TWAS hub - NCK1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0470	0.0240	0.00230	0.002	0.012	0.008	0.011	0.004	1.7e-01	0.01200	3.0e-02	0.01500	8.6e-02
2	GTEx	Esophagus Mucosa	0.1150	0.0490	0.00090	0.037	NA	0.027	NA	0.046	1.7e-03	NA	6.2e-03	NA	4.5e-04
3	YFS	Blood	0.0146	0.0071	0.00079	0.018	0.010	0.017	0.011	0.017	9.5e-07	0.00019	2.2e-06	0.00012	2.5e-06
4	TCGA	Breast Invasive Carcinoma	0.0094	0.0065	0.00500	0.002	0.006	0.002	NA	0.004	9.1e-02	0.01600	1.0e-01	NA	4.4e-02
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0353	0.0267	0.00093	0.017	0.013	0.006	NA	0.008	4.6e-03	0.01000	7.0e-02	NA	4.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Relative age voice broke	7.7	11.7	18.5	-3.2	-0.5	-3.6	-4.3	4.0
Heart attack/myocardial infarction (self-reported)	6.4	8.3	15.8	2.7	0.8	4.0	3.4	-2.6
Medication: Simvastatin	5.9	8.7	16.3	2.2	2.7	4.0	3.2	-2.1
Falls in the last year	5.9	8.0	11.5	3.0	-0.0	3.4	3.2	-3.0
Medication: Cholesterol lowering	5.8	9.1	17.7	2.6	1.9	4.2	3.4	-2.4
Illnesses of father: None of the above (group 1)	5.8	7.2	11.0	-3.3	1.3	-2.6	-2.7	3.0
Relative age of first facial hair	5.7	11.6	16.6	-3.5	0.3	-3.8	-4.1	3.9
Heart attack	5.7	7.3	14.6	2.5	1.0	3.8	3.1	-2.3
Commuting to job workplace: Cycle	5.5	6.6	9.4	2.8	-1.9	2.2	2.6	-3.1
Birth weight of first child	5.4	9.8	17.4	-4.2	0.7	-3.6	-3.1	3.0
Medication: Aspirin	5.2	6.9	10.1	3.1	0.2	3.2	3.0	-2.5
BMI	5.1	29.6	57.8	5.9	0.4	7.6	5.9	-4.5
Nervous feelings	5.1	9.5	20.1	-1.4	-0.5	-2.8	-4.5	4.2
Blood White Count	5.0	36.8	53.6	6.5	-1.1	5.8	7.3	-7.3
Medication for pain relief, constipation, heartburn	5.0	8.6	11.0	-3.3	1.0	-3.1	-3.3	3.3
Medication: Aspirin	5.0	6.5	10.1	2.9	0.3	3.2	2.9	-2.4
Other serious medical condition/disability diagnosed by doctor	4.9	6.4	9.1	3.0	-2.2	1.7	2.5	-3.0
Tense / ‘highly strung’	4.6	7.5	15.6	-1.6	-0.3	-2.5	-4.0	3.7
Suffer from ‘nerves’	4.6	7.2	13.1	-2.6	1.9	-1.6	-3.2	3.6
Diabetes diagnosed by doctor	4.5	7.3	17.8	4.2	-2.5	1.8	1.9	-2.4
Supplements: Calcium	4.3	4.7	8.5	-1.8	-1.7	-2.9	-2.5	1.7
Cardiovascular Disease	4.2	13.9	29.5	2.0	3.5	5.4	4.2	-2.6
Noisy workplace	4.2	5.2	13.2	1.9	1.1	3.6	2.3	-1.6
Medication: Paracetamol	4.0	6.2	9.2	2.9	-1.5	2.1	2.7	-3.0
Type 2 Diabetes (T2D) (2018)	3.9	7.2	13.2	3.6	-1.9	2.0	2.5	-3.0
Had other major operations	3.9	4.8	12.4	1.4	-3.5	0.1	1.6	-2.6
Chest pain or discomfort	3.9	5.6	12.0	3.5	-1.0	3.0	1.8	-1.7
Illnesses of father: Heart disease	3.9	5.4	13.4	2.5	0.4	3.7	2.2	-1.5
High cholesterol (Self-reported)	3.8	6.7	14.6	1.6	3.0	3.8	2.5	-1.1
Blood Platelet Count	3.7	42.8	68.6	5.2	1.3	7.7	8.3	-7.6
Waist circumference	3.7	13.6	27.2	3.0	1.1	5.2	4.4	-3.4
Leg fat percentage (right)	3.7	13.4	26.6	3.8	0.0	5.2	4.0	-3.1
Medication: Ibuprofen	3.7	4.5	7.0	1.9	-0.5	2.6	2.4	-2.3
Medication: Ibuprofen (e.g. Nurofen)	3.6	4.5	7.7	2.0	-0.4	2.8	2.4	-2.2
