Best TWAS P=1.54e-09 · Best GWAS P=8.31e-13 conditioned to 1.06e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DNAJC10 | 0.11 | 0.04 | enet | 19 | 0.06 | 2.1e-07 | 3.7 | -5.2 | 1.9e-07 | -0.25 | 0.99 | 0.00 | FALSE |
| 2 | GTEx | Brain Hypothalamus | PDE1A | 0.24 | -0.01 | enet | 21 | -0.01 | 7.6e-01 | -5.0 | -6.0 | 1.5e-09 | -0.60 | 0.07 | 0.31 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | PDE1A | 0.11 | 0.03 | bslmm | 526 | 0.06 | 3.2e-08 | 7.2 | -5.3 | 1.4e-07 | -0.62 | 0.00 | 1.00 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PDE1A | 0.03 | 0.01 | blup | 209 | 0.02 | 1.3e-05 | 1.5 | -5.3 | 1.2e-07 | -0.37 | 0.48 | 0.02 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PDE1A | 0.05 | 0.04 | blup | 206 | 0.04 | 5.0e-05 | 4.9 | -5.6 | 1.8e-08 | -0.42 | 0.64 | 0.03 | FALSE |