TWAS hub - SLC35G2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Coronary	0.157	0.067	9.4e-04	0.028	NA	0.053	NA	0.055	3.8e-02	NA	7.2e-03	NA	6.4e-03
2	GTEx	Esophagus Mucosa	0.126	0.052	3.8e-05	0.098	NA	0.087	NA	0.090	4.2e-07	NA	1.9e-06	NA	1.3e-06
3	GTEx	Testis	0.166	0.055	3.0e-07	0.187	NA	0.156	NA	0.183	1.0e-08	NA	2.1e-07	NA	1.5e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Impedance of arm (right)	10.1	47.1	86.1	9.3	4.8	5.7
Falls in the last year	9.2	12.4	13.0	-3.6	-3.4	-3.6
BMI	9.0	52.2	64.3	-8.0	-6.3	-7.2
Chest pain or discomfort	8.8	12.6	21.6	-4.7	-2.8	-3.0
Impedance of arm (left)	8.6	39.8	76.7	8.8	4.2	5.0
Heart attack/myocardial infarction (self-reported)	8.4	10.8	13.4	-3.0	-3.2	-3.7
Body mass index (BMI)	8.2	35.1	54.0	-7.3	-4.7	-5.4
Commuting to job workplace: Cycle	7.8	9.4	12.4	-2.3	-3.5	-3.2
Heart attack	7.7	9.9	11.6	-3.1	-2.9	-3.4
Height	7.6	147.4	234.1	15.3	10.2	10.2
Relative age voice broke	7.4	11.3	16.3	1.5	3.9	4.0
Standing height	7.4	73.6	123.2	11.1	7.1	6.9
Illnesses of father: None of the above (group 1)	7.3	9.0	12.4	1.7	3.5	3.4
Medication: Aspirin	7.2	9.4	11.0	-2.9	-3.0	-3.3
Birth weight of first child	7.1	12.9	14.1	3.4	3.6	3.8
Medication: Aspirin	7.1	9.3	11.4	-2.7	-3.0	-3.4
Relative age of first facial hair	6.9	14.1	18.5	2.5	4.2	4.3
Noisy workplace	6.9	8.5	9.9	-3.0	-2.6	-3.1
Leg fat percentage (right)	6.9	24.9	29.2	-5.4	-4.5	-5.0
Impedance of whole body	6.9	35.0	64.2	8.0	4.1	4.9
Leg fat percentage (left)	6.7	24.2	30.7	-5.5	-4.3	-4.9
Medication for pain relief, constipation, heartburn	6.0	10.2	13.8	1.9	3.7	3.6
Ever used hormone-replacement therapy (HRT)	5.8	7.4	16.9	-4.1	-1.7	-1.6
Illnesses of father: Heart disease	5.8	8.0	10.4	-2.6	-2.6	-3.2
Body Mass Index (BMI) (2010)	5.7	7.8	12.3	-3.5	-2.3	-2.4
Medication: Cholesterol lowering	5.6	8.8	13.5	-2.0	-3.0	-3.7
Long-standing illness, disability or infirmity	5.5	8.4	13.5	-3.7	-2.5	-2.4
Triglycerides	5.4	8.8	19.6	-4.4	-1.6	-2.0
Waist circumference	5.2	18.9	23.6	-4.0	-4.1	-4.9
Diabetes diagnosed by doctor	5.1	8.3	9.2	-2.9	-3.0	-2.7
Exposure to tobacco smoke outside home	4.9	6.6	13.2	-3.6	-1.6	-2.0
Blood White Count	4.8	35.6	51.0	-2.4	-7.1	-7.1
Medication: Simvastatin	4.8	7.1	10.8	-2.1	-2.5	-3.3
Heart disease (mother)	4.8	5.9	6.3	-2.5	-2.3	-2.5
Forced expiratory volume in 1-second (FEV1), predicted	4.8	10.0	16.6	4.1	2.7	2.5
Overall health rating	4.6	9.9	10.4	-3.2	-3.2	-3.0
Medication: Ibuprofen	4.5	5.4	7.6	-1.4	-2.6	-2.8
Cardiovascular Disease	4.4	14.4	20.4	-3.4	-3.3	-4.5
Other serious medical condition/disability diagnosed by doctor	4.4	5.7	8.7	-1.2	-3.0	-2.6
Mouth/teeth dental problems	4.4	6.8	15.4	3.9	1.7	1.4
Mouth/teeth dental problems: Dentures	4.4	7.5	21.9	-4.7	-0.5	-0.5
Angina (self-reported)	4.3	5.7	11.2	-3.3	-1.7	-1.8
