TWAS hub - MRPL43

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1334	0.0485	3.1e-04	0.046	NA	0.049	NA	0.060	1.5e-04	NA	1.1e-04	NA	1.8e-05
2	GTEx	Heart Atrial Appendage	0.1560	0.0570	2.2e-03	0.074	NA	0.085	NA	0.093	3.1e-04	NA	1.2e-04	NA	5.8e-05
3	METSIM	Adipose	0.0483	0.0167	1.0e-04	0.035	0.034	0.025	0.038	0.027	4.5e-06	6.0e-06	8.5e-05	1.9e-06	4.9e-05
4	NTR	Blood	0.0380	0.0107	3.6e-07	0.018	0.029	0.022	0.029	0.021	1.3e-06	8.1e-10	1.2e-07	9.0e-10	1.4e-07
5	ROSMAP	Brain Pre-frontal Cortex	0.0964	0.0235	7.5e-10	0.085	0.080	0.086	0.090	0.088	5.2e-11	2.0e-10	3.7e-11	1.2e-11	1.8e-11
6	YFS	Blood	0.2127	0.0281	0.0e+00	0.281	0.261	0.277	0.284	0.283	1.1e-92	3.5e-85	3.1e-91	1.1e-93	2.2e-93
7	TCGA	Breast Invasive Carcinoma	0.0220	0.0102	7.2e-05	0.024	0.023	0.028	NA	0.027	6.8e-06	1.1e-05	1.5e-06	NA	2.7e-06
8	TCGA	Colon Adenocarcinoma	0.0740	0.0490	8.4e-03	0.018	0.004	0.002	NA	0.001	3.1e-02	1.7e-01	2.4e-01	NA	2.8e-01
9	TCGA	Glioblastoma Multiforme	0.3110	0.1180	1.1e-04	-0.007	0.101	0.151	NA	0.065	6.1e-01	5.7e-04	2.4e-05	NA	4.9e-03
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0282	0.0139	8.7e-04	0.020	0.029	0.004	NA	0.008	2.4e-03	3.0e-04	1.0e-01	NA	3.4e-02
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0223	0.0114	5.6e-03	0.020	0.018	0.016	NA	0.017	2.1e-03	3.5e-03	6.1e-03	NA	4.6e-03
12	TCGA	Brain Lower Grade Glioma	0.0792	0.0281	5.6e-10	0.117	0.087	0.097	NA	0.116	3.4e-13	4.5e-10	4.4e-11	NA	3.9e-13
13	TCGA	Liver Hepatocellular Carcinoma	0.0550	0.0290	8.3e-03	0.046	0.031	0.047	NA	0.046	3.2e-03	1.3e-02	3.0e-03	NA	3.2e-03
14	TCGA	Ovarian Serous Cystadenocarcinoma	0.0610	0.0300	2.1e-04	0.039	0.042	0.040	NA	0.032	1.2e-03	7.4e-04	1.1e-03	NA	3.0e-03
15	TCGA	Pheochromocytoma and Paraganglioma	0.2740	0.0780	1.6e-08	0.236	0.176	0.213	NA	0.211	8.1e-10	1.6e-07	6.4e-09	NA	7.8e-09
16	TCGA	Prostate Adenocarcinoma	0.1326	0.0426	2.7e-14	0.155	0.143	0.148	NA	0.149	6.5e-16	1.0e-14	3.1e-15	NA	2.4e-15
17	TCGA	Stomach Adenocarcinoma	0.1040	0.0400	1.2e-07	0.071	0.092	0.078	NA	0.067	7.9e-06	3.3e-07	2.9e-06	NA	1.3e-05
18	TCGA	Thyroid Carcinoma	0.1970	0.0500	0.0e+00	0.228	0.256	0.245	NA	0.242	5.4e-22	8.0e-25	1.2e-23	NA	2.4e-23

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Maternal smoking around birth	11.0	15.9	22.1	-2.6	-3.2	2.7	-3.5	-4.3	-4.7	-4.3	-3.2	-3.2	-3.2	-4.4	-4.6	-4.5	-4.3	-4.2	-4.5	-4.6	-4.7
Smoking status: Current	10.4	16.4	22.0	-3.0	-3.1	3.7	-3.3	-4.6	-4.4	-4.0	-3.1	-2.9	-4.4	-4.5	-4.4	-4.7	-4.5	-4.4	-4.6	-4.3	-4.2
Current tobacco smoking	10.0	16.3	21.8	-2.9	-3.1	3.7	-3.3	-4.6	-4.3	-4.1	-3.2	-2.7	-4.5	-4.5	-4.3	-4.7	-4.6	-4.4	-4.5	-4.3	-4.1
Comparative height size at age 10	9.6	52.6	106.1	-5.6	-7.9	9.1	-2.4	-8.3	-6.2	-7.5	-10.3	-3.4	-8.3	-6.7	-7.0	-7.7	-7.9	-6.4	-6.7	-8.0	-7.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	8.5	17.9	28.7	2.6	2.8	-3.6	5.4	4.1	5.0	4.0	1.5	3.8	3.3	4.9	4.8	4.9	4.5	5.1	4.9	3.9	4.8
Relative age of first facial hair	7.1	14.6	26.0	3.0	4.5	-3.3	2.4	4.4	3.4	4.3	5.1	0.9	4.8	3.8	3.9	3.8	4.3	3.5	3.9	3.6	3.6
Wheeze or whistling in the chest in last year	7.0	12.5	20.0	-1.8	-3.4	3.2	-3.5	-4.2	-3.3	-4.0	-4.1	-0.7	-4.5	-3.6	-3.6	-3.6	-4.2	-3.7	-4.0	-3.0	-3.2
Age at First Birth	6.7	9.8	13.8	2.1	3.7	-2.4	1.5	3.7	2.8	3.5	3.6	2.2	3.7	3.4	3.1	3.4	3.4	3.0	3.0	3.6	3.0
Supplements: Zinc	6.5	7.1	10.1	-0.7	-2.4	2.9	-2.3	-2.9	-2.7	-2.6	-2.7	-2.6	-2.6	-3.2	-2.8	-2.7	-2.9	-2.7	-2.8	-3.0	-2.6
Leg predicted mass (right)	5.9	31.4	102.9	-2.2	-5.4	7.9	-2.4	-6.4	-4.3	-5.4	-10.1	-0.1	-7.2	-4.4	-5.2	-5.5	-6.1	-4.3	-5.5	-5.6	-4.9
Leg fat-free mass (right)	5.7	30.5	102.0	-2.1	-5.3	7.9	-2.3	-6.3	-4.2	-5.3	-10.1	-0.0	-7.1	-4.3	-5.1	-5.5	-6.0	-4.2	-5.4	-5.5	-4.8
Leg predicted mass (left)	5.6	29.7	99.7	-2.2	-5.3	7.9	-2.0	-6.3	-4.1	-5.2	-10.0	-0.1	-7.1	-4.1	-5.0	-5.4	-5.8	-4.2	-5.3	-5.3	-4.7
Leg fat-free mass (left)	5.5	29.2	98.8	-2.1	-5.2	7.9	-2.0	-6.2	-4.1	-5.2	-9.9	-0.1	-7.1	-4.0	-5.0	-5.4	-5.8	-4.1	-5.2	-5.3	-4.7
Whole body water mass	5.4	31.0	108.2	-1.9	-5.6	7.9	-1.6	-6.5	-4.1	-5.4	-10.4	-0.1	-7.4	-4.1	-5.1	-5.4	-6.1	-4.2	-5.3	-5.3	-4.7
Whole body fat-free mass	5.3	30.2	106.1	-1.9	-5.5	7.9	-1.5	-6.5	-4.1	-5.3	-10.3	-0.0	-7.3	-4.0	-5.0	-5.4	-6.0	-4.1	-5.3	-5.3	-4.6
Asthma (self-reported)	5.3	10.6	17.2	-2.3	-3.5	2.9	-3.8	-3.5	-2.8	-3.4	-4.2	-1.2	-3.7	-3.1	-3.2	-3.3	-3.8	-3.4	-3.2	-3.1	-3.0
Trunk fat-free mass	5.1	29.4	102.0	-1.7	-5.5	7.7	-1.2	-6.5	-4.0	-5.2	-10.1	-0.2	-7.2	-4.0	-5.0	-5.2	-6.0	-4.1	-5.2	-5.2	-4.5
Asthma	5.1	10.0	16.9	-2.5	-3.4	2.7	-3.8	-3.4	-2.6	-3.3	-4.1	-1.3	-3.6	-3.0	-3.0	-3.2	-3.7	-3.2	-3.0	-3.1	-2.9
Relative age voice broke	5.0	7.6	12.1	2.6	3.5	-2.8	1.4	2.9	2.4	3.2	3.4	1.2	2.9	2.6	2.8	3.0	3.5	2.5	2.7	2.4	2.7
Trunk predicted mass	5.0	28.5	100.0	-1.6	-5.4	7.7	-1.1	-6.4	-3.9	-5.2	-10.0	-0.2	-7.1	-3.9	-4.9	-5.1	-5.9	-4.0	-5.1	-5.1	-4.4
Basal metabolic rate	4.8	26.7	96.1	-1.6	-5.2	7.6	-1.5	-6.0	-3.7	-5.0	-9.8	0.2	-6.8	-3.6	-4.7	-5.0	-5.6	-3.8	-4.9	-4.8	-4.3
Smoking Status	4.6	11.1	19.4	-2.6	-3.8	2.5	-1.8	-3.9	-3.5	-4.0	-2.6	-2.8	-4.4	-3.3	-3.5	-3.4	-3.7	-3.4	-3.7	-2.9	-3.0
Age when periods started (menarche)	4.6	10.9	25.0	0.6	4.4	-2.2	1.3	4.1	3.1	4.0	5.0	0.5	3.8	2.8	3.5	3.2	3.8	3.3	3.5	2.8	3.6
Hearing difficulty/problems: Yes	4.5	6.9	12.5	-2.1	-2.7	3.5	-1.5	-3.2	-2.5	-2.8	-3.4	-1.6	-2.9	-2.2	-2.7	-2.8	-2.5	-2.3	-2.5	-2.7	-2.4
Loud music exposure frequency	4.5	4.9	7.1	-2.0	-2.6	1.7	-2.0	-2.4	-1.9	-2.4	-2.1	-1.6	-2.7	-2.2	-2.2	-2.4	-2.5	-2.3	-2.3	-2.0	-2.2
Arm fat-free mass (left)	4.4	22.4	83.4	-1.3	-5.0	6.9	-1.1	-5.6	-3.3	-4.6	-9.1	0.6	-6.3	-3.2	-4.3	-4.5	-5.1	-3.3	-4.5	-4.5	-4.0