Body mass index (BMI)	3.5	15.1	34.9	4.4	0.1	5.9	3.8	-2.6
Impedance of arm (right)	3.5	16.3	42.1	-4.8	-0.0	-6.5	-3.3	2.1
Overall health rating	3.5	7.5	19.1	4.4	-2.2	2.2	1.9	-2.3
Leg fat percentage (left)	3.4	12.4	25.6	3.8	0.1	5.1	3.8	-2.8
Alzheimer’s Disease (including proxy)	3.1	4.5	14.5	2.1	-3.8	-0.2	0.6	-1.8
Height	3.1	60.1	123.2	-11.1	6.5	-8.5	-5.3	5.9
Medication for cholesterol, blood pressure or diabetes	2.9	4.8	10.0	-1.9	-1.5	-3.2	-2.4	1.6
Reason for reducing amount of alcohol drunk: Health precaution	2.9	3.4	5.6	-1.5	-0.7	-2.2	-2.4	1.9
Long-standing illness, disability or infirmity	2.9	4.4	9.3	3.0	-1.9	1.8	1.6	-1.9
Schizophrenia (2018)	2.8	5.8	11.6	-1.7	0.1	-1.7	-3.4	3.4
Medication: Metformin	2.8	3.9	9.1	3.0	-2.4	1.2	1.0	-1.6
Diabetes (self-reported)	2.8	4.4	10.9	3.3	-2.5	0.9	1.0	-1.7
Neck or shoulder pain in last month	2.8	3.9	6.6	2.5	-0.0	2.6	2.0	-1.6
Mineral and other dietary supplements	2.8	3.8	4.9	2.2	1.1	2.2	2.1	-1.9
Cholesterol lowering medication	2.8	4.1	9.5	1.5	2.0	3.1	1.9	-1.1
Schizophrenia (2014)	2.7	6.0	12.2	-1.6	0.2	-2.1	-3.5	3.3
Number of treatments/medications taken	2.7	4.8	7.3	2.7	-0.5	2.1	2.4	-2.5
Medication: Lansoprazole	2.7	3.0	7.2	2.5	-2.7	0.4	0.6	-1.2
Impedance of arm (left)	2.7	12.4	34.0	-4.3	0.2	-5.8	-2.7	1.6
Standing height	2.7	26.8	53.9	-7.3	4.7	-5.5	-3.5	4.0
Medication: Paracetamol	2.7	4.4	6.7	2.6	-1.6	1.9	2.0	-2.3
Pulse wave peak to peak time	2.7	3.2	5.5	-1.3	-0.4	-1.9	-2.3	2.3
Heart disease (mother)	2.7	3.3	6.1	2.0	0.1	2.5	2.0	-1.6
Alzheimer’s Disease (in father)	2.6	2.9	6.1	1.8	-2.5	0.4	1.1	-1.9
Chronic bronchitis/emphysema (father)	2.6	3.1	5.0	1.7	0.5	1.9	2.2	-1.9
High blood pressure (mother)	2.6	3.6	11.9	-0.1	3.5	2.2	0.9	0.5
Tinnitus: Yes, now most or all of the time	2.6	3.0	4.2	-2.0	-0.2	-1.8	-2.0	2.0
Pain type(s) experienced in last month: Hip pain	2.6	3.3	9.6	2.3	-3.1	-0.0	0.3	-1.2
Vitamin and mineral supplements	2.5	3.4	5.5	1.9	1.2	2.3	2.1	-1.6
Leg fat mass (right)	2.5	9.6	23.1	2.9	1.1	4.8	3.3	-2.1
Worry (Nagel 2018)	2.4	5.0	11.7	0.4	-1.0	-1.6	-3.4	3.1
Illnesses of siblings: Diabetes	2.4	3.0	5.5	1.8	-0.2	2.3	1.9	-1.6
Vascular/heart problems diagnosed by doctor	2.4	6.6	12.3	-1.9	-1.6	-3.5	-3.0	2.3
Bipolar Disorder or Schizophrenia	2.3	5.6	9.3	-2.4	0.6	-1.9	-3.0	3.1
Body Mass Index (BMI) (2010)	2.3	3.1	5.7	2.4	-1.3	1.9	1.5	-1.5
Impedance of whole body	2.3	11.9	31.4	-4.1	0.3	-5.6	-2.8	1.8
Neuroticism (2016)	2.2	3.2	7.7	-0.9	0.4	-0.9	-2.5	2.8
Leg fat mass (left)	2.2	8.5	21.3	2.8	1.1	4.6	3.0	-1.8
Waist Hip Ratio (WHR)	2.1	9.2	18.8	1.0	1.4	3.0	4.3	-4.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.5	11.0	-3.3	2.4	-1.7	-2.2	2.8
Pulse wave Arterial Stiffness index	2.0	2.3	4.4	0.8	0.5	1.4	2.1	-2.0
Eye problems/disorders: None of the above	2.0	2.3	4.9	-2.2	0.9	-1.5	-1.3	1.4
