Best TWAS P=2.12e-14 · Best GWAS P=2.01e-14 conditioned to 0.0832
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HHATL | 0.25 | 0.22 | lasso | 8 | 0.27 | 5.5e-33 | -7.7 | -7.6 | 2.1e-14 | 0.90 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | RP4-613B23.1 | 0.07 | 0.02 | lasso | 2 | 0.02 | 9.0e-03 | -5.8 | -5.6 | 1.7e-08 | 0.53 | 0.15 | 0.27 | FALSE |
| 3 | GTEx | Artery Aorta | CCDC13 | 0.19 | 0.13 | enet | 29 | 0.14 | 5.0e-08 | -6.7 | -5.2 | 2.2e-07 | 0.47 | 0.43 | 0.55 | FALSE |
| 4 | GTEx | Brain Cortex | HIGD1A | 0.28 | 0.02 | enet | 36 | 0.12 | 3.6e-04 | -7.5 | 5.6 | 2.3e-08 | -0.60 | 0.01 | 0.92 | FALSE |
| 5 | GTEx | Muscle Skeletal | CCDC13 | 0.08 | 0.00 | enet | 5 | 0.00 | 5.8e-01 | -6.6 | -6.4 | 1.5e-10 | 0.65 | 0.06 | 0.48 | FALSE |
| 6 | GTEx | Thyroid | HIGD1A | 0.10 | 0.09 | lasso | 5 | 0.07 | 2.5e-06 | -4.9 | 5.1 | 3.0e-07 | -0.86 | 0.01 | 0.98 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | HHATL | 0.21 | 0.15 | bslmm | 465 | 0.18 | 1.3e-22 | 3.5 | -6.3 | 2.3e-10 | 0.75 | 0.72 | 0.28 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | HIGD1A | 0.40 | 0.38 | enet | 35 | 0.41 | 3.1e-56 | -4.9 | 5.3 | 9.8e-08 | -0.82 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Glioblastoma Multiforme | HHATL | 0.18 | 0.12 | enet | 7 | 0.21 | 5.2e-07 | 3.5 | -6.3 | 3.0e-10 | 0.74 | 0.03 | 0.91 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HHATL | 0.09 | 0.05 | enet | 10 | 0.10 | 7.4e-12 | -7.5 | -6.8 | 1.3e-11 | 0.78 | 0.01 | 0.99 | FALSE |