Hub : Genes

SLC28A2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0227	0.0091	2.4e-04	0.000	0.009	0.005	0.009	0.001	0.27000	4.0e-04	0.00650	0.00051	9.8e-02
2	TCGA	Colon Adenocarcinoma	0.3280	0.1460	3.2e-03	0.022	0.011	0.048	NA	0.047	0.01900	7.0e-02	0.00088	NA	1.0e-03
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0350	0.0260	7.6e-03	0.038	0.030	0.017	NA	0.022	0.00310	7.3e-03	0.03600	NA	1.9e-02
4	TCGA	Brain Lower Grade Glioma	0.0636	0.0427	1.7e-05	0.030	0.042	0.043	NA	0.046	0.00022	1.2e-05	0.00001	NA	5.9e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.2	1.9	3.5	0.4	-0.7	1.9	1.9
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	-0.0	0.6	0.3	0.6
Depressed Affect (Nagel 2018)	0.2	0.3	1.0	-1.0	-0.1	0.4	0.4
Depression (Nagel 2018)	2.4	3.6	6.5	-0.7	1.6	-2.5	-2.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	-0.9	0.4	-0.5	-0.5
Neuroticism (Nagel 2018)	0.1	0.2	0.5	0.1	-0.7	0.4	0.1
Schizophrenia (2018)	0.4	0.9	1.8	-0.3	1.3	-1.1	-0.7
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	-0.8	0.4	0.1	0.3
Worry (Nagel 2018)	0.5	1.0	2.0	0.9	-0.6	1.4	0.9
Alzheimer’s Disease (in mother)	0.2	0.3	0.9	0.2	0.9	-0.3	-0.1
Alzheimer’s Disease (in father)	1.5	1.6	2.4	-1.5	1.2	-1.3	-1.0
Alzheimer’s Disease (including proxy)	1.3	1.9	2.7	-1.0	1.6	-1.6	-1.2
Crohns Disease (2017)	1.2	2.6	4.5	-1.3	0.9	-2.1	-1.9
Irritable Bowel Disease (IBD)	0.8	1.9	4.0	-0.4	-0.7	-1.7	-2.0
Ulcerative Colitis (UC)	0.6	1.2	2.6	0.5	-1.6	-0.6	-1.3
Major Depression (MDD)	0.2	0.3	0.9	-0.9	-0.3	-0.2	-0.2
Reaction Time	0.1	0.1	0.3	0.0	-0.2	0.5	0.3
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.5	-1.2	0.2	0.6	0.4
Breast Cancer	0.4	0.9	1.6	0.6	0.5	1.2	1.3
Ovarian Cancer	0.3	0.4	1.4	-1.2	-0.3	0.3	0.4
Prostate Cancer	0.5	0.7	1.4	1.2	-1.1	0.5	0.2
Age at First Birth	0.6	0.9	1.2	1.1	0.7	-0.9	-1.0
Bipolar Disorder (2011)	0.5	0.5	1.4	-0.0	0.1	0.8	1.2
Body Mass Index (BMI) (2010)	0.8	1.1	2.1	-0.6	1.4	-1.1	-0.8
Coronary Artery Disease (CAD)	2.3	2.8	6.0	2.5	-1.8	1.1	0.9
Crohns Disease (2012)	1.7	2.7	3.8	-1.1	1.9	-1.9	-1.4
Mean Putamen Volume	1.5	1.8	3.5	1.4	-1.9	1.1	0.6
Fasting Glucose	0.5	0.5	1.0	0.8	-0.5	-0.6	-1.0
HbA1C	1.0	1.2	1.3	-1.0	1.1	-1.0	-1.2
HDL Cholesterol	0.2	0.3	0.8	0.9	0.6	0.2	0.1
LDL Cholesterol	0.4	0.6	1.2	-1.1	1.0	-0.2	-0.3
Lupus	2.1	3.1	8.3	-1.0	2.9	-1.6	-0.7
Neuroticism (2016)	0.7	1.0	1.3	-1.1	-0.5	1.1	1.1
Primary Biliary Cirrhosis	0.5	0.7	1.9	1.4	-0.6	0.4	-0.5
Rheumatoid Arthritis	0.4	0.5	1.6	-0.3	1.3	-0.4	-0.6
Schizophrenia (2014)	0.2	0.4	1.2	-0.6	1.1	-0.3	-0.1
Triglycerides	0.4	0.7	1.3	-0.5	0.5	-1.1	-1.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.9	0.4	0.1	-1.3	-1.4