Pack years adult smoking proportion	4.3	6.5	9.5	-2.4	-2.3	2.2	-2.9	-2.9	-2.4	-2.6	-3.0	-1.7	-3.0	-2.4	-2.6	-3.1	-2.7	-2.1	-2.6	-2.6	-1.9
Arm predicted mass (left)	4.3	21.7	79.2	-1.3	-5.0	6.8	-0.9	-5.5	-3.3	-4.6	-8.9	0.7	-6.2	-3.1	-4.2	-4.5	-5.1	-3.3	-4.4	-4.3	-3.9
Worrier / anxious feelings	4.2	7.9	12.8	2.1	3.2	-2.1	2.6	2.9	2.9	3.6	2.4	1.3	3.1	3.3	3.1	3.0	3.1	3.2	3.1	2.3	2.3
Arm fat-free mass (right)	4.2	21.7	76.7	-1.6	-4.8	6.7	-0.9	-5.6	-3.3	-4.5	-8.8	0.7	-6.3	-3.2	-4.2	-4.5	-5.0	-3.3	-4.5	-4.3	-4.0
Impedance of leg (left)	4.0	19.4	74.2	1.2	4.1	-5.9	3.0	4.8	3.1	4.2	8.6	0.7	5.8	3.6	3.9	3.9	5.2	3.2	4.4	4.3	3.3
Medication: Seretide 50 evohaler	4.0	4.7	7.9	-1.7	-2.8	1.6	-1.7	-2.5	-2.3	-2.7	-1.9	-1.0	-2.3	-2.2	-2.4	-2.4	-2.3	-2.3	-2.2	-1.7	-2.1
Arm predicted mass (right)	3.9	20.1	74.5	-1.3	-4.7	6.6	-0.7	-5.3	-3.1	-4.4	-8.6	0.8	-6.2	-3.0	-4.0	-4.3	-4.8	-3.0	-4.2	-4.1	-3.7
Sitting height	3.7	26.1	67.2	-2.9	-5.4	7.2	-1.3	-6.1	-4.2	-5.2	-8.2	-1.4	-6.5	-4.2	-4.8	-5.3	-5.2	-4.3	-4.7	-5.2	-4.6
Medication: Amlodipine	3.7	5.2	8.1	2.4	2.6	-2.0	0.8	2.6	2.2	2.6	2.1	1.6	2.8	2.4	2.3	2.5	2.4	2.6	2.2	2.0	1.8
Impedance of leg (right)	3.6	17.3	67.2	0.9	3.9	-5.2	3.4	4.5	2.9	3.9	8.2	0.6	5.3	3.4	3.7	3.7	5.1	2.9	4.1	4.1	3.2
Alzheimer’s Disease (including proxy)	3.5	5.1	9.5	0.8	1.8	-2.6	1.1	2.9	2.5	2.3	3.1	1.4	1.9	2.1	2.6	2.5	2.4	2.3	2.4	2.3	2.4
Emphysema/chronic bronchitis	3.5	4.0	11.1	-1.0	-1.8	2.2	-2.4	-2.5	-1.5	-2.1	-3.3	-0.7	-2.7	-1.6	-1.8	-2.0	-2.0	-1.8	-1.8	-1.5	-1.4
Body Mass Index (BMI) (2010)	3.4	4.7	8.1	2.9	1.3	-2.4	2.1	2.2	2.7	1.7	0.4	2.5	0.3	2.3	2.2	2.5	2.4	2.1	2.0	2.3	2.8
Chronic bronchitis/emphysema (father)	3.4	4.0	9.3	-1.5	-0.6	1.5	-2.8	-1.7	-2.3	-1.4	-1.3	-2.2	-0.8	-2.2	-2.2	-2.5	-1.7	-1.9	-2.0	-3.0	-2.4
Respiratory disease	3.3	7.4	14.1	-1.5	-2.8	2.6	-3.4	-3.0	-2.2	-2.8	-3.8	-2.0	-3.1	-2.7	-2.6	-2.7	-3.1	-2.8	-2.6	-2.7	-2.0
Allergy	3.3	7.6	15.2	1.7	2.3	-3.1	3.9	2.7	2.4	2.6	2.8	2.1	2.9	2.9	2.7	2.6	3.0	3.0	3.0	2.5	2.6
Blood clot in the leg (DVT)	3.3	4.3	6.9	-2.1	-2.5	1.9	-1.2	-2.0	-2.1	-2.3	-1.4	-1.9	-2.3	-2.6	-2.0	-1.9	-2.3	-1.9	-2.1	-2.5	-1.8
Alcohol intake versus 10 years previously	3.2	4.9	11.6	-2.5	-3.2	1.3	-0.7	-2.5	-1.7	-2.8	-3.4	0.5	-3.0	-1.4	-2.1	-2.2	-2.7	-2.0	-2.2	-1.1	-1.7
Deep venous thrombosis (DVT) (self-reported)	3.1	4.0	6.7	-2.1	-2.2	1.8	-1.1	-1.9	-2.1	-2.1	-1.2	-1.9	-2.0	-2.6	-2.0	-1.9	-2.2	-1.9	-2.1	-2.5	-1.8
Pack years of smoking	3.1	4.5	8.2	-2.0	-1.8	1.7	-2.9	-2.4	-1.9	-2.1	-2.7	-1.8	-2.5	-1.9	-2.1	-2.6	-2.3	-1.6	-2.1	-2.1	-1.4
Financial difficulties in last 2 years	3.0	4.0	6.9	-2.4	-2.3	0.8	-1.7	-2.0	-1.7	-2.2	-2.5	-0.2	-2.6	-1.9	-2.1	-2.0	-2.1	-1.8	-2.2	-2.0	-1.8
Impedance of whole body	2.8	14.2	65.4	0.6	3.9	-4.5	2.0	4.3	2.3	3.6	8.1	-0.2	5.3	2.8	3.2	3.0	4.6	2.5	3.7	3.2	2.4
Height	2.7	51.7	130.0	-4.6	-6.5	10.8	-2.2	-8.2	-6.2	-6.6	-11.4	-2.1	-8.2	-6.0	-6.8	-7.8	-7.4	-6.0	-6.6	-8.2	-7.1
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	6.9	1.1	2.3	-2.0	1.0	2.0	1.6	2.0	1.7	0.8	2.6	1.7	1.9	1.9	1.4	2.1	1.9	1.6	1.6
Illnesses of father: High blood pressure	2.7	3.4	9.0	0.8	3.0	-1.2	0.6	2.0	1.4	2.3	2.0	1.4	2.4	2.3	1.7	1.9	2.0	1.4	1.6	2.1	1.0
Mean Putamen Volume	2.6	3.0	5.5	1.8	1.6	-0.0	1.4	1.6	2.3	2.0	0.7	1.5	1.3	2.0	2.2	1.8	1.7	2.1	2.1	1.4	2.0
Heel bone mineral density (BMD) T-score, automated (right)	2.6	5.9	10.3	2.2	1.1	-3.0	3.2	2.2	2.6	1.9	2.7	1.8	1.4	2.4	2.5	2.2	2.7	2.3	2.6	2.8	2.9
Shortness of breath walking on level ground	2.5	3.0	5.5	-0.6	-1.1	2.3	-1.4	-1.7	-1.9	-1.6	-1.9	-0.9	-1.2	-1.9	-1.9	-1.7	-2.0	-2.0	-2.1	-1.7	-2.1
Suffer from ‘nerves’	2.5	3.8	6.3	1.8	2.1	-2.1	1.9	2.0	2.0	2.2	0.9	2.5	1.8	2.2	2.0	2.2	2.1	2.2	2.0	1.3	1.3
Weight	2.4	11.7	52.4	-0.2	-3.4	5.7	-1.1	-3.8	-2.0	-3.1	-7.2	0.8	-4.5	-1.7	-2.9	-3.1	-3.5	-2.1	-3.1	-2.8	-2.7
Severe depression (siblings)	2.3	2.5	9.8	0.0	-1.3	0.7	-1.9	-1.7	-1.4	-1.6	-1.5	-3.1	-1.7	-1.6	-1.5	-1.3	-1.9	-1.9	-1.5	-1.1	-1.0
Standing height	2.3	23.1	61.3	-2.9	-4.4	7.8	-0.2	-5.6	-4.1	-4.3	-7.6	-1.3	-5.7	-3.8	-4.5	-5.2	-4.7	-3.8	-4.2	-5.5	-4.6
Alcohol intake frequency.	2.3	5.4	14.9	-1.6	-2.7	2.1	-2.2	-2.5	-1.9	-2.7	-3.9	0.2	-2.8	-1.6	-2.3	-2.3	-2.3	-1.8	-2.3	-2.1	-2.6
Mood swings	2.3	4.1	15.7	-1.7	-2.0	2.2	-1.5	-2.3	-1.4	-1.8	-4.0	-0.4	-2.9	-1.3	-1.7	-2.1	-2.0	-1.5	-1.9	-2.0	-1.6
Coronary Artery Disease (CAD)	2.2	2.6	4.3	1.6	1.2	-1.0	0.0	1.5	2.0	1.5	1.3	-0.7	1.3	1.8	1.9	2.1	1.9	1.8	1.8	2.0	1.9
High blood pressure (siblings)	2.2	3.1	5.3	1.4	2.1	-1.5	0.8	2.3	1.8	2.2	2.0	0.2	2.1	1.6	1.9	2.0	1.7	2.1	1.8	1.1	1.6
Age at first live birth	2.2	4.0	7.1	1.1	2.7	-2.3	1.3	2.2	1.6	2.1	2.4	1.5	2.0	1.8	1.9	2.0	2.6	1.5	2.1	2.0	2.1
Alzheimer’s Disease (in mother)	2.1	2.5	4.4	0.2	1.1	-1.7	0.7	2.0	1.9	1.7	1.5	1.6	0.7	1.2	1.9	2.0	1.6	1.5	1.6	1.7	2.1
Fractured/broken bones in last 5 years	2.1	2.7	6.2	-1.9	-1.6	2.5	-1.5	-1.3	-1.7	-1.5	-1.5	0.4	-1.2	-1.5	-1.7	-1.6	-1.8	-1.9	-1.9	-1.2	-2.1
Heel T-Score	2.0	16.1	29.3	3.6	2.9	-5.4	5.0	3.6	4.3	3.8	3.8	2.2	3.2	3.7	4.3	4.1	4.1	3.9	4.4	4.0	4.8
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	10.7	1.9	1.0	-2.6	3.3	1.8	2.4	1.7	1.7	1.6	1.1	2.1	2.2	2.2	2.2	2.0	2.2	2.6	2.9
Glaucoma (self-reported)	2.0	2.3	3.7	0.6	1.6	-1.6	1.1	1.7	1.9	1.8	1.5	1.0	1.0	1.4	1.7	1.6	1.7	1.8	1.6	1.1	1.9
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	13.3	-1.3	-2.1	3.6	0.7	-2.4	-2.1	-2.0	-2.4	0.0	-1.9	-1.7	-2.1	-2.2	-1.8	-1.8	-1.9	-2.2	-2.3
Lung FEV1/FVC ratio	1.9	9.9	17.1	2.6	2.7	-1.9	3.1	3.4	4.1	3.5	0.9	3.4	2.5	3.1	3.8	3.4	3.1	3.6	3.7	2.7	3.5
Medication: Cholesterol lowering	1.9	2.9	7.9	0.7	2.8	-1.0	-0.6	2.2	1.7	2.4	2.2	0.6	2.5	1.0	1.8	1.6	1.8	1.5	2.0	0.7	1.3
Health satisfaction	1.9	2.5	4.4	-0.5	-1.7	2.1	-0.9	-1.6	-1.8	-1.8	-1.3	-1.3	-1.8	-1.8	-1.7	-1.2	-1.6	-2.0	-1.7	-1.6	-1.5
