Best TWAS P=8.31e-17 · Best GWAS P=1.03e-15 conditioned to 0.0236
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HOXD11 | 0.03 | 0.02 | enet | 7 | 0.03 | 5.8e-04 | -8.0 | 8.3 | 8.3e-17 | -0.78 | 0.01 | 0.96 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | HOXD-AS1 | 0.11 | 0.06 | lasso | 6 | 0.09 | 1.4e-11 | -6.3 | 7.0 | 2.6e-12 | -0.01 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Skin Sun Exposed Lower leg | ATP5G3 | 0.11 | 0.06 | lasso | 4 | 0.04 | 2.7e-04 | -5.1 | -5.3 | 1.3e-07 | 0.00 | 0.01 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Esophageal Carcinoma | HOXD12 | 0.21 | 0.05 | blup | 48 | 0.13 | 6.3e-05 | -7.0 | 8.0 | 1.5e-15 | -0.63 | 0.01 | 0.65 | FALSE |
| 9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HOXD9 | 0.05 | 0.02 | blup | 54 | 0.03 | 6.1e-03 | 5.5 | 7.8 | 5.5e-15 | -0.42 | 0.03 | 0.18 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | HOXD10 | 0.06 | 0.03 | enet | 6 | 0.03 | 5.6e-03 | 6.3 | 6.4 | 1.5e-10 | -0.67 | 0.01 | 0.69 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | HOXD9 | 0.06 | 0.04 | blup | 53 | 0.02 | 2.0e-02 | 5.2 | 6.0 | 1.5e-09 | -0.53 | 0.10 | 0.22 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | ATP5G3 | 0.11 | 0.05 | enet | 8 | 0.07 | 1.2e-03 | -4.6 | -5.2 | 1.9e-07 | 0.12 | 0.04 | 0.77 | FALSE |
| 1 | GTEx | Cells Transformed fibroblasts | ATP5G3 | 0.07 | 0.04 | lasso | 6 | 0.01 | 4.6e-02 | -5.1 | -5.2 | 2.1e-07 | -0.01 | 0.01 | 0.98 | FALSE |