Hub : Genes

NCK1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0470 0.0240 0.00230 0.002 0.012 0.008 0.011 0.004 1.7e-01 0.01200 3.0e-02 0.01500 8.6e-02
2 GTEx Esophagus Mucosa 0.1150 0.0490 0.00090 0.037 NA 0.027 NA 0.046 1.7e-03 NA 6.2e-03 NA 4.5e-04
3 YFS Blood 0.0146 0.0071 0.00079 0.018 0.010 0.017 0.011 0.017 9.5e-07 0.00019 2.2e-06 0.00012 2.5e-06
4 TCGA Breast Invasive Carcinoma 0.0094 0.0065 0.00500 0.002 0.006 0.002 NA 0.004 9.1e-02 0.01600 1.0e-01 NA 4.4e-02
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0353 0.0267 0.00093 0.017 0.013 0.006 NA 0.008 4.6e-03 0.01000 7.0e-02 NA 4.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.7 1.0 3.1 -1.8 0.7 -0.9 -0.6 0.7
Bipolar Disorder or Schizophrenia 2.3 5.6 9.3 -2.4 0.6 -1.9 -3.0 3.1
Depressed Affect (Nagel 2018) 0.6 1.3 2.6 1.6 0.0 1.5 -0.7 1.0
Depression (Nagel 2018) 1.0 1.5 3.0 1.7 -0.3 0.5 -1.4 1.5
Intelligence (Savage-Jansen 2018) 0.4 1.4 2.9 -1.7 0.6 -1.0 1.0 -1.2
Neuroticism (Nagel 2018) 1.2 2.8 6.4 1.1 -0.3 -0.1 -2.5 2.5
Schizophrenia (2018) 2.8 5.8 11.6 -1.7 0.1 -1.7 -3.4 3.4
Schizophrenia vs Biploar Disorder 0.8 1.0 2.5 0.8 -1.6 -0.9 -1.0 0.4
Worry (Nagel 2018) 2.4 5.0 11.7 0.4 -1.0 -1.6 -3.4 3.1
Alzheimer’s Disease (in mother) 1.1 1.2 4.9 0.1 -2.2 -1.0 -0.6 -0.1
Alzheimer’s Disease (in father) 2.6 2.9 6.1 1.8 -2.5 0.4 1.1 -1.9
Alzheimer’s Disease (including proxy) 3.1 4.5 14.5 2.1 -3.8 -0.2 0.6 -1.8
Crohns Disease (2017) 1.4 3.2 6.4 -2.0 2.5 -1.1 -1.1 1.7
Irritable Bowel Disease (IBD) 1.7 4.1 5.7 -2.4 2.0 -1.5 -1.8 2.2
Ulcerative Colitis (UC) 0.9 1.7 2.4 -1.6 1.1 -0.8 -1.3 1.6
Major Depression (MDD) 0.9 1.1 2.3 -0.2 1.5 1.5 -0.3 1.0
Reaction Time 0.7 1.2 2.5 0.2 -1.4 -1.0 -1.6 0.9
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.5 -1.2 0.9 -0.8 0.6 -0.8
Breast Cancer 0.9 2.2 3.9 1.0 -0.5 1.5 1.9 -2.0
Ovarian Cancer 0.3 0.4 1.1 0.4 -0.4 0.1 0.8 -1.1
Prostate Cancer 1.2 1.7 3.0 0.9 -0.1 1.4 1.7 -1.7
Age at First Birth 0.9 1.3 4.3 -0.5 -0.5 -2.1 -1.2 0.7
Bipolar Disorder (2011) 1.9 1.9 5.9 -1.2 2.4 -0.3 -0.6 1.2
Body Mass Index (BMI) (2010) 2.3 3.1 5.7 2.4 -1.3 1.9 1.5 -1.5
Coronary Artery Disease (CAD) 1.3 1.5 3.6 1.0 1.2 1.9 1.1 -0.7
Crohns Disease (2012) 0.6 1.0 3.1 -0.9 1.8 -0.0 -0.3 1.0
Mean Putamen Volume 1.0 1.2 3.6 0.3 -1.9 -1.4 -0.3 -0.4
Fasting Glucose 1.6 1.9 5.1 2.2 -1.6 0.6 0.8 -1.0
HbA1C 0.2 0.2 0.5 -0.7 0.6 0.1 0.2 -0.2
HDL Cholesterol 1.5 2.4 3.6 -1.9 1.0 -1.6 -1.5 1.6
LDL Cholesterol 0.1 0.2 0.7 0.5 0.2 0.8 -0.0 0.1
Lupus 0.6 1.0 1.8 -1.1 0.1 -0.8 -1.2 1.3
Neuroticism (2016) 2.2 3.2 7.7 -0.9 0.4 -0.9 -2.5 2.8
Primary Biliary Cirrhosis 0.2 0.3 0.5 -0.3 -0.7 -0.3 0.4 -0.7
Rheumatoid Arthritis 0.5 0.7 1.8 0.2 1.4 0.5 -0.5 1.1
Schizophrenia (2014) 2.7 6.0 12.2 -1.6 0.2 -2.1 -3.5 3.3
Triglycerides 0.7 1.2 4.0 1.0 0.3 2.0 0.8 -0.5