Age started oral contraceptive pill	1.9	2.4	4.4	2.1	1.6	-0.3	0.5	2.1	1.6	1.8	1.5	0.9	1.8	1.6	1.6	1.5	1.7	1.9	1.8	1.2	1.4
Mouth/teeth dental problems: Loose teeth	1.8	2.1	3.7	-1.2	-1.8	1.7	-1.0	-1.4	-1.1	-1.6	-1.7	-0.2	-1.9	-1.5	-1.4	-1.7	-1.5	-1.2	-1.4	-1.9	-1.1
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.7	0.2	1.5	-1.8	1.3	1.9	1.6	1.6	1.4	0.7	1.8	0.9	1.7	1.4	1.1	1.4	1.9	0.8	1.5
Medication: Simvastatin	1.7	2.5	8.3	1.2	2.4	-0.9	0.8	1.6	1.4	2.1	2.9	0.1	2.1	1.3	1.6	1.1	1.8	1.3	1.7	1.1	0.9
Back pain experienced in last month	1.7	2.5	5.3	-1.7	-2.0	0.6	-0.9	-1.7	-1.1	-1.9	-1.9	-0.1	-2.3	-1.5	-1.5	-1.8	-1.8	-1.3	-1.6	-1.4	-1.6
HDL Cholesterol	1.6	2.7	4.6	-1.0	-1.6	1.3	-1.5	-1.8	-2.1	-1.9	-0.6	-0.7	-1.3	-1.8	-2.0	-1.8	-1.9	-1.7	-2.1	-1.5	-1.9
Sensitivity / hurt feelings	1.6	2.8	4.6	1.1	1.7	-2.1	2.1	1.8	1.7	2.0	0.8	0.8	1.4	1.8	1.8	1.7	1.9	1.7	1.8	1.3	1.4
Exposure to tobacco smoke outside home	1.6	2.1	9.3	-1.1	-1.4	1.5	-0.3	-1.2	-1.1	-1.4	-0.7	-3.1	-1.1	-1.7	-1.1	-1.7	-1.8	-0.9	-0.9	-1.9	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	6.3	-0.5	-1.4	0.9	-1.1	-1.7	-0.6	-1.2	-2.5	-1.0	-1.4	-1.3	-1.1	-1.2	-1.7	-1.0	-1.2	-1.3	-0.8
High cholesterol (Self-reported)	1.6	2.9	10.4	0.2	3.2	-1.4	-0.3	1.8	1.4	2.3	3.0	-0.6	2.4	0.9	1.6	1.2	1.9	1.2	1.8	0.6	1.1
Type 2 Diabetes (T2D) (2012)	1.5	1.7	7.4	-0.1	-1.2	1.4	-1.0	-1.1	-1.3	-1.4	0.1	-2.7	-1.2	-1.7	-1.2	-1.2	-1.1	-1.6	-1.0	-1.3	-1.0
Multivitamins +/- minerals	1.5	1.8	3.3	1.8	1.4	-1.4	1.8	0.8	1.8	1.6	-0.6	-0.4	0.6	1.2	1.6	1.5	0.9	1.6	1.4	0.9	1.8
Depression (self-reported)	1.5	1.8	5.0	-1.3	-0.8	0.9	-1.9	-1.3	-1.0	-1.0	-2.2	-0.7	-1.1	-1.3	-1.2	-1.5	-1.7	-1.2	-1.1	-1.7	-1.5
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	5.0	-1.1	-2.1	1.8	0.6	-2.0	-1.4	-1.7	-2.2	0.0	-2.1	-0.8	-1.5	-1.8	-1.6	-1.1	-1.6	-1.2	-1.5
Lupus	1.4	2.1	3.3	-1.0	-1.8	1.0	-1.7	-1.6	-1.4	-1.8	-1.5	-1.3	-1.7	-1.7	-1.4	-1.3	-1.3	-1.6	-1.5	-1.2	-1.3
Vitamin and mineral supplements	1.4	2.0	4.0	-1.3	-1.1	2.0	-1.4	-1.0	-2.0	-1.5	0.4	0.3	-0.4	-1.4	-1.8	-1.6	-1.1	-1.8	-1.5	-1.0	-1.8
Pain all over the body in last month	1.4	1.6	4.3	-0.2	-0.4	2.1	-2.0	-1.3	-1.0	-0.8	-1.4	-1.2	-0.9	-1.0	-1.1	-1.4	-1.1	-1.0	-1.0	-1.7	-1.2
Irritability	1.4	2.4	6.2	-2.3	-0.9	2.5	-0.8	-1.4	-1.3	-1.2	-1.9	-1.4	-1.9	-1.4	-1.3	-1.5	-1.6	-1.5	-1.3	-1.4	-1.1
Neuroticism (2016)	1.3	1.9	3.3	1.2	0.8	-0.8	1.8	1.2	1.4	1.4	1.1	1.5	1.1	1.7	1.4	1.7	1.7	1.6	1.3	1.4	1.2
Hand grip strength (left)	1.3	3.3	10.4	-1.1	-1.8	3.2	0.8	-1.7	-2.0	-1.7	-2.2	-0.2	-1.2	-1.6	-1.9	-2.1	-1.7	-1.4	-1.6	-2.5	-1.9
Alcohol usually taken with meals	1.3	2.0	3.9	1.4	1.0	-1.9	1.8	1.3	1.4	1.1	1.9	0.1	1.0	1.4	1.4	1.4	1.4	1.2	1.3	2.0	1.4
Fluid intelligence score	1.3	2.6	6.3	-2.5	-1.3	1.4	-1.4	-1.6	-1.3	-1.4	-1.1	-1.8	-1.9	-1.9	-1.5	-1.8	-1.4	-1.9	-1.5	-1.5	-1.2
Impedance of arm (left)	1.3	6.1	34.7	0.1	2.9	-2.5	0.8	2.9	1.0	2.4	5.9	-1.0	3.8	1.4	1.8	1.7	3.2	1.2	2.3	1.8	1.1
Ever had bowel cancer screening	1.3	1.5	2.6	0.4	1.5	-0.8	0.0	1.6	1.5	1.6	0.8	-0.3	1.5	1.1	1.5	1.4	1.3	1.5	1.6	0.7	1.5
Ovarian Cancer	1.2	1.6	3.4	0.3	1.1	-0.6	0.3	0.9	1.6	1.6	0.5	1.2	0.6	1.5	1.4	1.4	1.8	1.7	1.5	0.9	1.9
Primary Biliary Cirrhosis	1.2	1.7	2.9	1.7	0.0	-1.7	0.9	1.1	1.7	1.1	0.8	1.0	0.8	1.4	1.5	1.6	1.7	1.2	1.4	1.6	1.5
Townsend deprivation index at recruitment	1.2	1.8	7.4	1.4	-1.4	0.9	-0.7	-1.8	-0.9	-1.4	-2.7	0.6	-1.9	-0.7	-1.2	-1.0	-1.1	-1.2	-1.4	-0.9	-1.0
Supplements: Glucosamine	1.2	1.5	2.7	0.9	1.5	-1.1	1.6	1.0	1.4	1.5	0.8	0.4	1.2	1.3	1.4	1.3	1.1	1.5	1.3	1.1	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.1	1.6	0.1	-1.0	1.9	0.8	1.0	0.7	0.9	0.7	0.8	1.3	1.1	1.6	1.1	0.7	0.9	2.0	1.1
Exposure to tobacco smoke at home	1.2	1.3	3.7	1.4	1.6	-1.4	0.8	0.9	1.0	1.1	1.9	1.0	0.9	0.8	0.9	1.1	1.2	0.9	0.7	1.1	0.9
Medication: Blood pressure	1.2	2.2	4.7	1.4	1.7	-2.1	0.2	1.7	1.1	1.4	2.2	0.3	1.8	1.0	1.3	1.8	1.7	0.9	1.3	1.8	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	5.5	2.1	0.4	-1.1	0.6	0.9	1.1	0.7	-0.0	2.3	0.3	1.4	1.1	1.2	0.9	0.8	1.1	1.5	1.1
Ever smoked	1.2	2.1	4.8	-0.5	-2.0	1.4	-0.3	-1.7	-1.6	-2.0	-0.4	-1.0	-2.2	-1.4	-1.5	-1.3	-1.8	-1.7	-1.7	-0.3	-0.8
Cholesterol lowering medication	1.2	1.8	5.7	0.9	2.4	-0.6	1.0	1.5	1.0	1.9	2.0	0.1	1.9	1.4	1.2	0.8	1.6	1.2	1.2	0.8	0.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	4.2	1.0	1.0	-0.9	-0.1	1.0	2.0	1.4	-0.8	0.2	0.1	1.3	1.7	1.2	0.7	1.5	1.6	1.2	2.0
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.1	1.6	1.3	-1.8	1.1	1.0	1.0	0.9	1.1	1.2	0.3	1.3	0.9	1.1	1.7	1.0	0.9	1.3	0.9
Average weekly red wine intake	1.1	1.6	3.0	0.6	1.3	-1.2	1.3	1.5	1.2	1.4	1.7	0.9	1.3	1.0	1.2	1.6	1.5	1.2	1.1	0.9	1.0
Osteoarthritis (self-reported)	1.1	1.4	4.2	-0.6	-0.8	1.4	-1.6	-1.4	-0.7	-1.0	-1.9	-0.6	-2.1	-1.2	-1.0	-0.9	-0.9	-1.0	-1.2	-1.1	-0.6
Arm fat mass (left)	1.1	4.6	21.5	0.7	-2.1	3.8	-1.0	-2.1	-1.2	-1.9	-4.6	1.1	-2.7	-0.7	-1.8	-1.9	-2.1	-1.2	-2.0	-1.2	-1.7
Serious illness, injury or assault to yourself	1.0	1.2	3.8	0.6	-0.9	1.9	-0.9	-1.0	-1.2	-1.2	-1.5	1.1	-0.7	-0.6	-1.1	-0.9	-0.7	-1.1	-1.0	-1.1	-1.3
Past tobacco smoking	1.0	1.9	4.7	0.4	2.2	-0.8	0.1	1.5	1.5	2.0	0.4	1.2	2.0	1.3	1.4	1.2	1.8	1.5	1.6	0.5	1.0
Medication: Ramipril	1.0	1.3	4.0	-0.1	0.9	1.2	-0.8	-0.6	-1.5	-0.1	-0.4	-2.0	0.5	-1.4	-1.2	-0.8	-1.0	-1.0	-1.3	-1.9	-1.7
Impedance of arm (right)	1.0	4.5	29.2	-0.2	2.5	-2.2	0.2	2.5	0.7	2.0	5.4	-1.6	3.2	0.9	1.4	1.3	2.6	0.8	1.9	1.3	1.0
Arm fat mass (right)	1.0	4.1	20.9	0.7	-2.0	3.6	-1.1	-2.0	-1.0	-1.8	-4.6	1.2	-2.7	-0.5	-1.6	-1.7	-1.9	-1.1	-1.8	-1.1	-1.5
Medication: Aspirin	1.0	1.3	2.5	0.5	1.4	-0.9	0.1	1.3	1.6	1.3	0.5	1.3	0.8	1.0	1.4	1.1	0.7	1.4	1.4	0.6	1.3
