.1 -2.7 -1.2 -1.7 -1.2 -1.2 -1.1 -1.6 -1.0 -1.3 -1.0
Ulcerative Colitis 0.5 0.8 3.2 1.8 1.0 -1.0 0.5 0.5 0.2 0.9 1.5 -1.2 1.0 0.6 0.5 0.3 0.9 0.4 0.6 0.5 0.2
Blood Eosinophil Count 0.2 1.2 4.2 -0.1 -1.6 1.1 -0.7 -1.5 -0.7 -1.2 -2.1 0.8 -1.6 -0.5 -1.0 -1.0 -0.6 -1.0 -1.0 -0.3 -1.0
Blood Platelet Count 0.9 10.6 27.5 5.2 3.4 -0.9 2.9 3.1 2.7 3.6 3.5 1.1 3.8 3.2 3.1 3.5 3.9 2.6 3.1 3.4 2.9
Blood Red Count 0.4 4.1 10.1 -3.2 -1.7 0.4 -1.1 -1.9 -2.6 -2.2 -0.7 -2.1 -1.5 -2.0 -2.4 -2.4 -1.8 -2.1 -2.4 -1.8 -2.1
Blood White Count 0.1 0.9 3.3 1.8 0.2 -1.5 1.0 -0.2 0.7 0.5 -0.5 1.0 -0.3 1.3 0.6 0.7 0.8 0.7 0.4 1.4 0.9
Heel T-Score 2.0 16.1 29.3 3.6 2.9 -5.4 5.0 3.6 4.3 3.8 3.8 2.2 3.2 3.7 4.3 4.1 4.1 3.9 4.4 4.0 4.8
BMI 0.4 2.5 22.3 1.6 -1.5 1.9 0.5 -0.9 0.6 -0.8 -4.7 2.4 -2.2 0.6 -0.2 -0.3 -1.0 0.4 -0.6 -0.4 -0.1
Height 2.7 51.7 130.0 -4.6 -6.5 10.8 -2.2 -8.2 -6.2 -6.6 -11.4 -2.1 -8.2 -6.0 -6.8 -7.8 -7.4 -6.0 -6.6 -8.2 -7.1
Waist Hip Ratio (WHR) 0.2 0.8 4.9 -1.1 0.8 -2.0 0.8 0.3 -0.3 0.4 2.2 -1.2 0.6 -0.3 0.2 0.1 0.6 -0.3 0.2 0.5 0.5
Systolic Blood Pressure 0.2 0.9 3.2 -1.4 -0.1 -0.6 -0.7 0.1 -1.3 -0.6 1.8 -1.5 1.2 -1.0 -0.7 0.1 -0.4 -1.1 -0.6 -0.2 -0.8
Smoking Status 4.6 11.1 19.4 -2.6 -3.8 2.5 -1.8 -3.9 -3.5 -4.0 -2.6 -2.8 -4.4 -3.3 -3.5 -3.4 -3.7 -3.4 -3.7 -2.9 -3.0
Allergy or Eczema 0.2 0.4 3.9 -0.1 -0.5 1.2 -2.0 0.2 0.0 -0.2 -0.3 -0.9 -0.3 -0.2 -0.2 0.3 -0.3 -0.6 -0.5 0.5 -0.2
Cardiovascular Disease 0.2 0.8 2.0 1.0 1.0 -0.7 0.0 0.8 0.7 0.8 0.6 0.7 1.2 0.9 0.7 1.4 1.0 0.6 0.8 1.1 0.9
Hypothyroidism (self reported) 0.1 0.2 1.3 0.3 -0.2 0.8 1.1 -0.2 -0.5 -0.4 -0.4 -0.1 -0.2 -0.1 -0.2 -0.1 -0.1 -0.1 -0.1 -0.3 -0.3
Respiratory disease 3.3 7.4 14.1 -1.5 -2.8 2.6 -3.4 -3.0 -2.2 -2.8 -3.8 -2.0 -3.1 -2.7 -2.6 -2.7 -3.1 -2.8 -2.6 -2.7 -2.0
Type 2 Diabetes (T2D) (2018) 0.2 0.4 4.5 -2.1 0.0 0.7 0.8 0.2 0.5 0.2 -0.5 -0.6 -0.6 -0.2 0.4 -0.2 -0.3 0.2 0.2 -0.6 0.2
Lung FEV1/FVC ratio 1.9 9.9 17.1 2.6 2.7 -1.9 3.1 3.4 4.1 3.5 0.9 3.4 2.5 3.1 3.8 3.4 3.1 3.6 3.7 2.7 3.5
Lung FVC 0.4 1.8 4.6 1.2 -1.0 -0.7 2.1 0.4 1.6 0.2 -1.1 1.8 -0.5 1.8 1.2 1.3 0.7 1.7 1.2 1.6 1.8
Neuroticism 0.3 0.6 1.7 0.4 0.5 -0.1 1.2 0.5 0.9 1.0 -1.3 0.8 0.0 0.9 0.8 0.8 0.8 0.9 0.9 0.0 0.7
Chronotype (morning person) 0.1 0.2 0.4 -0.3 -0.5 0.1 0.1 -0.6 -0.6 -0.6 0.3 0.1 -0.3 -0.4 -0.5 -0.6 -0.3 0.2 -0.5 -0.3 -0.1
Hair Pigment 0.2 6.9 13.0 1.5 2.4 -2.6 3.6 2.9 2.4 2.6 2.7 3.1 2.2 2.5 2.6 2.7 2.8 2.4 2.6 2.6 2.5
Tanning 0.0 0.4 2.0 -1.4 -0.4 0.7 -0.2 -0.6 0.3 -0.2 -0.9 -0.5 -1.0 0.2 0.1 -0.5 -0.9 0.7 -0.1 -0.1 0.5
Hand grip strength (left) 1.3 3.3 10.4 -1.1 -1.8 3.2 0.8 -1.7 -2.0 -1.7 -2.2 -0.2 -1.2 -1.6 -1.9 -2.1 -1.7 -1.4 -1.6 -2.5 -1.9
Number of treatments/medications taken 0.3 0.6 1.5 0.3 1.1 -1.2 -0.3 0.9 0.9 0.9 0.5 0.4 0.9 0.6 0.9 1.0 0.4 0.8 0.8 0.4 0.6
Average weekly spirits intake 0.2 0.2 1.0 -1.0 0.1 1.0 -0.1 -0.2 -0.3 -0.1 -0.3 0.8 -0.2 -0.1 -0.3 -0.3 -0.1 -0.2 -0.3 -0.5 -0.7
Sensitivity / hurt feelings 1.6 2.8 4.6 1.1 1.7 -2.1 2.1 1.8 1.7 2.0 0.8 0.8 1.4 1.8 1.8 1.7 1.9 1.7 1.8 1.3 1.4
Frequency of depressed mood in last 2 weeks 1.1 1.5 4.2 1.0 1.0 -0.9 -0.1 1.0 2.0 1.4 -0.8 0.2 0.1 1.3 1.7 1.2 0.7 1.5 1.6 1.2 2.0
Hearing difficulty/problems: Yes 4.5 6.9 12.5 -2.1 -2.7 3.5 -1.5 -3.2 -2.5 -2.8 -3.4 -1.6 -2.9 -2.2 -2.7 -2.8 -2.5 -2.3 -2.5 -2.7 -2.4
Relative age of first facial hair 7.1 14.6 26.0 3.0 4.5 -3.3 2.4 4.4 3.4 4.3 5.1 0.9 4.8 3.8 3.9 3.8 4.3 3.5 3.9 3.6 3.6
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.9 0.5 0.5 1.0 -0.9 0.6 0.2 0.4 0.4 -0.7 0.5 0.2 0.2 0.3 0.5 0.3 0.3 0.1 0.1
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.2 0.2 0.8 -0.1 -0.8 0.6 0.3 0.6 1.1 -0.1 0.6 0.7 0.5 0.4 1.0 0.7 0.4 0.8 0.5
Ever had hysterectomy (womb removed) 0.1 0.2 0.9 -0.7 -0.2 1.0 -0.2 -0.6 -0.3 -0.1 -0.3 -0.8 -0.1 0.1 -0.2 -0.3 -0.1 -0.0 -0.1 -0.4 -0.2
Systolic blood pressure, automated reading 0.2 0.5 1.3 -0.0 0.4 -0.8 -1.0 0.8 0.3 0.3 1.2 0.4 1.0 0.5 0.4 0.8 0.5 0.3 0.3 1.1 0.5
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.7 -0.5 0.9 0.2 0.1 0.7 0.2 0.6 0.8 -0.8 0.1 -0.1 0.3 0.3 0.5 0.5 0.3 -0.6 0.7
Angina 0.2 0.2 1.3 -0.6 0.2 0.3 -0.8 -0.1 -0.2 -0.2 0.3 -1.1 -0.1 -0.4 -0.1 -0.3 -0.3 -0.1 -0.1 -0.8 -0.4
Medication for hormone replacement therapy 0.1 0.2 0.7 -0.1 0.4 0.3 -0.6 0.1 0.3 0.4 0.2 -0.1 0.3 0.3 0.4 -0.1 0.8 0.6 0.5 -0.2 0.4
Vitamin and mineral supplements 1.4 2.0 4.0 -1.3 -1.1 2.0 -1.4 -1.0 -2.0 -1.5 0.4 0.3 -0.4 -1.4 -1.8 -1.6 -1.1 -1.8 -1.5 -1.0 -1.8
Supplements: Zinc 6.5 7.1 10.1 -0.7 -2.4 2.9 -2.3 -2.9 -2.7 -2.6 -2.7 -2.6 -2.6 -3.2 -2.8 -2.7 -2.9 -2.7 -2.8 -3.0 -2.6
Medication: Co-codamol 0.4 0.4 1.8 -0.6 -0.3 1.4 -0.8 -0.4 -0.2 -0.0 -0.9 0.9 -0.5 -0.4 -0.4 -0.5 -0.4 0.1 -0.5 -1.1 -0.8
Medication: Metformin 0.2 0.3 1.8 -0.2 0.1 1.3 -0.0 -0.3 -0.6 -0.3 0.2 -0.4 -0.8 -0.5 -0.5 -0.7 -0.1 -0.6 -0.5 -0.8 -0.6