Type 2 Diabetes (T2D) (2012) 0.4 0.5 0.9 0.8 -0.9 0.7 0.3 -0.5
Ulcerative Colitis 0.6 0.8 1.4 -0.7 -0.2 -1.0 -1.2 1.1
Blood Eosinophil Count 0.9 7.1 13.1 3.6 -1.5 2.7 2.5 -2.5
Blood Platelet Count 3.7 42.8 68.6 5.2 1.3 7.7 8.3 -7.6
Blood Red Count 0.6 5.6 9.8 3.1 -3.0 0.8 1.8 -2.3
Blood White Count 5.0 36.8 53.6 6.5 -1.1 5.8 7.3 -7.3
Heel T-Score 1.2 9.3 13.1 3.6 -0.6 3.0 3.4 -3.5
BMI 5.1 29.6 57.8 5.9 0.4 7.6 5.9 -4.5
Height 3.1 60.1 123.2 -11.1 6.5 -8.5 -5.3 5.9
Waist Hip Ratio (WHR) 2.1 9.2 18.8 1.0 1.4 3.0 4.3 -4.0
Systolic Blood Pressure 1.0 5.0 14.9 -3.0 3.9 -0.1 -0.1 1.1
Smoking Status 0.7 1.7 3.3 1.3 -1.1 0.3 1.5 -1.8
Allergy or Eczema 0.1 0.2 0.3 0.4 0.3 -0.2 -0.6 0.5
Cardiovascular Disease 4.2 13.9 29.5 2.0 3.5 5.4 4.2 -2.6
Hypothyroidism (self reported) 0.1 0.3 1.2 0.3 1.1 0.1 -0.1 0.2
Respiratory disease 1.4 3.1 5.2 2.3 -1.8 1.3 1.3 -1.9
Type 2 Diabetes (T2D) (2018) 3.9 7.2 13.2 3.6 -1.9 2.0 2.5 -3.0
Lung FEV1/FVC ratio 0.4 1.9 4.3 -2.1 0.9 -1.7 -0.8 0.9
Lung FVC 0.1 0.5 1.7 0.6 -0.6 1.3 0.1 -0.1
Neuroticism 1.7 4.0 9.4 0.9 -1.1 -0.8 -3.1 2.8
Chronotype (morning person) 0.2 0.5 1.3 -0.4 1.1 0.7 -0.0 0.5
Hair Pigment 0.2 6.7 24.7 2.2 -5.0 -1.6 -0.9 -0.7
Tanning 0.2 2.6 6.3 -1.9 2.5 0.0 -0.7 1.6
Hand grip strength (left) 1.1 2.9 5.5 -2.0 2.4 -0.7 -1.0 1.9
Number of treatments/medications taken 2.7 4.8 7.3 2.7 -0.5 2.1 2.4 -2.5
Average weekly spirits intake 0.6 0.7 1.9 1.1 0.1 1.4 0.7 -0.3
Sensitivity / hurt feelings 0.8 1.4 2.7 0.9 -1.2 -0.7 -1.6 1.3
Frequency of depressed mood in last 2 weeks 0.8 1.2 2.6 0.9 -0.2 0.1 -1.6 1.6
Hearing difficulty/problems: Yes 0.2 0.3 1.0 0.1 -0.6 -0.1 0.6 -1.0
Relative age of first facial hair 5.7 11.6 16.6 -3.5 0.3 -3.8 -4.1 3.9
Other serious medical condition/disability diagnosed by doctor 4.9 6.4 9.1 3.0 -2.2 1.7 2.5 -3.0
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.0 1.4 -0.8 1.3 0.5 -0.6
Ever had hysterectomy (womb removed) 0.4 0.5 1.8 -1.4 -0.6 -0.5 -0.2 -0.1
Systolic blood pressure, automated reading 1.2 3.4 12.3 -0.9 3.5 1.7 0.9 0.4
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 2.9 -0.4 1.7 0.6 0.1 0.5
Angina 1.5 2.0 4.8 2.2 -0.9 1.8 0.8 -0.8
Medication for hormone replacement therapy 1.8 2.0 5.4 1.6 -2.3 0.1 0.5 -1.2
Vitamin and mineral supplements 2.5 3.4 5.5 1.9 1.2 2.3 2.1 -1.6
Supplements: Zinc 0.4 0.4 1.1 -1.0 0.8 -0.3 -0.3 0.3
Medication: Co-codamol 1.8 2.1 5.3 0.5 2.0 2.3 0.9 -0.0
Medication: Metformin 2.8 3.9 9.1 3.0 -2.4 1.2 1.0 -1.6
Diabetes (father) 0.2 0.3 0.5 -0.0 -0.6 0.3 -0.7 0.7
Diabetes (mother) 0.8 1.1 1.9 0.8 0.2 1.2 1.4 -1.1
Severe depression (siblings) 0.1 0.1 0.3 0.1 0.5 0.1 0.0 0.3
Pack years adult smoking proportion 1.4 2.2 5.2 1.3 1.3 2.3 1.3 -0.7
Impedance of leg (right) 1.0 5.1 13.0 -2.9 0.5 -3.6 -1.6 1.0
Leg fat-free mass (left) 0.4 2.3 5.1 0.2 2.2 2.3 1.2 -0.1