Basal cell carcinoma (self-reported)	1.0	1.2	2.9	-1.5	-0.8	0.8	-0.9	-1.3	-1.0	-0.9	-0.9	-0.4	-1.0	-1.1	-1.1	-1.2	-0.7	-1.0	-1.0	-1.7	-1.3
Blood Platelet Count	0.9	10.6	27.5	5.2	3.4	-0.9	2.9	3.1	2.7	3.6	3.5	1.1	3.8	3.2	3.1	3.5	3.9	2.6	3.1	3.4	2.9
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.3	0.4	-1.2	0.8	-1.3	-0.9	-1.0	-1.2	-0.5	-1.8	-1.1	-1.1	-0.9	-0.7	-0.6	-0.9	-1.0	-1.0	-0.6
Nervous feelings	0.9	1.6	3.3	0.6	1.6	-1.1	1.7	1.2	1.0	1.5	0.1	1.8	1.6	1.6	1.1	1.5	1.5	1.0	1.3	0.7	0.3
Had menopause	0.9	1.1	2.7	0.8	1.0	-1.1	0.6	1.4	1.0	1.1	0.7	1.0	1.2	1.5	1.0	1.0	1.0	1.6	1.0	0.9	0.7
Illnesses of siblings	0.9	1.2	2.1	-1.0	-1.4	0.8	0.4	-1.3	-1.4	-1.4	-1.0	0.5	-1.2	-1.0	-1.3	-1.3	-0.8	-1.4	-1.1	-0.8	-1.1
Breastfed as a baby	0.9	1.1	2.6	-0.7	1.5	-0.3	-0.7	1.6	0.8	1.3	1.6	-0.2	1.5	0.7	1.1	0.9	0.8	0.9	1.1	0.8	1.0
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.1	0.5	-0.3	1.0	-1.3	-1.0	-1.1	-0.8	-0.7	-1.4	-1.1	-1.0	-1.1	-1.4	-0.5	-1.0	-1.1	-1.4	-1.0
Pulse rate, automated reading	0.9	2.9	9.6	-0.1	-1.8	3.1	-0.7	-1.5	-2.2	-2.0	-0.8	-2.1	-1.2	-1.5	-1.9	-1.7	-1.6	-1.6	-1.7	-1.5	-1.5
Chest pain or discomfort	0.9	1.3	4.3	-0.1	-0.6	1.7	-2.1	-1.0	-0.9	-0.9	-1.1	-0.6	-1.5	-1.0	-1.1	-1.0	-0.9	-1.4	-1.2	-1.0	-1.0
Age at last live birth	0.9	1.4	2.3	0.9	1.5	-1.4	0.3	1.3	1.2	1.4	0.8	0.7	1.2	0.9	1.2	1.4	1.5	0.9	1.3	0.9	1.4
Ever taken oral contraceptive pill	0.9	1.1	3.1	0.7	0.6	-0.9	0.5	1.2	1.1	0.8	1.6	0.6	0.6	1.3	1.1	0.8	1.0	0.9	1.0	1.8	1.0
Supplements: Fish oil (including cod liver oil)	0.9	1.2	5.4	-0.2	-0.7	0.7	-0.8	-1.0	-0.9	-0.9	-1.2	-2.3	-1.0	-1.1	-0.9	-1.0	-1.6	-0.6	-1.0	-1.1	-0.9
Crohns Disease (2017)	0.8	1.7	3.6	-0.7	-1.0	1.0	-1.9	-1.1	-1.7	-1.4	-0.5	-1.6	-0.6	-1.1	-1.5	-1.6	-1.2	-1.1	-1.2	-1.6	-1.6
Reaction Time	0.8	1.6	3.9	-1.4	-0.9	0.5	-1.7	-1.3	-1.0	-1.4	-2.0	-0.9	-1.6	-1.1	-1.2	-1.4	-1.3	-1.1	-1.2	-0.9	-0.5
Mouth/teeth dental problems	0.8	1.3	4.4	-0.6	-1.9	1.0	-0.2	-0.9	-0.8	-1.6	-2.1	1.4	-1.1	-0.7	-1.1	-0.9	-1.3	-0.8	-1.0	-0.5	-0.9
Medication: Lansoprazole	0.8	0.9	3.0	1.1	1.7	-1.2	1.0	0.7	1.1	1.2	0.3	0.5	0.5	0.8	1.0	0.9	0.8	0.9	0.8	0.6	0.7
Prospective memory result	0.8	1.0	2.3	0.4	1.5	-0.8	1.4	0.7	0.8	1.4	0.3	1.0	1.1	1.5	1.0	0.7	0.9	1.4	1.0	0.5	0.4
Length of working week for main job	0.8	0.9	2.8	-0.5	-0.7	1.7	-0.6	-0.8	-1.4	-1.0	0.2	-0.0	-0.5	-0.8	-1.3	-1.0	-0.8	-1.3	-1.3	-0.3	-1.3
Migraine (self-reported)	0.8	1.0	5.2	2.3	1.0	-0.6	0.5	1.0	0.8	0.9	1.4	-0.6	1.1	0.6	0.8	1.1	1.1	0.6	0.9	0.8	0.8
Medication: Allopurinol	0.8	1.0	2.5	0.2	-0.8	0.5	-1.6	-0.9	-1.0	-1.0	-0.8	-1.2	-1.0	-1.2	-1.0	-0.8	-1.2	-0.5	-1.0	-1.5	-0.8
Handedness (chirality/laterality): Left-handed	0.8	0.9	4.6	0.3	-1.5	0.1	-0.5	-0.9	-0.3	-1.1	-2.1	-0.3	-1.3	-0.9	-0.7	-0.4	-1.5	-1.1	-0.8	-0.6	-0.5
Loneliness, isolation	0.8	1.2	2.4	1.1	1.2	-0.5	0.3	1.0	1.3	1.5	-0.6	1.5	0.8	1.4	1.1	0.9	1.0	1.3	1.2	0.6	0.9
Breast cancer (self-reported)	0.8	1.0	2.3	-0.1	-1.2	0.2	-0.5	-1.2	-0.8	-1.3	-1.0	-1.2	-1.1	-1.0	-0.9	-1.0	-1.5	-1.1	-0.9	-0.8	-0.8
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.8	0.4	-1.3	0.3	-0.7	-1.0	-0.7	-1.2	-1.9	0.7	-1.0	-0.8	-0.8	-0.3	-1.3	-1.1	-1.0	-0.2	-0.7
Triglycerides	0.7	1.2	2.5	1.5	0.5	-1.3	1.3	1.1	1.2	0.8	0.1	0.7	0.5	1.1	1.0	1.2	1.0	1.3	1.1	0.9	1.6
Hand grip strength (right)	0.7	1.9	6.6	-1.5	-1.0	2.6	0.6	-1.3	-1.4	-0.9	-1.2	-0.4	-1.0	-1.5	-1.3	-1.6	-1.2	-0.8	-1.1	-2.4	-1.3
Qualifications: CSEs or equivalent	0.7	0.9	1.6	-1.2	-0.6	0.3	-0.9	-1.2	-1.1	-1.1	-1.3	0.1	-0.7	-0.7	-1.1	-0.9	-1.2	-0.9	-1.1	-0.7	-1.1
Hayfever, allergic rhinitis or eczema	0.7	1.5	6.2	-0.7	-1.0	1.6	-2.5	-0.7	-0.9	-1.0	-0.8	-1.6	-1.0	-1.2	-1.1	-0.8	-1.2	-1.5	-1.4	-0.4	-1.0
Medication: Atenolol	0.7	0.9	5.2	-2.3	0.1	0.2	-0.0	-0.7	-1.0	-0.4	-0.1	-1.0	-0.3	-0.9	-0.8	-1.1	-0.6	-0.7	-0.9	-1.2	-1.2
Forced vital capacity (FVC)	0.7	2.8	13.3	-0.7	-2.7	2.9	1.9	-2.0	-0.4	-1.5	-3.6	0.8	-2.6	-0.1	-0.8	-1.1	-1.0	-0.1	-0.7	-0.9	-0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.8	-0.5	-0.8	1.1	-0.3	-1.2	-0.6	-0.7	-1.7	0.4	-1.1	-1.0	-0.8	-0.7	-1.1	-1.0	-0.9	-0.8	-0.8
Hip circumference	0.7	3.2	20.3	1.5	-1.6	3.8	0.2	-1.4	-0.3	-1.0	-4.5	2.2	-1.9	0.4	-0.9	-1.0	-1.3	-0.2	-1.2	-0.7	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	5.3	-0.8	-0.4	2.3	-1.5	-0.8	-0.2	-0.4	-2.2	-0.1	-1.9	-0.8	-0.5	-0.6	-0.9	-0.7	-0.7	-0.9	-0.4
Noisy workplace	0.7	0.8	1.5	-0.9	-0.5	1.1	-0.6	-0.6	-1.0	-0.9	0.2	-1.1	-0.7	-1.0	-1.0	-1.0	-0.8	-1.0	-1.0	-0.8	-1.2
Mouth/teeth dental problems: Dentures	0.7	1.2	7.7	-0.1	1.8	0.4	-0.6	0.6	-0.3	1.1	2.8	-2.3	1.3	-0.4	0.3	0.2	0.7	-0.1	0.3	-0.1	-0.1
Pulse wave Arterial Stiffness index	0.7	0.8	1.8	0.7	-0.7	1.0	-0.8	-0.8	-1.2	-0.8	0.1	-0.9	0.0	-1.0	-1.1	-0.9	-1.0	-1.3	-0.9	-0.8	-1.4
Gout (self-reported)	0.7	0.9	1.8	0.3	-1.0	0.5	-1.0	-1.2	-0.9	-1.2	-0.4	-0.6	-1.3	-1.2	-1.0	-1.0	-1.2	-0.6	-1.1	-1.4	-0.8
Leg fat percentage (right)	0.7	2.6	5.6	1.9	1.1	-0.8	1.4	1.5	1.8	1.4	0.6	2.4	1.1	2.4	1.5	1.6	1.7	1.7	1.3	2.3	1.4
Number of full brothers	0.7	0.8	3.0	0.9	-1.4	1.7	-0.6	-0.7	-0.6	-0.9	-1.5	-0.1	-1.0	-0.6	-0.7	-0.4	-0.7	-0.9	-0.6	-0.8	-0.5
Medication: Omeprazole	0.7	0.8	3.7	0.7	-1.5	0.6	-0.7	-0.9	-0.6	-1.2	-1.3	-0.4	-1.9	-0.4	-0.8	-0.6	-0.4	-0.9	-0.8	-0.4	-0.3
Hypertension (Self-reported)	0.7	1.9	3.8	1.4	1.4	-1.9	0.6	1.4	1.0	1.2	1.6	1.0	1.7	1.4	1.1	2.0	1.4	1.1	1.1	1.7	1.3
Miserableness	0.7	1.2	9.8	-0.1	-1.1	1.6	0.5	-1.3	0.2	-0.3	-3.1	0.5	-1.7	-0.2	-0.1	-0.6	-0.8	-0.3	-0.3	-0.7	-0.3
Hearing aid user	0.7	0.7	1.9	-0.4	-0.9	1.4	-0.6	-0.6	-0.5	-1.1	-1.2	-0.7	-1.3	-0.9	-0.7	-0.8	-0.7	-0.5	-0.6	-1.3	-0.4
Medication: Blood pressure	0.7	1.2	3.0	1.0	1.1	-0.6	0.4	1.6	0.8	1.3	1.4	0.5	1.7	1.1	1.0	1.4	1.0	1.6	0.9	0.6	0.6