Diabetes (father) 0.4 0.5 2.2 -0.1 0.4 1.5 -0.9 -0.1 -1.0 -0.1 0.5 -0.8 0.5 -0.5 -0.7 -0.3 -0.4 -0.7 -0.8 -0.3 -0.8
Diabetes (mother) 0.6 0.7 2.7 -0.4 -0.2 1.2 -1.4 -0.7 -0.6 -0.5 -1.6 -1.1 -0.6 -0.6 -0.8 -0.7 -0.4 -0.7 -0.6 -1.1 -0.7
Severe depression (siblings) 2.3 2.5 9.8 0.0 -1.3 0.7 -1.9 -1.7 -1.4 -1.6 -1.5 -3.1 -1.7 -1.6 -1.5 -1.3 -1.9 -1.9 -1.5 -1.1 -1.0
Pack years adult smoking proportion 4.3 6.5 9.5 -2.4 -2.3 2.2 -2.9 -2.9 -2.4 -2.6 -3.0 -1.7 -3.0 -2.4 -2.6 -3.1 -2.7 -2.1 -2.6 -2.6 -1.9
Impedance of leg (right) 3.6 17.3 67.2 0.9 3.9 -5.2 3.4 4.5 2.9 3.9 8.2 0.6 5.3 3.4 3.7 3.7 5.1 2.9 4.1 4.1 3.2
Leg fat-free mass (left) 5.5 29.2 98.8 -2.1 -5.2 7.9 -2.0 -6.2 -4.1 -5.2 -9.9 -0.1 -7.1 -4.0 -5.0 -5.4 -5.8 -4.1 -5.2 -5.3 -4.7
Trunk fat percentage 0.1 0.4 2.5 0.8 -0.1 1.6 -0.7 0.0 0.2 -0.1 -1.0 1.0 -0.3 0.7 -0.1 -0.3 0.1 0.2 -0.2 0.4 -0.4
Hand grip strength (right) 0.7 1.9 6.6 -1.5 -1.0 2.6 0.6 -1.3 -1.4 -0.9 -1.2 -0.4 -1.0 -1.5 -1.3 -1.6 -1.2 -0.8 -1.1 -2.4 -1.3
Townsend deprivation index at recruitment 1.2 1.8 7.4 1.4 -1.4 0.9 -0.7 -1.8 -0.9 -1.4 -2.7 0.6 -1.9 -0.7 -1.2 -1.0 -1.1 -1.2 -1.4 -0.9 -1.0
Current tobacco smoking 10.0 16.3 21.8 -2.9 -3.1 3.7 -3.3 -4.6 -4.3 -4.1 -3.2 -2.7 -4.5 -4.5 -4.3 -4.7 -4.6 -4.4 -4.5 -4.3 -4.1
Average weekly fortified wine intake 0.2 0.2 1.2 -0.7 -0.2 -0.4 0.4 0.4 0.1 0.1 1.1 -0.1 0.0 0.3 0.2 0.0 0.5 0.5 0.2 0.5 0.6
Maternal smoking around birth 11.0 15.9 22.1 -2.6 -3.2 2.7 -3.5 -4.3 -4.7 -4.3 -3.2 -3.2 -3.2 -4.4 -4.6 -4.5 -4.3 -4.2 -4.5 -4.6 -4.7
Fed-up feelings 0.2 0.3 2.4 -0.5 0.2 0.9 0.0 0.1 0.6 0.6 -1.5 -0.2 -0.5 0.3 0.5 0.0 -0.0 0.5 0.4 -0.5 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 4.9 -0.4 -0.6 1.3 -1.1 -0.4 0.3 -0.3 -2.2 0.1 -1.4 -0.6 -0.0 -0.4 -1.3 -0.0 -0.2 -1.0 0.1
Relative age voice broke 5.0 7.6 12.1 2.6 3.5 -2.8 1.4 2.9 2.4 3.2 3.4 1.2 2.9 2.6 2.8 3.0 3.5 2.5 2.7 2.4 2.7
Taking other prescription medications 0.4 0.6 1.7 0.9 0.8 -1.3 -0.2 0.8 1.0 0.9 -0.2 -0.0 0.4 0.7 0.9 0.7 0.6 0.8 0.8 0.2 0.8
Age when periods started (menarche) 4.6 10.9 25.0 0.6 4.4 -2.2 1.3 4.1 3.1 4.0 5.0 0.5 3.8 2.8 3.5 3.2 3.8 3.3 3.5 2.8 3.6
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 3.3 0.4 -1.2 0.8 -1.3 -0.9 -1.0 -1.2 -0.5 -1.8 -1.1 -1.1 -0.9 -0.7 -0.6 -0.9 -1.0 -1.0 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.6 10.7 1.9 1.0 -2.6 3.3 1.8 2.4 1.7 1.7 1.6 1.1 2.1 2.2 2.2 2.2 2.0 2.2 2.6 2.9
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 -0.4 0.1 -0.5 0.3 0.1 0.0 -0.1 0.4 0.6 -0.3 0.1 0.1 0.3 0.0 -0.1 -0.0 0.4 0.5
Qualifications: CSEs or equivalent 0.7 0.9 1.6 -1.2 -0.6 0.3 -0.9 -1.2 -1.1 -1.1 -1.3 0.1 -0.7 -0.7 -1.1 -0.9 -1.2 -0.9 -1.1 -0.7 -1.1
Serious illness, injury or assault to yourself 1.0 1.2 3.8 0.6 -0.9 1.9 -0.9 -1.0 -1.2 -1.2 -1.5 1.1 -0.7 -0.6 -1.1 -0.9 -0.7 -1.1 -1.0 -1.1 -1.3
High blood pressure 0.5 1.5 3.3 1.1 1.2 -1.6 -0.1 1.3 0.9 1.0 1.4 0.6 1.7 1.2 1.0 1.8 1.1 0.9 1.0 1.7 1.1
Hayfever, allergic rhinitis or eczema 0.7 1.5 6.2 -0.7 -1.0 1.6 -2.5 -0.7 -0.9 -1.0 -0.8 -1.6 -1.0 -1.2 -1.1 -0.8 -1.2 -1.5 -1.4 -0.4 -1.0
Multivitamins +/- minerals 1.5 1.8 3.3 1.8 1.4 -1.4 1.8 0.8 1.8 1.6 -0.6 -0.4 0.6 1.2 1.6 1.5 0.9 1.6 1.4 0.9 1.8
Stomach or abdominal pain in last month 0.1 0.1 0.4 0.3 -0.0 -0.2 -0.3 0.2 0.3 0.1 0.7 -0.7 -0.1 0.0 0.3 0.5 0.3 -0.0 0.1 0.6 0.5
Supplements: Glucosamine 1.2 1.5 2.7 0.9 1.5 -1.1 1.6 1.0 1.4 1.5 0.8 0.4 1.2 1.3 1.4 1.3 1.1 1.5 1.3 1.1 1.2
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.9 1.0 0.4 -0.5 -0.4 0.7 0.5 0.5 0.5 0.7 1.4 0.8 0.6 0.8 0.8 0.4 0.7 0.7 0.3
Medication: Atenolol 0.7 0.9 5.2 -2.3 0.1 0.2 -0.0 -0.7 -1.0 -0.4 -0.1 -1.0 -0.3 -0.9 -0.8 -1.1 -0.6 -0.7 -0.9 -1.2 -1.2
Medication: Levothyroxine sodium 0.2 0.3 0.9 0.8 0.4 -0.5 0.9 0.6 0.4 0.4 0.2 0.4 0.4 0.8 0.6 0.6 0.7 0.7 0.7 0.4 0.4
Sitting height 3.7 26.1 67.2 -2.9 -5.4 7.2 -1.3 -6.1 -4.2 -5.2 -8.2 -1.4 -6.5 -4.2 -4.8 -5.3 -5.2 -4.3 -4.7 -5.2 -4.6
Chronic bronchitis/emphysema (father) 3.4 4.0 9.3 -1.5 -0.6 1.5 -2.8 -1.7 -2.3 -1.4 -1.3 -2.2 -0.8 -2.2 -2.2 -2.5 -1.7 -1.9 -2.0 -3.0 -2.4
High blood pressure (mother) 0.3 0.5 1.6 0.8 0.1 -1.3 0.6 0.6 0.3 0.3 0.9 0.4 0.4 0.6 0.5 0.7 1.2 0.7 0.5 0.5 0.5
Body mass index (BMI) 0.6 2.7 17.6 1.1 -1.5 2.5 -1.1 -1.5 -0.4 -1.3 -4.2 1.5 -2.2 -0.1 -1.0 -1.0 -1.6 -0.5 -1.4 -0.5 -0.8
Impedance of leg (left) 4.0 19.4 74.2 1.2 4.1 -5.9 3.0 4.8 3.1 4.2 8.6 0.7 5.8 3.6 3.9 3.9 5.2 3.2 4.4 4.3 3.3
Leg predicted mass (left) 5.6 29.7 99.7 -2.2 -5.3 7.9 -2.0 -6.3 -4.1 -5.2 -10.0 -0.1 -7.1 -4.1 -5.0 -5.4 -5.8 -4.2 -5.3 -5.3 -4.7
Trunk fat mass 0.6 2.5 12.4 0.4 -1.4 3.3 -0.7 -1.4 -0.6 -1.2 -3.5 1.1 -2.0 -0.1 -1.1 -1.4 -1.3 -0.7 -1.3 -0.8 -1.2
Waist circumference 0.6 2.3 13.2 0.4 -1.7 2.4 -0.2 -1.6 -0.7 -1.4 -3.6 0.7 -2.2 -0.4 -1.2 -1.3 -1.6 -0.8 -1.4 -0.8 -1.0