Medication: Paracetamol	4.3	6.7	9.9	-1.4	-3.1	-2.9
Nervous feelings	4.2	7.8	11.2	-1.5	3.2	3.3
Leg fat mass (right)	4.2	16.5	21.0	-4.6	-3.4	-4.2
Type 2 Diabetes (T2D) (2018)	4.1	7.8	10.0	-2.2	-3.2	-2.9
Cholesterol lowering medication	4.1	6.0	9.4	-3.1	-1.7	-2.4
Angina	4.0	5.3	9.6	-3.1	-1.7	-1.8
Medication: Ibuprofen (e.g. Nurofen)	4.0	5.0	7.6	-1.0	-2.6	-2.8
Comparative height size at age 10	4.0	22.2	51.1	7.2	2.7	2.8
Leg fat mass (left)	4.0	15.4	21.4	-4.6	-3.1	-3.9
Wheeze or whistling in the chest in last year	3.9	7.0	12.0	-3.5	-2.0	-2.2
Neck or shoulder pain in last month	3.9	5.5	6.7	-2.0	-2.4	-2.6
Suffer from ‘nerves’	3.9	6.2	10.2	0.7	3.2	2.8
Average weekly beer plus cider intake	3.9	5.6	13.6	-3.7	-0.8	-1.6
Impedance of leg (left)	3.8	18.4	34.0	5.8	3.0	3.5
HDL Cholesterol	3.7	6.1	8.2	2.9	2.3	2.2
Tense / ‘highly strung’	3.7	6.1	9.0	-1.0	2.9	3.0
Number of treatments/medications taken	3.6	6.4	7.3	-2.3	-2.7	-2.6
Miserableness	3.6	6.3	17.5	-4.2	-0.6	-1.0
Worrier / anxious feelings	3.5	6.5	18.7	-4.3	0.6	0.7
Arm fat percentage (left)	3.5	14.0	18.2	-4.3	-3.2	-3.6
High cholesterol (Self-reported)	3.5	6.1	7.7	-2.7	-1.9	-2.8
Blood Platelet Count	3.4	39.1	62.7	-0.9	-7.3	-7.9
Medication: Metformin	3.4	4.9	5.9	-2.4	-2.3	-1.9
Qualifications: O levels/GCSEs or equivalent	3.4	5.4	11.3	3.4	1.3	1.8
Heart disease (siblings)	3.4	4.2	5.3	-2.3	-1.9	-1.9
Impedance of leg (right)	3.3	16.2	31.7	5.6	2.6	3.1
Illnesses of siblings: Diabetes	3.3	4.0	5.0	-1.8	-2.0	-2.2
Chronic bronchitis/emphysema (father)	3.2	3.8	4.3	-1.8	-1.9	-2.1
Alcohol usually taken with meals	3.2	5.2	13.8	3.7	0.7	1.2
Depressed Affect (Nagel 2018)	3.1	6.4	18.2	-4.3	-0.6	-0.8
Diabetes (self-reported)	3.1	4.8	5.7	-2.4	-2.2	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	10.0	11.6	3.4	3.2	2.8
Medication: Paracetamol	3.1	5.1	7.3	-1.3	-2.7	-2.5
Pain experienced in last month	3.1	5.1	11.0	3.3	1.4	1.5
Pack years of smoking	3.1	4.5	8.5	-2.9	-1.4	-1.8
Medication for cholesterol, blood pressure or diabetes	3.0	5.0	7.6	1.7	2.1	2.8
Knee pain experienced in last month	3.0	4.7	12.6	-3.5	-0.8	-1.0
Vascular/heart problems diagnosed by doctor	3.0	8.2	10.8	2.6	2.7	3.3
Fed-up feelings	2.9	5.4	14.7	-3.8	1.0	0.6
Arm fat percentage (right)	2.9	11.3	14.9	-3.9	-2.9	-3.3
Health satisfaction	2.9	3.7	6.0	-2.5	-1.6	-1.6
Asthma (self-reported)	2.9	5.7	9.3	-3.0	-2.1	-1.8
Supplements: Calcium	2.9	3.2	5.4	0.8	1.9	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.8	10.8	-3.3	0.6	0.4
Age started oral contraceptive pill	2.8	3.5	6.4	2.5	1.2	1.6
Depression (Nagel 2018)	2.7	4.0	12.0	-3.5	0.2	0.1
Schizophrenia (2014)	2.7	5.9	9.2	-0.7	3.0	2.8
Neuroticism score	2.7	5.6	12.7	-3.6	1.5	1.4
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.1	5.1	0.4	2.0	2.3
Schizophrenia (2018)	2.6	5.3	7.6	-1.4	2.8	2.5