Supplements: Fish oil (including cod liver oil)	2.0	2.6	3.7	-1.7	-0.8	-1.7	-1.9	1.7
Bipolar Disorder (2011)	1.9	1.9	5.9	-1.2	2.4	-0.3	-0.6	1.2
Breastfed as a baby	1.9	2.3	7.4	0.7	1.0	2.7	1.5	-0.6
Comparative body size at age 10	1.9	5.1	7.9	2.1	0.5	2.6	2.8	-2.5
Health satisfaction	1.9	2.4	6.1	2.5	-1.6	1.5	0.7	-0.9
Heart disease (siblings)	1.9	2.4	3.3	1.8	-0.7	1.5	1.7	-1.7
Medication for hormone replacement therapy	1.8	2.0	5.4	1.6	-2.3	0.1	0.5	-1.2
Medication: Co-codamol	1.8	2.1	5.3	0.5	2.0	2.3	0.9	-0.0
Pulse wave reflection index	1.8	2.2	4.6	1.5	-1.2	0.8	1.6	-2.1
Number of children fathered	1.8	2.1	3.3	-1.8	1.2	-0.7	-1.3	1.8
Arm fat percentage (left)	1.8	7.1	14.2	2.9	0.1	3.8	2.9	-2.1
Ever depressed for a whole week	1.8	2.2	3.1	1.4	-1.7	0.9	1.4	-1.8
Irritable Bowel Disease (IBD)	1.7	4.1	5.7	-2.4	2.0	-1.5	-1.8	2.2
Neuroticism	1.7	4.0	9.4	0.9	-1.1	-0.8	-3.1	2.8
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	6.7	0.3	-0.5	-0.6	-2.6	2.4
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	4.9	-1.9	2.2	-0.6	-0.9	1.3
Worrier / anxious feelings	1.7	3.1	5.8	1.7	-1.4	-0.6	-2.4	2.2
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	6.0	1.4	-2.5	-0.7	0.5	-1.6
Exposure to tobacco smoke outside home	1.7	2.3	6.3	1.5	0.8	2.5	1.4	-0.7
Medication: Seretide 50 evohaler	1.7	1.9	3.3	1.8	0.1	1.0	1.6	-1.7
Asthma (self-reported)	1.7	3.4	6.4	2.5	-2.3	0.9	1.1	-1.9
Fasting Glucose	1.6	1.9	5.1	2.2	-1.6	0.6	0.8	-1.0
High blood pressure	1.6	4.3	6.9	1.2	1.6	2.6	2.6	-2.0
Neuroticism score	1.6	3.4	8.3	0.2	-0.2	-0.7	-2.9	2.9
Illnesses of mother	1.6	2.0	3.6	-1.0	-1.4	-1.9	-1.5	0.9
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	6.1	-1.7	-1.5	-2.5	-1.1	0.3
Hypertension (Self-reported)	1.6	4.6	7.0	1.7	1.0	2.6	2.6	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	4.8	-2.2	2.1	-1.8	-1.3	1.7
Medication: Bendroflumethiazide	1.6	2.5	5.7	-0.3	2.4	1.9	1.5	-0.7
Risk taking	1.6	2.4	5.0	0.4	-0.1	1.5	2.2	-2.1
HDL Cholesterol	1.5	2.4	3.6	-1.9	1.0	-1.6	-1.5	1.6
Angina	1.5	2.0	4.8	2.2	-0.9	1.8	0.8	-0.8
Mouth/teeth dental problems	1.5	2.4	6.6	-2.6	2.0	-0.8	-0.3	0.8
Arm fat percentage (right)	1.5	5.7	11.7	2.6	0.1	3.4	2.6	-1.9
Hip circumference	1.5	6.3	15.8	2.0	1.5	4.0	2.7	-1.6
Forced vital capacity (FVC), Best measure	1.5	5.7	9.9	-3.2	1.8	-1.7	-2.2	2.7
Angina (self-reported)	1.5	2.0	5.2	2.3	-1.0	1.7	0.7	-0.7
Number of full sisters	1.5	1.8	2.6	-1.6	0.7	-1.2	-1.5	1.4
Breast cancer (self-reported)	1.5	1.8	3.8	0.8	1.9	1.7	1.2	-0.4
Medication: Blood pressure	1.5	2.8	4.9	1.0	1.1	1.9	2.2	-1.9
Average weekly beer plus cider intake	1.5	2.2	7.5	0.9	1.4	2.7	0.6	0.6
Crohns Disease (2017)	1.4	3.2	6.4	-2.0	2.5	-1.1	-1.1	1.7
Respiratory disease	1.4	3.1	5.2	2.3	-1.8	1.3	1.3	-1.9
Pack years adult smoking proportion	1.4	2.2	5.2	1.3	1.3	2.3	1.3	-0.7
Fed-up feelings	1.4	2.5	7.0	0.3	0.9	0.4	-2.1	2.6