Number of incorrect matches in round 0.2 0.4 1.9 -0.4 0.1 -0.3 -1.4 -0.4 -0.3 0.1 -0.7 0.7 0.2 -0.3 -0.3 -0.4 -0.1 -0.0 -0.3 -1.3 -0.9
Past tobacco smoking 1.0 1.9 4.7 0.4 2.2 -0.8 0.1 1.5 1.5 2.0 0.4 1.2 2.0 1.3 1.4 1.2 1.8 1.5 1.6 0.5 1.0
Alcohol usually taken with meals 1.3 2.0 3.9 1.4 1.0 -1.9 1.8 1.3 1.4 1.1 1.9 0.1 1.0 1.4 1.4 1.4 1.4 1.2 1.3 2.0 1.4
Nervous feelings 0.9 1.6 3.3 0.6 1.6 -1.1 1.7 1.2 1.0 1.5 0.1 1.8 1.6 1.6 1.1 1.5 1.5 1.0 1.3 0.7 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.7 -0.4 0.4 0.4 -0.8 0.4 0.6 0.5 -0.7 -0.3 -0.4 -0.0 0.5 0.2 0.3 0.2 0.5 -0.2 0.2
Hearing difficulty/problems with background noise 0.2 0.3 1.4 -0.4 0.4 0.5 0.7 -0.1 -0.2 0.1 -1.0 -0.8 0.2 -0.0 -0.2 -0.3 -0.3 0.4 0.1 -1.2 -0.1
Hair/balding pattern: Pattern 2 0.6 0.8 3.1 0.7 -0.4 -1.3 1.8 0.2 0.9 -0.1 0.8 1.1 -0.2 0.7 0.8 0.7 0.5 0.5 0.8 1.3 1.4
Had menopause 0.9 1.1 2.7 0.8 1.0 -1.1 0.6 1.4 1.0 1.1 0.7 1.0 1.2 1.5 1.0 1.0 1.0 1.6 1.0 0.9 0.7
Had other major operations 0.2 0.2 0.6 -0.5 0.8 0.1 0.4 0.3 0.6 0.7 -0.4 -0.1 0.4 0.5 0.4 0.4 0.2 0.4 0.3 0.4 0.2
Forced vital capacity (FVC) 0.7 2.8 13.3 -0.7 -2.7 2.9 1.9 -2.0 -0.4 -1.5 -3.6 0.8 -2.6 -0.1 -0.8 -1.1 -1.0 -0.1 -0.7 -0.9 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 2.6 5.9 10.3 2.2 1.1 -3.0 3.2 2.2 2.6 1.9 2.7 1.8 1.4 2.4 2.5 2.2 2.7 2.3 2.6 2.8 2.9
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.8 -0.5 -0.8 1.1 -0.3 -1.2 -0.6 -0.7 -1.7 0.4 -1.1 -1.0 -0.8 -0.7 -1.1 -1.0 -0.9 -0.8 -0.8
Qualifications: None of the above 0.3 0.7 2.7 -0.5 -1.5 0.3 -0.2 -0.6 -0.4 -1.1 -1.6 1.0 -1.2 -0.6 -0.6 -0.6 -1.2 -0.2 -0.8 -0.5 -0.3
Financial difficulties in last 2 years 3.0 4.0 6.9 -2.4 -2.3 0.8 -1.7 -2.0 -1.7 -2.2 -2.5 -0.2 -2.6 -1.9 -2.1 -2.0 -2.1 -1.8 -2.2 -2.0 -1.8
Mouth/teeth dental problems 0.8 1.3 4.4 -0.6 -1.9 1.0 -0.2 -0.9 -0.8 -1.6 -2.1 1.4 -1.1 -0.7 -1.1 -0.9 -1.3 -0.8 -1.0 -0.5 -0.9
Heart attack 0.2 0.2 0.7 -0.8 -0.3 -0.1 -0.3 -0.4 -0.1 -0.3 -0.5 0.4 -0.7 -0.7 -0.2 -0.3 -0.3 -0.3 -0.3 -0.7 -0.3
Allergy 3.3 7.6 15.2 1.7 2.3 -3.1 3.9 2.7 2.4 2.6 2.8 2.1 2.9 2.9 2.7 2.6 3.0 3.0 3.0 2.5 2.6
Pain all over the body in last month 1.4 1.6 4.3 -0.2 -0.4 2.1 -2.0 -1.3 -1.0 -0.8 -1.4 -1.2 -0.9 -1.0 -1.1 -1.4 -1.1 -1.0 -1.0 -1.7 -1.2
Diabetes (self-reported) 0.1 0.2 0.8 -0.7 0.7 0.8 0.3 0.3 0.3 0.5 0.2 -0.9 -0.4 -0.2 0.3 0.1 0.3 0.1 0.2 -0.3 0.3
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 2.6 -0.5 -0.2 0.8 -1.6 -0.4 -0.5 -0.4 0.1 -0.9 -0.4 -0.7 -0.5 -0.2 -0.5 -0.7 -0.6 -0.1 -0.6
Medication: Ramipril 1.0 1.3 4.0 -0.1 0.9 1.2 -0.8 -0.6 -1.5 -0.1 -0.4 -2.0 0.5 -1.4 -1.2 -0.8 -1.0 -1.0 -1.3 -1.9 -1.7
Medication: Simvastatin 1.7 2.5 8.3 1.2 2.4 -0.9 0.8 1.6 1.4 2.1 2.9 0.1 2.1 1.3 1.6 1.1 1.8 1.3 1.7 1.1 0.9
Fluid intelligence score 1.3 2.6 6.3 -2.5 -1.3 1.4 -1.4 -1.6 -1.3 -1.4 -1.1 -1.8 -1.9 -1.9 -1.5 -1.8 -1.4 -1.9 -1.5 -1.5 -1.2
Illnesses of siblings 0.9 1.2 2.1 -1.0 -1.4 0.8 0.4 -1.3 -1.4 -1.4 -1.0 0.5 -1.2 -1.0 -1.3 -1.3 -0.8 -1.4 -1.1 -0.8 -1.1
Neuroticism score 0.2 0.4 1.5 -0.4 0.3 -0.4 1.0 0.2 0.6 0.7 -1.2 1.2 -0.2 0.8 0.4 0.4 0.5 0.6 0.4 -0.2 0.0
Weight 2.4 11.7 52.4 -0.2 -3.4 5.7 -1.1 -3.8 -2.0 -3.1 -7.2 0.8 -4.5 -1.7 -2.9 -3.1 -3.5 -2.1 -3.1 -2.8 -2.7
Impedance of arm (right) 1.0 4.5 29.2 -0.2 2.5 -2.2 0.2 2.5 0.7 2.0 5.4 -1.6 3.2 0.9 1.4 1.3 2.6 0.8 1.9 1.3 1.0
Arm fat percentage (right) 0.2 0.8 4.2 1.1 -0.5 2.1 -1.1 -0.4 -0.2 -0.5 -2.0 1.0 -0.9 0.3 -0.6 -0.6 -0.6 -0.3 -0.8 0.1 -0.6
Trunk fat-free mass 5.1 29.4 102.0 -1.7 -5.5 7.7 -1.2 -6.5 -4.0 -5.2 -10.1 -0.2 -7.2 -4.0 -5.0 -5.2 -6.0 -4.1 -5.2 -5.2 -4.5
Hip circumference 0.7 3.2 20.3 1.5 -1.6 3.8 0.2 -1.4 -0.3 -1.0 -4.5 2.2 -1.9 0.4 -0.9 -1.0 -1.3 -0.2 -1.2 -0.7 -1.1
Time employed in main current job 0.2 0.2 0.6 0.7 0.7 0.5 0.7 -0.1 -0.4 0.1 0.1 0.7 0.3 0.4 -0.2 -0.2 0.2 -0.1 -0.3 0.6 -0.3
Alcohol intake versus 10 years previously 3.2 4.9 11.6 -2.5 -3.2 1.3 -0.7 -2.5 -1.7 -2.8 -3.4 0.5 -3.0 -1.4 -2.1 -2.2 -2.7 -2.0 -2.2 -1.1 -1.7
Father’s age at death 0.4 0.6 1.4 0.3 1.0 0.1 0.2 1.2 0.7 1.2 0.9 -0.6 1.0 0.1 0.9 0.6 0.7 0.6 1.0 -0.5 0.5
Worrier / anxious feelings 4.2 7.9 12.8 2.1 3.2 -2.1 2.6 2.9 2.9 3.6 2.4 1.3 3.1 3.3 3.1 3.0 3.1 3.2 3.1 2.3 2.3
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 5.3 -0.8 -0.4 2.3 -1.5 -0.8 -0.2 -0.4 -2.2 -0.1 -1.9 -0.8 -0.5 -0.6 -0.9 -0.7 -0.7 -0.9 -0.4
Falls in the last year 0.4 0.6 3.1 0.2 0.0 0.7 -1.7 -0.2 0.4 -0.1 -1.0 -1.8 -1.4 -0.4 -0.0 0.0 -0.2 -0.3 -0.2 -0.1 0.6
Hair/balding pattern: Pattern 3 0.6 0.9 2.4 -0.1 1.5 0.1 -0.5 1.2 0.5 1.4 0.8 -1.4 1.5 0.9 0.6 0.5 1.2 1.1 0.9 -0.2 0.6
Number of live births 0.5 0.7 2.9 0.6 -0.8 0.7 -1.7 -1.0 -0.4 -0.5 -1.7 -0.4 -0.1 -0.3 -0.7 -0.4 -1.0 -0.6 -0.8 -0.1 -0.9
