Best TWAS P=3.5e-11 · Best GWAS P=1.98e-10 conditioned to 0.0152
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | SLC35G2 | 0.16 | 0.03 | lasso | 8 | 0.05 | 6.4e-03 | 4.4 | -5.4 | 6.8e-08 | 0.51 | 0.15 | 0.37 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | RP11-731C17.2 | 0.16 | 0.02 | enet | 24 | 0.09 | 3.0e-03 | -4.5 | 5.7 | 9.9e-09 | -0.85 | 0.07 | 0.70 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | RP11-85F14.5 | 0.10 | 0.08 | enet | 38 | 0.09 | 3.9e-07 | -4.5 | 5.4 | 6.2e-08 | -0.54 | 0.94 | 0.05 | FALSE |
| 4 | GTEx | Esophagus Mucosa | RP11-85F14.5 | 0.13 | 0.10 | lasso | 3 | 0.11 | 5.1e-08 | -5.2 | 5.2 | 2.5e-07 | -0.64 | 0.84 | 0.16 | FALSE |
| 5 | GTEx | Lung | RP11-85F14.5 | 0.07 | 0.05 | lasso | 19 | 0.05 | 8.8e-05 | -5.2 | 5.5 | 2.9e-08 | -0.67 | 0.86 | 0.10 | FALSE |
| 6 | GTEx | Muscle Skeletal | RP11-731C17.2 | 0.15 | 0.12 | lasso | 16 | 0.12 | 3.8e-12 | -4.5 | 5.3 | 1.5e-07 | -0.50 | 0.99 | 0.01 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | RP11-85F14.5 | 0.04 | 0.01 | enet | 9 | 0.03 | 2.8e-03 | -4.5 | 5.2 | 2.2e-07 | -0.51 | 0.29 | 0.37 | FALSE |
| 8 | GTEx | Testis | RP11-85F14.5 | 0.12 | 0.03 | enet | 28 | 0.02 | 3.8e-02 | -4.5 | 5.8 | 7.7e-09 | -0.55 | 0.49 | 0.17 | FALSE |
| 9 | GTEx | Thyroid | RP11-85F14.5 | 0.07 | 0.00 | lasso | 7 | 0.01 | 4.7e-02 | -5.2 | 6.6 | 3.5e-11 | -0.70 | 0.06 | 0.55 | TRUE |
| 10 | YFS | Blood | NCK1 | 0.01 | 0.02 | enet | 4 | 0.02 | 2.2e-06 | -5.2 | 5.2 | 2.4e-07 | -0.64 | 0.76 | 0.22 | FALSE |