Medication: Atenolol	1.4	1.7	3.2	1.4	0.8	1.8	1.4	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	5.3	1.8	0.6	1.5	2.3	-2.2
Pain all over the body in last month	1.4	1.5	2.2	1.3	0.0	1.5	1.4	-1.2
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	8.9	-3.0	2.5	-0.8	-1.4	2.2
Arm fat mass (right)	1.4	5.9	13.9	2.4	0.9	3.7	2.6	-1.6
Headache pain in last month	1.4	2.3	5.2	-0.3	-0.7	-1.2	-2.3	2.1
Body fat percentage	1.4	5.5	11.7	2.3	0.5	3.4	2.7	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.6	0.9	1.0	2.2	1.3	-0.6
Medication for cholesterol	1.4	2.1	3.4	-1.4	-0.8	-1.8	-1.7	1.4
Arm fat mass (left)	1.4	5.7	13.8	2.3	0.9	3.7	2.5	-1.5
Ever smoked	1.4	2.5	4.9	1.3	-0.2	1.1	2.1	-2.2
Myopia	1.4	2.0	3.7	-1.9	0.5	-1.3	-1.5	1.5
Coronary Artery Disease (CAD)	1.3	1.5	3.6	1.0	1.2	1.9	1.1	-0.7
Hand grip strength (right)	1.3	3.7	7.0	-2.4	2.6	-0.4	-1.0	2.1
Number of incorrect matches in round	1.3	2.2	4.1	-1.3	-0.1	-2.0	-1.7	1.4
Hair/balding pattern: Pattern 2	1.3	1.6	6.2	0.1	2.5	1.1	0.8	-0.1
Asthma	1.3	2.5	4.7	2.2	-2.2	0.7	0.7	-1.5
Wheeze or whistling in the chest in last year	1.3	2.4	3.9	2.0	-0.6	1.8	1.4	-1.6
Whole body fat mass	1.3	5.6	13.2	1.9	1.3	3.6	2.6	-1.6
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.6	-1.6	0.2	-1.9	-1.1	0.6
Number of operations (self-reported)	1.3	1.9	4.9	0.8	-2.2	-0.2	1.0	-1.7
Neuroticism (Nagel 2018)	1.2	2.8	6.4	1.1	-0.3	-0.1	-2.5	2.5
Prostate Cancer	1.2	1.7	3.0	0.9	-0.1	1.4	1.7	-1.7
Heel T-Score	1.2	9.3	13.1	3.6	-0.6	3.0	3.4	-3.5
Systolic blood pressure, automated reading	1.2	3.4	12.3	-0.9	3.5	1.7	0.9	0.4
Multivitamins +/- minerals	1.2	1.5	3.0	-1.0	-1.7	-1.5	-1.1	0.4
Impedance of leg (left)	1.2	6.0	15.2	-3.0	0.7	-3.9	-1.9	1.3
Gout (self-reported)	1.2	1.7	3.1	1.8	-0.4	1.0	1.4	-1.5
Ever had prostate specific antigen (PSA) test	1.2	1.4	4.4	0.1	-2.1	-1.0	-1.1	0.6
Pack years of smoking	1.2	1.8	4.1	1.4	0.9	2.0	1.2	-0.8
Alzheimer’s Disease (in mother)	1.1	1.2	4.9	0.1	-2.2	-1.0	-0.6	-0.1
Hand grip strength (left)	1.1	2.9	5.5	-2.0	2.4	-0.7	-1.0	1.9
Townsend deprivation index at recruitment	1.1	1.6	4.5	-0.8	-0.7	-2.1	-1.2	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.2	0.9	-0.6	0.1	-1.8	1.7
Supplements: Glucosamine	1.1	1.4	4.2	-0.3	-2.1	-1.3	-1.0	0.3
Shortness of breath walking on level ground	1.1	1.4	2.3	1.5	-1.5	0.5	0.9	-1.1
Mean time to correctly identify matches	1.1	2.2	5.2	0.4	-2.3	-1.5	-1.6	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.5	1.1	-2.1	-0.7	-0.1	-0.7
Friendships satisfaction	1.1	1.4	4.3	1.4	-2.1	-0.6	-0.1	-0.5
Mother’s age at death	1.1	1.4	3.3	-1.1	-0.7	-1.8	-1.2	0.8
Medication: Atorvastatin	1.1	1.3	3.2	1.3	0.5	1.8	1.1	-0.6
Depression (Nagel 2018)	1.0	1.5	3.0	1.7	-0.3	0.5	-1.4	1.5
Mean Putamen Volume	1.0	1.2	3.6	0.3	-1.9	-1.4	-0.3	-0.4
Systolic Blood Pressure	1.0	5.0	14.9	-3.0	3.9	-0.1	-0.1	1.1