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 9.4 0.4 -1.7 1.8 3.1 -0.5 1.1 -0.3 -2.7 2.1 -1.5 1.1 0.6 0.4 0.3 1.2 0.7 0.3 0.8
Pulse rate 0.5 0.9 2.2 -0.4 -0.5 1.3 -1.1 -0.9 -1.0 -0.7 -0.5 -1.5 -0.5 -1.0 -1.0 -1.2 -0.9 -1.1 -1.0 -0.8 -1.1
Happiness 0.2 0.2 1.4 0.3 -0.2 1.2 -0.8 -0.4 -0.2 -0.1 -0.7 0.1 -0.6 -0.3 -0.3 -0.1 -0.0 -0.6 -0.4 0.0 -0.4
Noisy workplace 0.7 0.8 1.5 -0.9 -0.5 1.1 -0.6 -0.6 -1.0 -0.9 0.2 -1.1 -0.7 -1.0 -1.0 -1.0 -0.8 -1.0 -1.0 -0.8 -1.2
Qualifications: A levels/AS levels or equivalent 0.4 0.8 2.5 -0.5 -0.7 1.0 -0.1 -0.6 -0.9 -1.0 -0.7 -1.6 -0.9 -1.2 -0.8 -1.0 -1.2 -1.1 -0.8 -0.6 -0.7
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 4.1 1.6 0.1 -1.0 1.9 0.8 1.0 0.7 0.9 0.7 0.8 1.3 1.1 1.6 1.1 0.7 0.9 2.0 1.1
Mouth/teeth dental problems: Dentures 0.7 1.2 7.7 -0.1 1.8 0.4 -0.6 0.6 -0.3 1.1 2.8 -2.3 1.3 -0.4 0.3 0.2 0.7 -0.1 0.3 -0.1 -0.1
Asthma 5.1 10.0 16.9 -2.5 -3.4 2.7 -3.8 -3.4 -2.6 -3.3 -4.1 -1.3 -3.6 -3.0 -3.0 -3.2 -3.7 -3.2 -3.0 -3.1 -2.9
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.1 -0.8 -0.6 1.1 -0.2 -0.7 -0.6 -0.8 -0.5 0.8 -0.7 -0.4 -0.6 -0.9 -0.8 -0.6 -0.7 -0.3 -0.9
Medication: Cholesterol lowering 1.9 2.9 7.9 0.7 2.8 -1.0 -0.6 2.2 1.7 2.4 2.2 0.6 2.5 1.0 1.8 1.6 1.8 1.5 2.0 0.7 1.3
Depression (self-reported) 1.5 1.8 5.0 -1.3 -0.8 0.9 -1.9 -1.3 -1.0 -1.0 -2.2 -0.7 -1.1 -1.3 -1.2 -1.5 -1.7 -1.2 -1.1 -1.7 -1.5
Medication: Lansoprazole 0.8 0.9 3.0 1.1 1.7 -1.2 1.0 0.7 1.1 1.2 0.3 0.5 0.5 0.8 1.0 0.9 0.8 0.9 0.8 0.6 0.7
Prospective memory result 0.8 1.0 2.3 0.4 1.5 -0.8 1.4 0.7 0.8 1.4 0.3 1.0 1.1 1.5 1.0 0.7 0.9 1.4 1.0 0.5 0.4
Lung cancer (father) 0.3 0.4 0.8 -0.2 -0.9 -0.2 0.8 -0.6 -0.8 -0.9 -0.5 -0.1 -0.7 -0.5 -0.8 -0.5 -0.4 -0.6 -0.9 -0.0 -0.2
Illnesses of mother 0.3 0.4 1.5 -1.0 -0.9 0.3 0.8 -0.7 -0.4 -0.8 -0.9 -0.1 -0.4 -0.5 -0.5 -0.5 -1.2 -0.6 -0.5 -0.2 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 8.8 1.0 -0.9 1.1 3.0 -0.1 1.3 0.2 -2.1 1.6 -1.0 1.0 0.9 0.7 0.8 1.2 1.0 0.4 1.1
Pulse wave Arterial Stiffness index 0.7 0.8 1.8 0.7 -0.7 1.0 -0.8 -0.8 -1.2 -0.8 0.1 -0.9 0.0 -1.0 -1.1 -0.9 -1.0 -1.3 -0.9 -0.8 -1.4
Impedance of arm (left) 1.3 6.1 34.7 0.1 2.9 -2.5 0.8 2.9 1.0 2.4 5.9 -1.0 3.8 1.4 1.8 1.7 3.2 1.2 2.3 1.8 1.1
Arm fat mass (right) 1.0 4.1 20.9 0.7 -2.0 3.6 -1.1 -2.0 -1.0 -1.8 -4.6 1.2 -2.7 -0.5 -1.6 -1.7 -1.9 -1.1 -1.8 -1.1 -1.5
Trunk predicted mass 5.0 28.5 100.0 -1.6 -5.4 7.7 -1.1 -6.4 -3.9 -5.2 -10.0 -0.2 -7.1 -3.9 -4.9 -5.1 -5.9 -4.0 -5.1 -5.1 -4.4
Standing height 2.3 23.1 61.3 -2.9 -4.4 7.8 -0.2 -5.6 -4.1 -4.3 -7.6 -1.3 -5.7 -3.8 -4.5 -5.2 -4.7 -3.8 -4.2 -5.5 -4.6
Length of working week for main job 0.8 0.9 2.8 -0.5 -0.7 1.7 -0.6 -0.8 -1.4 -1.0 0.2 -0.0 -0.5 -0.8 -1.3 -1.0 -0.8 -1.3 -1.3 -0.3 -1.3
Exposure to tobacco smoke at home 1.2 1.3 3.7 1.4 1.6 -1.4 0.8 0.9 1.0 1.1 1.9 1.0 0.9 0.8 0.9 1.1 1.2 0.9 0.7 1.1 0.9
Breastfed as a baby 0.9 1.1 2.6 -0.7 1.5 -0.3 -0.7 1.6 0.8 1.3 1.6 -0.2 1.5 0.7 1.1 0.9 0.8 0.9 1.1 0.8 1.0
Tense / ‘highly strung’ 0.4 0.6 2.1 -0.8 -0.7 -0.5 -0.2 -0.8 -0.6 -0.8 -1.0 -0.4 -1.4 -0.8 -0.8 -0.4 -0.8 -1.1 -0.9 -0.5 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.8 0.2 -0.7 0.5 0.1 0.7 0.3 -0.7 -0.7 -0.4 0.3 0.5 0.5 0.2 0.4 0.6 -0.0 0.7
Hair/balding pattern: Pattern 4 0.2 0.5 3.6 -0.2 -0.1 -1.0 1.7 0.1 0.4 0.1 -0.6 1.9 -0.4 0.5 0.3 0.4 0.5 0.4 0.2 0.2 -0.1
Birth weight of first child 0.1 0.2 1.8 -0.3 0.3 0.1 1.3 0.2 0.3 0.3 -0.2 0.3 -0.1 0.4 0.4 0.5 0.2 0.5 0.3 0.4 0.6
Peak expiratory flow (PEF) 0.6 1.4 7.1 0.9 -1.4 1.6 2.7 -0.5 1.0 -0.3 -1.8 1.8 -1.4 0.8 0.5 0.3 0.4 0.8 0.5 0.4 0.5
Pulse wave reflection index 0.1 0.2 2.0 1.4 -0.4 0.4 0.2 0.0 0.0 -0.1 -0.6 0.2 0.2 -0.1 -0.0 0.2 -0.3 -0.1 0.0 -0.4 -0.1
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.7 0.9 1.3 1.0 -0.7 0.7 0.5 1.0 0.6 0.2 0.6 0.7 0.6 0.5 1.0 0.7 0.5 0.4 0.1
Loud music exposure frequency 4.5 4.9 7.1 -2.0 -2.6 1.7 -2.0 -2.4 -1.9 -2.4 -2.1 -1.6 -2.7 -2.2 -2.2 -2.4 -2.5 -2.3 -2.3 -2.0 -2.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.2 0.4 0.5 -0.3 0.6 0.4 0.5 0.6 -0.1 0.0 0.4 0.9 0.5 0.8 0.6 0.4 0.6 1.1 0.6
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 3.1 1.6 1.3 -1.8 1.1 1.0 1.0 0.9 1.1 1.2 0.3 1.3 0.9 1.1 1.7 1.0 0.9 1.3 0.9
Blood clot in the leg (DVT) 3.3 4.3 6.9 -2.1 -2.5 1.9 -1.2 -2.0 -2.1 -2.3 -1.4 -1.9 -2.3 -2.6 -2.0 -1.9 -2.3 -1.9 -2.1 -2.5 -1.8
Medication: Paracetamol 0.2 0.3 1.3 -0.8 -0.4 0.6 -0.8 -0.6 -0.4 -0.3 -0.6 0.2 0.0 -0.3 -0.3 -0.8 -0.8 -0.4 -0.4 -0.4 -1.1
Headache pain in last month 0.4 0.7 4.4 0.9 -0.7 2.1 -1.0 -0.7 -0.8 -0.6 -0.2 -1.1 -0.6 -0.6 -0.7 -0.5 -0.6 -0.5 -0.7 -0.6 -0.9
Medication for cholesterol, blood pressure or diabetes 1.5 2.4 5.0 -1.1 -2.1 1.8 0.6 -2.0 -1.4 -1.7 -2.2 0.0 -2.1 -0.8 -1.5 -1.8 -1.6 -1.1 -1.6 -1.2 -1.5