Depressed Affect (Nagel 2018)	0.6	1.2	8.6	-1.0	-0.9	1.6	-1.0	-1.0	-0.0	-0.4	-2.9	0.3	-1.7	-0.4	-0.3	-0.8	-0.8	-0.2	-0.5	-1.2	-0.5
Schizophrenia (2018)	0.6	1.2	3.3	0.8	-0.0	-0.3	-0.2	0.6	1.5	0.7	-1.8	1.7	0.1	1.5	1.2	1.1	0.7	1.3	1.2	1.0	1.2
Alzheimer’s Disease (in father)	0.6	0.6	2.2	0.6	1.5	-0.5	0.0	0.9	0.5	0.9	1.3	0.4	1.0	0.8	0.6	0.5	0.8	0.6	0.7	0.6	0.4
Diabetes (mother)	0.6	0.7	2.7	-0.4	-0.2	1.2	-1.4	-0.7	-0.6	-0.5	-1.6	-1.1	-0.6	-0.6	-0.8	-0.7	-0.4	-0.7	-0.6	-1.1	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	4.9	-0.4	-0.6	1.3	-1.1	-0.4	0.3	-0.3	-2.2	0.1	-1.4	-0.6	-0.0	-0.4	-1.3	-0.0	-0.2	-1.0	0.1
Body mass index (BMI)	0.6	2.7	17.6	1.1	-1.5	2.5	-1.1	-1.5	-0.4	-1.3	-4.2	1.5	-2.2	-0.1	-1.0	-1.0	-1.6	-0.5	-1.4	-0.5	-0.8
Trunk fat mass	0.6	2.5	12.4	0.4	-1.4	3.3	-0.7	-1.4	-0.6	-1.2	-3.5	1.1	-2.0	-0.1	-1.1	-1.4	-1.3	-0.7	-1.3	-0.8	-1.2
Waist circumference	0.6	2.3	13.2	0.4	-1.7	2.4	-0.2	-1.6	-0.7	-1.4	-3.6	0.7	-2.2	-0.4	-1.2	-1.3	-1.6	-0.8	-1.4	-0.8	-1.0
Hair/balding pattern: Pattern 2	0.6	0.8	3.1	0.7	-0.4	-1.3	1.8	0.2	0.9	-0.1	0.8	1.1	-0.2	0.7	0.8	0.7	0.5	0.5	0.8	1.3	1.4
Hair/balding pattern: Pattern 3	0.6	0.9	2.4	-0.1	1.5	0.1	-0.5	1.2	0.5	1.4	0.8	-1.4	1.5	0.9	0.6	0.5	1.2	1.1	0.9	-0.2	0.6
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	9.4	0.4	-1.7	1.8	3.1	-0.5	1.1	-0.3	-2.7	2.1	-1.5	1.1	0.6	0.4	0.3	1.2	0.7	0.3	0.8
Peak expiratory flow (PEF)	0.6	1.4	7.1	0.9	-1.4	1.6	2.7	-0.5	1.0	-0.3	-1.8	1.8	-1.4	0.8	0.5	0.3	0.4	0.8	0.5	0.4	0.5
Neck or shoulder pain in last month	0.6	0.8	2.9	0.5	-0.0	0.3	1.3	0.8	0.8	0.6	1.1	1.7	0.4	0.7	1.0	1.0	0.6	1.1	0.9	1.0	1.0
Whole body fat mass	0.6	2.5	13.9	0.6	-1.5	3.1	-0.3	-1.5	-0.6	-1.3	-3.7	1.5	-2.2	-0.0	-1.1	-1.3	-1.3	-0.6	-1.3	-0.6	-1.1
Had major operations	0.6	0.7	1.8	0.9	0.4	-0.6	0.5	1.1	0.9	0.6	0.7	-0.7	0.6	0.5	0.9	1.0	0.6	0.8	1.1	0.6	1.4
Family relationship satisfaction	0.6	0.8	2.5	1.1	-1.0	1.4	-0.4	-0.8	-0.6	-0.9	-1.6	-0.3	-1.1	-0.8	-0.6	-0.6	-0.8	-0.9	-0.7	-0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	4.6	-2.2	0.5	0.0	-0.8	0.1	0.1	0.3	0.2	-2.1	-0.0	-0.7	0.0	-0.6	-0.5	0.3	0.1	-1.1	0.1
Medication: Aspirin	0.6	0.8	1.8	0.4	1.1	-0.7	0.1	1.0	1.3	1.0	-0.0	1.4	0.4	0.8	1.1	0.8	0.4	1.1	1.1	0.4	1.1
Medication for cholesterol	0.6	0.9	2.5	-0.1	-1.5	0.0	0.1	-1.2	-0.7	-1.4	-0.9	-0.3	-1.6	-1.0	-0.9	-0.7	-1.2	-1.3	-1.0	0.0	-0.4
Osteoporosis (self-reported)	0.6	0.8	3.3	-0.4	0.0	0.7	-1.1	-1.1	-1.2	-0.7	-0.4	-0.0	-0.2	-0.4	-1.1	-1.1	-0.6	-0.9	-1.1	-0.9	-1.8
Guilty feelings	0.6	1.0	7.6	-0.1	-1.2	0.8	0.4	-1.2	-0.4	-0.7	-2.8	1.1	-1.5	0.1	-0.6	-0.4	-0.7	-0.0	-0.7	-0.5	-0.6
Wears glasses or contact lenses	0.6	0.7	2.4	-0.1	1.1	-1.0	-0.8	0.9	1.0	1.1	0.2	-0.4	0.6	0.7	1.0	0.5	0.6	1.5	1.0	-0.0	1.0
Financial situation satisfaction	0.6	0.8	2.3	0.6	-0.1	1.3	0.2	-1.0	-0.8	-0.6	-1.5	1.0	-1.0	-0.6	-0.7	-0.9	-0.9	-0.7	-0.9	-0.9	-1.2
Commuting to job workplace: Public transport	0.6	0.8	2.9	-0.1	-0.5	0.8	-0.5	-0.8	-1.0	-0.8	-0.5	-1.7	-1.0	-0.8	-1.0	-0.8	-0.7	-0.9	-1.1	-0.5	-0.8
Alcohol drinker status: Never	0.6	0.7	8.1	0.2	0.3	1.0	-2.8	-0.3	-0.2	0.0	-1.0	-0.1	-0.6	-0.2	-0.4	-0.0	0.2	-0.3	-0.4	-0.6	-0.6
Leg fat percentage (left)	0.6	2.1	4.8	1.9	0.9	-0.9	1.0	1.3	1.6	1.2	0.4	2.2	1.0	2.1	1.4	1.4	1.4	1.5	1.1	2.1	1.2
Unable to work because of sickness or disability	0.6	0.8	4.5	-1.3	-0.3	0.5	-0.6	-1.0	-0.4	-0.8	-2.1	0.2	-1.4	-0.7	-0.6	-0.9	-0.8	-0.4	-0.6	-1.1	-0.6
Depression (Nagel 2018)	0.5	0.7	2.2	-0.1	1.1	0.3	-0.6	0.8	1.5	1.3	-0.5	0.5	0.2	0.8	1.3	0.8	0.5	1.3	1.0	0.3	1.0
Schizophrenia vs Biploar Disorder	0.5	0.6	4.5	-1.1	-1.1	0.1	-1.0	-0.5	0.1	-0.7	-2.1	0.7	-1.4	0.0	-0.3	-0.3	-0.3	-0.1	-0.3	-0.2	0.0
Breast Cancer	0.5	1.1	5.0	-2.2	-1.6	1.0	-0.6	-1.0	-0.4	-1.0	-1.6	-0.1	-1.5	-0.8	-0.7	-0.9	-1.2	-0.3	-0.6	-0.9	-0.2
Schizophrenia (2014)	0.5	1.2	11.0	-0.5	-1.6	0.9	-1.3	-0.8	0.2	-0.7	-3.3	0.7	-1.5	-0.1	-0.2	-0.4	-0.8	0.3	-0.2	-0.9	-0.1
Ulcerative Colitis	0.5	0.8	3.2	1.8	1.0	-1.0	0.5	0.5	0.2	0.9	1.5	-1.2	1.0	0.6	0.5	0.3	0.9	0.4	0.6	0.5	0.2
High blood pressure	0.5	1.5	3.3	1.1	1.2	-1.6	-0.1	1.3	0.9	1.0	1.4	0.6	1.7	1.2	1.0	1.8	1.1	0.9	1.0	1.7	1.1
Number of live births	0.5	0.7	2.9	0.6	-0.8	0.7	-1.7	-1.0	-0.4	-0.5	-1.7	-0.4	-0.1	-0.3	-0.7	-0.4	-1.0	-0.6	-0.8	-0.1	-0.9
Pulse rate	0.5	0.9	2.2	-0.4	-0.5	1.3	-1.1	-0.9	-1.0	-0.7	-0.5	-1.5	-0.5	-1.0	-1.0	-1.2	-0.9	-1.1	-1.0	-0.8	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	8.8	1.0	-0.9	1.1	3.0	-0.1	1.3	0.2	-2.1	1.6	-1.0	1.0	0.9	0.7	0.8	1.2	1.0	0.4	1.1
Forced vital capacity (FVC), Best measure	0.5	1.7	8.5	-0.0	-1.8	2.4	1.7	-1.4	-0.2	-1.0	-2.9	0.5	-2.0	-0.2	-0.6	-0.7	-0.4	-0.1	-0.4	-0.8	-0.3
Comparative body size at age 10	0.5	1.3	9.4	-0.0	0.5	1.1	-2.0	-0.8	-0.0	0.1	-3.1	0.4	-0.9	-0.6	-0.4	-0.9	-0.9	-0.3	-0.5	-1.8	-1.0
Leg fat mass (right)	0.5	1.8	12.0	0.6	-1.3	2.3	0.2	-1.1	-0.1	-1.0	-3.5	2.0	-2.0	0.4	-0.7	-0.8	-0.8	-0.2	-1.0	-0.0	-0.5
Average weekly champagne plus white wine intake	0.5	0.7	3.7	1.1	1.1	-1.2	0.1	0.9	0.2	0.8	1.9	-0.1	1.6	0.1	0.5	0.4	0.7	0.5	0.6	-0.2	-0.1
Leg fat mass (left)	0.5	2.0	12.9	0.6	-1.5	2.2	-0.0	-1.3	-0.2	-1.1	-3.6	1.8	-2.1	0.2	-0.8	-0.9	-1.0	-0.3	-1.1	-0.2	-0.7
Verbal and Numeric Reasoning (VNR)	0.4	1.1	4.4	-1.2	-0.7	1.2	-1.1	-0.8	-0.5	-0.6	-0.7	-2.1	-1.2	-1.3	-0.7	-0.9	-1.2	-1.0	-0.8	-0.8	-0.4
Crohns Disease (2012)	0.4	0.6	2.0	0.6	0.7	0.4	-1.3	0.0	-0.9	0.1	0.3	-1.2	0.6	-0.2	-0.6	-0.8	0.2	-0.3	-0.4	-1.4	-1.4
Blood Red Count	0.4	4.1	10.1	-3.2	-1.7	0.4	-1.1	-1.9	-2.6	-2.2	-0.7	-2.1	-1.5	-2.0	-2.4	-2.4	-1.8	-2.1	-2.4	-1.8	-2.1
BMI	0.4	2.5	22.3	1.6	-1.5	1.9	0.5	-0.9	0.6	-0.8	-4.7	2.4	-2.2	0.6	-0.2	-0.3	-1.0	0.4	-0.6	-0.4	-0.1
