Best TWAS P=3.4e-12 · Best GWAS P=5.11e-18 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADAMTSL3 | 0.10 | 0.04 | lasso | 4 | 0.04 | 8.7e-06 | -6.9 | -6.2 | 6.2e-10 | 0.60 | 0.22 | 0.14 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LOC388152 | 0.14 | 0.14 | enet | 20 | 0.18 | 6.7e-22 | 3.3 | -5.2 | 1.7e-07 | 0.48 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Artery Tibial | SCAND2P | 0.12 | 0.05 | enet | 16 | 0.08 | 8.7e-07 | -2.9 | -5.2 | 1.8e-07 | 0.39 | 0.64 | 0.07 | FALSE |
| 4 | GTEx | Brain Cerebellum | AC103965.1 | 0.13 | 0.02 | enet | 21 | 0.01 | 2.1e-01 | 3.3 | -5.6 | 2.4e-08 | 0.49 | 0.08 | 0.43 | FALSE |
| 5 | GTEx | Brain Cortex | GOLGA6L4 | 0.42 | 0.21 | lasso | 7 | 0.28 | 2.8e-08 | -5.4 | -6.4 | 1.9e-10 | 0.61 | 0.20 | 0.70 | TRUE |
| 6 | GTEx | Brain Nucleus accumbens basal ganglia | GOLGA6L4 | 0.21 | 0.04 | lasso | 5 | 0.09 | 2.3e-03 | -6.9 | -5.6 | 2.0e-08 | 0.55 | 0.06 | 0.18 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Male) | GOLGA6L4 | 0.23 | 0.07 | lasso | 2 | 0.12 | 8.3e-04 | -5.4 | -5.6 | 2.2e-08 | 0.49 | 0.07 | 0.31 | TRUE |
| 8 | GTEx | Breast Mammary Tissue (Male) | AC103965.1 | 0.24 | 0.14 | lasso | 4 | 0.11 | 1.4e-03 | 3.2 | -5.4 | 8.0e-08 | 0.53 | 0.07 | 0.57 | TRUE |
| 9 | GTEx | Cells Transformed fibroblasts | AC103965.1 | 0.15 | 0.09 | lasso | 7 | 0.11 | 1.3e-08 | 3.3 | -5.2 | 1.7e-07 | 0.50 | 0.75 | 0.24 | FALSE |
| 10 | GTEx | Colon Transverse | AC103965.1 | 0.15 | 0.07 | enet | 33 | 0.06 | 7.1e-04 | -4.8 | -5.5 | 3.7e-08 | 0.45 | 0.11 | 0.45 | TRUE |
| 11 | GTEx | Esophagus Mucosa | CSPG4P11 | 0.21 | 0.01 | enet | 28 | 0.08 | 3.7e-06 | -4.8 | -5.2 | 2.0e-07 | 0.49 | 0.70 | 0.21 | TRUE |
| 12 | GTEx | Esophagus Muscularis | UBE2Q2P1 | 0.34 | 0.03 | lasso | 7 | 0.15 | 1.9e-09 | 3.7 | 7.0 | 3.4e-12 | -0.35 | 0.16 | 0.67 | TRUE |
| 13 | GTEx | Pancreas | RP11-182J1.16 | 0.08 | -0.01 | enet | 11 | -0.01 | 7.9e-01 | -4.8 | -5.2 | 2.0e-07 | 0.58 | 0.03 | 0.51 | FALSE |
| 14 | GTEx | Prostate | CSPG4P11 | 0.34 | 0.07 | enet | 13 | 0.18 | 2.3e-05 | -1.0 | -5.3 | 1.1e-07 | 0.36 | 0.07 | 0.67 | FALSE |
| 15 | GTEx | Skin Sun Exposed Lower leg | AC103965.1 | 0.33 | 0.17 | enet | 24 | 0.23 | 4.8e-19 | 3.3 | -5.7 | 1.5e-08 | 0.49 | 1.00 | 0.00 | TRUE |
| 16 | GTEx | Small Intestine Terminal Ileum | RP11-182J1.14 | 0.26 | 0.01 | enet | 27 | 0.12 | 1.3e-03 | -6.9 | 5.3 | 1.0e-07 | -0.41 | 0.05 | 0.24 | TRUE |
| 17 | GTEx | Spleen | GOLGA6L4 | 0.55 | 0.20 | enet | 19 | 0.40 | 2.6e-11 | -5.0 | -5.8 | 5.6e-09 | 0.46 | 0.88 | 0.03 | TRUE |
| 18 | GTEx | Whole Blood | GOLGA6L4 | 0.12 | 0.08 | enet | 16 | 0.11 | 2.1e-10 | -4.8 | -5.8 | 8.8e-09 | 0.49 | 0.86 | 0.14 | FALSE |