Best TWAS P=1.85e-14 · Best GWAS P=6.19e-15 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PEF1 | 0.04 | 0.04 | lasso | 4 | 0.03 | 2.8e-04 | 5.1 | -5.1 | 3.0e-07 | -0.01 | 0.02 | 0.98 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | TMEM54 | 0.05 | 0.00 | blup | 281 | 0.02 | 4.5e-03 | -3.1 | 7.7 | 1.9e-14 | 0.50 | 0.12 | 0.21 | TRUE |
3 | CommonMind | Brain Pre-frontal Cortex | ZNF362 | 0.05 | 0.06 | lasso | 1 | 0.06 | 2.2e-07 | 7.4 | 7.4 | 1.5e-13 | 0.98 | 0.01 | 0.99 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | PHC2 | 0.58 | 0.34 | lasso | 7 | 0.28 | 7.3e-10 | 7.6 | -7.5 | 6.2e-14 | -0.99 | 0.01 | 0.99 | TRUE |
5 | GTEx | Heart Atrial Appendage | RN7SKP16 | 0.08 | 0.06 | enet | 11 | 0.03 | 1.9e-02 | -3.8 | 5.1 | 2.7e-07 | 0.56 | 0.15 | 0.45 | FALSE |
6 | METSIM | Adipose | ZNF362 | 0.09 | 0.02 | enet | 32 | 0.03 | 1.5e-05 | 7.4 | 5.3 | 1.4e-07 | 0.70 | 0.01 | 0.98 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | PHC2 | 0.11 | 0.07 | lasso | 3 | 0.05 | 2.2e-07 | 7.6 | 7.3 | 3.1e-13 | 0.99 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | S100PBP | 0.03 | 0.02 | blup | 46 | 0.02 | 6.6e-06 | 4.9 | -5.2 | 2.0e-07 | -0.07 | 0.01 | 0.97 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF362 | 0.03 | 0.01 | blup | 49 | 0.01 | 1.3e-03 | -2.4 | 6.0 | 1.7e-09 | 0.72 | 0.01 | 0.32 | FALSE |
10 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | S100PBP | 0.06 | 0.03 | blup | 48 | 0.06 | 6.8e-04 | 4.6 | -5.7 | 1.1e-08 | -0.06 | 0.01 | 0.64 | TRUE |