Lung FVC	0.4	1.8	4.6	1.2	-1.0	-0.7	2.1	0.4	1.6	0.2	-1.1	1.8	-0.5	1.8	1.2	1.3	0.7	1.7	1.2	1.6	1.8
Medication: Co-codamol	0.4	0.4	1.8	-0.6	-0.3	1.4	-0.8	-0.4	-0.2	-0.0	-0.9	0.9	-0.5	-0.4	-0.4	-0.5	-0.4	0.1	-0.5	-1.1	-0.8
Diabetes (father)	0.4	0.5	2.2	-0.1	0.4	1.5	-0.9	-0.1	-1.0	-0.1	0.5	-0.8	0.5	-0.5	-0.7	-0.3	-0.4	-0.7	-0.8	-0.3	-0.8
Taking other prescription medications	0.4	0.6	1.7	0.9	0.8	-1.3	-0.2	0.8	1.0	0.9	-0.2	-0.0	0.4	0.7	0.9	0.7	0.6	0.8	0.8	0.2	0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.9	1.0	0.4	-0.5	-0.4	0.7	0.5	0.5	0.5	0.7	1.4	0.8	0.6	0.8	0.8	0.4	0.7	0.7	0.3
Father’s age at death	0.4	0.6	1.4	0.3	1.0	0.1	0.2	1.2	0.7	1.2	0.9	-0.6	1.0	0.1	0.9	0.6	0.7	0.6	1.0	-0.5	0.5
Falls in the last year	0.4	0.6	3.1	0.2	0.0	0.7	-1.7	-0.2	0.4	-0.1	-1.0	-1.8	-1.4	-0.4	-0.0	0.0	-0.2	-0.3	-0.2	-0.1	0.6
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.5	-0.5	-0.7	1.0	-0.1	-0.6	-0.9	-1.0	-0.7	-1.6	-0.9	-1.2	-0.8	-1.0	-1.2	-1.1	-0.8	-0.6	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	-0.8	-0.6	1.1	-0.2	-0.7	-0.6	-0.8	-0.5	0.8	-0.7	-0.4	-0.6	-0.9	-0.8	-0.6	-0.7	-0.3	-0.9
Tense / ‘highly strung’	0.4	0.6	2.1	-0.8	-0.7	-0.5	-0.2	-0.8	-0.6	-0.8	-1.0	-0.4	-1.4	-0.8	-0.8	-0.4	-0.8	-1.1	-0.9	-0.5	-0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.7	0.9	1.3	1.0	-0.7	0.7	0.5	1.0	0.6	0.2	0.6	0.7	0.6	0.5	1.0	0.7	0.5	0.4	0.1
Headache pain in last month	0.4	0.7	4.4	0.9	-0.7	2.1	-1.0	-0.7	-0.8	-0.6	-0.2	-1.1	-0.6	-0.6	-0.7	-0.5	-0.6	-0.5	-0.7	-0.6	-0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.0	0.5	-0.7	0.5	-1.4	-0.8	-0.4	-0.6	-1.4	0.1	-1.0	-0.4	-0.6	-0.2	-0.6	-0.5	-0.7	-0.5	-0.7
Birth weight	0.4	1.0	3.5	-0.6	0.6	0.4	1.8	1.2	0.7	0.9	1.9	-0.0	0.9	0.5	1.0	0.5	0.9	1.1	1.1	0.2	1.1
Number of children fathered	0.4	0.4	1.8	0.0	0.7	-1.0	1.3	0.1	0.3	0.4	1.0	0.7	0.3	0.5	0.4	0.7	0.7	0.4	0.2	0.8	0.4
Pulse wave peak to peak time	0.4	0.4	1.0	-1.0	0.3	-0.3	0.8	0.2	0.8	0.3	-0.8	0.9	-0.6	0.6	0.6	0.4	0.5	0.9	0.5	0.3	0.9
Medication: Ibuprofen	0.4	0.4	1.5	-0.4	-0.4	1.0	-0.6	-0.6	-0.6	-0.7	-0.3	1.2	-0.7	-0.3	-0.6	-0.7	-0.5	-0.6	-0.7	-0.2	-0.9
Overall health rating	0.4	0.8	2.6	0.7	-0.9	0.7	-1.3	-0.6	-0.5	-0.7	-1.6	0.5	-1.1	-0.8	-0.7	-0.5	-0.8	-0.7	-0.9	-1.2	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.3	-0.1	1.0	-0.2	-0.8	0.8	0.1	0.6	1.3	-1.5	1.0	-0.4	0.3	-0.1	0.0	0.2	0.4	-0.9	0.0
Illnesses of siblings: Diabetes	0.4	0.5	1.6	0.2	1.3	-0.4	0.1	0.5	1.0	1.0	-0.2	0.6	0.4	0.8	0.8	0.7	0.3	0.5	0.6	0.6	0.8
Long-standing illness, disability or infirmity	0.4	0.6	3.6	1.0	-0.7	0.8	-0.4	-0.2	0.7	-0.2	-1.9	1.4	-1.3	0.4	0.3	0.3	0.3	0.0	0.2	0.3	0.7
Eye problems/disorders: Cataract	0.4	0.5	1.6	-0.2	-1.1	1.1	0.5	-0.9	-0.3	-0.8	-1.3	0.5	-0.9	-0.2	-0.4	-0.5	-0.3	-0.2	-0.2	-0.6	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.0	-0.0	-0.5	-0.1	-0.0	-0.6	-0.8	-0.8	-0.2	-0.9	-0.9	-0.8	-0.9	-0.5	-0.4	-0.8	-1.0	-0.4	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.6	3.3	0.3	-1.4	-1.8	1.0	-0.2	0.2	-1.0	-0.1	-0.0	-1.1	-0.4	-0.1	0.1	-0.4	0.1	-0.3	0.5	0.8
Medication: Atorvastatin	0.4	0.5	2.4	-1.5	1.3	-0.4	-1.3	0.1	-0.0	0.5	0.2	-1.1	0.2	-0.4	-0.1	-0.4	-0.1	0.2	-0.0	-1.1	-0.2
Risk taking	0.4	0.6	1.1	-1.0	-0.1	0.1	-1.0	-1.0	-1.1	-0.8	-0.3	0.0	-0.5	-0.9	-1.0	-0.9	-0.9	-0.9	-1.0	-0.7	-0.7
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.7	-1.3	-1.0	1.5	-0.3	-1.0	-0.8	-0.9	-1.1	-0.7	-1.4	-1.0	-0.9	-1.6	-0.9	-0.8	-0.8	-1.3	-1.0
Bipolar Disorder or Schizophrenia	0.3	0.7	2.2	1.1	-0.4	-0.2	0.1	0.5	1.0	0.4	-1.5	1.3	-0.1	1.2	0.8	0.7	0.5	1.0	0.9	0.7	0.9
Worry (Nagel 2018)	0.3	0.7	1.6	-0.2	1.3	-0.6	1.2	0.7	0.5	1.3	0.5	0.3	1.2	1.0	0.7	1.0	1.0	0.8	0.7	0.5	0.1
HbA1C	0.3	0.3	1.2	-0.8	-0.6	0.7	-0.6	-0.2	-0.3	-0.5	0.1	-1.1	-0.6	-0.7	-0.3	-0.4	-0.3	-0.6	-0.2	-0.3	-0.3
Neuroticism	0.3	0.6	1.7	0.4	0.5	-0.1	1.2	0.5	0.9	1.0	-1.3	0.8	0.0	0.9	0.8	0.8	0.8	0.9	0.9	0.0	0.7
Number of treatments/medications taken	0.3	0.6	1.5	0.3	1.1	-1.2	-0.3	0.9	0.9	0.9	0.5	0.4	0.9	0.6	0.9	1.0	0.4	0.8	0.8	0.4	0.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	0.2	0.8	-0.1	-0.8	0.6	0.3	0.6	1.1	-0.1	0.6	0.7	0.5	0.4	1.0	0.7	0.4	0.8	0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	-0.5	0.9	0.2	0.1	0.7	0.2	0.6	0.8	-0.8	0.1	-0.1	0.3	0.3	0.5	0.5	0.3	-0.6	0.7
High blood pressure (mother)	0.3	0.5	1.6	0.8	0.1	-1.3	0.6	0.6	0.3	0.3	0.9	0.4	0.4	0.6	0.5	0.7	1.2	0.7	0.5	0.5	0.5
Qualifications: None of the above	0.3	0.7	2.7	-0.5	-1.5	0.3	-0.2	-0.6	-0.4	-1.1	-1.6	1.0	-1.2	-0.6	-0.6	-0.6	-1.2	-0.2	-0.8	-0.5	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	2.6	-0.5	-0.2	0.8	-1.6	-0.4	-0.5	-0.4	0.1	-0.9	-0.4	-0.7	-0.5	-0.2	-0.5	-0.7	-0.6	-0.1	-0.6
Lung cancer (father)	0.3	0.4	0.8	-0.2	-0.9	-0.2	0.8	-0.6	-0.8	-0.9	-0.5	-0.1	-0.7	-0.5	-0.8	-0.5	-0.4	-0.6	-0.9	-0.0	-0.2
Illnesses of mother	0.3	0.4	1.5	-1.0	-0.9	0.3	0.8	-0.7	-0.4	-0.8	-0.9	-0.1	-0.4	-0.5	-0.5	-0.5	-1.2	-0.6	-0.5	-0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.5	1.2	0.6	-0.3	1.2	0.7	0.5	0.5	0.2	0.3	0.7	1.0	0.7	0.9	0.7	0.9	0.8	0.7	0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.3	0.1	-0.2	1.2	-0.9	-0.6	-0.9	-0.5	-0.1	-0.8	-0.4	-0.6	-0.9	-0.3	-0.2	-1.0	-0.9	-0.3	-0.7
Heart disease (mother)	0.3	0.4	1.0	0.6	-0.5	1.0	-0.6	-0.8	-0.5	-0.6	-0.5	-0.4	-0.9	-0.2	-0.6	-0.6	-0.2	-0.6	-0.7	-0.3	-0.7
Knee pain experienced in last month	0.3	0.4	1.0	0.1	0.2	-0.2	-0.3	1.0	1.0	0.6	0.7	0.7	0.3	0.3	0.9	0.7	0.2	0.9	0.8	0.4	0.7
Smoking status: Previous	0.3	0.4	1.8	0.3	-0.7	-1.0	1.3	0.4	0.5	-0.1	0.8	-0.3	-0.1	0.5	0.5	0.8	0.0	0.6	0.4	0.9	0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.6	-0.6	-0.5	-0.3	-0.1	0.2	1.2	0.3	-0.4	-0.4	-1.3	0.2	0.8	0.1	-0.0	1.0	0.5	0.0	0.8