Impedance of leg (right)	1.0	5.1	13.0	-2.9	0.5	-3.6	-1.6	1.0
Past tobacco smoking	1.0	1.8	3.7	-1.1	0.2	-1.0	-1.7	1.9
Forced vital capacity (FVC)	1.0	3.7	7.0	-2.7	2.5	-0.4	-1.2	1.9
Medication: Ramipril	1.0	1.2	2.6	1.2	0.4	1.6	1.2	-0.8
Peak expiratory flow (PEF)	1.0	2.3	5.2	-2.3	0.9	-1.4	-1.2	1.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.9	1.4	-2.0	-0.1	-0.0	-0.6
Number of full brothers	1.0	1.3	2.2	-1.3	1.1	-0.5	-1.0	1.5
Worry too long after embarrassment	1.0	1.6	3.7	1.0	-0.5	-0.4	-1.9	1.8
Pulse rate, automated reading	1.0	3.2	6.0	0.2	2.2	2.5	2.1	-0.9
Had major operations	1.0	1.2	2.7	0.7	-1.4	-0.3	1.0	-1.6
Supplements: Vitamin C	1.0	1.1	1.8	-0.5	-0.7	-1.4	-1.3	1.1
Medication: Gliclazide	1.0	1.1	3.7	1.9	-0.7	0.7	0.6	-0.8
Age started oral contraceptive pill	1.0	1.3	4.3	-1.2	0.0	-2.1	-0.8	0.3
Diastolic blood pressure, automated reading	1.0	3.2	11.3	-1.3	3.4	1.4	0.5	0.8
Pain experienced in last month	1.0	1.7	4.8	-2.2	0.8	-1.6	-0.6	0.3
Ulcerative Colitis (UC)	0.9	1.7	2.4	-1.6	1.1	-0.8	-1.3	1.6
Major Depression (MDD)	0.9	1.1	2.3	-0.2	1.5	1.5	-0.3	1.0
Breast Cancer	0.9	2.2	3.9	1.0	-0.5	1.5	1.9	-2.0
Age at First Birth	0.9	1.3	4.3	-0.5	-0.5	-2.1	-1.2	0.7
Blood Eosinophil Count	0.9	7.1	13.1	3.6	-1.5	2.7	2.5	-2.5
Weight	0.9	4.3	10.6	1.1	2.1	3.3	2.1	-0.9
Comparative height size at age 10	0.9	5.0	12.2	-3.5	2.5	-2.5	-0.4	0.6
Age at last live birth	0.9	1.3	3.5	-0.3	-0.9	-1.9	-1.3	0.8
Back pain experienced in last month	0.9	1.2	2.8	-0.5	1.5	0.3	-1.0	1.7
Schizophrenia vs Biploar Disorder	0.8	1.0	2.5	0.8	-1.6	-0.9	-1.0	0.4
Sensitivity / hurt feelings	0.8	1.4	2.7	0.9	-1.2	-0.7	-1.6	1.3
Frequency of depressed mood in last 2 weeks	0.8	1.2	2.6	0.9	-0.2	0.1	-1.6	1.6
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	1.4	-0.8	1.3	0.5	-0.6
Diabetes (mother)	0.8	1.1	1.9	0.8	0.2	1.2	1.4	-1.1
Current tobacco smoking	0.8	1.3	2.5	1.6	-0.6	0.9	1.2	-1.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.6	0.1	0.5	0.9	1.3	-1.3
Sitting height	0.8	5.8	12.5	-3.0	3.5	-0.8	-1.3	2.3
Trunk fat mass	0.8	3.6	7.8	1.1	1.6	2.8	2.2	-1.2
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.8	-1.7	-1.0	-1.9	-0.8	0.1
Depression (self-reported)	0.8	1.0	2.0	-1.4	0.9	-0.7	-0.8	0.9
Birth weight	0.8	1.8	3.5	-1.9	1.8	-0.8	-0.5	1.0
Medication: Allopurinol	0.8	1.1	3.2	1.8	-1.1	0.4	0.4	-0.8
Average weekly red wine intake	0.8	1.2	2.7	-1.3	0.1	-1.6	-1.1	0.6
Bipolar Disorder (2018)	0.7	1.0	3.1	-1.8	0.7	-0.9	-0.6	0.7
Reaction Time	0.7	1.2	2.5	0.2	-1.4	-1.0	-1.6	0.9
Triglycerides	0.7	1.2	4.0	1.0	0.3	2.0	0.8	-0.5
Smoking Status	0.7	1.7	3.3	1.3	-1.1	0.3	1.5	-1.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.9	-0.4	1.7	0.6	0.1	0.5
Trunk fat percentage	0.7	2.9	5.4	1.4	0.7	2.3	2.1	-1.4
Taking other prescription medications	0.7	1.0	2.4	1.6	-1.1	0.1	0.6	-1.1