Pack years adult smoking proportion	2.6	4.0	6.8	-2.6	-1.4	-1.8
Hearing difficulty/problems with background noise	2.6	4.1	12.3	-3.5	-0.1	0.0
Hip circumference	2.6	11.3	17.3	-4.2	-2.5	-3.2
Arm fat mass (left)	2.6	10.8	15.4	-3.9	-2.6	-3.2
Fluid intelligence score	2.5	5.2	15.4	3.9	0.1	0.5
Asthma	2.5	4.9	9.1	-3.0	-1.8	-1.5
Arm fat mass (right)	2.5	10.3	14.3	-3.8	-2.6	-3.1
Body fat percentage	2.4	9.3	10.7	-3.3	-2.7	-3.2
Respiratory disease	2.3	5.2	7.1	-2.7	-2.1	-2.0
Medication: Ventolin 100micrograms inhaler	2.3	3.0	7.1	-2.7	-1.1	-0.7
Irritable Bowel Disease (IBD)	2.2	5.3	7.2	1.9	2.7	2.3
Average weekly spirits intake	2.2	2.7	6.0	-2.4	-0.9	-1.1
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.7	3.4	-1.9	-1.2	-1.7
Pain type(s) experienced in last month: Hip pain	2.2	2.7	4.3	-2.1	-1.7	-1.0
Medication: Atorvastatin	2.2	2.7	4.4	-2.1	-1.2	-1.5
Bipolar Disorder or Schizophrenia	2.1	5.2	8.6	0.2	2.9	2.6
Intelligence (Savage-Jansen 2018)	2.1	6.6	19.3	4.4	0.4	0.6
Alzheimer’s Disease (in father)	2.1	2.2	4.0	-0.4	-2.0	-1.6
Verbal and Numeric Reasoning (VNR)	2.1	5.0	14.5	3.8	0.4	0.6
Coronary Artery Disease (CAD)	2.1	2.5	3.6	-1.9	-1.1	-1.6
Neuroticism (2016)	2.1	3.0	3.3	-1.8	1.8	1.6
Neuroticism	2.1	5.1	12.3	-3.5	1.2	1.3
Medication for hormone replacement therapy	2.1	2.3	3.0	-1.7	-1.7	-1.1
Pain all over the body in last month	2.1	2.3	2.4	-1.5	-1.5	-1.5
Forced vital capacity (FVC), Best measure	2.1	7.7	8.9	2.7	3.0	2.6
Worry too long after embarrassment	2.1	3.6	9.8	-3.1	0.7	0.7
Townsend deprivation index at recruitment	2.0	2.8	4.1	2.0	1.2	1.7
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	6.5	-2.5	1.3	1.2
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	9.7	-3.1	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1)	2.0	6.6	9.7	3.1	2.5	2.0
Breastfed as a baby	2.0	2.5	3.4	-1.6	-1.3	-1.8
Birth weight	2.0	4.4	8.8	3.0	1.6	1.4
Hypertension (Self-reported)	2.0	5.5	7.3	-2.0	-2.3	-2.7
Mood swings	2.0	3.6	10.4	-3.2	-0.2	-0.6
Mother’s age at death	2.0	2.4	2.9	1.7	1.3	1.6
Tinnitus: Yes, now most or all of the time	2.0	2.4	3.8	0.2	1.8	1.9
Neuroticism (Nagel 2018)	1.9	4.6	11.9	-3.4	1.1	0.8
Vitamin and mineral supplements	1.9	2.5	3.8	-0.9	-1.7	-1.9
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	3.0	1.6	1.7	1.4
Qualifications: A levels/AS levels or equivalent	1.9	4.1	8.7	3.0	1.2	1.5
Pulse wave peak to peak time	1.9	2.2	3.5	0.1	1.8	1.9
Eye problems/disorders: None of the above	1.9	2.2	3.0	0.8	1.7	1.7
Average weekly red wine intake	1.9	2.9	4.2	2.0	1.4	1.6
Handedness (chirality/laterality): Left-handed	1.9	2.3	2.8	1.7	1.3	1.6
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	9.1	-3.0	0.0	-0.2
Mineral and other dietary supplements	1.9	2.6	4.3	-0.2	-1.8	-2.1
Osteoarthritis (self-reported)	1.9	2.4	4.9	-2.2	-1.2	-1.0