Medication: Bendroflumethiazide	0.3	0.4	1.5	0.1	1.2	0.0	-0.5	1.0	0.1	0.7	1.0	-0.7	1.1	0.3	0.3	0.6	0.2	0.5	0.1	0.4	0.2
Average weekly beer plus cider intake	0.3	0.4	1.4	0.8	-0.2	-1.2	-0.0	0.5	0.9	0.3	0.1	0.8	0.3	0.3	0.7	0.8	0.1	0.6	0.6	0.7	1.0
Diastolic blood pressure, automated reading	0.3	0.9	3.8	1.9	0.0	0.3	1.0	0.5	0.5	0.1	0.5	1.5	0.2	1.1	0.6	1.4	0.7	0.3	0.3	2.0	1.0
Ever depressed for a whole week	0.3	0.4	2.2	-0.2	-0.8	0.8	-0.3	-0.7	-0.2	-0.5	-1.5	-0.1	-0.9	-0.5	-0.3	-0.4	-0.7	-0.5	-0.4	-0.5	-0.3
Myopia	0.3	0.4	3.2	0.3	-0.6	0.0	-0.7	-0.5	-0.2	-0.2	-1.8	1.4	-0.4	-0.0	-0.4	-0.2	-0.2	-0.6	-0.2	-0.3	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	2.7	0.9	-1.0	-0.1	-0.2	-0.5	-0.1	-0.8	-1.0	-0.2	-1.6	-0.0	-0.3	-0.2	-0.0	-0.4	-0.4	0.1	0.2
Pain experienced in last month	0.3	0.5	1.2	-0.9	-0.4	-0.7	-0.5	-0.8	-0.8	-0.8	-1.1	-0.3	-0.5	-0.8	-0.9	-0.5	-0.6	-1.1	-0.8	-0.6	-0.5
Heart disease (siblings)	0.3	0.4	3.3	1.8	0.5	0.1	-0.1	0.4	0.0	0.4	1.1	0.6	0.6	0.1	0.2	0.3	0.5	0.0	0.1	-0.0	-0.3
Neuroticism (Nagel 2018)	0.2	0.4	4.4	-0.4	-0.2	1.1	-0.1	-0.6	0.1	0.2	-2.1	0.2	-0.9	0.1	-0.0	0.0	-0.1	0.2	-0.1	-0.7	-0.2
Irritable Bowel Disease (IBD)	0.2	0.6	1.3	0.0	-0.6	0.6	-0.5	-0.7	-1.1	-0.8	0.2	-1.0	-0.2	-0.5	-0.9	-1.1	-0.5	-0.5	-0.7	-1.0	-1.2
Major Depression (MDD)	0.2	0.2	1.8	-0.1	-0.3	0.0	0.2	-0.7	-0.3	-0.2	-1.4	0.0	-0.7	-0.0	-0.3	-0.3	-0.3	-0.5	-0.3	-0.2	-0.3
Fasting Glucose	0.2	0.2	1.1	0.3	0.1	-1.0	0.7	0.2	0.4	0.2	-0.2	0.7	0.6	0.8	0.1	0.2	0.3	0.7	0.2	0.5	0.5
LDL Cholesterol	0.2	0.3	1.8	1.3	0.3	-0.5	-0.2	-0.5	-0.6	-0.2	-0.2	0.6	0.3	-0.2	-0.7	-0.5	-0.3	-0.4	-0.7	-0.4	-0.6
Rheumatoid Arthritis	0.2	0.2	0.7	0.4	-0.7	0.3	-0.5	-0.5	-0.2	-0.6	-0.9	0.5	-0.8	-0.2	-0.3	-0.3	-0.0	-0.1	-0.3	-0.4	-0.4
Blood Eosinophil Count	0.2	1.2	4.2	-0.1	-1.6	1.1	-0.7	-1.5	-0.7	-1.2	-2.1	0.8	-1.6	-0.5	-1.0	-1.0	-0.6	-1.0	-1.0	-0.3	-1.0
Waist Hip Ratio (WHR)	0.2	0.8	4.9	-1.1	0.8	-2.0	0.8	0.3	-0.3	0.4	2.2	-1.2	0.6	-0.3	0.2	0.1	0.6	-0.3	0.2	0.5	0.5
Systolic Blood Pressure	0.2	0.9	3.2	-1.4	-0.1	-0.6	-0.7	0.1	-1.3	-0.6	1.8	-1.5	1.2	-1.0	-0.7	0.1	-0.4	-1.1	-0.6	-0.2	-0.8
Allergy or Eczema	0.2	0.4	3.9	-0.1	-0.5	1.2	-2.0	0.2	0.0	-0.2	-0.3	-0.9	-0.3	-0.2	-0.2	0.3	-0.3	-0.6	-0.5	0.5	-0.2
Cardiovascular Disease	0.2	0.8	2.0	1.0	1.0	-0.7	0.0	0.8	0.7	0.8	0.6	0.7	1.2	0.9	0.7	1.4	1.0	0.6	0.8	1.1	0.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	4.5	-2.1	0.0	0.7	0.8	0.2	0.5	0.2	-0.5	-0.6	-0.6	-0.2	0.4	-0.2	-0.3	0.2	0.2	-0.6	0.2
Hair Pigment	0.2	6.9	13.0	1.5	2.4	-2.6	3.6	2.9	2.4	2.6	2.7	3.1	2.2	2.5	2.6	2.7	2.8	2.4	2.6	2.6	2.5
Average weekly spirits intake	0.2	0.2	1.0	-1.0	0.1	1.0	-0.1	-0.2	-0.3	-0.1	-0.3	0.8	-0.2	-0.1	-0.3	-0.3	-0.1	-0.2	-0.3	-0.5	-0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.9	0.5	0.5	1.0	-0.9	0.6	0.2	0.4	0.4	-0.7	0.5	0.2	0.2	0.3	0.5	0.3	0.3	0.1	0.1
Systolic blood pressure, automated reading	0.2	0.5	1.3	-0.0	0.4	-0.8	-1.0	0.8	0.3	0.3	1.2	0.4	1.0	0.5	0.4	0.8	0.5	0.3	0.3	1.1	0.5
Angina	0.2	0.2	1.3	-0.6	0.2	0.3	-0.8	-0.1	-0.2	-0.2	0.3	-1.1	-0.1	-0.4	-0.1	-0.3	-0.3	-0.1	-0.1	-0.8	-0.4
Medication: Metformin	0.2	0.3	1.8	-0.2	0.1	1.3	-0.0	-0.3	-0.6	-0.3	0.2	-0.4	-0.8	-0.5	-0.5	-0.7	-0.1	-0.6	-0.5	-0.8	-0.6
Average weekly fortified wine intake	0.2	0.2	1.2	-0.7	-0.2	-0.4	0.4	0.4	0.1	0.1	1.1	-0.1	0.0	0.3	0.2	0.0	0.5	0.5	0.2	0.5	0.6
Fed-up feelings	0.2	0.3	2.4	-0.5	0.2	0.9	0.0	0.1	0.6	0.6	-1.5	-0.2	-0.5	0.3	0.5	0.0	-0.0	0.5	0.4	-0.5	0.4
Medication: Levothyroxine sodium	0.2	0.3	0.9	0.8	0.4	-0.5	0.9	0.6	0.4	0.4	0.2	0.4	0.4	0.8	0.6	0.6	0.7	0.7	0.7	0.4	0.4
Number of incorrect matches in round	0.2	0.4	1.9	-0.4	0.1	-0.3	-1.4	-0.4	-0.3	0.1	-0.7	0.7	0.2	-0.3	-0.3	-0.4	-0.1	-0.0	-0.3	-1.3	-0.9
Hearing difficulty/problems with background noise	0.2	0.3	1.4	-0.4	0.4	0.5	0.7	-0.1	-0.2	0.1	-1.0	-0.8	0.2	-0.0	-0.2	-0.3	-0.3	0.4	0.1	-1.2	-0.1
Had other major operations	0.2	0.2	0.6	-0.5	0.8	0.1	0.4	0.3	0.6	0.7	-0.4	-0.1	0.4	0.5	0.4	0.4	0.2	0.4	0.3	0.4	0.2
Heart attack	0.2	0.2	0.7	-0.8	-0.3	-0.1	-0.3	-0.4	-0.1	-0.3	-0.5	0.4	-0.7	-0.7	-0.2	-0.3	-0.3	-0.3	-0.3	-0.7	-0.3
Neuroticism score	0.2	0.4	1.5	-0.4	0.3	-0.4	1.0	0.2	0.6	0.7	-1.2	1.2	-0.2	0.8	0.4	0.4	0.5	0.6	0.4	-0.2	0.0
Arm fat percentage (right)	0.2	0.8	4.2	1.1	-0.5	2.1	-1.1	-0.4	-0.2	-0.5	-2.0	1.0	-0.9	0.3	-0.6	-0.6	-0.6	-0.3	-0.8	0.1	-0.6
Time employed in main current job	0.2	0.2	0.6	0.7	0.7	0.5	0.7	-0.1	-0.4	0.1	0.1	0.7	0.3	0.4	-0.2	-0.2	0.2	-0.1	-0.3	0.6	-0.3
Happiness	0.2	0.2	1.4	0.3	-0.2	1.2	-0.8	-0.4	-0.2	-0.1	-0.7	0.1	-0.6	-0.3	-0.3	-0.1	-0.0	-0.6	-0.4	0.0	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.8	0.2	-0.7	0.5	0.1	0.7	0.3	-0.7	-0.7	-0.4	0.3	0.5	0.5	0.2	0.4	0.6	-0.0	0.7
Hair/balding pattern: Pattern 4	0.2	0.5	3.6	-0.2	-0.1	-1.0	1.7	0.1	0.4	0.1	-0.6	1.9	-0.4	0.5	0.3	0.4	0.5	0.4	0.2	0.2	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.2	0.4	0.5	-0.3	0.6	0.4	0.5	0.6	-0.1	0.0	0.4	0.9	0.5	0.8	0.6	0.4	0.6	1.1	0.6
Medication: Paracetamol	0.2	0.3	1.3	-0.8	-0.4	0.6	-0.8	-0.6	-0.4	-0.3	-0.6	0.2	0.0	-0.3	-0.3	-0.8	-0.8	-0.4	-0.4	-0.4	-1.1
Worry too long after embarrassment	0.2	0.3	2.6	0.9	-0.3	-0.1	-0.5	-0.5	0.2	0.0	-1.6	0.2	-1.0	-0.2	-0.0	0.2	0.1	0.0	-0.1	-0.4	0.2
Eye problems/disorders: None of the above	0.2	0.2	1.0	0.6	0.5	-0.8	-0.2	0.6	0.3	0.4	0.3	0.1	0.8	0.4	0.2	0.6	-0.1	0.0	0.2	1.0	0.1
Angina (self-reported)	0.2	0.2	1.0	-0.6	0.1	0.2	-1.0	-0.2	-0.3	-0.4	0.3	-0.9	-0.2	-0.5	-0.2	-0.4	-0.4	-0.2	-0.2	-0.9	-0.5
Mean time to correctly identify matches	0.2	0.3	1.9	-0.7	0.8	-0.9	-1.4	0.5	0.3	0.4	-0.4	-0.5	0.1	0.2	0.3	-0.0	0.2	0.6	0.2	-0.3	0.6
Number of full sisters	0.2	0.2	1.7	1.0	-0.0	1.3	0.2	0.1	-0.0	0.2	-0.8	0.4	-0.1	0.1	0.1	0.1	0.1	-0.0	0.1	-0.2	0.1
