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chr17:60,916,262-62,694,738

Best TWAS P=1.76e-10 · Best GWAS P=1.65e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Lung	MAP3K3	0.07	0.07	lasso	2	0.06	2.8e-05	-6.4	-6.4	1.8e-10	1.00	0.03	0.97	TRUE
27	GTEx	Stomach	DCAF7	0.24	0.00	enet	33	0.08	1.2e-04	-1.7	-6.0	2.3e-09	0.41	0.04	0.46	TRUE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRADA	0.03	0.00	blup	57	0.01	5.2e-02	6.0	-5.7	1.6e-08	0.24	0.02	0.19	TRUE
7	GTEx	Breast Mammary Tissue	MAP3K3	0.10	0.11	lasso	8	0.08	8.9e-05	-6.2	-6.3	2.2e-10	1.00	0.03	0.97	FALSE
28	GTEx	Testis	PSMC5	0.14	0.13	lasso	6	0.14	6.0e-07	-6.4	6.3	2.3e-10	-0.98	0.03	0.97	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K3	0.12	0.13	enet	10	0.15	1.8e-08	-6.2	-6.3	3.2e-10	0.99	0.03	0.97	FALSE
13	GTEx	Cells Transformed fibroblasts	PSMC5	0.19	0.09	lasso	5	0.10	7.1e-08	6.0	6.3	3.5e-10	-0.40	0.09	0.90	FALSE
19	GTEx	Nerve Tibial	MAP3K3	0.07	0.10	lasso	2	0.08	4.1e-06	-6.3	-6.3	3.5e-10	0.99	0.03	0.97	FALSE
17	GTEx	Esophagus Muscularis	DCAF7	0.08	0.06	lasso	7	0.05	6.7e-04	-6.2	-6.3	3.7e-10	0.98	0.04	0.95	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	DDX42	0.11	0.14	lasso	2	0.12	1.3e-04	-6.2	6.2	4.4e-10	-0.98	0.04	0.89	FALSE
26	GTEx	Spleen	MAP3K3	0.21	0.14	lasso	10	0.10	1.4e-03	-6.3	-6.2	4.8e-10	0.98	0.04	0.92	FALSE
3	GTEx	Adipose Subcutaneous	MAP3K3	0.09	0.07	lasso	6	0.07	3.5e-06	-6.3	-6.2	5.3e-10	0.98	0.03	0.97	FALSE
11	GTEx	Breast Mammary Tissue (Female)	MAP3K3	0.07	0.01	lasso	1	0.00	4.1e-01	-6.2	-6.2	5.5e-10	0.99	0.03	0.49	FALSE
9	GTEx	Breast Mammary Tissue (Female)	CD79B	0.04	0.07	lasso	2	0.03	4.2e-02	6.3	-6.1	9.9e-10	0.38	0.04	0.29	FALSE
30	YFS	Blood	LIMD2	0.03	0.03	enet	11	0.03	3.6e-11	-5.7	6.1	1.0e-09	-0.84	0.24	0.76	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC5	0.04	0.03	lasso	1	0.03	5.6e-04	6.1	6.1	1.0e-09	-0.41	0.01	0.92	FALSE
25	GTEx	Skin Sun Exposed Lower leg	MAP3K3	0.08	0.08	lasso	3	0.08	6.8e-07	-6.2	-6.1	1.1e-09	0.98	0.03	0.97	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STRADA	0.05	0.03	lasso	1	0.02	1.7e-03	6.0	6.0	1.5e-09	-0.42	0.03	0.32	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	DDX42	0.23	0.04	lasso	12	0.07	8.1e-03	-6.3	5.9	3.1e-09	-0.83	0.04	0.82	FALSE
2	GTEx	Adipose Subcutaneous	CD79B	0.15	0.16	enet	9	0.17	3.5e-14	5.5	-5.9	3.2e-09	0.48	0.68	0.32	FALSE
4	GTEx	Adipose Visceral Omentum	MAP3K3	0.10	0.04	enet	12	0.05	9.0e-04	-6.2	-5.9	3.8e-09	0.83	0.03	0.90	FALSE
22	GTEx	Pituitary	MAP3K3	0.11	0.07	lasso	6	0.04	3.5e-02	-6.2	-5.8	4.8e-09	0.98	0.05	0.63	FALSE
10	GTEx	Breast Mammary Tissue (Female)	DCAF7	0.10	0.02	lasso	3	0.00	4.4e-01	-5.7	-5.8	5.1e-09	0.94	0.04	0.50	FALSE
15	GTEx	Esophagus Mucosa	STRADA	0.05	0.07	lasso	2	0.05	1.9e-04	5.9	5.8	5.3e-09	-0.42	0.13	0.60	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	MAP3K3	0.02	0.02	blup	52	0.01	1.4e-02	-6.4	-5.8	7.3e-09	0.98	0.02	0.75	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KCNH6	0.04	0.02	enet	9	0.04	1.4e-05	-6.2	-5.7	1.1e-08	0.78	0.05	0.93	FALSE
29	NTR	Blood	MAP3K3	0.02	0.01	lasso	2	0.01	2.0e-04	-5.1	5.7	1.4e-08	-0.81	0.33	0.67	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMARCD2	0.08	0.04	blup	28	0.04	5.1e-05	-6.4	-5.5	3.1e-08	0.97	0.00	1.00	FALSE
8	GTEx	Breast Mammary Tissue (Male)	MAP3K3	0.12	0.14	lasso	2	0.07	1.2e-02	-6.4	-5.5	5.1e-08	0.95	0.04	0.78	FALSE
16	GTEx	Esophagus Muscularis	PSMC5	0.12	0.08	lasso	3	0.07	3.8e-05	6.1	5.4	5.2e-08	-0.33	0.10	0.81	FALSE
5	GTEx	Artery Tibial	MAP3K3	0.05	0.07	lasso	5	0.07	2.9e-06	-5.1	-5.4	6.4e-08	0.89	0.06	0.93	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD79B	0.02	0.02	lasso	2	0.01	3.0e-03	5.5	-5.4	7.8e-08	0.32	0.02	0.43	FALSE
24	GTEx	Skin Sun Exposed Lower leg	DDX42	0.07	0.04	lasso	4	0.05	2.5e-05	-6.4	5.3	1.1e-07	-0.96	0.03	0.97	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	SMARCD2	0.04	0.02	blup	28	0.01	1.6e-02	-6.2	-5.2	1.8e-07	0.95	0.00	0.70	FALSE
20	GTEx	Pancreas	DDX42	0.17	0.18	lasso	3	0.16	3.6e-07	-6.2	5.1	2.8e-07	-0.96	0.04	0.96	FALSE
21	GTEx	Pancreas	MAP3K3	0.10	0.08	lasso	4	0.07	9.0e-04	-6.2	-5.1	3.0e-07	0.88	0.03	0.79	FALSE
14	GTEx	Esophagus Mucosa	DDX42	0.08	0.06	lasso	3	0.09	1.3e-06	-6.3	5.1	3.1e-07	-0.95	0.04	0.96	FALSE