Ulcerative Colitis	1.1	1.6	2.4	1.5	-1.1	-0.7	-1.6
Blood Eosinophil Count	0.8	6.3	9.2	1.0	-2.8	3.0	2.7
Blood Platelet Count	0.3	3.7	8.0	0.9	-1.3	2.8	2.2
Blood Red Count	0.6	5.4	6.6	2.0	-2.2	2.6	2.5
Blood White Count	0.1	0.5	1.7	-0.4	1.3	-0.2	-0.0
Heel T-Score	0.2	1.7	2.7	-1.6	0.7	-1.6	-0.9
BMI	0.5	2.8	9.1	-1.0	3.0	-0.9	-0.3
Height	0.1	1.9	3.5	-1.2	0.3	-1.9	-1.6
Waist Hip Ratio (WHR)	0.3	1.1	4.0	0.3	-2.0	0.2	-0.7
Systolic Blood Pressure	0.1	0.3	0.6	0.6	0.3	-0.4	-0.8
Smoking Status	0.6	1.5	5.7	2.4	-0.2	0.1	-0.6
Allergy or Eczema	0.8	2.1	3.9	-1.7	2.0	-0.9	-0.7
Cardiovascular Disease	0.2	0.7	1.5	-0.3	1.2	0.6	0.8
Hypothyroidism (self reported)	0.1	0.2	0.6	0.2	-0.8	-0.3	-0.6
Respiratory disease	0.3	0.7	2.0	1.4	0.7	0.4	0.3
Type 2 Diabetes (T2D) (2018)	1.4	2.6	4.4	0.8	-1.0	2.1	2.1
Lung FEV1/FVC ratio	0.1	0.7	1.2	-1.0	0.1	-0.8	-1.1
Lung FVC	0.7	3.6	8.7	2.9	-2.0	1.3	0.3
Neuroticism	0.8	1.8	3.3	-0.3	-1.2	1.8	1.6
Chronotype (morning person)	0.2	0.5	1.0	-0.1	-0.4	-0.9	-1.0
Hair Pigment	0.1	3.9	7.6	-0.8	0.6	-2.8	-2.7
Tanning	0.0	0.4	0.6	-0.4	0.6	0.7	0.8
Hand grip strength (left)	0.7	2.0	3.9	-1.2	0.3	-2.0	-1.6
Number of treatments/medications taken	0.4	0.7	2.7	-0.1	1.6	0.1	0.4
Average weekly spirits intake	0.5	0.7	1.0	-0.8	0.7	0.6	1.0
Sensitivity / hurt feelings	0.9	1.6	2.6	0.8	-1.6	1.5	1.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.6	-0.2	1.3	-1.1	-1.1
Hearing difficulty/problems: Yes	0.5	0.7	1.0	-0.7	0.6	-1.0	-0.9
Relative age of first facial hair	0.8	1.6	3.2	-1.8	-1.0	-0.9	-1.1
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	4.4	-2.1	1.7	-1.5	-1.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.3	-1.5	0.2	-1.0	-1.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	-0.3	0.5	0.9	1.1
Systolic blood pressure, automated reading	0.3	0.7	1.2	1.0	0.1	-0.9	-1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.7	-0.7	0.3	0.7	0.8
Angina	0.2	0.3	0.6	-0.7	0.8	-0.2	-0.1
Medication for hormone replacement therapy	1.1	1.2	2.2	-0.2	1.5	-1.0	-1.2
Vitamin and mineral supplements	1.1	1.5	2.6	-0.4	-1.2	1.3	1.6
Supplements: Zinc	0.2	0.3	0.4	-0.5	0.4	-0.5	-0.6
Medication: Co-codamol	0.3	0.3	1.2	0.2	-1.1	0.3	0.0
Medication: Metformin	1.4	2.0	5.0	0.2	0.4	1.7	2.2
Diabetes (father)	0.7	0.9	2.4	-1.6	0.2	-0.9	-0.6
Diabetes (mother)	0.6	0.8	1.5	-1.2	0.5	0.5	1.1
Severe depression (siblings)	0.5	0.6	1.2	0.6	-0.2	1.1	0.9
Pack years adult smoking proportion	0.6	0.9	2.9	-1.7	0.3	0.2	0.8
Impedance of leg (right)	1.8	8.7	15.5	2.0	-3.9	3.1	2.4
Leg fat-free mass (left)	0.9	4.5	8.7	-1.2	3.0	-2.3	-1.7
Trunk fat percentage	1.0	3.9	7.8	0.9	0.4	2.8	2.6