Leg pain on walking	0.2	0.3	2.0	-0.4	-0.1	0.9	-1.4	0.2	-0.1	-0.2	-0.7	0.9	-0.2	-0.2	-0.2	-0.5	-0.2	-0.2	-0.2	-0.5	-0.5
Arm fat percentage (left)	0.2	0.7	3.4	1.2	-0.4	1.9	-0.9	-0.3	-0.1	-0.4	-1.8	1.1	-0.7	0.5	-0.4	-0.4	-0.4	-0.1	-0.6	0.3	-0.5
Diabetes diagnosed by doctor	0.2	0.3	1.1	-1.0	0.4	1.0	-0.6	0.0	-0.0	0.2	-0.2	-0.8	-0.6	-0.6	-0.1	-0.2	-0.0	-0.3	-0.2	-0.7	-0.1
Friendships satisfaction	0.2	0.2	1.7	0.3	-0.3	1.3	-0.9	-0.2	-0.1	0.1	-0.2	-1.0	-0.1	-0.2	-0.1	-0.2	-0.4	-0.1	-0.3	-0.0	-0.2
Commuting to job workplace: Walk	0.2	0.2	1.1	1.1	-0.1	0.4	-0.1	-0.4	0.1	-0.1	-0.6	0.8	-0.3	0.4	0.1	0.3	0.2	0.2	-0.0	0.4	0.1
Mineral and other dietary supplements	0.2	0.3	1.6	-1.0	0.3	0.4	-0.5	0.5	-0.2	0.2	0.7	1.3	0.5	0.1	-0.1	0.2	0.5	-0.3	0.0	0.3	-0.1
Medication: Gliclazide	0.2	0.3	2.3	-0.9	0.3	0.1	-0.0	0.1	-0.2	-0.1	-0.0	-1.5	-0.1	-0.4	-0.2	-0.3	-0.4	0.0	-0.2	-0.9	-0.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.9	-0.7	0.4	-0.9	-0.1	0.7	0.7	0.4	0.7	0.3	-0.3	0.0	0.5	0.3	0.3	0.5	0.4	0.1	0.9
Medication: Paracetamol	0.2	0.4	1.3	-0.4	-0.1	1.0	-1.1	-0.8	-0.4	-0.2	-0.4	-0.1	-0.1	-0.5	-0.4	-0.8	-0.8	-0.5	-0.5	-0.5	-1.0
Supplements: Calcium	0.2	0.3	1.3	-0.1	-0.7	-0.7	-0.7	-0.2	0.1	-0.5	-1.1	0.7	-0.4	-0.3	-0.2	-0.2	-0.6	0.1	-0.1	-0.7	-0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.7	-0.8	-0.4	0.1	-0.3	-0.4	-0.1	-0.3	-0.6	0.5	-0.7	-0.7	-0.2	-0.4	-0.5	-0.2	-0.3	-0.9	-0.3
Alcohol drinker status: Previous	0.2	0.2	0.7	-0.5	-0.8	0.3	-0.3	-0.2	-0.4	-0.7	0.0	-0.3	-0.1	-0.4	-0.4	-0.5	-0.4	-0.1	-0.4	-0.8	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	1.0	0.5	1.0	0.8	0.2	0.2	0.1	0.6	0.8	-0.8	0.0	-0.2	0.2	0.1	0.7	-0.2	0.2	-0.1	0.4
Ulcerative Colitis (UC)	0.1	0.1	0.7	0.4	-0.0	0.1	0.8	0.0	-0.1	0.2	0.7	-0.1	0.4	0.4	-0.0	-0.2	0.5	0.3	0.1	-0.1	-0.3
Prostate Cancer	0.1	0.1	0.6	0.3	-0.4	-0.8	0.6	-0.1	0.3	-0.2	-0.1	-0.2	-0.1	0.0	0.2	0.1	-0.4	0.1	0.2	0.2	0.2
Bipolar Disorder (2011)	0.1	0.1	0.5	-0.5	-0.4	0.6	0.3	-0.3	-0.4	-0.3	-0.5	0.0	-0.4	-0.3	-0.3	-0.5	-0.2	-0.1	-0.1	-0.7	-0.1
Blood White Count	0.1	0.9	3.3	1.8	0.2	-1.5	1.0	-0.2	0.7	0.5	-0.5	1.0	-0.3	1.3	0.6	0.7	0.8	0.7	0.4	1.4	0.9
Hypothyroidism (self reported)	0.1	0.2	1.3	0.3	-0.2	0.8	1.1	-0.2	-0.5	-0.4	-0.4	-0.1	-0.2	-0.1	-0.2	-0.1	-0.1	-0.1	-0.1	-0.3	-0.3
Chronotype (morning person)	0.1	0.2	0.4	-0.3	-0.5	0.1	0.1	-0.6	-0.6	-0.6	0.3	0.1	-0.3	-0.4	-0.5	-0.6	-0.3	0.2	-0.5	-0.3	-0.1
Ever had hysterectomy (womb removed)	0.1	0.2	0.9	-0.7	-0.2	1.0	-0.2	-0.6	-0.3	-0.1	-0.3	-0.8	-0.1	0.1	-0.2	-0.3	-0.1	-0.0	-0.1	-0.4	-0.2
Medication for hormone replacement therapy	0.1	0.2	0.7	-0.1	0.4	0.3	-0.6	0.1	0.3	0.4	0.2	-0.1	0.3	0.3	0.4	-0.1	0.8	0.6	0.5	-0.2	0.4
Trunk fat percentage	0.1	0.4	2.5	0.8	-0.1	1.6	-0.7	0.0	0.2	-0.1	-1.0	1.0	-0.3	0.7	-0.1	-0.3	0.1	0.2	-0.2	0.4	-0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.4	0.1	-0.5	0.3	0.1	0.0	-0.1	0.4	0.6	-0.3	0.1	0.1	0.3	0.0	-0.1	-0.0	0.4	0.5
Stomach or abdominal pain in last month	0.1	0.1	0.4	0.3	-0.0	-0.2	-0.3	0.2	0.3	0.1	0.7	-0.7	-0.1	0.0	0.3	0.5	0.3	-0.0	0.1	0.6	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.7	-0.4	0.4	0.4	-0.8	0.4	0.6	0.5	-0.7	-0.3	-0.4	-0.0	0.5	0.2	0.3	0.2	0.5	-0.2	0.2
Diabetes (self-reported)	0.1	0.2	0.8	-0.7	0.7	0.8	0.3	0.3	0.3	0.5	0.2	-0.9	-0.4	-0.2	0.3	0.1	0.3	0.1	0.2	-0.3	0.3
Birth weight of first child	0.1	0.2	1.8	-0.3	0.3	0.1	1.3	0.2	0.3	0.3	-0.2	0.3	-0.1	0.4	0.4	0.5	0.2	0.5	0.3	0.4	0.6
Pulse wave reflection index	0.1	0.2	2.0	1.4	-0.4	0.4	0.2	0.0	0.0	-0.1	-0.6	0.2	0.2	-0.1	-0.0	0.2	-0.3	-0.1	0.0	-0.4	-0.1
Body fat percentage	0.1	0.4	2.2	1.1	0.2	0.9	-0.2	0.4	0.6	0.3	-0.6	1.5	0.0	1.1	0.3	0.1	0.5	0.6	0.1	0.9	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.1	0.5	0.2	-0.7	-0.1	-0.3	0.2	-0.5	0.7	0.4	-0.4	-0.2	-0.1	-0.2	-0.5	-0.1	-0.7	-0.7
Qualifications: College or University degree	0.1	0.3	0.7	0.8	0.2	-0.1	0.4	0.5	0.7	0.4	0.6	0.2	-0.1	0.6	0.6	0.5	0.9	0.4	0.7	0.6	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	1.6	-1.3	-0.4	-0.3	0.2	-0.0	0.2	-0.0	0.3	0.1	-0.2	-0.0	-0.0	-0.1	-0.4	0.1	-0.1	0.2	-0.2
Supplements: Vitamin C	0.1	0.1	0.6	-0.4	0.0	0.1	-0.1	0.0	0.2	0.1	-0.8	-0.1	-0.2	0.4	0.1	0.0	0.3	0.2	0.1	0.0	-0.1
Illnesses of father: Heart disease	0.1	0.2	1.0	-0.4	-0.3	1.0	0.3	-0.2	-0.1	0.0	-0.9	-0.4	0.2	0.4	-0.1	-0.0	-0.4	-0.3	0.1	0.1	-0.5
Qualifications: nursing, teaching	0.1	0.1	0.6	-0.5	0.2	0.4	-0.8	-0.3	-0.4	-0.0	0.4	0.2	0.2	-0.3	-0.3	-0.2	-0.2	-0.6	-0.3	0.1	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.5	-0.7	0.3	-0.2	-0.1	-0.4	0.1	0.1	-0.1	-0.6	-0.2	-0.2	-0.1	-0.2	-0.3	-0.2	-0.0	-0.2	0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.8	0.8	0.9	-0.4	-0.5	0.3	0.2	0.4	0.2	-0.0	0.4	0.1	0.2	0.6	0.5	-0.0	0.1	0.2	0.2
Mother’s age at death	0.1	0.2	1.1	-0.0	-0.5	-0.9	1.1	0.2	0.1	-0.2	0.0	-0.7	0.2	0.1	0.2	0.2	-0.2	-0.1	0.4	0.3	0.4
Medication: Lisinopril	0.1	0.2	1.6	0.1	0.1	-0.6	-1.3	-0.1	-0.2	-0.1	0.2	0.3	0.3	-0.0	-0.2	0.4	0.0	-0.2	-0.2	0.4	-0.2
Number of operations (self-reported)	0.1	0.2	0.7	-0.2	0.2	0.8	-0.9	-0.4	0.0	-0.1	-0.8	-0.4	-0.4	-0.3	-0.1	-0.3	-0.6	-0.1	-0.1	-0.4	0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	1.0	-0.7	-0.7	-1.0	-0.2	-0.3	-0.1	-0.4	0.1	-0.1	-0.5	-0.3	-0.1	-0.2	-0.2	-0.0	-0.1	-0.1	0.1
Commuting to job workplace: Cycle	0.1	0.1	1.2	1.1	-0.1	-0.1	0.2	-0.1	0.1	-0.1	-0.0	0.2	-0.1	0.5	0.1	0.3	0.1	0.1	0.1	0.3	0.2
Bipolar Disorder (2018)	0.0	0.1	0.6	0.7	-0.5	-0.0	0.3	-0.0	-0.2	-0.3	-0.4	0.0	-0.2	-0.0	-0.1	-0.3	-0.1	-0.1	-0.0	-0.1	-0.0
Tanning	0.0	0.4	2.0	-1.4	-0.4	0.7	-0.2	-0.6	0.3	-0.2	-0.9	-0.5	-1.0	0.2	0.1	-0.5	-0.9	0.7	-0.1	-0.1	0.5

Hub : Genes

MRPL43

Models

Trait associations