Best TWAS P=4.5e-09 · Best GWAS P=1e-10 conditioned to 0.00914
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CCDC152 | 0.09 | 0.04 | lasso | 4 | 0.02 | 6.4e-03 | -5.4 | -5.5 | 4.5e-08 | 0.46 | 0.46 | 0.48 | FALSE |
2 | GTEx | Adipose Visceral Omentum | CCDC152 | 0.09 | 0.06 | lasso | 9 | 0.05 | 1.9e-03 | -5.3 | -5.2 | 1.5e-07 | 0.45 | 0.16 | 0.15 | FALSE |
3 | GTEx | Artery Aorta | CCDC152 | 0.31 | 0.24 | lasso | 8 | 0.24 | 2.5e-13 | -5.3 | -5.3 | 1.2e-07 | 0.45 | 0.49 | 0.51 | FALSE |
4 | GTEx | Artery Coronary | CCDC152 | 0.20 | 0.13 | lasso | 2 | 0.12 | 7.7e-05 | -5.3 | -5.3 | 1.1e-07 | 0.46 | 0.42 | 0.41 | FALSE |
5 | GTEx | Brain Frontal Cortex BA9 | GHR | 0.14 | 0.02 | lasso | 9 | 0.06 | 9.9e-03 | -5.8 | 5.9 | 4.5e-09 | -0.31 | 0.11 | 0.19 | TRUE |
6 | GTEx | Thyroid | CCDC152 | 0.10 | 0.07 | lasso | 4 | 0.04 | 4.2e-04 | -5.3 | -5.3 | 8.9e-08 | 0.45 | 0.44 | 0.46 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | SEPP1 | 0.18 | 0.19 | lasso | 11 | 0.21 | 1.3e-26 | -5.1 | 5.4 | 5.6e-08 | -0.48 | 0.52 | 0.48 | FALSE |
8 | YFS | Blood | CCDC152 | 0.07 | 0.06 | enet | 16 | 0.06 | 2.0e-19 | -5.4 | -5.3 | 9.1e-08 | 0.47 | 0.45 | 0.55 | TRUE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC152 | 0.15 | 0.12 | lasso | 6 | 0.12 | 1.0e-12 | -5.2 | 5.2 | 2.7e-07 | -0.46 | 0.02 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GHR | 0.12 | 0.11 | enet | 6 | 0.13 | 2.5e-13 | 4.9 | 5.8 | 8.8e-09 | -0.26 | 0.42 | 0.58 | FALSE |