Hand grip strength (right)	0.2	0.7	1.8	-0.5	-1.4	-0.5	-0.5
Townsend deprivation index at recruitment	1.8	2.5	4.6	1.1	-0.2	2.0	2.1
Current tobacco smoking	0.7	1.1	2.1	1.0	-1.4	-0.5	-1.1
Average weekly fortified wine intake	0.4	0.4	0.8	0.1	-0.7	-0.9	-0.6
Maternal smoking around birth	0.4	0.6	1.8	-1.3	-0.2	0.0	0.6
Fed-up feelings	0.3	0.6	1.9	-1.4	0.5	0.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.6	0.6	1.3	-1.0	-0.8
Relative age voice broke	1.3	2.0	3.9	-2.0	0.3	-1.5	-1.4
Taking other prescription medications	1.4	2.1	4.0	-1.6	2.0	-1.2	-0.7
Age when periods started (menarche)	0.5	1.2	3.2	0.6	-1.8	0.5	0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.5	0.5	0.5	0.6	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	3.4	-1.2	1.7	-1.8	-1.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.2	0.4	-0.3	-0.2
Qualifications: CSEs or equivalent	0.4	0.5	1.4	0.6	1.2	-0.5	-0.4
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.3	0.5	-0.4	-0.1
High blood pressure	0.2	0.5	1.3	1.1	0.6	0.1	-0.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.7	-0.9	1.3	-0.1	-0.0
Multivitamins +/- minerals	1.2	1.5	4.0	2.0	-1.0	1.0	0.3
Stomach or abdominal pain in last month	1.1	1.4	3.3	-0.7	1.8	-1.1	-0.8
Supplements: Glucosamine	0.2	0.2	0.4	-0.6	0.6	-0.0	-0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.5	-0.2	0.6	0.7	0.7
Medication: Atenolol	0.8	1.0	1.9	0.9	0.2	-1.1	-1.4
Medication: Levothyroxine sodium	0.2	0.4	0.5	0.6	-0.7	-0.5	-0.7
Sitting height	0.1	0.5	1.5	-0.4	0.1	0.7	1.2
Chronic bronchitis/emphysema (father)	1.1	1.3	1.9	1.4	-0.9	-0.9	-1.4
High blood pressure (mother)	0.1	0.1	0.2	0.3	0.5	-0.1	-0.2
Body mass index (BMI)	0.6	2.6	8.8	-0.9	3.0	-0.8	-0.2
Impedance of leg (left)	1.8	9.0	15.8	1.7	-4.0	3.3	2.5
Leg predicted mass (left)	0.9	4.8	9.1	-1.3	3.0	-2.3	-1.7
Trunk fat mass	0.4	1.6	2.6	0.3	1.3	1.5	1.6
Waist circumference	0.1	0.3	1.1	-0.2	1.1	0.2	0.4
Number of incorrect matches in round	0.6	0.9	1.7	-0.6	1.3	-1.0	-0.9
Past tobacco smoking	1.4	2.5	7.8	-2.8	-0.5	0.7	1.2
Alcohol usually taken with meals	1.1	1.7	2.6	-1.4	1.3	-1.6	-0.8
Nervous feelings	0.1	0.3	0.4	-0.6	0.2	-0.6	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.4	0.0	-0.0	-0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.6	-0.2	-0.4	-0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.1	-0.4	-0.3	-0.3
Had menopause	0.3	0.4	0.8	-0.5	-0.9	-0.3	-0.6
Had other major operations	0.6	0.8	2.7	0.6	1.6	-0.0	0.2
Forced vital capacity (FVC)	0.4	1.5	3.0	1.2	-1.7	-0.6	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.0	-0.5	1.7	-1.7	-1.0