Risk taking	1.9	2.7	4.0	-0.7	-2.0	-1.9
Myopia	1.9	2.7	3.3	1.6	1.8	1.5
Worry (Nagel 2018)	1.8	3.9	4.1	-1.9	2.0	2.0
Glaucoma (self-reported)	1.8	2.1	4.5	2.1	0.9	1.0
Whole body fat mass	1.8	7.7	8.9	-3.0	-2.3	-3.0
Medication for cholesterol	1.8	2.8	3.4	1.4	1.7	1.9
Crohns Disease (2017)	1.7	3.8	5.4	1.6	2.3	1.8
Waist Hip Ratio (WHR)	1.7	7.5	10.4	1.9	-2.9	-3.2
Sensitivity / hurt feelings	1.7	2.8	7.8	-2.8	0.5	0.7
Maternal smoking around birth	1.7	2.5	4.9	-2.2	-1.1	-1.1
Had other major operations	1.7	2.0	4.2	0.4	-2.0	-1.4
Prostate Cancer	1.6	2.3	3.0	-1.1	-1.7	-1.7
Blood Eosinophil Count	1.6	12.7	16.5	-4.1	-3.3	-3.2
Frequency of depressed mood in last 2 weeks	1.6	2.2	6.0	-2.5	0.6	0.5
High blood pressure	1.6	4.5	6.4	-1.7	-2.0	-2.5
Stomach or abdominal pain in last month	1.6	2.0	5.8	-2.4	0.1	-0.3
Medication: Lansoprazole	1.6	1.9	2.5	-1.2	-1.6	-1.2
Peak expiratory flow (PEF)	1.6	3.7	4.1	2.0	1.9	1.8
Pulse wave reflection index	1.6	2.0	3.2	-0.7	-1.8	-1.5
Gout (self-reported)	1.6	2.2	2.3	-1.5	-1.5	-1.5
Comparative body size at age 10	1.6	4.5	7.1	-0.3	-2.5	-2.7
Bipolar Disorder (2018)	1.5	2.3	4.3	2.1	1.3	1.1
Exposure to tobacco smoke at home	1.5	1.7	4.5	-2.1	0.7	0.2
Age at last live birth	1.5	2.2	3.2	1.8	1.1	1.4
Loneliness, isolation	1.5	2.1	6.2	-2.5	-0.1	-0.2
Alzheimer’s Disease (including proxy)	1.4	2.0	4.4	-0.3	-2.1	-1.2
Bipolar Disorder (2011)	1.4	1.4	2.2	0.9	1.5	1.0
LDL Cholesterol	1.4	2.2	5.2	-2.3	-0.7	-0.9
Lung FEV1/FVC ratio	1.4	6.9	13.8	3.7	1.8	1.9
Diabetes (father)	1.4	1.7	5.0	-2.2	-0.2	-0.3
Illnesses of mother	1.4	1.8	2.5	1.0	1.4	1.6
Age at first live birth	1.4	2.4	5.4	2.3	1.0	1.0
Number of full sisters	1.4	1.7	2.7	-0.4	1.6	1.5
Leg pain on walking	1.4	1.8	4.8	-2.2	-0.3	-0.6
Supplements: Vitamin C	1.4	1.7	3.2	-1.8	1.0	0.9
Supplements: Fish oil (including cod liver oil)	1.4	1.8	2.9	-0.4	1.6	1.7
Major Depression (MDD)	1.3	1.6	4.5	-2.1	0.2	-0.5
Medication: Co-codamol	1.3	1.5	2.2	-1.5	-0.7	-1.4
Medication: Atenolol	1.3	1.6	2.3	-0.8	-1.3	-1.5
Number of incorrect matches in round	1.3	2.1	3.6	0.3	1.6	1.9
Hair/balding pattern: Pattern 4	1.3	3.2	7.6	-2.8	-0.9	-1.1
Number of children fathered	1.3	1.5	2.6	-0.6	1.6	1.2
Medication: Seretide 50 evohaler	1.3	1.5	2.0	-0.9	-1.3	-1.4
Ever depressed for a whole week	1.3	1.6	2.8	0.7	-1.7	-1.3
Age at First Birth	1.2	1.7	3.0	0.8	1.2	1.7
Heel T-Score	1.2	9.3	13.1	-1.4	-3.6	-3.6
Hand grip strength (left)	1.2	3.2	4.2	1.6	2.1	1.7
Hand grip strength (right)	1.2	3.1	4.6	1.5	2.1	1.6
Sitting height	1.2	8.7	10.7	3.3	3.1	2.3
Forced vital capacity (FVC)	1.2	4.6	7.0	2.6	2.1	1.6
Pulse wave Arterial Stiffness index	1.2	1.4	2.0	0.6	-1.4	-1.4
Back pain experienced in last month	1.2	1.7	4.2	-2.0	0.9	0.5
Medication: Blood pressure	1.2	2.3	3.6	-0.6	-1.7	-1.9
