Best TWAS P=1.03e-11 · Best GWAS P=1.05e-11 conditioned to 0.000315
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SNF8 | 0.08 | 0.07 | lasso | 5 | 0.08 | 9.3e-10 | -4.2 | 5.4 | 8.4e-08 | -0.74 | 0.42 | 0.58 | TRUE |
2 | GTEx | Brain Caudate basal ganglia | RP11-6N17.9 | 0.45 | -0.01 | enet | 28 | 0.16 | 3.3e-05 | -1.0 | -5.7 | 1.2e-08 | 0.06 | 0.06 | 0.13 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | CDK5RAP3 | 0.22 | 0.10 | lasso | 6 | 0.09 | 2.6e-03 | 4.3 | -5.2 | 2.2e-07 | 0.09 | 0.08 | 0.40 | FALSE |
4 | GTEx | Esophagus Muscularis | COPZ2 | 0.14 | 0.04 | lasso | 5 | 0.06 | 1.3e-04 | 3.3 | 5.6 | 2.2e-08 | -0.04 | 0.18 | 0.04 | FALSE |
5 | GTEx | Heart Left Ventricle | ATP5G1 | 0.24 | 0.22 | lasso | 4 | 0.22 | 9.3e-12 | -4.7 | 5.2 | 2.3e-07 | -0.57 | 1.00 | 0.00 | FALSE |
6 | GTEx | Muscle Skeletal | AC003665.1 | 0.05 | 0.03 | enet | 8 | 0.03 | 1.4e-03 | 4.4 | 5.3 | 9.7e-08 | -0.10 | 0.12 | 0.72 | FALSE |
7 | GTEx | Ovary | ATP5G1 | 0.15 | 0.08 | enet | 13 | 0.09 | 2.8e-03 | -3.8 | 5.3 | 1.4e-07 | -0.62 | 0.05 | 0.78 | FALSE |
8 | GTEx | Pancreas | CDK5RAP3 | 0.11 | -0.01 | lasso | 4 | 0.02 | 5.1e-02 | 4.3 | -5.4 | 7.2e-08 | 0.06 | 0.09 | 0.18 | FALSE |
9 | GTEx | Pancreas | RP11-6N17.9 | 0.15 | 0.04 | lasso | 5 | 0.04 | 9.3e-03 | -1.3 | -5.2 | 2.6e-07 | 0.08 | 0.13 | 0.17 | FALSE |
10 | GTEx | Stomach | RP11-6N17.9 | 0.13 | 0.02 | lasso | 6 | 0.04 | 8.0e-03 | 4.9 | -5.8 | 6.6e-09 | 0.05 | 0.11 | 0.69 | FALSE |
11 | GTEx | Testis | RP11-6N17.4 | 0.14 | 0.02 | lasso | 10 | 0.02 | 4.8e-02 | 5.3 | 5.2 | 1.7e-07 | -0.06 | 0.17 | 0.67 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CBX1 | 0.03 | 0.04 | lasso | 4 | 0.04 | 3.7e-05 | 5.4 | -5.3 | 1.2e-07 | 0.07 | 0.01 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CDK5RAP3 | 0.06 | 0.00 | blup | 62 | 0.03 | 1.0e-03 | -4.8 | -6.8 | 1.0e-11 | 0.06 | 0.01 | 0.58 | TRUE |