[Hub]/) : Traits : Impedance of arm (left) :

chr15:44,959,112-46,410,543

Best TWAS P=1.91e-09 · Best GWAS P=2.27e-09 conditioned to 0.303

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex SPATA5L1 0.12 0.24 lasso 7 0.24 6.8e-29 -5.2 -5.2 1.5e-07 0.72 0.31 0.69 FALSE
2 GTEx Adipose Subcutaneous SPATA5L1 0.15 0.21 enet 19 0.21 2.4e-17 -5.2 -5.6 2.4e-08 0.82 0.30 0.70 FALSE
3 GTEx Adipose Visceral Omentum SPATA5L1 0.15 0.14 enet 21 0.13 3.0e-07 -5.2 -5.3 1.0e-07 0.76 0.30 0.70 FALSE
4 GTEx Adrenal Gland SPATA5L1 0.16 0.21 lasso 3 0.18 6.3e-07 -5.0 -5.1 2.8e-07 0.71 0.30 0.67 FALSE
5 GTEx Artery Aorta SPATA5L1 0.24 0.30 enet 13 0.29 2.1e-16 -5.2 -5.2 1.7e-07 0.73 0.30 0.70 FALSE
6 GTEx Artery Coronary SPATA5L1 0.26 0.30 lasso 3 0.28 3.8e-10 -5.2 -5.2 1.7e-07 0.72 0.30 0.70 FALSE
7 GTEx Artery Tibial SPATA5L1 0.21 0.21 enet 20 0.22 4.6e-17 -5.2 -5.2 2.4e-07 0.68 0.29 0.71 FALSE
8 GTEx Breast Mammary Tissue SPATA5L1 0.31 0.17 lasso 7 0.18 2.4e-09 -5.2 -5.1 2.8e-07 0.70 0.30 0.70 FALSE
9 GTEx Cells EBV-transformed lymphocytes SPATA5L1 0.17 0.18 enet 18 0.18 2.1e-06 -5.2 -5.2 2.0e-07 0.70 0.27 0.62 FALSE
10 GTEx Cells Transformed fibroblasts SPATA5L1 0.30 0.41 lasso 5 0.41 9.7e-33 -5.2 -5.2 1.8e-07 0.73 0.30 0.70 FALSE
11 GTEx Colon Sigmoid SPATA5L1 0.17 0.21 lasso 3 0.18 6.4e-07 -5.2 -5.2 2.0e-07 0.72 0.29 0.70 FALSE
12 GTEx Colon Transverse SPATA5L1 0.19 0.16 lasso 2 0.14 2.7e-07 -5.2 -5.2 2.3e-07 0.73 0.30 0.69 FALSE
13 GTEx Esophagus Gastroesophageal Junction SPATA5L1 0.18 0.20 lasso 10 0.14 8.2e-06 -5.2 -5.2 2.2e-07 0.73 0.31 0.67 FALSE
14 GTEx Esophagus Mucosa SPATA5L1 0.17 0.14 enet 21 0.15 5.0e-10 -5.2 -5.4 5.3e-08 0.75 0.30 0.70 FALSE
15 GTEx Esophagus Mucosa GATM 0.10 0.04 enet 20 0.10 5.7e-07 -4.9 5.5 3.2e-08 -0.89 0.06 0.94 FALSE
16 GTEx Esophagus Muscularis SPATA5L1 0.24 0.24 lasso 4 0.24 4.7e-15 -5.2 -5.2 1.7e-07 0.74 0.30 0.70 FALSE
17 GTEx Heart Atrial Appendage SPATA5L1 0.15 0.10 lasso 5 0.06 1.4e-03 -5.2 -5.3 1.1e-07 0.72 0.18 0.71 FALSE
18 GTEx Heart Left Ventricle SPATA5L1 0.10 0.09 enet 9 0.06 4.3e-04 -5.2 -5.3 1.3e-07 0.72 0.27 0.66 FALSE
19 GTEx Lung GATM 0.04 0.04 lasso 2 0.02 8.2e-03 -5.2 5.2 2.1e-07 -0.89 0.05 0.82 FALSE