Trunk fat percentage 0.7 2.9 5.4 1.4 0.7 2.3 2.1 -1.4
Hand grip strength (right) 1.3 3.7 7.0 -2.4 2.6 -0.4 -1.0 2.1
Townsend deprivation index at recruitment 1.1 1.6 4.5 -0.8 -0.7 -2.1 -1.2 0.8
Current tobacco smoking 0.8 1.3 2.5 1.6 -0.6 0.9 1.2 -1.2
Average weekly fortified wine intake 0.3 0.4 0.9 -0.5 -0.9 -0.9 -0.2 -0.1
Maternal smoking around birth 0.5 0.7 1.3 1.2 -0.4 1.0 0.7 -0.5
Fed-up feelings 1.4 2.5 7.0 0.3 0.9 0.4 -2.1 2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 3.2 0.9 -0.6 0.1 -1.8 1.7
Relative age voice broke 7.7 11.7 18.5 -3.2 -0.5 -3.6 -4.3 4.0
Taking other prescription medications 0.7 1.0 2.4 1.6 -1.1 0.1 0.6 -1.1
Age when periods started (menarche) 0.3 0.8 2.0 -0.1 0.1 -0.6 -1.2 1.4
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.6 0.1 0.5 0.9 1.3 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 2.3 0.9 0.4 0.7 1.4 -1.5
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.2 0.9 -1.1 0.0 -0.3 -0.1
Qualifications: CSEs or equivalent 0.3 0.4 1.6 0.4 0.4 1.3 0.4 -0.2
Serious illness, injury or assault to yourself 0.5 0.6 1.2 0.2 0.7 0.6 1.1 -0.9
High blood pressure 1.6 4.3 6.9 1.2 1.6 2.6 2.6 -2.0
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.2 0.4 -0.1 -0.2 -0.2 -0.1
Multivitamins +/- minerals 1.2 1.5 3.0 -1.0 -1.7 -1.5 -1.1 0.4
Stomach or abdominal pain in last month 0.7 0.9 1.5 0.9 0.6 1.1 -0.8 1.2
Supplements: Glucosamine 1.1 1.4 4.2 -0.3 -2.1 -1.3 -1.0 0.3
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 -0.1 -0.2 -0.1 0.3 -0.6
Medication: Atenolol 1.4 1.7 3.2 1.4 0.8 1.8 1.4 -0.9
Medication: Levothyroxine sodium 0.2 0.3 0.5 0.5 -0.7 -0.6 -0.0 -0.5
Sitting height 0.8 5.8 12.5 -3.0 3.5 -0.8 -1.3 2.3
Chronic bronchitis/emphysema (father) 2.6 3.1 5.0 1.7 0.5 1.9 2.2 -1.9
High blood pressure (mother) 2.6 3.6 11.9 -0.1 3.5 2.2 0.9 0.5
Body mass index (BMI) 3.5 15.1 34.9 4.4 0.1 5.9 3.8 -2.6
Impedance of leg (left) 1.2 6.0 15.2 -3.0 0.7 -3.9 -1.9 1.3
Leg predicted mass (left) 0.4 2.3 5.2 0.2 2.2 2.3 1.2 -0.1
Trunk fat mass 0.8 3.6 7.8 1.1 1.6 2.8 2.2 -1.2
Waist circumference 3.7 13.6 27.2 3.0 1.1 5.2 4.4 -3.4
Number of incorrect matches in round 1.3 2.2 4.1 -1.3 -0.1 -2.0 -1.7 1.4
Past tobacco smoking 1.0 1.8 3.7 -1.1 0.2 -1.0 -1.7 1.9
Alcohol usually taken with meals 0.6 1.0 3.4 -0.3 -0.8 -1.8 0.2 -0.9
Nervous feelings 5.1 9.5 20.1 -1.4 -0.5 -2.8 -4.5 4.2
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.7 6.7 0.3 -0.5 -0.6 -2.6 2.4
Hearing difficulty/problems with background noise 0.4 0.6 2.1 0.4 -1.4 -0.2 -0.8 0.5
Hair/balding pattern: Pattern 2 1.3 1.6 6.2 0.1 2.5 1.1 0.8 -0.1
Had menopause 0.0 0.0 0.1 0.2 -0.3 0.2 -0.0 0.0
Had other major operations 3.9 4.8 12.4 1.4 -3.5 0.1 1.6 -2.6
Forced vital capacity (FVC) 1.0 3.7 7.0 -2.7 2.5 -0.4 -1.2 1.9
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.2 5.3 1.8 0.6 1.5 2.3 -2.2