Ulcerative Colitis (UC)	1.1	2.0	2.7	1.2	1.6	1.4
Breast Cancer	1.1	2.6	4.0	-0.5	-2.0	-1.9
Fasting Glucose	1.1	1.3	2.1	-0.7	-1.4	-1.1
Had menopause	1.1	1.3	3.6	-1.9	-0.5	-0.3
Qualifications: None of the above	1.1	2.3	6.1	-2.5	-0.4	-0.8
Number of live births	1.1	1.6	4.8	-2.2	0.2	-0.0
Headache pain in last month	1.1	1.8	2.6	-1.6	1.1	1.3
Emphysema/chronic bronchitis	1.1	1.2	1.5	-1.0	-1.2	-1.0
Medication: Allopurinol	1.1	1.4	1.7	-1.3	-1.3	-1.0
Ulcerative Colitis	1.0	1.4	1.5	1.2	1.2	1.2
Medication: Ramipril	1.0	1.3	2.0	-0.6	-1.2	-1.4
Depression (self-reported)	1.0	1.2	2.0	0.6	1.4	1.1
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.4	-1.8	-0.4	-0.4
Systolic Blood Pressure	0.9	4.7	10.2	3.2	1.7	1.0
Qualifications: CSEs or equivalent	0.9	1.1	2.0	-1.4	-0.7	-0.9
High blood pressure (mother)	0.9	1.3	2.8	-1.7	-0.3	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.0	0.4	-1.7	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.9	-1.7	-0.3	-0.3
Ever smoked	0.9	1.6	1.9	1.1	-1.3	-1.4
Trunk fat percentage	0.8	3.4	4.4	-1.6	-1.8	-2.1
Current tobacco smoking	0.8	1.2	1.4	-1.0	-1.2	-1.1
Illnesses of siblings	0.8	1.1	3.1	1.7	0.1	0.5
Weight	0.8	3.9	5.0	-2.2	-1.4	-2.2
Number of full brothers	0.8	1.0	1.7	0.3	1.3	1.1
Migraine (self-reported)	0.8	1.0	1.3	0.8	1.1	1.1
Commuting to job workplace: Walk	0.8	0.8	1.7	1.3	0.5	0.7
Osteoporosis (self-reported)	0.8	1.0	2.4	-1.5	0.5	0.6
Medication: Gliclazide	0.8	0.9	1.2	-0.8	-1.1	-0.9
Hearing aid user	0.8	0.9	1.3	-0.2	-1.2	-1.1
Eye problems/disorders: Glaucoma	0.8	0.9	2.6	1.6	0.2	0.4
Basal cell carcinoma (self-reported)	0.8	0.9	1.9	-0.2	1.4	0.9
Crohns Disease (2012)	0.7	1.2	1.5	1.1	1.2	0.8
HbA1C	0.7	0.8	2.4	1.6	0.1	0.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.7	-1.3	-0.5	-0.6
Blood Red Count	0.7	6.6	8.5	-2.9	-2.6	-2.1
Taking other prescription medications	0.7	1.1	1.8	-1.3	-1.1	-0.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.3	-0.2	-1.1	-1.1
Multivitamins +/- minerals	0.7	0.9	1.4	1.2	0.6	1.0
Trunk fat mass	0.7	3.1	4.6	-1.5	-1.6	-2.1
Past tobacco smoking	0.7	1.3	1.7	-0.8	1.3	1.3
Pulse rate	0.7	1.2	3.1	1.8	0.6	0.4
Qualifications: College or University degree	0.7	2.2	4.5	2.1	0.7	1.3
Qualifications: nursing, teaching	0.7	1.1	1.5	-0.7	-1.2	-1.2
Number of self-reported non-cancer illnesses	0.7	1.1	2.0	-1.4	-0.9	-0.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	-1.3	0.4	0.6
Lupus	0.6	0.9	1.4	0.3	1.2	1.1
Diabetes (mother)	0.6	0.8	1.4	-0.2	-1.0	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.2	1.1	1.0	0.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.9	-0.1	-1.4	-0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	3.1	1.8	0.5	0.7
Shortness of breath walking on level ground	0.6	0.7	1.2	-0.5	-1.1	-0.9
Schizophrenia vs Biploar Disorder	0.5	0.7	1.5	-1.2	0.2	0.6