20 GTEx Muscle Skeletal SPATA5L1 0.10 0.12 lasso 6 0.10 1.9e-10 -5.2 -5.3 1.4e-07 0.73 0.31 0.68 FALSE
21 GTEx Muscle Skeletal GATM 0.13 0.10 lasso 6 0.11 9.3e-11 -5.2 -5.2 2.3e-07 0.72 0.30 0.70 FALSE
22 GTEx Nerve Tibial SPATA5L1 0.20 0.33 lasso 10 0.33 5.3e-24 -5.2 -5.2 1.9e-07 0.72 0.30 0.70 FALSE
23 GTEx Nerve Tibial GATM 0.07 0.04 lasso 2 0.08 1.9e-06 2.2 5.2 1.8e-07 -0.49 0.23 0.54 FALSE
24 GTEx Skin Sun Exposed Lower leg SPATA5L1 0.07 0.10 lasso 4 0.10 2.4e-08 -5.2 -5.2 1.7e-07 0.72 0.30 0.70 FALSE
25 GTEx Skin Sun Exposed Lower leg GATM 0.11 0.11 lasso 7 0.11 3.5e-09 -5.2 5.4 8.4e-08 -0.72 0.31 0.69 FALSE
26 GTEx Small Intestine Terminal Ileum SPATA5L1 0.23 0.26 lasso 1 0.26 1.6e-06 -5.2 -5.2 1.7e-07 0.72 0.19 0.48 FALSE
27 GTEx Spleen SPATA5L1 0.27 0.19 lasso 1 0.15 9.8e-05 -5.2 -5.2 1.7e-07 0.72 0.18 0.43 FALSE
28 GTEx Thyroid SPATA5L1 0.19 0.23 lasso 6 0.23 1.6e-17 -5.2 -5.2 2.7e-07 0.71 0.31 0.69 FALSE
29 GTEx Thyroid GATM 0.14 0.13 lasso 5 0.17 8.4e-13 -5.2 5.9 3.9e-09 -0.91 0.04 0.96 FALSE
30 GTEx Whole Blood SPATA5L1 0.24 0.26 lasso 5 0.26 2.4e-24 -5.2 -5.2 2.6e-07 0.71 0.29 0.71 FALSE
31 METSIM Adipose GATM 0.11 0.22 lasso 12 0.22 6.7e-33 -5.1 5.3 1.5e-07 -0.75 0.30 0.70 FALSE
32 METSIM Adipose SPATA5L1 0.16 0.26 lasso 20 0.25 2.0e-37 -5.2 -5.2 2.3e-07 0.73 0.31 0.69 FALSE
33 NTR Blood GATM 0.03 0.02 lasso 7 0.02 8.3e-08 -5.2 5.4 8.5e-08 -0.76 0.25 0.75 FALSE
34 NTR Blood SPATA5L1 0.05 0.08 lasso 11 0.08 1.6e-25 -5.2 -5.2 2.1e-07 0.76 0.34 0.66 FALSE
35 YFS Blood GATM 0.03 0.05 lasso 19 0.06 4.1e-19 -5.8 6.0 1.9e-09 -0.94 0.01 0.99 TRUE
36 YFS Blood SPATA5L1 0.21 0.45 lasso 16 0.45 7.5e-166 -5.1 -5.2 2.7e-07 0.74 0.36 0.64 FALSE
37 The Cancer Genome Atlas Breast Invasive Carcinoma GATM 0.02 0.03 lasso 3 0.02 7.3e-06 -5.2 5.2 1.8e-07 -0.73 0.29 0.70 FALSE
38 The Cancer Genome Atlas Breast Invasive Carcinoma SPATA5L1 0.05 0.08 lasso 2 0.07 7.6e-15 -5.1 -5.1 2.8e-07 0.73 0.20 0.80 FALSE
39 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma SPATA5L1 0.08 0.01 blup 33 0.03 1.2e-02 -5.0 -5.6 2.2e-08 0.89 0.01 0.67 FALSE
40 The Cancer Genome Atlas Colon Adenocarcinoma GATM 0.35 0.18 blup 41 0.18 2.4e-10 -5.8 5.7 1.2e-08 -0.95 0.01 0.99 FALSE