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.2 0.9 -1.1 0.9 0.7 -1.0
Qualifications: None of the above 0.5 1.1 3.0 0.3 1.7 1.4 0.3 0.5
Financial difficulties in last 2 years 0.3 0.5 1.5 -0.2 1.2 0.7 0.4 0.2
Mouth/teeth dental problems 1.5 2.4 6.6 -2.6 2.0 -0.8 -0.3 0.8
Heart attack 5.7 7.3 14.6 2.5 1.0 3.8 3.1 -2.3
Allergy 0.3 0.7 1.9 -1.4 0.3 -0.9 -0.5 0.8
Pain all over the body in last month 1.4 1.5 2.2 1.3 0.0 1.5 1.4 -1.2
Diabetes (self-reported) 2.8 4.4 10.9 3.3 -2.5 0.9 1.0 -1.7
Hayfever/allergic rhinitis (self-reported) 1.7 2.2 4.9 -1.9 2.2 -0.6 -0.9 1.3
Medication: Ramipril 1.0 1.2 2.6 1.2 0.4 1.6 1.2 -0.8
Medication: Simvastatin 5.9 8.7 16.3 2.2 2.7 4.0 3.2 -2.1
Fluid intelligence score 0.4 0.8 1.4 -0.9 -0.4 -1.2 0.6 -1.2
Illnesses of siblings 0.2 0.2 0.7 0.4 -0.5 -0.8 -0.2 -0.3
Neuroticism score 1.6 3.4 8.3 0.2 -0.2 -0.7 -2.9 2.9
Weight 0.9 4.3 10.6 1.1 2.1 3.3 2.1 -0.9
Impedance of arm (right) 3.5 16.3 42.1 -4.8 -0.0 -6.5 -3.3 2.1
Arm fat percentage (right) 1.5 5.7 11.7 2.6 0.1 3.4 2.6 -1.9
Trunk fat-free mass 0.3 1.9 6.0 -0.8 2.4 1.5 0.7 0.3
Hip circumference 1.5 6.3 15.8 2.0 1.5 4.0 2.7 -1.6
Time employed in main current job 0.2 0.2 0.4 0.6 0.3 0.4 -0.2 0.4
Alcohol intake versus 10 years previously 0.1 0.1 0.3 -0.5 0.2 -0.4 0.0 -0.2
Father’s age at death 0.5 0.6 2.2 0.8 -1.5 -0.0 0.0 -0.5
Worrier / anxious feelings 1.7 3.1 5.8 1.7 -1.4 -0.6 -2.4 2.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 2.9 1.7 -0.9 0.7 -0.9 1.1
Falls in the last year 5.9 8.0 11.5 3.0 -0.0 3.4 3.2 -3.0
Hair/balding pattern: Pattern 3 0.5 0.7 2.7 0.4 -1.6 -0.4 0.0 -0.6
Number of live births 0.4 0.6 1.3 -0.1 -0.5 0.5 -1.1 1.1
Forced expiratory volume in 1-second (FEV1) 1.4 4.6 8.9 -3.0 2.5 -0.8 -1.4 2.2
Pulse rate 0.3 0.5 1.7 -0.7 1.3 0.2 0.1 0.5
Happiness 0.1 0.2 0.4 0.0 -0.5 -0.3 -0.6 0.3
Noisy workplace 4.2 5.2 13.2 1.9 1.1 3.6 2.3 -1.6
Qualifications: A levels/AS levels or equivalent 0.8 1.7 3.8 -1.7 -1.0 -1.9 -0.8 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.1 0.2 -0.1 0.3 -0.0 0.1
Mouth/teeth dental problems: Dentures 0.6 1.0 2.4 1.6 -1.1 0.5 -0.8 0.8
Asthma 1.3 2.5 4.7 2.2 -2.2 0.7 0.7 -1.5
Medication: Ibuprofen (e.g. Nurofen) 3.6 4.5 7.7 2.0 -0.4 2.8 2.4 -2.2
Medication: Cholesterol lowering 5.8 9.1 17.7 2.6 1.9 4.2 3.4 -2.4
Depression (self-reported) 0.8 1.0 2.0 -1.4 0.9 -0.7 -0.8 0.9
Medication: Lansoprazole 2.7 3.0 7.2 2.5 -2.7 0.4 0.6 -1.2
Prospective memory result 0.5 0.6 2.2 0.2 -1.5 -0.3 0.2 -0.7
Lung cancer (father) 0.2 0.3 0.6 0.2 0.8 0.3 0.7 -0.5
Illnesses of mother 1.6 2.0 3.6 -1.0 -1.4 -1.9 -1.5 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.5 11.0 -3.3 2.4 -1.7 -2.2 2.8
Pulse wave Arterial Stiffness index 2.0 2.3 4.4 0.8 0.5 1.4 2.1 -2.0
Impedance of arm (left) 2.7 12.4 34.0 -4.3 0.2 -5.8 -2.7 1.6