Glaucoma (self-reported) 2.0 2.3 3.7 0.6 1.6 -1.6 1.1 1.7 1.9 1.8 1.5 1.0 1.0 1.4 1.7 1.6 1.7 1.8 1.6 1.1 1.9
Gout (self-reported) 0.7 0.9 1.8 0.3 -1.0 0.5 -1.0 -1.2 -0.9 -1.2 -0.4 -0.6 -1.3 -1.2 -1.0 -1.0 -1.2 -0.6 -1.1 -1.4 -0.8
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.5 1.2 0.6 -0.3 1.2 0.7 0.5 0.5 0.2 0.3 0.7 1.0 0.7 0.9 0.7 0.9 0.8 0.7 0.6
Medication: Amlodipine 3.7 5.2 8.1 2.4 2.6 -2.0 0.8 2.6 2.2 2.6 2.1 1.6 2.8 2.4 2.3 2.5 2.4 2.6 2.2 2.0 1.8
Medication: Ventolin 100micrograms inhaler 0.4 0.5 2.0 0.5 -0.7 0.5 -1.4 -0.8 -0.4 -0.6 -1.4 0.1 -1.0 -0.4 -0.6 -0.2 -0.6 -0.5 -0.7 -0.5 -0.7
Birth weight 0.4 1.0 3.5 -0.6 0.6 0.4 1.8 1.2 0.7 0.9 1.9 -0.0 0.9 0.5 1.0 0.5 0.9 1.1 1.1 0.2 1.1
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.1 0.5 -0.3 1.0 -1.3 -1.0 -1.1 -0.8 -0.7 -1.4 -1.1 -1.0 -1.1 -1.4 -0.5 -1.0 -1.1 -1.4 -1.0
High blood pressure (siblings) 2.2 3.1 5.3 1.4 2.1 -1.5 0.8 2.3 1.8 2.2 2.0 0.2 2.1 1.6 1.9 2.0 1.7 2.1 1.8 1.1 1.6
Forced vital capacity (FVC), Best measure 0.5 1.7 8.5 -0.0 -1.8 2.4 1.7 -1.4 -0.2 -1.0 -2.9 0.5 -2.0 -0.2 -0.6 -0.7 -0.4 -0.1 -0.4 -0.8 -0.3
Body fat percentage 0.1 0.4 2.2 1.1 0.2 0.9 -0.2 0.4 0.6 0.3 -0.6 1.5 0.0 1.1 0.3 0.1 0.5 0.6 0.1 0.9 0.1
Leg fat percentage (right) 0.7 2.6 5.6 1.9 1.1 -0.8 1.4 1.5 1.8 1.4 0.6 2.4 1.1 2.4 1.5 1.6 1.7 1.7 1.3 2.3 1.4
Arm fat-free mass (right) 4.2 21.7 76.7 -1.6 -4.8 6.7 -0.9 -5.6 -3.3 -4.5 -8.8 0.7 -6.3 -3.2 -4.2 -4.5 -5.0 -3.3 -4.5 -4.3 -4.0
Exposure to tobacco smoke outside home 1.6 2.1 9.3 -1.1 -1.4 1.5 -0.3 -1.2 -1.1 -1.4 -0.7 -3.1 -1.1 -1.7 -1.1 -1.7 -1.8 -0.9 -0.9 -1.9 -1.1
Comparative body size at age 10 0.5 1.3 9.4 -0.0 0.5 1.1 -2.0 -0.8 -0.0 0.1 -3.1 0.4 -0.9 -0.6 -0.4 -0.9 -0.9 -0.3 -0.5 -1.8 -1.0
Number of full brothers 0.7 0.8 3.0 0.9 -1.4 1.7 -0.6 -0.7 -0.6 -0.9 -1.5 -0.1 -1.0 -0.6 -0.7 -0.4 -0.7 -0.9 -0.6 -0.8 -0.5
Worry too long after embarrassment 0.2 0.3 2.6 0.9 -0.3 -0.1 -0.5 -0.5 0.2 0.0 -1.6 0.2 -1.0 -0.2 -0.0 0.2 0.1 0.0 -0.1 -0.4 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.6 0.1 0.5 0.2 -0.7 -0.1 -0.3 0.2 -0.5 0.7 0.4 -0.4 -0.2 -0.1 -0.2 -0.5 -0.1 -0.7 -0.7
Wheeze or whistling in the chest in last year 7.0 12.5 20.0 -1.8 -3.4 3.2 -3.5 -4.2 -3.3 -4.0 -4.1 -0.7 -4.5 -3.6 -3.6 -3.6 -4.2 -3.7 -4.0 -3.0 -3.2
Number of children fathered 0.4 0.4 1.8 0.0 0.7 -1.0 1.3 0.1 0.3 0.4 1.0 0.7 0.3 0.5 0.4 0.7 0.7 0.4 0.2 0.8 0.4
Reason for reducing amount of alcohol drunk: Health precaution 2.7 3.2 6.9 1.1 2.3 -2.0 1.0 2.0 1.6 2.0 1.7 0.8 2.6 1.7 1.9 1.9 1.4 2.1 1.9 1.6 1.6
Age at first live birth 2.2 4.0 7.1 1.1 2.7 -2.3 1.3 2.2 1.6 2.1 2.4 1.5 2.0 1.8 1.9 2.0 2.6 1.5 2.1 2.0 2.1
Pulse wave peak to peak time 0.4 0.4 1.0 -1.0 0.3 -0.3 0.8 0.2 0.8 0.3 -0.8 0.9 -0.6 0.6 0.6 0.4 0.5 0.9 0.5 0.3 0.9
Health satisfaction 1.9 2.5 4.4 -0.5 -1.7 2.1 -0.9 -1.6 -1.8 -1.8 -1.3 -1.3 -1.8 -1.8 -1.7 -1.2 -1.6 -2.0 -1.7 -1.6 -1.5
Shortness of breath walking on level ground 2.5 3.0 5.5 -0.6 -1.1 2.3 -1.4 -1.7 -1.9 -1.6 -1.9 -0.9 -1.2 -1.9 -1.9 -1.7 -2.0 -2.0 -2.1 -1.7 -2.1
Qualifications: College or University degree 0.1 0.3 0.7 0.8 0.2 -0.1 0.4 0.5 0.7 0.4 0.6 0.2 -0.1 0.6 0.6 0.5 0.9 0.4 0.7 0.6 0.9
Eye problems/disorders: None of the above 0.2 0.2 1.0 0.6 0.5 -0.8 -0.2 0.6 0.3 0.4 0.3 0.1 0.8 0.4 0.2 0.6 -0.1 0.0 0.2 1.0 0.1
Mouth/teeth dental problems: Loose teeth 1.8 2.1 3.7 -1.2 -1.8 1.7 -1.0 -1.4 -1.1 -1.6 -1.7 -0.2 -1.9 -1.5 -1.4 -1.7 -1.5 -1.2 -1.4 -1.9 -1.1
Emphysema/chronic bronchitis 3.5 4.0 11.1 -1.0 -1.8 2.2 -2.4 -2.5 -1.5 -2.1 -3.3 -0.7 -2.7 -1.6 -1.8 -2.0 -2.0 -1.8 -1.8 -1.5 -1.4
Medication for pain relief, constipation, heartburn 0.3 0.5 1.3 0.1 -0.2 1.2 -0.9 -0.6 -0.9 -0.5 -0.1 -0.8 -0.4 -0.6 -0.9 -0.3 -0.2 -1.0 -0.9 -0.3 -0.7
Neck or shoulder pain in last month 0.6 0.8 2.9 0.5 -0.0 0.3 1.3 0.8 0.8 0.6 1.1 1.7 0.4 0.7 1.0 1.0 0.6 1.1 0.9 1.0 1.0
Medication: Blood pressure 1.2 2.2 4.7 1.4 1.7 -2.1 0.2 1.7 1.1 1.4 2.2 0.3 1.8 1.0 1.3 1.8 1.7 0.9 1.3 1.8 1.4
Angina (self-reported) 0.2 0.2 1.0 -0.6 0.1 0.2 -1.0 -0.2 -0.3 -0.4 0.3 -0.9 -0.2 -0.5 -0.2 -0.4 -0.4 -0.2 -0.2 -0.9 -0.5
Migraine (self-reported) 0.8 1.0 5.2 2.3 1.0 -0.6 0.5 1.0 0.8 0.9 1.4 -0.6 1.1 0.6 0.8 1.1 1.1 0.6 0.9 0.8 0.8
Medication: Ibuprofen 0.4 0.4 1.5 -0.4 -0.4 1.0 -0.6 -0.6 -0.6 -0.7 -0.3 1.2 -0.7 -0.3 -0.6 -0.7 -0.5 -0.6 -0.7 -0.2 -0.9
Medication: Allopurinol 0.8 1.0 2.5 0.2 -0.8 0.5 -1.6 -0.9 -1.0 -1.0 -0.8 -1.2 -1.0 -1.2 -1.0 -0.8 -1.2 -0.5 -1.0 -1.5 -0.8
Medication: Omeprazole 0.7 0.8 3.7 0.7 -1.5 0.6 -0.7 -0.9 -0.6 -1.2 -1.3 -0.4 -1.9 -0.4 -0.8 -0.6 -0.4 -0.9 -0.8 -0.4 -0.3
Medication: Seretide 50 evohaler 4.0 4.7 7.9 -1.7 -2.8 1.6 -1.7 -2.5 -2.3 -2.7 -1.9 -1.0 -2.3 -2.2 -2.4 -2.4 -2.3 -2.3 -2.2 -1.7 -2.1
Mean time to correctly identify matches 0.2 0.3 1.9 -0.7 0.8 -0.9 -1.4 0.5 0.3 0.4 -0.4 -0.5 0.1 0.2 0.3 -0.0 0.2 0.6 0.2 -0.3 0.6