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.4	-0.1	0.6	-1.1	-1.2
Qualifications: None of the above	0.0	0.1	0.3	0.1	0.6	-0.2	-0.1
Financial difficulties in last 2 years	0.3	0.4	0.7	0.3	0.2	-0.8	-0.9
Mouth/teeth dental problems	0.2	0.3	0.9	-1.0	0.2	0.0	0.4
Heart attack	3.6	4.7	8.8	-0.5	-1.0	3.0	2.9
Allergy	0.4	1.0	3.7	0.1	-1.9	0.2	0.3
Pain all over the body in last month	1.3	1.4	3.3	1.2	-0.2	-1.0	-1.8
Diabetes (self-reported)	1.0	1.6	3.3	0.1	1.0	1.4	1.8
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.5	0.9	0.6	-1.3	-1.6
Medication: Ramipril	0.1	0.2	0.4	-0.1	-0.7	0.5	0.2
Medication: Simvastatin	0.4	0.6	0.9	0.7	0.7	0.8	0.9
Fluid intelligence score	0.4	0.8	2.2	-1.5	-0.1	0.8	0.7
Illnesses of siblings	0.3	0.5	0.7	0.4	-0.9	0.7	0.8
Neuroticism score	0.2	0.4	1.0	-1.0	-0.5	0.4	0.4
Weight	0.5	2.3	6.6	-1.1	2.6	-1.0	-0.4
Impedance of arm (right)	3.4	16.1	23.7	2.6	-4.2	4.9	4.0
Arm fat percentage (right)	0.6	2.3	4.2	0.6	1.0	2.0	2.0
Trunk fat-free mass	1.9	10.8	18.1	-2.2	2.9	-4.3	-3.4
Hip circumference	0.3	1.1	2.4	0.0	1.5	0.7	1.3
Time employed in main current job	0.5	0.6	1.8	1.4	-0.4	-0.0	-0.6
Alcohol intake versus 10 years previously	0.4	0.6	0.8	-0.9	0.8	-0.6	-0.7
Father’s age at death	0.0	0.0	0.1	-0.3	-0.0	-0.3	0.0
Worrier / anxious feelings	0.0	0.1	0.1	0.3	-0.1	-0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	1.1	0.0	0.7	0.5
Falls in the last year	3.4	4.5	6.4	-1.6	2.5	-2.4	-1.9
Hair/balding pattern: Pattern 3	0.4	0.5	1.2	0.1	0.6	-0.8	-1.1
Number of live births	1.4	2.0	4.0	1.1	-0.8	2.0	1.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.4	0.4	-1.0	-1.0	-1.5
Pulse rate	1.0	1.7	2.1	-1.3	1.2	-1.4	-1.3
Happiness	0.6	0.7	1.2	-0.3	-0.8	0.8	1.1
Noisy workplace	0.1	0.1	0.2	-0.2	-0.4	0.0	0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.1	-0.0	-0.2	-0.9	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.0	-1.0	0.3	-1.0	-0.6
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	0.0	-0.1	-0.3	-0.5
Asthma	0.7	1.3	2.7	-0.0	1.0	-1.2	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.3	-0.2	0.5	1.3	1.5
Medication: Cholesterol lowering	0.7	1.1	2.7	-0.2	1.6	0.8	1.0
Depression (self-reported)	0.3	0.3	0.9	-0.3	-0.9	0.6	-0.0
Medication: Lansoprazole	2.1	2.4	4.4	0.8	1.0	-1.9	-2.1
Prospective memory result	0.8	1.0	3.4	-0.7	1.8	-0.4	-0.1
Lung cancer (father)	0.8	1.0	1.9	0.3	-0.7	1.4	1.2
Illnesses of mother	0.4	0.5	0.6	0.7	-0.4	0.8	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.3	1.5	-1.4	-0.0	-0.9
Pulse wave Arterial Stiffness index	1.9	2.2	4.2	0.3	1.0	-1.9	-2.1
Impedance of arm (left)	3.9	18.1	26.8	2.9	-4.5	5.2	4.2
Arm fat mass (right)	0.3	1.4	5.0	-0.6	2.2	0.1	0.5