Arm fat mass (right) 1.4 5.9 13.9 2.4 0.9 3.7 2.6 -1.6
Trunk predicted mass 0.3 1.9 6.0 -0.8 2.5 1.5 0.6 0.4
Standing height 2.7 26.8 53.9 -7.3 4.7 -5.5 -3.5 4.0
Length of working week for main job 0.7 0.8 2.3 0.3 -0.9 -1.5 -0.8 0.2
Exposure to tobacco smoke at home 0.6 0.7 1.6 -0.4 0.9 0.5 -0.7 1.2
Breastfed as a baby 1.9 2.3 7.4 0.7 1.0 2.7 1.5 -0.6
Tense / ‘highly strung’ 4.6 7.5 15.6 -1.6 -0.3 -2.5 -4.0 3.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.5 -0.7 0.7 -0.6 -0.6 0.5
Hair/balding pattern: Pattern 4 0.3 0.8 2.4 1.5 -0.5 1.2 0.2 0.0
Birth weight of first child 5.4 9.8 17.4 -4.2 0.7 -3.6 -3.1 3.0
Peak expiratory flow (PEF) 1.0 2.3 5.2 -2.3 0.9 -1.4 -1.2 1.4
Pulse wave reflection index 1.8 2.2 4.6 1.5 -1.2 0.8 1.6 -2.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.6 -0.8 0.0 -0.5 -0.4 0.4
Loud music exposure frequency 0.6 0.7 2.3 1.0 -1.5 -0.1 -0.3 -0.2
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 6.1 -1.7 -1.5 -2.5 -1.1 0.3
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 6.0 1.4 -2.5 -0.7 0.5 -1.6
Blood clot in the leg (DVT) 0.5 0.6 1.1 0.5 0.4 1.1 0.9 -0.8
Medication: Paracetamol 2.7 4.4 6.7 2.6 -1.6 1.9 2.0 -2.3
Headache pain in last month 1.4 2.3 5.2 -0.3 -0.7 -1.2 -2.3 2.1
Medication for cholesterol, blood pressure or diabetes 2.9 4.8 10.0 -1.9 -1.5 -3.2 -2.4 1.6
Glaucoma (self-reported) 0.5 0.6 1.0 -0.9 0.1 -1.0 -0.7 0.6
Gout (self-reported) 1.2 1.7 3.1 1.8 -0.4 1.0 1.4 -1.5
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.3 -0.0 0.4 -0.5 -0.4 0.2
Medication: Amlodipine 0.2 0.3 0.9 -0.0 0.5 0.6 -0.6 0.9
Medication: Ventolin 100micrograms inhaler 1.0 1.3 3.9 1.4 -2.0 -0.1 -0.0 -0.6
Birth weight 0.8 1.8 3.5 -1.9 1.8 -0.8 -0.5 1.0
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.3 0.6 0.1 0.6 -0.3 0.4
High blood pressure (siblings) 0.4 0.6 1.3 -1.0 1.2 0.1 -0.2 0.6
Forced vital capacity (FVC), Best measure 1.5 5.7 9.9 -3.2 1.8 -1.7 -2.2 2.7
Body fat percentage 1.4 5.5 11.7 2.3 0.5 3.4 2.7 -1.9
Leg fat percentage (right) 3.7 13.4 26.6 3.8 0.0 5.2 4.0 -3.1
Arm fat-free mass (right) 0.6 3.1 7.6 0.5 2.4 2.8 1.4 -0.2
Exposure to tobacco smoke outside home 1.7 2.3 6.3 1.5 0.8 2.5 1.4 -0.7
Comparative body size at age 10 1.9 5.1 7.9 2.1 0.5 2.6 2.8 -2.5
Number of full brothers 1.0 1.3 2.2 -1.3 1.1 -0.5 -1.0 1.5
Worry too long after embarrassment 1.0 1.6 3.7 1.0 -0.5 -0.4 -1.9 1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.1 -0.5 1.0 -0.7 -0.4 0.2
Wheeze or whistling in the chest in last year 1.3 2.4 3.9 2.0 -0.6 1.8 1.4 -1.6
Number of children fathered 1.8 2.1 3.3 -1.8 1.2 -0.7 -1.3 1.8
Reason for reducing amount of alcohol drunk: Health precaution 2.9 3.4 5.6 -1.5 -0.7 -2.2 -2.4 1.9
Age at first live birth 0.2 0.4 1.0 -0.8 0.4 -1.0 -0.4 0.4
Pulse wave peak to peak time 2.7 3.2 5.5 -1.3 -0.4 -1.9 -2.3 2.3