Heart disease (mother) 0.3 0.4 1.0 0.6 -0.5 1.0 -0.6 -0.8 -0.5 -0.6 -0.5 -0.4 -0.9 -0.2 -0.6 -0.6 -0.2 -0.6 -0.7 -0.3 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 1.6 -1.3 -0.4 -0.3 0.2 -0.0 0.2 -0.0 0.3 0.1 -0.2 -0.0 -0.0 -0.1 -0.4 0.1 -0.1 0.2 -0.2
Whole body fat mass 0.6 2.5 13.9 0.6 -1.5 3.1 -0.3 -1.5 -0.6 -1.3 -3.7 1.5 -2.2 -0.0 -1.1 -1.3 -1.3 -0.6 -1.3 -0.6 -1.1
Leg fat mass (right) 0.5 1.8 12.0 0.6 -1.3 2.3 0.2 -1.1 -0.1 -1.0 -3.5 2.0 -2.0 0.4 -0.7 -0.8 -0.8 -0.2 -1.0 -0.0 -0.5
Arm predicted mass (right) 3.9 20.1 74.5 -1.3 -4.7 6.6 -0.7 -5.3 -3.1 -4.4 -8.6 0.8 -6.2 -3.0 -4.0 -4.3 -4.8 -3.0 -4.2 -4.1 -3.7
Pulse rate, automated reading 0.9 2.9 9.6 -0.1 -1.8 3.1 -0.7 -1.5 -2.2 -2.0 -0.8 -2.1 -1.2 -1.5 -1.9 -1.7 -1.6 -1.6 -1.7 -1.5 -1.5
Alcohol intake frequency. 2.3 5.4 14.9 -1.6 -2.7 2.1 -2.2 -2.5 -1.9 -2.7 -3.9 0.2 -2.8 -1.6 -2.3 -2.3 -2.3 -1.8 -2.3 -2.1 -2.6
Comparative height size at age 10 9.6 52.6 106.1 -5.6 -7.9 9.1 -2.4 -8.3 -6.2 -7.5 -10.3 -3.4 -8.3 -6.7 -7.0 -7.7 -7.9 -6.4 -6.7 -8.0 -7.0
Number of full sisters 0.2 0.2 1.7 1.0 -0.0 1.3 0.2 0.1 -0.0 0.2 -0.8 0.4 -0.1 0.1 0.1 0.1 0.1 -0.0 0.1 -0.2 0.1
Suffer from ‘nerves’ 2.5 3.8 6.3 1.8 2.1 -2.1 1.9 2.0 2.0 2.2 0.9 2.5 1.8 2.2 2.0 2.2 2.1 2.2 2.0 1.3 1.3
Overall health rating 0.4 0.8 2.6 0.7 -0.9 0.7 -1.3 -0.6 -0.5 -0.7 -1.6 0.5 -1.1 -0.8 -0.7 -0.5 -0.8 -0.7 -0.9 -1.2 -0.8
Chest pain or discomfort 0.9 1.3 4.3 -0.1 -0.6 1.7 -2.1 -1.0 -0.9 -0.9 -1.1 -0.6 -1.5 -1.0 -1.1 -1.0 -0.9 -1.4 -1.2 -1.0 -1.0
Had major operations 0.6 0.7 1.8 0.9 0.4 -0.6 0.5 1.1 0.9 0.6 0.7 -0.7 0.6 0.5 0.9 1.0 0.6 0.8 1.1 0.6 1.4
Age at last live birth 0.9 1.4 2.3 0.9 1.5 -1.4 0.3 1.3 1.2 1.4 0.8 0.7 1.2 0.9 1.2 1.4 1.5 0.9 1.3 0.9 1.4
Family relationship satisfaction 0.6 0.8 2.5 1.1 -1.0 1.4 -0.4 -0.8 -0.6 -0.9 -1.6 -0.3 -1.1 -0.8 -0.6 -0.6 -0.8 -0.9 -0.7 -0.5 -0.5
Leg pain on walking 0.2 0.3 2.0 -0.4 -0.1 0.9 -1.4 0.2 -0.1 -0.2 -0.7 0.9 -0.2 -0.2 -0.2 -0.5 -0.2 -0.2 -0.2 -0.5 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.3 -0.1 1.0 -0.2 -0.8 0.8 0.1 0.6 1.3 -1.5 1.0 -0.4 0.3 -0.1 0.0 0.2 0.4 -0.9 0.0
Commuting to job workplace: Car/motor vehicle 1.8 2.1 3.7 0.2 1.5 -1.8 1.3 1.9 1.6 1.6 1.4 0.7 1.8 0.9 1.7 1.4 1.1 1.4 1.9 0.8 1.5
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 4.6 -2.2 0.5 0.0 -0.8 0.1 0.1 0.3 0.2 -2.1 -0.0 -0.7 0.0 -0.6 -0.5 0.3 0.1 -1.1 0.1
Medication: Aspirin 0.6 0.8 1.8 0.4 1.1 -0.7 0.1 1.0 1.3 1.0 -0.0 1.4 0.4 0.8 1.1 0.8 0.4 1.1 1.1 0.4 1.1
Supplements: Vitamin C 0.1 0.1 0.6 -0.4 0.0 0.1 -0.1 0.0 0.2 0.1 -0.8 -0.1 -0.2 0.4 0.1 0.0 0.3 0.2 0.1 0.0 -0.1
Knee pain experienced in last month 0.3 0.4 1.0 0.1 0.2 -0.2 -0.3 1.0 1.0 0.6 0.7 0.7 0.3 0.3 0.9 0.7 0.2 0.9 0.8 0.4 0.7
Hypertension (Self-reported) 0.7 1.9 3.8 1.4 1.4 -1.9 0.6 1.4 1.0 1.2 1.6 1.0 1.7 1.4 1.1 2.0 1.4 1.1 1.1 1.7 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 5.5 2.1 0.4 -1.1 0.6 0.9 1.1 0.7 -0.0 2.3 0.3 1.4 1.1 1.2 0.9 0.8 1.1 1.5 1.1
Illnesses of father: Heart disease 0.1 0.2 1.0 -0.4 -0.3 1.0 0.3 -0.2 -0.1 0.0 -0.9 -0.4 0.2 0.4 -0.1 -0.0 -0.4 -0.3 0.1 0.1 -0.5
Illnesses of siblings: Diabetes 0.4 0.5 1.6 0.2 1.3 -0.4 0.1 0.5 1.0 1.0 -0.2 0.6 0.4 0.8 0.8 0.7 0.3 0.5 0.6 0.6 0.8
Smoking status: Previous 0.3 0.4 1.8 0.3 -0.7 -1.0 1.3 0.4 0.5 -0.1 0.8 -0.3 -0.1 0.5 0.5 0.8 0.0 0.6 0.4 0.9 0.7
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.2 13.3 -1.3 -2.1 3.6 0.7 -2.4 -2.1 -2.0 -2.4 0.0 -1.9 -1.7 -2.1 -2.2 -1.8 -1.8 -1.9 -2.2 -2.3
Whole body fat-free mass 5.3 30.2 106.1 -1.9 -5.5 7.9 -1.5 -6.5 -4.1 -5.3 -10.3 -0.0 -7.3 -4.0 -5.0 -5.4 -6.0 -4.1 -5.3 -5.3 -4.6
Leg fat-free mass (right) 5.7 30.5 102.0 -2.1 -5.3 7.9 -2.3 -6.3 -4.2 -5.3 -10.1 -0.0 -7.1 -4.3 -5.1 -5.5 -6.0 -4.2 -5.4 -5.5 -4.8
Arm fat percentage (left) 0.2 0.7 3.4 1.2 -0.4 1.9 -0.9 -0.3 -0.1 -0.4 -1.8 1.1 -0.7 0.5 -0.4 -0.4 -0.4 -0.1 -0.6 0.3 -0.5
Average weekly red wine intake 1.1 1.6 3.0 0.6 1.3 -1.2 1.3 1.5 1.2 1.4 1.7 0.9 1.3 1.0 1.2 1.6 1.5 1.2 1.1 0.9 1.0
Handedness (chirality/laterality): Left-handed 0.8 0.9 4.6 0.3 -1.5 0.1 -0.5 -0.9 -0.3 -1.1 -2.1 -0.3 -1.3 -0.9 -0.7 -0.4 -1.5 -1.1 -0.8 -0.6 -0.5
Mood swings 2.3 4.1 15.7 -1.7 -2.0 2.2 -1.5 -2.3 -1.4 -1.8 -4.0 -0.4 -2.9 -1.3 -1.7 -2.1 -2.0 -1.5 -1.9 -2.0 -1.6
Loneliness, isolation 0.8 1.2 2.4 1.1 1.2 -0.5 0.3 1.0 1.3 1.5 -0.6 1.5 0.8 1.4 1.1 0.9 1.0 1.3 1.2 0.6 0.9
Long-standing illness, disability or infirmity 0.4 0.6 3.6 1.0 -0.7 0.8 -0.4 -0.2 0.7 -0.2 -1.9 1.4 -1.3 0.4 0.3 0.3 0.3 0.0 0.2 0.3 0.7
Ever had bowel cancer screening 1.3 1.5 2.6 0.4 1.5 -0.8 0.0 1.6 1.5 1.6 0.8 -0.3 1.5 1.1 1.5 1.4 1.3 1.5 1.6 0.7 1.5