Trunk predicted mass	1.9	10.8	18.3	-2.2	2.9	-4.3	-3.4
Standing height	0.0	0.5	0.6	-0.7	-0.8	-0.7	-0.6
Length of working week for main job	2.3	2.6	6.0	-0.2	-2.4	1.6	1.3
Exposure to tobacco smoke at home	1.3	1.5	4.3	1.0	-2.1	0.7	0.3
Breastfed as a baby	0.1	0.1	0.4	0.6	-0.2	0.4	-0.1
Tense / ‘highly strung’	0.1	0.1	0.4	-0.6	0.3	-0.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.3	0.1	1.1	-1.0	-0.9
Hair/balding pattern: Pattern 4	0.1	0.4	1.1	1.1	-0.3	0.3	0.3
Birth weight of first child	0.2	0.3	1.2	-1.1	0.2	0.3	0.3
Peak expiratory flow (PEF)	0.3	0.6	1.0	0.9	-0.6	-0.5	-1.0
Pulse wave reflection index	1.6	1.9	3.4	0.5	1.1	-1.7	-1.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.9	-0.3	-1.4	-0.5	-0.8
Loud music exposure frequency	1.0	1.1	2.8	-1.0	1.7	0.5	0.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	5.0	-0.2	-2.2	1.1	0.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.7	1.1	-0.0	1.3	1.1
Blood clot in the leg (DVT)	0.4	0.6	1.7	1.3	0.3	0.5	0.5
Medication: Paracetamol	0.6	0.9	3.4	0.2	1.8	-0.5	-0.2
Headache pain in last month	0.7	1.2	2.3	-1.5	1.5	-0.3	0.4
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	5.9	1.3	-2.4	-1.1	-1.8
Glaucoma (self-reported)	0.2	0.2	0.4	-0.7	0.3	-0.4	-0.2
Gout (self-reported)	4.2	5.8	12.2	1.0	-0.8	3.0	3.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.2	0.4	-1.1	0.2	0.2
Medication: Amlodipine	1.0	1.4	3.0	1.7	-0.6	1.3	0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	0.2	-1.3	0.4	0.4
Birth weight	0.5	1.1	1.7	-0.5	0.9	-1.3	-1.3
Chronic bronchitis/emphysema (mother)	2.4	2.8	3.2	-1.6	1.8	-1.6	-1.7
High blood pressure (siblings)	1.3	1.8	2.4	0.7	1.5	-1.6	-1.5
Forced vital capacity (FVC), Best measure	0.7	2.5	4.7	2.2	-2.0	0.0	-1.1
Body fat percentage	0.9	3.6	7.0	0.9	0.6	2.6	2.5
Leg fat percentage (right)	0.3	1.1	1.8	0.2	1.0	1.2	1.4
Arm fat-free mass (right)	1.4	7.3	11.2	-1.6	2.8	-3.3	-2.7
Exposure to tobacco smoke outside home	0.7	1.0	1.2	1.0	1.0	-0.8	-1.1
Comparative body size at age 10	1.1	2.9	4.2	-0.2	1.9	-2.0	-1.9
Number of full brothers	0.1	0.1	0.3	0.0	0.5	-0.1	-0.2
Worry too long after embarrassment	0.8	1.3	4.5	0.5	-2.1	0.7	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.9	-1.7	1.1	-0.9	-0.8
Wheeze or whistling in the chest in last year	0.3	0.5	1.4	-0.4	1.2	-0.5	-0.2
Number of children fathered	0.3	0.4	1.2	0.4	1.1	-0.3	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	0.6	0.3	0.2	0.7
Age at first live birth	0.2	0.3	0.8	0.0	0.0	0.5	0.9
Pulse wave peak to peak time	1.8	2.1	4.2	-0.5	-0.8	1.8	2.0
Health satisfaction	1.5	2.0	2.9	-1.7	1.0	-1.6	-1.1