Stomach or abdominal pain in last month	0.7	0.9	1.5	0.9	0.6	1.1	-0.8	1.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.2	0.9	-1.1	0.9	0.7	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.9	1.7	-0.9	0.7	-0.9	1.1
Length of working week for main job	0.7	0.8	2.3	0.3	-0.9	-1.5	-0.8	0.2
Family relationship satisfaction	0.7	0.8	2.6	0.9	-1.6	-0.1	0.2	-0.9
Miserableness	0.7	1.2	3.3	1.3	0.6	1.8	-0.2	0.8
Medication: Lisinopril	0.7	0.9	2.6	-0.1	1.6	0.8	1.0	-0.7
Basal cell carcinoma (self-reported)	0.7	0.9	1.7	-1.0	0.7	-0.5	-1.0	1.3
Depressed Affect (Nagel 2018)	0.6	1.3	2.6	1.6	0.0	1.5	-0.7	1.0
Crohns Disease (2012)	0.6	1.0	3.1	-0.9	1.8	-0.0	-0.3	1.0
Lupus	0.6	1.0	1.8	-1.1	0.1	-0.8	-1.2	1.3
Ulcerative Colitis	0.6	0.8	1.4	-0.7	-0.2	-1.0	-1.2	1.1
Blood Red Count	0.6	5.6	9.8	3.1	-3.0	0.8	1.8	-2.3
Average weekly spirits intake	0.6	0.7	1.9	1.1	0.1	1.4	0.7	-0.3
Alcohol usually taken with meals	0.6	1.0	3.4	-0.3	-0.8	-1.8	0.2	-0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	2.4	1.6	-1.1	0.5	-0.8	0.8
Exposure to tobacco smoke at home	0.6	0.7	1.6	-0.4	0.9	0.5	-0.7	1.2
Loud music exposure frequency	0.6	0.7	2.3	1.0	-1.5	-0.1	-0.3	-0.2
Arm fat-free mass (right)	0.6	3.1	7.6	0.5	2.4	2.8	1.4	-0.2
Qualifications: College or University degree	0.6	1.9	4.2	-0.6	-2.0	-2.0	-0.7	-0.3
Emphysema/chronic bronchitis	0.6	0.7	1.6	0.8	-0.4	0.5	0.8	-1.3
Migraine (self-reported)	0.6	0.8	1.4	-1.2	0.9	-1.0	-0.5	0.7
Arm predicted mass (right)	0.6	3.0	7.1	0.4	2.5	2.7	1.3	-0.1
Smoking status: Previous	0.6	0.9	2.2	0.7	-0.6	0.5	1.1	-1.5
Qualifications: nursing, teaching	0.6	1.0	1.4	0.6	-1.1	0.9	1.1	-1.2
Smoking status: Current	0.6	0.9	1.7	1.3	-0.9	0.4	0.9	-1.0
Ever taken oral contraceptive pill	0.6	0.7	1.6	-0.0	0.7	1.2	1.0	-0.7
Hearing aid user	0.6	0.7	1.3	0.1	0.1	1.0	1.1	-1.0
Rheumatoid Arthritis	0.5	0.7	1.8	0.2	1.4	0.5	-0.5	1.1
Maternal smoking around birth	0.5	0.7	1.3	1.2	-0.4	1.0	0.7	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.3	0.9	0.4	0.7	1.4	-1.5
Serious illness, injury or assault to yourself	0.5	0.6	1.2	0.2	0.7	0.6	1.1	-0.9
Qualifications: None of the above	0.5	1.1	3.0	0.3	1.7	1.4	0.3	0.5
Father’s age at death	0.5	0.6	2.2	0.8	-1.5	-0.0	0.0	-0.5
Hair/balding pattern: Pattern 3	0.5	0.7	2.7	0.4	-1.6	-0.4	0.0	-0.6
Prospective memory result	0.5	0.6	2.2	0.2	-1.5	-0.3	0.2	-0.7
Blood clot in the leg (DVT)	0.5	0.6	1.1	0.5	0.4	1.1	0.9	-0.8
Glaucoma (self-reported)	0.5	0.6	1.0	-0.9	0.1	-1.0	-0.7	0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.4	0.6	-1.6	-0.2	-0.2	-0.4
Mood swings	0.5	0.9	2.0	0.4	1.4	1.4	-0.2	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.7	-0.8	1.3	0.4	0.1	0.2
Eye problems/disorders: Cataract	0.5	0.6	1.8	-0.5	1.3	0.8	-0.2	0.6
Osteoporosis (self-reported)	0.5	0.6	0.9	-0.2	-1.0	-0.9	-1.0	0.7
Osteoarthritis (self-reported)	0.5	0.7	1.9	1.0	-1.4	0.5	0.0	-0.5