Diabetes diagnosed by doctor 0.2 0.3 1.1 -1.0 0.4 1.0 -0.6 0.0 -0.0 0.2 -0.2 -0.8 -0.6 -0.6 -0.1 -0.2 -0.0 -0.3 -0.2 -0.7 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 6.3 -0.5 -1.4 0.9 -1.1 -1.7 -0.6 -1.2 -2.5 -1.0 -1.4 -1.3 -1.1 -1.2 -1.7 -1.0 -1.2 -1.3 -0.8
Friendships satisfaction 0.2 0.2 1.7 0.3 -0.3 1.3 -0.9 -0.2 -0.1 0.1 -0.2 -1.0 -0.1 -0.2 -0.1 -0.2 -0.4 -0.1 -0.3 -0.0 -0.2
Qualifications: nursing, teaching 0.1 0.1 0.6 -0.5 0.2 0.4 -0.8 -0.3 -0.4 -0.0 0.4 0.2 0.2 -0.3 -0.3 -0.2 -0.2 -0.6 -0.3 0.1 -0.5
Commuting to job workplace: Walk 0.2 0.2 1.1 1.1 -0.1 0.4 -0.1 -0.4 0.1 -0.1 -0.6 0.8 -0.3 0.4 0.1 0.3 0.2 0.2 -0.0 0.4 0.1
Eye problems/disorders: Cataract 0.4 0.5 1.6 -0.2 -1.1 1.1 0.5 -0.9 -0.3 -0.8 -1.3 0.5 -0.9 -0.2 -0.4 -0.5 -0.3 -0.2 -0.2 -0.6 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.5 -0.7 0.3 -0.2 -0.1 -0.4 0.1 0.1 -0.1 -0.6 -0.2 -0.2 -0.1 -0.2 -0.3 -0.2 -0.0 -0.2 0.2
Medication for cholesterol 0.6 0.9 2.5 -0.1 -1.5 0.0 0.1 -1.2 -0.7 -1.4 -0.9 -0.3 -1.6 -1.0 -0.9 -0.7 -1.2 -1.3 -1.0 0.0 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.0 -0.0 -0.5 -0.1 -0.0 -0.6 -0.8 -0.8 -0.2 -0.9 -0.9 -0.8 -0.9 -0.5 -0.4 -0.8 -1.0 -0.4 -0.4
Back pain experienced in last month 1.7 2.5 5.3 -1.7 -2.0 0.6 -0.9 -1.7 -1.1 -1.9 -1.9 -0.1 -2.3 -1.5 -1.5 -1.8 -1.8 -1.3 -1.6 -1.4 -1.6
Mineral and other dietary supplements 0.2 0.3 1.6 -1.0 0.3 0.4 -0.5 0.5 -0.2 0.2 0.7 1.3 0.5 0.1 -0.1 0.2 0.5 -0.3 0.0 0.3 -0.1
Breast cancer (self-reported) 0.8 1.0 2.3 -0.1 -1.2 0.2 -0.5 -1.2 -0.8 -1.3 -1.0 -1.2 -1.1 -1.0 -0.9 -1.0 -1.5 -1.1 -0.9 -0.8 -0.8
Asthma (self-reported) 5.3 10.6 17.2 -2.3 -3.5 2.9 -3.8 -3.5 -2.8 -3.4 -4.2 -1.2 -3.7 -3.1 -3.2 -3.3 -3.8 -3.4 -3.2 -3.1 -3.0
Osteoporosis (self-reported) 0.6 0.8 3.3 -0.4 0.0 0.7 -1.1 -1.1 -1.2 -0.7 -0.4 -0.0 -0.2 -0.4 -1.1 -1.1 -0.6 -0.9 -1.1 -0.9 -1.8
Osteoarthritis (self-reported) 1.1 1.4 4.2 -0.6 -0.8 1.4 -1.6 -1.4 -0.7 -1.0 -1.9 -0.6 -2.1 -1.2 -1.0 -0.9 -0.9 -1.0 -1.2 -1.1 -0.6
Medication: Aspirin 1.0 1.3 2.5 0.5 1.4 -0.9 0.1 1.3 1.6 1.3 0.5 1.3 0.8 1.0 1.4 1.1 0.7 1.4 1.4 0.6 1.3
Medication: Gliclazide 0.2 0.3 2.3 -0.9 0.3 0.1 -0.0 0.1 -0.2 -0.1 -0.0 -1.5 -0.1 -0.4 -0.2 -0.3 -0.4 0.0 -0.2 -0.9 -0.4
Illnesses of father: None of the above (group 1) 0.4 0.6 3.3 0.3 -1.4 -1.8 1.0 -0.2 0.2 -1.0 -0.1 -0.0 -1.1 -0.4 -0.1 0.1 -0.4 0.1 -0.3 0.5 0.8
Smoking status: Current 10.4 16.4 22.0 -3.0 -3.1 3.7 -3.3 -4.6 -4.4 -4.0 -3.1 -2.9 -4.4 -4.5 -4.4 -4.7 -4.5 -4.4 -4.6 -4.3 -4.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 8.5 17.9 28.7 2.6 2.8 -3.6 5.4 4.1 5.0 4.0 1.5 3.8 3.3 4.9 4.8 4.9 4.5 5.1 4.9 3.9 4.8
Whole body water mass 5.4 31.0 108.2 -1.9 -5.6 7.9 -1.6 -6.5 -4.1 -5.4 -10.4 -0.1 -7.4 -4.1 -5.1 -5.4 -6.1 -4.2 -5.3 -5.3 -4.7
Leg predicted mass (right) 5.9 31.4 102.9 -2.2 -5.4 7.9 -2.4 -6.4 -4.3 -5.4 -10.1 -0.1 -7.2 -4.4 -5.2 -5.5 -6.1 -4.3 -5.5 -5.6 -4.9
Arm fat mass (left) 1.1 4.6 21.5 0.7 -2.1 3.8 -1.0 -2.1 -1.2 -1.9 -4.6 1.1 -2.7 -0.7 -1.8 -1.9 -2.1 -1.2 -2.0 -1.2 -1.7
Number of self-reported non-cancer illnesses 0.1 0.2 0.8 0.8 0.9 -0.4 -0.5 0.3 0.2 0.4 0.2 -0.0 0.4 0.1 0.2 0.6 0.5 -0.0 0.1 0.2 0.2
Average weekly champagne plus white wine intake 0.5 0.7 3.7 1.1 1.1 -1.2 0.1 0.9 0.2 0.8 1.9 -0.1 1.6 0.1 0.5 0.4 0.7 0.5 0.6 -0.2 -0.1
Miserableness 0.7 1.2 9.8 -0.1 -1.1 1.6 0.5 -1.3 0.2 -0.3 -3.1 0.5 -1.7 -0.2 -0.1 -0.6 -0.8 -0.3 -0.3 -0.7 -0.3
Guilty feelings 0.6 1.0 7.6 -0.1 -1.2 0.8 0.4 -1.2 -0.4 -0.7 -2.8 1.1 -1.5 0.1 -0.6 -0.4 -0.7 -0.0 -0.7 -0.5 -0.6
Wears glasses or contact lenses 0.6 0.7 2.4 -0.1 1.1 -1.0 -0.8 0.9 1.0 1.1 0.2 -0.4 0.6 0.7 1.0 0.5 0.6 1.5 1.0 -0.0 1.0
Ever taken oral contraceptive pill 0.9 1.1 3.1 0.7 0.6 -0.9 0.5 1.2 1.1 0.8 1.6 0.6 0.6 1.3 1.1 0.8 1.0 0.9 1.0 1.8 1.0
Hearing aid user 0.7 0.7 1.9 -0.4 -0.9 1.4 -0.6 -0.6 -0.5 -1.1 -1.2 -0.7 -1.3 -0.9 -0.7 -0.8 -0.7 -0.5 -0.6 -1.3 -0.4
Mother’s age at death 0.1 0.2 1.1 -0.0 -0.5 -0.9 1.1 0.2 0.1 -0.2 0.0 -0.7 0.2 0.1 0.2 0.2 -0.2 -0.1 0.4 0.3 0.4
Financial situation satisfaction 0.6 0.8 2.3 0.6 -0.1 1.3 0.2 -1.0 -0.8 -0.6 -1.5 1.0 -1.0 -0.6 -0.7 -0.9 -0.9 -0.7 -0.9 -0.9 -1.2
Tinnitus: Yes, now most or all of the time 0.8 0.9 3.8 0.4 -1.3 0.3 -0.7 -1.0 -0.7 -1.2 -1.9 0.7 -1.0 -0.8 -0.8 -0.3 -1.3 -1.1 -1.0 -0.2 -0.7
Commuting to job workplace: Public transport 0.6 0.8 2.9 -0.1 -0.5 0.8 -0.5 -0.8 -1.0 -0.8 -0.5 -1.7 -1.0 -0.8 -1.0 -0.8 -0.7 -0.9 -1.1 -0.5 -0.8
Eye problems/disorders: Glaucoma 0.2 0.3 0.9 -0.7 0.4 -0.9 -0.1 0.7 0.7 0.4 0.7 0.3 -0.3 0.0 0.5 0.3 0.3 0.5 0.4 0.1 0.9
Medication: Blood pressure 0.7 1.2 3.0 1.0 1.1 -0.6 0.4 1.6 0.8 1.3 1.4 0.5 1.7 1.1 1.0 1.4 1.0 1.6 0.9 0.6 0.6
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.6 -0.6 -0.5 -0.3 -0.1 0.2 1.2 0.3 -0.4 -0.4 -1.3 0.2 0.8 0.1 -0.0 1.0 0.5 0.0 0.8
Supplements: Fish oil (including cod liver oil) 0.9 1.2 5.4 -0.2 -0.7 0.7 -0.8 -1.0 -0.9 -0.9 -1.2 -2.3 -1.0 -1.1 -0.9 -1.0 -1.6 -0.6 -1.0 -1.1 -0.9