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.4	0.1	-0.3	-0.4
Qualifications: College or University degree	0.2	0.5	0.9	0.1	0.7	-1.0	-0.8
Eye problems/disorders: None of the above	1.3	1.5	2.3	1.5	-0.8	-0.9	-1.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.3	1.1	-1.0	0.5	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.1	0.4	0.4	0.4
Medication for pain relief, constipation, heartburn	1.3	2.2	8.6	-0.0	-2.9	-0.0	-0.4
Neck or shoulder pain in last month	4.0	5.6	10.8	-1.2	2.1	-3.3	-2.4
Medication: Blood pressure	1.4	2.5	6.1	-1.7	2.5	0.4	0.9
Angina (self-reported)	0.2	0.3	0.5	-0.7	0.7	-0.3	-0.3
Migraine (self-reported)	0.2	0.3	1.1	0.2	1.0	-0.1	0.0
Medication: Ibuprofen	0.4	0.5	0.8	-0.9	0.2	0.5	0.9
Medication: Allopurinol	0.3	0.4	0.9	-0.3	-0.4	0.7	1.0
Medication: Omeprazole	2.5	3.0	4.4	-2.1	2.0	-1.6	-0.9
Medication: Seretide 50 evohaler	1.9	2.2	6.5	-2.5	1.4	-0.4	-0.2
Mean time to correctly identify matches	0.0	0.1	0.2	0.1	-0.0	0.4	0.2
Heart disease (mother)	0.2	0.3	0.8	-0.9	-0.3	0.3	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.9	4.7	6.5	-2.5	1.1	-2.5	-2.1
Whole body fat mass	0.3	1.4	2.5	0.0	1.6	1.1	1.3
Leg fat mass (right)	0.3	1.0	3.7	-0.2	1.9	0.3	0.5
Arm predicted mass (right)	1.3	6.5	10.6	-1.5	2.5	-3.3	-2.6
Pulse rate, automated reading	0.1	0.5	1.0	-0.6	-0.2	0.7	1.0
Alcohol intake frequency.	0.3	0.6	1.7	-1.3	-0.4	-0.6	-0.4
Comparative height size at age 10	0.1	0.5	0.9	-1.0	-0.9	0.0	-0.3
Number of full sisters	0.2	0.3	0.6	0.6	-0.8	-0.1	-0.3
Suffer from ‘nerves’	0.4	0.6	1.7	1.3	-0.1	0.8	0.4
Overall health rating	2.2	4.7	6.6	-1.9	1.6	-2.6	-2.4
Chest pain or discomfort	1.1	1.5	3.0	-0.3	1.0	-1.4	-1.7
Had major operations	1.1	1.2	2.7	-1.2	1.6	-0.9	-0.3
Age at last live birth	1.7	2.4	5.3	-0.1	-0.7	2.0	2.3
Family relationship satisfaction	1.9	2.3	7.2	-2.7	0.7	-1.2	-0.5
Leg pain on walking	0.1	0.1	0.2	0.1	-0.2	-0.4	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.0	1.4	0.3	0.3	0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.5	-0.4	0.4	-0.7	-0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.3	-0.5	-0.2	-0.4
Medication: Aspirin	0.9	1.2	1.7	1.3	1.2	1.1	0.8
Supplements: Vitamin C	3.4	4.1	6.8	-0.4	1.6	-2.6	-2.6
Knee pain experienced in last month	1.0	1.5	2.6	-1.6	1.3	-1.2	-0.5
Hypertension (Self-reported)	0.2	0.5	1.2	1.1	0.7	-0.1	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.4	6.3	0.2	1.1	-2.5	-2.5
Illnesses of father: Heart disease	0.1	0.1	0.4	-0.4	0.2	-0.1	-0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.3	-0.6	0.1	-0.5	-0.4
Smoking status: Previous	1.0	1.5	4.5	2.1	0.9	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.4	-0.4	-0.1	-0.3