41 The Cancer Genome Atlas Glioblastoma Multiforme SPATA5L1 0.13 0.10 enet 8 0.06 5.0e-03 -5.2 -5.2 1.8e-07 0.73 0.07 0.39 FALSE
42 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma GATM 0.02 0.01 blup 41 0.01 1.0e-02 -5.1 5.8 8.5e-09 -0.88 0.04 0.78 FALSE
43 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SLC28A2 0.03 0.04 blup 55 0.03 7.3e-03 -5.3 5.2 2.2e-07 -0.89 0.03 0.58 FALSE
44 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SPATA5L1 0.12 0.17 lasso 7 0.15 3.7e-09 -5.2 -5.2 1.7e-07 0.72 0.19 0.81 FALSE
45 The Cancer Genome Atlas Brain Lower Grade Glioma GATM 0.02 0.02 enet 8 0.02 1.8e-03 -5.2 5.2 2.2e-07 -0.73 0.19 0.55 FALSE
46 The Cancer Genome Atlas Brain Lower Grade Glioma SPATA5L1 0.10 0.18 enet 15 0.18 2.7e-20 -5.2 -5.2 2.0e-07 0.73 0.19 0.81 FALSE
47 The Cancer Genome Atlas Lung Adenocarcinoma GATM 0.04 0.01 blup 41 0.02 1.8e-03 -5.7 6.0 2.0e-09 -0.97 0.01 0.85 FALSE
48 The Cancer Genome Atlas Lung Squamous Cell Carcinoma GATM 0.02 0.01 blup 41 0.02 5.1e-03 -5.2 5.9 4.2e-09 -0.88 0.02 0.74 FALSE
49 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SPATA5L1 0.06 0.09 enet 6 0.08 5.2e-06 -5.2 -5.2 1.8e-07 0.73 0.14 0.85 FALSE
50 The Cancer Genome Atlas Pancreatic Adenocarcinoma SPATA5L1 0.13 0.21 lasso 7 0.20 1.1e-08 -5.2 -5.2 2.0e-07 0.73 0.18 0.82 FALSE
51 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma GATM 0.09 0.10 lasso 1 0.09 1.6e-04 -5.5 5.5 3.0e-08 -0.75 0.14 0.55 FALSE
52 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma SPATA5L1 0.12 0.11 enet 14 0.11 3.1e-05 -5.2 -5.2 2.0e-07 0.73 0.12 0.76 FALSE
53 The Cancer Genome Atlas Prostate Adenocarcinoma GATM 0.03 0.03 blup 41 0.04 7.3e-05 -5.2 5.8 5.4e-09 -0.86 0.07 0.91 FALSE
54 The Cancer Genome Atlas Prostate Adenocarcinoma SPATA5L1 0.14 0.21 lasso 2 0.21 1.5e-21 -5.2 -5.2 2.5e-07 0.73 0.20 0.80 FALSE
55 The Cancer Genome Atlas Soft Tissue Sarcoma SPATA5L1 0.05 0.07 enet 6 0.05 7.2e-04 -5.1 -5.2 1.8e-07 0.73 0.15 0.78 FALSE
56 The Cancer Genome Atlas Stomach Adenocarcinoma SPATA5L1 0.05 0.06 blup 33 0.06 2.9e-05 -5.2 -5.3 1.3e-07 0.77 0.09 0.88 FALSE
57 The Cancer Genome Atlas Thyroid Carcinoma GATM 0.03 0.03 blup 41 0.02 1.7e-03 -5.2 5.5 3.7e-08 -0.80 0.11 0.63 FALSE