Health satisfaction 1.9 2.4 6.1 2.5 -1.6 1.5 0.7 -0.9
Shortness of breath walking on level ground 1.1 1.4 2.3 1.5 -1.5 0.5 0.9 -1.1
Qualifications: College or University degree 0.6 1.9 4.2 -0.6 -2.0 -2.0 -0.7 -0.3
Eye problems/disorders: None of the above 2.0 2.3 4.9 -2.2 0.9 -1.5 -1.3 1.4
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.1 0.3 -0.1 -0.1 0.1 -0.0
Emphysema/chronic bronchitis 0.6 0.7 1.6 0.8 -0.4 0.5 0.8 -1.3
Medication for pain relief, constipation, heartburn 5.0 8.6 11.0 -3.3 1.0 -3.1 -3.3 3.3
Neck or shoulder pain in last month 2.8 3.9 6.6 2.5 -0.0 2.6 2.0 -1.6
Medication: Blood pressure 0.1 0.2 0.8 0.1 0.9 0.5 0.4 -0.1
Angina (self-reported) 1.5 2.0 5.2 2.3 -1.0 1.7 0.7 -0.7
Migraine (self-reported) 0.6 0.8 1.4 -1.2 0.9 -1.0 -0.5 0.7
Medication: Ibuprofen 3.7 4.5 7.0 1.9 -0.5 2.6 2.4 -2.3
Medication: Allopurinol 0.8 1.1 3.2 1.8 -1.1 0.4 0.4 -0.8
Medication: Omeprazole 0.2 0.2 0.6 -0.0 0.8 0.4 0.4 -0.3
Medication: Seretide 50 evohaler 1.7 1.9 3.3 1.8 0.1 1.0 1.6 -1.7
Mean time to correctly identify matches 1.1 2.2 5.2 0.4 -2.3 -1.5 -1.6 0.6
Heart disease (mother) 2.7 3.3 6.1 2.0 0.1 2.5 2.0 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.2 -0.5 0.2 -0.2 0.1
Whole body fat mass 1.3 5.6 13.2 1.9 1.3 3.6 2.6 -1.6
Leg fat mass (right) 2.5 9.6 23.1 2.9 1.1 4.8 3.3 -2.1
Arm predicted mass (right) 0.6 3.0 7.1 0.4 2.5 2.7 1.3 -0.1
Pulse rate, automated reading 1.0 3.2 6.0 0.2 2.2 2.5 2.1 -0.9
Alcohol intake frequency. 0.1 0.3 0.9 1.0 -0.0 0.4 0.4 -0.3
Comparative height size at age 10 0.9 5.0 12.2 -3.5 2.5 -2.5 -0.4 0.6
Number of full sisters 1.5 1.8 2.6 -1.6 0.7 -1.2 -1.5 1.4
Suffer from ‘nerves’ 4.6 7.2 13.1 -2.6 1.9 -1.6 -3.2 3.6
Overall health rating 3.5 7.5 19.1 4.4 -2.2 2.2 1.9 -2.3
Chest pain or discomfort 3.9 5.6 12.0 3.5 -1.0 3.0 1.8 -1.7
Had major operations 1.0 1.2 2.7 0.7 -1.4 -0.3 1.0 -1.6
Age at last live birth 0.9 1.3 3.5 -0.3 -0.9 -1.9 -1.3 0.8
Family relationship satisfaction 0.7 0.8 2.6 0.9 -1.6 -0.1 0.2 -0.9
Leg pain on walking 0.3 0.4 1.1 0.7 0.3 1.0 -0.2 0.5
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 4.6 0.9 1.0 2.2 1.3 -0.6
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.7 0.7 -0.8 0.4 0.1 -0.2
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 2.4 0.6 -1.6 -0.2 -0.2 -0.4
Medication: Aspirin 5.2 6.9 10.1 3.1 0.2 3.2 3.0 -2.5
Supplements: Vitamin C 1.0 1.1 1.8 -0.5 -0.7 -1.4 -1.3 1.1
Knee pain experienced in last month 0.3 0.5 1.4 1.1 0.3 1.2 0.1 0.2
Hypertension (Self-reported) 1.6 4.6 7.0 1.7 1.0 2.6 2.6 -2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 4.5 1.1 -2.1 -0.7 -0.1 -0.7
Illnesses of father: Heart disease 3.9 5.4 13.4 2.5 0.4 3.7 2.2 -1.5
Illnesses of siblings: Diabetes 2.4 3.0 5.5 1.8 -0.2 2.3 1.9 -1.6