Average weekly champagne plus white wine intake	0.5	0.7	1.4	0.6	-0.7	-0.7	0.8	-1.2
Basal metabolic rate	0.5	2.8	6.2	0.2	2.5	2.5	1.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.0	0.6	0.6	1.0	0.9	-0.8
Arm predicted mass (left)	0.5	2.5	6.1	0.3	2.3	2.5	1.0	0.1
Intelligence (Savage-Jansen 2018)	0.4	1.4	2.9	-1.7	0.6	-1.0	1.0	-1.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.9	0.8	-0.9	0.7	0.3	-0.5
Lung FEV1/FVC ratio	0.4	1.9	4.3	-2.1	0.9	-1.7	-0.8	0.9
Ever had hysterectomy (womb removed)	0.4	0.5	1.8	-1.4	-0.6	-0.5	-0.2	-0.1
Supplements: Zinc	0.4	0.4	1.1	-1.0	0.8	-0.3	-0.3	0.3
Leg fat-free mass (left)	0.4	2.3	5.1	0.2	2.2	2.3	1.2	-0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.9	-1.1	0.0	-0.3	-0.1
Leg predicted mass (left)	0.4	2.3	5.2	0.2	2.2	2.3	1.2	-0.1
Hearing difficulty/problems with background noise	0.4	0.6	2.1	0.4	-1.4	-0.2	-0.8	0.5
Fluid intelligence score	0.4	0.8	1.4	-0.9	-0.4	-1.2	0.6	-1.2
Number of live births	0.4	0.6	1.3	-0.1	-0.5	0.5	-1.1	1.1
High blood pressure (siblings)	0.4	0.6	1.3	-1.0	1.2	0.1	-0.2	0.6
Whole body fat-free mass	0.4	2.2	6.0	-0.3	2.4	2.0	0.9	0.2
Leg fat-free mass (right)	0.4	2.2	5.1	0.2	2.3	2.1	1.1	-0.0
Whole body water mass	0.4	2.0	5.9	-0.4	2.4	1.8	0.8	0.3
Leg predicted mass (right)	0.4	2.2	5.2	0.2	2.3	2.1	1.1	0.0
Number of self-reported non-cancer illnesses	0.4	0.6	1.1	1.0	-0.8	0.2	0.6	-1.0
Financial situation satisfaction	0.4	0.5	1.2	-0.1	0.2	-0.1	-1.1	1.1
Commuting to job workplace: Public transport	0.4	0.5	0.7	0.6	-0.1	0.7	0.8	-0.8
Arm fat-free mass (left)	0.4	2.0	5.0	0.2	2.1	2.2	0.8	0.3
Irritability	0.4	0.6	1.5	-0.6	0.6	0.3	-0.9	1.2
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.5	-1.2	0.9	-0.8	0.6	-0.8
Ovarian Cancer	0.3	0.4	1.1	0.4	-0.4	0.1	0.8	-1.1
Average weekly fortified wine intake	0.3	0.4	0.9	-0.5	-0.9	-0.9	-0.2	-0.1
Age when periods started (menarche)	0.3	0.8	2.0	-0.1	0.1	-0.6	-1.2	1.4
Qualifications: CSEs or equivalent	0.3	0.4	1.6	0.4	0.4	1.3	0.4	-0.2
Financial difficulties in last 2 years	0.3	0.5	1.5	-0.2	1.2	0.7	0.4	0.2
Allergy	0.3	0.7	1.9	-1.4	0.3	-0.9	-0.5	0.8
Trunk fat-free mass	0.3	1.9	6.0	-0.8	2.4	1.5	0.7	0.3
Pulse rate	0.3	0.5	1.7	-0.7	1.3	0.2	0.1	0.5
Trunk predicted mass	0.3	1.9	6.0	-0.8	2.5	1.5	0.6	0.4
Hair/balding pattern: Pattern 4	0.3	0.8	2.4	1.5	-0.5	1.2	0.2	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.5	1.0	-0.7	-0.4	0.2
Leg pain on walking	0.3	0.4	1.1	0.7	0.3	1.0	-0.2	0.5
Knee pain experienced in last month	0.3	0.5	1.4	1.1	0.3	1.2	0.1	0.2
Loneliness, isolation	0.3	0.5	0.9	1.0	-0.2	0.4	-0.9	0.7
Commuting to job workplace: Walk	0.3	0.4	0.9	-0.9	0.7	-0.8	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.1	-1.0	0.8	-0.3	-0.5	0.9
Alcohol drinker status: Never	0.3	0.3	1.0	0.5	1.0	0.6	0.0	0.4
HbA1C	0.2	0.2	0.5	-0.7	0.6	0.1	0.2	-0.2
Primary Biliary Cirrhosis	0.2	0.3	0.5	-0.3	-0.7	-0.3	0.4	-0.7