Hearing difficulty/problems: Yes	0.5	0.8	1.6	-1.3	-0.7	-0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	1.6	1.3	-0.2	-0.1
Medication: Levothyroxine sodium	0.5	0.9	2.5	1.6	-0.2	0.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	-0.2	-1.0	-0.9
Blood clot in the leg (DVT)	0.5	0.6	1.0	0.0	-0.9	-1.0
Mean time to correctly identify matches	0.5	0.9	1.5	-1.2	0.5	1.0
Pulse rate, automated reading	0.5	1.5	2.8	0.5	-1.1	-1.7
Smoking status: Previous	0.5	0.7	1.0	0.6	-1.0	-0.9
Ever taken oral contraceptive pill	0.5	0.6	1.1	-0.5	-0.7	-1.1
Number of operations (self-reported)	0.5	0.8	1.7	0.2	-1.3	-0.7
Alcohol drinker status: Previous	0.5	0.5	1.6	-1.3	-0.1	0.0
Smoking Status	0.4	0.9	1.3	0.8	-1.2	-0.9
Hypothyroidism (self reported)	0.4	0.9	2.4	1.6	0.4	0.4
Lung FVC	0.4	1.9	3.2	-1.8	-1.0	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.1	0.8	-1.1	-0.9
Supplements: Glucosamine	0.4	0.5	0.9	-0.9	0.3	0.7
Allergy	0.4	1.0	1.5	1.2	0.8	1.0
Time employed in main current job	0.4	0.5	1.4	-1.2	-0.2	-0.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	-1.0	-0.8	-0.3
Length of working week for main job	0.4	0.4	0.9	-0.1	0.6	1.0
Medication: Amlodipine	0.4	0.6	1.7	-1.3	0.4	-0.1
Arm fat-free mass (right)	0.4	2.0	3.1	-1.8	-0.7	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	0.6	0.8	0.8	0.7
Had major operations	0.4	0.5	0.7	0.7	-0.8	-0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	-1.0	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.1	1.0	1.0	0.7
Average weekly champagne plus white wine intake	0.4	0.5	1.5	1.2	-0.2	0.0
Guilty feelings	0.4	0.6	1.7	-1.3	0.0	-0.0
Wears glasses or contact lenses	0.4	0.5	1.4	-1.2	-0.1	-0.1
Financial situation satisfaction	0.4	0.5	0.6	-0.6	0.8	0.7
Commuting to job workplace: Public transport	0.4	0.4	0.6	0.4	-0.7	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	0.0	-0.8	-1.0
Reaction Time	0.3	0.6	0.8	-0.9	0.7	0.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.8	0.5	0.1
Severe depression (siblings)	0.3	0.4	0.9	1.0	0.3	0.3
Age when periods started (menarche)	0.3	0.6	1.0	0.2	1.0	0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	-0.8	-0.5	-0.2
Serious illness, injury or assault to yourself	0.3	0.3	0.4	0.5	-0.6	-0.7
Hair/balding pattern: Pattern 2	0.3	0.3	0.7	0.8	0.2	-0.5
Alcohol intake versus 10 years previously	0.3	0.4	1.1	1.0	-0.0	0.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	0.8	0.3	0.6
Loud music exposure frequency	0.3	0.3	0.8	-0.9	-0.3	-0.2
Arm predicted mass (right)	0.3	1.7	2.9	-1.7	-0.6	-1.4
Breast cancer (self-reported)	0.3	0.4	0.9	-0.2	-0.4	-0.9
Smoking status: Current	0.3	0.4	0.6	-0.4	-0.8	-0.7
Medication: Bendroflumethiazide	0.3	0.5	1.2	0.3	-0.5	-1.1
Illnesses of father: High blood pressure	0.3	0.4	1.1	1.1	0.2	0.2
Arm fat-free mass (left)	0.3	1.3	2.8	-1.7	-0.3	-1.0