Whole body fat-free mass	1.4	8.2	12.5	-1.8	3.1	-3.5	-2.8
Leg fat-free mass (right)	1.0	5.2	9.4	-1.5	3.1	-2.4	-1.8
Arm fat percentage (left)	0.6	2.4	4.2	0.7	1.0	2.0	2.0
Average weekly red wine intake	0.2	0.3	0.7	-0.3	0.3	-0.8	-0.6
Handedness (chirality/laterality): Left-handed	1.4	1.7	2.2	-0.9	1.4	-1.4	-1.5
Mood swings	0.1	0.3	0.5	-0.7	-0.5	0.3	0.5
Loneliness, isolation	1.4	2.0	5.2	-2.3	1.6	-0.1	0.3
Long-standing illness, disability or infirmity	2.1	3.2	5.0	-1.4	2.2	-1.9	-1.4
Ever had bowel cancer screening	6.0	7.0	12.1	-0.4	2.0	-3.5	-3.4
Diabetes diagnosed by doctor	1.3	2.1	4.9	-0.1	0.4	1.9	2.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.3	1.5	-0.1	-0.1	-0.5
Friendships satisfaction	0.2	0.2	0.6	-0.8	0.2	-0.2	-0.2
Qualifications: nursing, teaching	0.6	1.0	3.4	-1.8	-0.3	-0.5	-0.3
Commuting to job workplace: Walk	0.9	0.9	1.7	-1.1	-1.3	0.6	0.8
Eye problems/disorders: Cataract	0.6	0.7	1.5	-1.0	1.2	0.2	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	0.4	1.2	-0.6	-0.1
Medication for cholesterol	0.3	0.5	1.3	-1.1	-0.3	0.1	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	-0.3	1.2	0.4	0.8
Back pain experienced in last month	2.1	3.1	5.3	0.7	2.3	-1.9	-1.7
Mineral and other dietary supplements	0.3	0.4	0.9	0.9	-0.4	0.4	0.6
Breast cancer (self-reported)	0.3	0.3	0.5	0.5	-0.7	0.5	0.5
Asthma (self-reported)	0.4	0.9	1.6	-0.2	1.0	-0.9	-1.3
Osteoporosis (self-reported)	0.1	0.2	0.5	-0.7	0.5	-0.0	0.1
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.2	0.3	0.4	0.5
Medication: Aspirin	1.3	1.7	3.3	1.8	1.2	1.1	1.0
Medication: Gliclazide	0.3	0.3	0.7	-0.7	-0.0	0.3	0.8
Illnesses of father: None of the above (group 1)	0.8	1.0	1.8	1.3	-0.5	1.0	1.0
Smoking status: Current	0.7	1.0	2.0	1.2	-1.4	-0.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.6	0.7	-0.3	0.8	0.2
Whole body water mass	1.5	8.5	12.9	-1.9	3.1	-3.6	-2.8
Leg predicted mass (right)	1.0	5.3	9.7	-1.5	3.1	-2.4	-1.8
Arm fat mass (left)	0.3	1.1	3.4	-0.5	1.8	0.4	0.8
Number of self-reported non-cancer illnesses	1.1	1.8	3.7	-0.9	1.9	-1.4	-0.9
Average weekly champagne plus white wine intake	0.6	0.8	1.6	-0.9	0.8	-1.2	-0.5
Miserableness	0.2	0.4	1.3	-1.1	0.0	-0.3	-0.5
Guilty feelings	2.5	3.7	5.9	-1.5	1.1	-2.4	-2.3
Wears glasses or contact lenses	0.7	0.8	1.8	0.7	1.3	-0.7	-0.6
Ever taken oral contraceptive pill	0.5	0.6	1.0	0.5	1.0	0.9	0.5
Hearing aid user	3.3	3.7	5.9	-2.4	1.7	1.1	2.2
Mother’s age at death	2.1	2.6	3.6	0.5	-1.7	1.9	1.9
Financial situation satisfaction	0.9	1.1	2.2	-0.4	0.6	-1.5	-1.4
Tinnitus: Yes, now most or all of the time	1.7	2.0	4.0	0.3	0.6	-1.9	-2.0