High cholesterol (Self-reported) 1.6 2.9 10.4 0.2 3.2 -1.4 -0.3 1.8 1.4 2.3 3.0 -0.6 2.4 0.9 1.6 1.2 1.9 1.2 1.8 0.6 1.1
Medication: Bendroflumethiazide 0.3 0.4 1.5 0.1 1.2 0.0 -0.5 1.0 0.1 0.7 1.0 -0.7 1.1 0.3 0.3 0.6 0.2 0.5 0.1 0.4 0.2
Medication: Paracetamol 0.2 0.4 1.3 -0.4 -0.1 1.0 -1.1 -0.8 -0.4 -0.2 -0.4 -0.1 -0.1 -0.5 -0.4 -0.8 -0.8 -0.5 -0.5 -0.5 -1.0
Medication: Lisinopril 0.1 0.2 1.6 0.1 0.1 -0.6 -1.3 -0.1 -0.2 -0.1 0.2 0.3 0.3 -0.0 -0.2 0.4 0.0 -0.2 -0.2 0.4 -0.2
Medication: Atorvastatin 0.4 0.5 2.4 -1.5 1.3 -0.4 -1.3 0.1 -0.0 0.5 0.2 -1.1 0.2 -0.4 -0.1 -0.4 -0.1 0.2 -0.0 -1.1 -0.2
Illnesses of father: High blood pressure 2.7 3.4 9.0 0.8 3.0 -1.2 0.6 2.0 1.4 2.3 2.0 1.4 2.4 2.3 1.7 1.9 2.0 1.4 1.6 2.1 1.0
Alcohol drinker status: Never 0.6 0.7 8.1 0.2 0.3 1.0 -2.8 -0.3 -0.2 0.0 -1.0 -0.1 -0.6 -0.2 -0.4 -0.0 0.2 -0.3 -0.4 -0.6 -0.6
Ever smoked 1.2 2.1 4.8 -0.5 -2.0 1.4 -0.3 -1.7 -1.6 -2.0 -0.4 -1.0 -2.2 -1.4 -1.5 -1.3 -1.8 -1.7 -1.7 -0.3 -0.8
Basal metabolic rate 4.8 26.7 96.1 -1.6 -5.2 7.6 -1.5 -6.0 -3.7 -5.0 -9.8 0.2 -6.8 -3.6 -4.7 -5.0 -5.6 -3.8 -4.9 -4.8 -4.3
Leg fat percentage (left) 0.6 2.1 4.8 1.9 0.9 -0.9 1.0 1.3 1.6 1.2 0.4 2.2 1.0 2.1 1.4 1.4 1.4 1.5 1.1 2.1 1.2
Arm fat-free mass (left) 4.4 22.4 83.4 -1.3 -5.0 6.9 -1.1 -5.6 -3.3 -4.6 -9.1 0.6 -6.3 -3.2 -4.3 -4.5 -5.1 -3.3 -4.5 -4.5 -4.0
Number of operations (self-reported) 0.1 0.2 0.7 -0.2 0.2 0.8 -0.9 -0.4 0.0 -0.1 -0.8 -0.4 -0.4 -0.3 -0.1 -0.3 -0.6 -0.1 -0.1 -0.4 0.0
Average weekly beer plus cider intake 0.3 0.4 1.4 0.8 -0.2 -1.2 -0.0 0.5 0.9 0.3 0.1 0.8 0.3 0.3 0.7 0.8 0.1 0.6 0.6 0.7 1.0
Irritability 1.4 2.4 6.2 -2.3 -0.9 2.5 -0.8 -1.4 -1.3 -1.2 -1.9 -1.4 -1.9 -1.4 -1.3 -1.5 -1.6 -1.5 -1.3 -1.4 -1.1
Risk taking 0.4 0.6 1.1 -1.0 -0.1 0.1 -1.0 -1.0 -1.1 -0.8 -0.3 0.0 -0.5 -0.9 -1.0 -0.9 -0.9 -0.9 -1.0 -0.7 -0.7
Ever had prostate specific antigen (PSA) test 0.1 0.1 1.0 -0.7 -0.7 -1.0 -0.2 -0.3 -0.1 -0.4 0.1 -0.1 -0.5 -0.3 -0.1 -0.2 -0.2 -0.0 -0.1 -0.1 0.1
Fractured/broken bones in last 5 years 2.1 2.7 6.2 -1.9 -1.6 2.5 -1.5 -1.3 -1.7 -1.5 -1.5 0.4 -1.2 -1.5 -1.7 -1.6 -1.8 -1.9 -1.9 -1.2 -2.1
Age started oral contraceptive pill 1.9 2.4 4.4 2.1 1.6 -0.3 0.5 2.1 1.6 1.8 1.5 0.9 1.8 1.6 1.6 1.5 1.7 1.9 1.8 1.2 1.4
Diastolic blood pressure, automated reading 0.3 0.9 3.8 1.9 0.0 0.3 1.0 0.5 0.5 0.1 0.5 1.5 0.2 1.1 0.6 1.4 0.7 0.3 0.3 2.0 1.0
Ever depressed for a whole week 0.3 0.4 2.2 -0.2 -0.8 0.8 -0.3 -0.7 -0.2 -0.5 -1.5 -0.1 -0.9 -0.5 -0.3 -0.4 -0.7 -0.5 -0.4 -0.5 -0.3
Unable to work because of sickness or disability 0.6 0.8 4.5 -1.3 -0.3 0.5 -0.6 -1.0 -0.4 -0.8 -2.1 0.2 -1.4 -0.7 -0.6 -0.9 -0.8 -0.4 -0.6 -1.1 -0.6
Commuting to job workplace: Cycle 0.1 0.1 1.2 1.1 -0.1 -0.1 0.2 -0.1 0.1 -0.1 -0.0 0.2 -0.1 0.5 0.1 0.3 0.1 0.1 0.1 0.3 0.2
Myopia 0.3 0.4 3.2 0.3 -0.6 0.0 -0.7 -0.5 -0.2 -0.2 -1.8 1.4 -0.4 -0.0 -0.4 -0.2 -0.2 -0.6 -0.2 -0.3 -0.6
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.7 -1.3 -1.0 1.5 -0.3 -1.0 -0.8 -0.9 -1.1 -0.7 -1.4 -1.0 -0.9 -1.6 -0.9 -0.8 -0.8 -1.3 -1.0
Cholesterol lowering medication 1.2 1.8 5.7 0.9 2.4 -0.6 1.0 1.5 1.0 1.9 2.0 0.1 1.9 1.4 1.2 0.8 1.6 1.2 1.2 0.8 0.5
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 2.7 0.9 -1.0 -0.1 -0.2 -0.5 -0.1 -0.8 -1.0 -0.2 -1.6 -0.0 -0.3 -0.2 -0.0 -0.4 -0.4 0.1 0.2
Pain experienced in last month 0.3 0.5 1.2 -0.9 -0.4 -0.7 -0.5 -0.8 -0.8 -0.8 -1.1 -0.3 -0.5 -0.8 -0.9 -0.5 -0.6 -1.1 -0.8 -0.6 -0.5
Supplements: Calcium 0.2 0.3 1.3 -0.1 -0.7 -0.7 -0.7 -0.2 0.1 -0.5 -1.1 0.7 -0.4 -0.3 -0.2 -0.2 -0.6 0.1 -0.1 -0.7 -0.1
Basal cell carcinoma (self-reported) 1.0 1.2 2.9 -1.5 -0.8 0.8 -0.9 -1.3 -1.0 -0.9 -0.9 -0.4 -1.0 -1.1 -1.1 -1.2 -0.7 -1.0 -1.0 -1.7 -1.3
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.7 -0.8 -0.4 0.1 -0.3 -0.4 -0.1 -0.3 -0.6 0.5 -0.7 -0.7 -0.2 -0.4 -0.5 -0.2 -0.3 -0.9 -0.3
Deep venous thrombosis (DVT) (self-reported) 3.1 4.0 6.7 -2.1 -2.2 1.8 -1.1 -1.9 -2.1 -2.1 -1.2 -1.9 -2.0 -2.6 -2.0 -1.9 -2.2 -1.9 -2.1 -2.5 -1.8
Heart disease (siblings) 0.3 0.4 3.3 1.8 0.5 0.1 -0.1 0.4 0.0 0.4 1.1 0.6 0.6 0.1 0.2 0.3 0.5 0.0 0.1 -0.0 -0.3
Alcohol drinker status: Previous 0.2 0.2 0.7 -0.5 -0.8 0.3 -0.3 -0.2 -0.4 -0.7 0.0 -0.3 -0.1 -0.4 -0.4 -0.5 -0.4 -0.1 -0.4 -0.8 -0.6
Pack years of smoking 3.1 4.5 8.2 -2.0 -1.8 1.7 -2.9 -2.4 -1.9 -2.1 -2.7 -1.8 -2.5 -1.9 -2.1 -2.6 -2.3 -1.6 -2.1 -2.1 -1.4
Impedance of whole body 2.8 14.2 65.4 0.6 3.9 -4.5 2.0 4.3 2.3 3.6 8.1 -0.2 5.3 2.8 3.2 3.0 4.6 2.5 3.7 3.2 2.4
Leg fat mass (left) 0.5 2.0 12.9 0.6 -1.5 2.2 -0.0 -1.3 -0.2 -1.1 -3.6 1.8 -2.1 0.2 -0.8 -0.9 -1.0 -0.3 -1.1 -0.2 -0.7
Arm predicted mass (left) 4.3 21.7 79.2 -1.3 -5.0 6.8 -0.9 -5.5 -3.3 -4.6 -8.9 0.7 -6.2 -3.1 -4.2 -4.5 -5.1 -3.3 -4.4 -4.3 -3.9