Irritability	0.3	0.4	0.7	-0.8	0.7	0.3
Fractured/broken bones in last 5 years	0.3	0.4	0.5	0.7	0.7	0.5
Arm predicted mass (left)	0.3	1.5	2.8	-1.7	-0.4	-1.2
Alzheimer’s Disease (in mother)	0.2	0.3	0.6	0.8	-0.2	0.4
Ovarian Cancer	0.2	0.3	0.5	-0.1	-0.7	-0.6
Mean Putamen Volume	0.2	0.2	0.4	0.4	-0.2	0.6
Rheumatoid Arthritis	0.2	0.3	0.5	0.7	0.7	0.3
Hair Pigment	0.2	4.5	11.9	-3.5	-1.3	-0.2
Tanning	0.2	3.0	5.7	2.4	1.5	1.0
Financial difficulties in last 2 years	0.2	0.3	0.8	0.9	0.3	-0.0
Lung cancer (father)	0.2	0.3	0.8	0.9	-0.2	-0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.2	-0.4	-0.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	0.6	-0.5	-0.1
Eye problems/disorders: Cataract	0.2	0.3	0.6	-0.8	0.4	-0.0
Primary Biliary Cirrhosis	0.1	0.1	0.1	0.3	-0.4	-0.2
Allergy or Eczema	0.1	0.2	0.3	-0.5	0.5	0.4
Systolic blood pressure, automated reading	0.1	0.2	0.3	0.4	0.2	-0.5
Supplements: Zinc	0.1	0.2	0.3	-0.2	0.6	0.3
Leg fat-free mass (left)	0.1	0.7	1.3	-0.8	-0.4	-1.1
Average weekly fortified wine intake	0.1	0.1	0.3	0.2	0.1	0.6
Leg predicted mass (left)	0.1	0.7	1.3	-0.8	-0.4	-1.1
Father’s age at death	0.1	0.1	0.2	-0.2	-0.5	-0.3
Happiness	0.1	0.1	0.1	0.1	0.4	0.3
Prospective memory result	0.1	0.1	0.2	0.2	-0.5	-0.2
High blood pressure (siblings)	0.1	0.2	0.5	-0.3	0.7	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.6	0.0	0.0
Medication: Omeprazole	0.1	0.1	0.1	-0.3	-0.3	-0.3
Alcohol intake frequency.	0.1	0.1	0.3	0.1	-0.5	-0.4
Family relationship satisfaction	0.1	0.2	0.3	0.4	-0.5	-0.3
Leg fat-free mass (right)	0.1	0.5	1.0	-0.6	-0.2	-1.0
Ever had bowel cancer screening	0.1	0.1	0.1	-0.3	-0.3	-0.3
Friendships satisfaction	0.1	0.1	0.2	0.1	-0.5	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.4	-0.3	-0.4
Leg predicted mass (right)	0.1	0.4	0.9	-0.6	-0.2	-0.9
Medication: Lisinopril	0.1	0.2	0.4	0.1	-0.4	-0.6
Basal metabolic rate	0.1	0.8	1.5	-0.9	-0.4	-1.2
Diastolic blood pressure, automated reading	0.1	0.3	0.6	0.6	0.8	-0.1
Unable to work because of sickness or disability	0.1	0.1	0.2	0.5	0.2	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.2	-0.5	-0.4	-0.4
Chronotype (morning person)	0.0	0.1	0.1	-0.3	0.4	-0.1
Ever had hysterectomy (womb removed)	0.0	0.1	0.1	0.3	0.0	0.2
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	0.3	0.2	0.2
Trunk fat-free mass	0.0	0.1	0.2	0.3	0.5	-0.3
Trunk predicted mass	0.0	0.1	0.2	0.2	0.5	-0.3
Medication: Blood pressure	0.0	0.1	0.1	-0.3	-0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	0.1	-0.2	-0.2
Whole body fat-free mass	0.0	0.2	0.5	-0.4	0.0	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	0.1	0.3	-0.0
Whole body water mass	0.0	0.2	0.4	-0.4	0.2	-0.6
Alcohol drinker status: Never	0.0	0.0	0.0	-0.2	0.1	-0.0

Hub : Genes

SLC35G2

Models

Trait associations