Chronotype (morning person)	0.2	0.5	1.3	-0.4	1.1	0.7	-0.0	0.5
Hair Pigment	0.2	6.7	24.7	2.2	-5.0	-1.6	-0.9	-0.7
Tanning	0.2	2.6	6.3	-1.9	2.5	0.0	-0.7	1.6
Hearing difficulty/problems: Yes	0.2	0.3	1.0	0.1	-0.6	-0.1	0.6	-1.0
Diabetes (father)	0.2	0.3	0.5	-0.0	-0.6	0.3	-0.7	0.7
Medication: Levothyroxine sodium	0.2	0.3	0.5	0.5	-0.7	-0.6	-0.0	-0.5
Illnesses of siblings	0.2	0.2	0.7	0.4	-0.5	-0.8	-0.2	-0.3
Time employed in main current job	0.2	0.2	0.4	0.6	0.3	0.4	-0.2	0.4
Lung cancer (father)	0.2	0.3	0.6	0.2	0.8	0.3	0.7	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.5	-0.7	0.7	-0.6	-0.6	0.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	-0.8	0.0	-0.5	-0.4	0.4
Medication: Amlodipine	0.2	0.3	0.9	-0.0	0.5	0.6	-0.6	0.9
Age at first live birth	0.2	0.4	1.0	-0.8	0.4	-1.0	-0.4	0.4
Medication: Omeprazole	0.2	0.2	0.6	-0.0	0.8	0.4	0.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	0.7	-0.8	0.4	0.1	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.7	0.2	0.5	0.6	-0.4
Guilty feelings	0.2	0.3	0.7	0.8	0.6	0.4	-0.5	0.6
Wears glasses or contact lenses	0.2	0.2	0.9	-0.5	-0.9	-0.0	-0.2	-0.0
LDL Cholesterol	0.1	0.2	0.7	0.5	0.2	0.8	-0.0	0.1
Allergy or Eczema	0.1	0.2	0.3	0.4	0.3	-0.2	-0.6	0.5
Hypothyroidism (self reported)	0.1	0.3	1.2	0.3	1.1	0.1	-0.1	0.2
Lung FVC	0.1	0.5	1.7	0.6	-0.6	1.3	0.1	-0.1
Severe depression (siblings)	0.1	0.1	0.3	0.1	0.5	0.1	0.0	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.1	-0.2	-0.1	0.3	-0.6
Alcohol intake versus 10 years previously	0.1	0.1	0.3	-0.5	0.2	-0.4	0.0	-0.2
Happiness	0.1	0.2	0.4	0.0	-0.5	-0.3	-0.6	0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	-0.0	0.4	-0.5	-0.4	0.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	0.6	0.1	0.6	-0.3	0.4
Medication: Blood pressure	0.1	0.2	0.8	0.1	0.9	0.5	0.4	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.2	-0.5	0.2	-0.2	0.1
Alcohol intake frequency.	0.1	0.3	0.9	1.0	-0.0	0.4	0.4	-0.3
Ever had bowel cancer screening	0.1	0.1	0.4	0.4	0.3	0.6	0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.7	-0.2	0.3	-0.6	0.4
Eye problems/disorders: Glaucoma	0.1	0.2	0.6	-0.1	-0.3	-0.8	-0.4	0.1
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.2	0.3	-0.0	-0.3	0.3
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.4	0.2	-0.5	-0.4	0.3
Unable to work because of sickness or disability	0.1	0.1	0.5	-0.3	0.7	0.2	-0.0	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	0.0	0.6	0.3	0.4	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.2	0.1	-0.4	-0.3	-0.3	-0.0
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.4	-0.1	-0.2	-0.2	-0.1
Had menopause	0.0	0.0	0.1	0.2	-0.3	0.2	-0.0	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.2	-0.1	0.3	-0.0	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.3	-0.1	-0.1	0.1	-0.0

Hub : Genes

NCK1

Models

Trait associations