Smoking status: Previous 0.6 0.9 2.2 0.7 -0.6 0.5 1.1 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.4 4.8 -2.2 2.1 -1.8 -1.3 1.7
Whole body fat-free mass 0.4 2.2 6.0 -0.3 2.4 2.0 0.9 0.2
Leg fat-free mass (right) 0.4 2.2 5.1 0.2 2.3 2.1 1.1 -0.0
Arm fat percentage (left) 1.8 7.1 14.2 2.9 0.1 3.8 2.9 -2.1
Average weekly red wine intake 0.8 1.2 2.7 -1.3 0.1 -1.6 -1.1 0.6
Handedness (chirality/laterality): Left-handed 1.3 1.5 3.6 -1.6 0.2 -1.9 -1.1 0.6
Mood swings 0.5 0.9 2.0 0.4 1.4 1.4 -0.2 0.8
Loneliness, isolation 0.3 0.5 0.9 1.0 -0.2 0.4 -0.9 0.7
Long-standing illness, disability or infirmity 2.9 4.4 9.3 3.0 -1.9 1.8 1.6 -1.9
Ever had bowel cancer screening 0.1 0.1 0.4 0.4 0.3 0.6 0.1 -0.1
Diabetes diagnosed by doctor 4.5 7.3 17.8 4.2 -2.5 1.8 1.9 -2.4
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.7 -0.8 1.3 0.4 0.1 0.2
Friendships satisfaction 1.1 1.4 4.3 1.4 -2.1 -0.6 -0.1 -0.5
Qualifications: nursing, teaching 0.6 1.0 1.4 0.6 -1.1 0.9 1.1 -1.2
Commuting to job workplace: Walk 0.3 0.4 0.9 -0.9 0.7 -0.8 -0.1 -0.1
Eye problems/disorders: Cataract 0.5 0.6 1.8 -0.5 1.3 0.8 -0.2 0.6
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.4 0.7 -0.2 0.3 -0.6 0.4
Medication for cholesterol 1.4 2.1 3.4 -1.4 -0.8 -1.8 -1.7 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.4 0.7 0.2 0.5 0.6 -0.4
Back pain experienced in last month 0.9 1.2 2.8 -0.5 1.5 0.3 -1.0 1.7
Mineral and other dietary supplements 2.8 3.8 4.9 2.2 1.1 2.2 2.1 -1.9
Breast cancer (self-reported) 1.5 1.8 3.8 0.8 1.9 1.7 1.2 -0.4
Asthma (self-reported) 1.7 3.4 6.4 2.5 -2.3 0.9 1.1 -1.9
Osteoporosis (self-reported) 0.5 0.6 0.9 -0.2 -1.0 -0.9 -1.0 0.7
Osteoarthritis (self-reported) 0.5 0.7 1.9 1.0 -1.4 0.5 0.0 -0.5
Medication: Aspirin 5.0 6.5 10.1 2.9 0.3 3.2 2.9 -2.4
Medication: Gliclazide 1.0 1.1 3.7 1.9 -0.7 0.7 0.6 -0.8
Illnesses of father: None of the above (group 1) 5.8 7.2 11.0 -3.3 1.3 -2.6 -2.7 3.0
Smoking status: Current 0.6 0.9 1.7 1.3 -0.9 0.4 0.9 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.1 -1.0 0.8 -0.3 -0.5 0.9
Whole body water mass 0.4 2.0 5.9 -0.4 2.4 1.8 0.8 0.3
Leg predicted mass (right) 0.4 2.2 5.2 0.2 2.3 2.1 1.1 0.0
Arm fat mass (left) 1.4 5.7 13.8 2.3 0.9 3.7 2.5 -1.5
Number of self-reported non-cancer illnesses 0.4 0.6 1.1 1.0 -0.8 0.2 0.6 -1.0
Average weekly champagne plus white wine intake 0.5 0.7 1.4 0.6 -0.7 -0.7 0.8 -1.2
Miserableness 0.7 1.2 3.3 1.3 0.6 1.8 -0.2 0.8
Guilty feelings 0.2 0.3 0.7 0.8 0.6 0.4 -0.5 0.6
Wears glasses or contact lenses 0.2 0.2 0.9 -0.5 -0.9 -0.0 -0.2 -0.0
Ever taken oral contraceptive pill 0.6 0.7 1.6 -0.0 0.7 1.2 1.0 -0.7
Hearing aid user 0.6 0.7 1.3 0.1 0.1 1.0 1.1 -1.0
Mother’s age at death 1.1 1.4 3.3 -1.1 -0.7 -1.8 -1.2 0.8
Financial situation satisfaction 0.4 0.5 1.2 -0.1 0.2 -0.1 -1.1 1.1
Tinnitus: Yes, now most or all of the time 2.6 3.0 4.2 -2.0 -0.2 -1.8 -2.0 2.0