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.4	0.2	-0.1	-0.5
Eye problems/disorders: Glaucoma	1.4	1.7	2.7	-1.3	-0.6	1.4	1.6
Medication: Blood pressure	1.4	2.7	6.5	2.5	-1.7	1.3	0.3
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.8	-0.4	1.7	-0.3	0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	0.7	0.0	-0.3	-0.7
High cholesterol (Self-reported)	0.4	0.8	2.9	-0.4	1.7	-0.2	0.0
Medication: Bendroflumethiazide	0.4	0.6	1.7	0.8	1.3	-0.2	-0.4
Medication: Paracetamol	0.5	0.7	2.5	-0.1	1.6	-0.6	-0.3
Medication: Lisinopril	0.4	0.6	0.9	-0.9	-0.4	0.7	0.9
Medication: Atorvastatin	1.2	1.5	3.9	-1.2	2.0	-0.6	-0.7
Illnesses of father: High blood pressure	0.2	0.2	0.7	0.8	-0.3	0.2	0.3
Alcohol drinker status: Never	1.0	1.2	2.2	-0.7	-0.9	1.1	1.5
Ever smoked	1.4	2.5	6.4	2.5	0.3	-0.9	-1.6
Basal metabolic rate	1.2	6.5	8.9	-1.8	3.0	-3.0	-2.3
Leg fat percentage (left)	0.4	1.3	1.9	-0.2	1.4	1.2	1.4
Arm fat-free mass (left)	1.7	8.8	12.1	-2.3	3.4	-3.5	-2.6
Number of operations (self-reported)	0.2	0.3	1.1	0.3	1.0	-0.2	0.2
Average weekly beer plus cider intake	0.3	0.4	1.2	0.5	-1.1	0.4	-0.2
Irritability	0.5	0.9	2.0	1.4	-0.8	0.0	-0.8
Risk taking	1.1	1.7	4.3	-0.3	0.5	1.4	2.1
Ever had prostate specific antigen (PSA) test	2.9	3.3	7.1	-0.6	2.7	-1.8	-1.7
Fractured/broken bones in last 5 years	5.7	7.4	9.7	-2.5	2.2	-3.1	-3.0
Age started oral contraceptive pill	0.5	0.7	1.3	-1.1	-1.1	0.3	0.1
Diastolic blood pressure, automated reading	0.2	0.6	1.1	1.1	0.9	-0.5	-0.2
Ever depressed for a whole week	0.2	0.3	0.7	0.8	0.3	0.2	0.4
Unable to work because of sickness or disability	1.1	1.4	3.6	-1.0	1.9	0.4	0.9
Commuting to job workplace: Cycle	0.4	0.4	0.6	0.8	-0.3	0.7	0.7
Myopia	0.1	0.2	0.5	-0.4	-0.7	0.2	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.6	-0.2	-0.6	-0.2
Cholesterol lowering medication	0.2	0.3	0.9	1.0	-0.0	-0.2	-0.3
Medication: Omeprazole (e.g. Zanprol)	2.9	3.5	6.5	-1.3	2.5	-1.9	-1.6
Pain experienced in last month	2.1	3.5	8.4	1.3	-2.9	1.8	1.0
Supplements: Calcium	1.8	2.0	3.6	1.4	-0.2	1.5	1.9
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	-0.5	0.8	-0.8	-0.2
Heart attack/myocardial infarction (self-reported)	3.7	4.7	8.9	-0.5	-1.1	3.0	2.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	0.9	0.4	0.6	0.6
Heart disease (siblings)	0.3	0.4	0.6	-0.6	0.6	-0.6	-0.8
Alcohol drinker status: Previous	0.3	0.4	1.0	0.4	-1.0	0.3	0.5
Pack years of smoking	0.8	1.1	3.3	-1.8	0.1	0.5	1.0
Impedance of whole body	3.6	18.3	26.9	2.9	-4.6	5.2	4.1
Leg fat mass (left)	0.3	1.3	4.6	-0.5	2.1	0.3	0.6
Arm predicted mass (left)	1.7	8.5	12.2	-2.0	3.2	-3.5	-2.7