Commuting to job workplace: Public transport 0.4 0.5 0.7 0.6 -0.1 0.7 0.8 -0.8
Eye problems/disorders: Glaucoma 0.1 0.2 0.6 -0.1 -0.3 -0.8 -0.4 0.1
Medication: Blood pressure 1.5 2.8 4.9 1.0 1.1 1.9 2.2 -1.9
Pain type(s) experienced in last month: Hip pain 2.6 3.3 9.6 2.3 -3.1 -0.0 0.3 -1.2
Supplements: Fish oil (including cod liver oil) 2.0 2.6 3.7 -1.7 -0.8 -1.7 -1.9 1.7
High cholesterol (Self-reported) 3.8 6.7 14.6 1.6 3.0 3.8 2.5 -1.1
Medication: Bendroflumethiazide 1.6 2.5 5.7 -0.3 2.4 1.9 1.5 -0.7
Medication: Paracetamol 4.0 6.2 9.2 2.9 -1.5 2.1 2.7 -3.0
Medication: Lisinopril 0.7 0.9 2.6 -0.1 1.6 0.8 1.0 -0.7
Medication: Atorvastatin 1.1 1.3 3.2 1.3 0.5 1.8 1.1 -0.6
Illnesses of father: High blood pressure 0.1 0.1 0.1 -0.2 0.3 -0.0 -0.3 0.3
Alcohol drinker status: Never 0.3 0.3 1.0 0.5 1.0 0.6 0.0 0.4
Ever smoked 1.4 2.5 4.9 1.3 -0.2 1.1 2.1 -2.2
Basal metabolic rate 0.5 2.8 6.2 0.2 2.5 2.5 1.4 -0.2
Leg fat percentage (left) 3.4 12.4 25.6 3.8 0.1 5.1 3.8 -2.8
Arm fat-free mass (left) 0.4 2.0 5.0 0.2 2.1 2.2 0.8 0.3
Number of operations (self-reported) 1.3 1.9 4.9 0.8 -2.2 -0.2 1.0 -1.7
Average weekly beer plus cider intake 1.5 2.2 7.5 0.9 1.4 2.7 0.6 0.6
Irritability 0.4 0.6 1.5 -0.6 0.6 0.3 -0.9 1.2
Risk taking 1.6 2.4 5.0 0.4 -0.1 1.5 2.2 -2.1
Ever had prostate specific antigen (PSA) test 1.2 1.4 4.4 0.1 -2.1 -1.0 -1.1 0.6
Fractured/broken bones in last 5 years 0.1 0.1 0.2 -0.4 0.2 -0.5 -0.4 0.3
Age started oral contraceptive pill 1.0 1.3 4.3 -1.2 0.0 -2.1 -0.8 0.3
Diastolic blood pressure, automated reading 1.0 3.2 11.3 -1.3 3.4 1.4 0.5 0.8
Ever depressed for a whole week 1.8 2.2 3.1 1.4 -1.7 0.9 1.4 -1.8
Unable to work because of sickness or disability 0.1 0.1 0.5 -0.3 0.7 0.2 -0.0 0.2
Commuting to job workplace: Cycle 5.5 6.6 9.4 2.8 -1.9 2.2 2.6 -3.1
Myopia 1.4 2.0 3.7 -1.9 0.5 -1.3 -1.5 1.5
Vascular/heart problems diagnosed by doctor 2.4 6.6 12.3 -1.9 -1.6 -3.5 -3.0 2.3
Cholesterol lowering medication 2.8 4.1 9.5 1.5 2.0 3.1 1.9 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.4 0.0 0.6 0.3 0.4 -0.4
Pain experienced in last month 1.0 1.7 4.8 -2.2 0.8 -1.6 -0.6 0.3
Supplements: Calcium 4.3 4.7 8.5 -1.8 -1.7 -2.9 -2.5 1.7
Basal cell carcinoma (self-reported) 0.7 0.9 1.7 -1.0 0.7 -0.5 -1.0 1.3
Heart attack/myocardial infarction (self-reported) 6.4 8.3 15.8 2.7 0.8 4.0 3.4 -2.6
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.0 0.6 0.6 1.0 0.9 -0.8
Heart disease (siblings) 1.9 2.4 3.3 1.8 -0.7 1.5 1.7 -1.7
Alcohol drinker status: Previous 0.1 0.1 0.2 0.1 -0.4 -0.3 -0.3 -0.0
Pack years of smoking 1.2 1.8 4.1 1.4 0.9 2.0 1.2 -0.8
Impedance of whole body 2.3 11.9 31.4 -4.1 0.3 -5.6 -2.8 1.8
Leg fat mass (left) 2.2 8.5 21.3 2.8 1.1 4.6 3.0 -1.8
Arm predicted mass (left) 0.5 2.5 6.1 0.3 2.3 2.5 1.0 0.1