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chr17:4,041,725-6,068,117

Best TWAS P=1.96e-11 · Best GWAS P=6.28e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	RPAIN	0.10	0.08	lasso	5	0.04	2.2e-04	4.6	-5.4	6.8e-08	-0.81	0.39	0.61	TRUE
2	GTEx	Adrenal Gland	RABEP1	0.13	0.03	lasso	13	0.02	7.2e-02	-4.7	-5.9	4.2e-09	-0.80	0.03	0.84	FALSE
3	GTEx	Artery Tibial	NUP88	0.10	0.05	lasso	3	0.04	2.5e-04	5.5	-5.4	8.5e-08	-0.82	0.65	0.28	FALSE
4	GTEx	Brain Putamen basal ganglia	AC012146.7	0.30	0.03	enet	23	0.03	7.6e-02	4.7	-6.5	6.4e-11	-0.45	0.08	0.26	FALSE
5	GTEx	Cells Transformed fibroblasts	NUP88	0.09	0.10	enet	15	0.10	8.8e-08	5.2	-5.3	1.4e-07	-0.82	0.86	0.14	FALSE
6	GTEx	Colon Sigmoid	GP1BA	0.25	0.17	lasso	4	0.12	3.6e-05	5.0	5.2	2.4e-07	0.28	0.26	0.04	FALSE
7	GTEx	Colon Transverse	RABEP1	0.13	0.11	lasso	4	0.08	8.7e-05	5.2	-5.2	2.1e-07	-0.82	0.32	0.67	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	DHX33	0.12	0.08	lasso	5	0.07	1.8e-03	6.5	-6.4	2.0e-10	-0.96	0.02	0.96	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	RABEP1	0.19	-0.01	lasso	13	0.00	4.2e-01	5.1	-5.9	3.9e-09	-0.82	0.03	0.81	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	GP1BA	0.35	0.16	lasso	11	0.18	5.9e-07	4.5	6.5	1.0e-10	0.56	0.26	0.59	FALSE
11	GTEx	Esophagus Muscularis	RABEP1	0.13	0.09	lasso	10	0.10	2.1e-06	6.5	-6.1	9.3e-10	-0.94	0.02	0.98	FALSE
12	GTEx	Heart Atrial Appendage	RABEP1	0.13	0.10	enet	11	0.12	7.2e-06	5.5	-5.7	1.1e-08	-0.85	0.06	0.93	FALSE
13	GTEx	Lung	RABEP1	0.11	0.12	lasso	6	0.10	3.4e-08	5.1	-5.2	1.6e-07	-0.82	0.19	0.81	FALSE
14	GTEx	Muscle Skeletal	NUP88	0.05	0.01	enet	7	0.00	1.0e-01	3.6	5.2	2.2e-07	0.72	0.09	0.77	FALSE
15	GTEx	Nerve Tibial	NUP88	0.08	0.07	lasso	3	0.09	5.0e-07	5.2	-5.2	1.7e-07	-0.87	0.10	0.89	TRUE
16	GTEx	Ovary	RABEP1	0.28	0.30	lasso	9	0.26	4.6e-07	5.2	-5.2	2.6e-07	-0.82	0.36	0.55	FALSE
17	GTEx	Skin Sun Exposed Lower leg	AC012146.7	0.21	0.07	enet	17	0.18	1.3e-14	3.1	-5.4	5.9e-08	-0.45	1.00	0.00	FALSE
18	GTEx	Testis	RABEP1	0.69	0.60	lasso	12	0.68	4.9e-40	5.2	-5.3	9.2e-08	-0.80	0.90	0.10	FALSE
19	GTEx	Thyroid	DHX33	0.09	0.09	enet	13	0.06	1.5e-05	5.7	-5.8	7.9e-09	-0.86	0.16	0.84	FALSE
20	GTEx	Thyroid	RABEP1	0.21	0.27	lasso	7	0.26	1.4e-19	5.2	-5.2	1.7e-07	-0.80	0.90	0.10	FALSE
21	METSIM	Adipose	SLC52A1	0.07	0.02	lasso	7	0.05	1.8e-07	3.9	-5.3	1.2e-07	-0.20	0.96	0.02	FALSE
22	NTR	Blood	MINK1	0.11	0.15	lasso	3	0.15	2.1e-46	5.3	5.2	2.1e-07	0.24	0.76	0.24	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	RABEP1	0.20	0.22	bslmm	546	0.20	7.4e-25	5.1	-5.7	1.1e-08	-0.75	0.91	0.09	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	RPAIN	0.06	0.06	lasso	3	0.06	3.1e-08	6.5	-6.7	2.0e-11	-0.98	0.00	1.00	TRUE
25	ROSMAP	Brain Pre-frontal Cortex	MINK1	0.08	0.06	lasso	3	0.05	4.0e-07	5.2	5.2	2.2e-07	0.31	0.92	0.08	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUP88	0.03	0.02	lasso	2	0.02	6.7e-06	3.9	-5.2	1.6e-07	-0.90	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Glioblastoma Multiforme	NUP88	0.12	0.07	enet	12	0.09	1.2e-03	5.1	-5.5	4.9e-08	-0.78	0.02	0.68	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	RABEP1	0.23	0.13	blup	79	0.15	3.4e-05	5.2	-6.1	1.2e-09	-0.77	0.06	0.84	FALSE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C17orf107	0.03	0.01	enet	8	0.03	5.1e-04	2.5	5.2	2.0e-07	0.19	0.03	0.12	TRUE
30	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RABEP1	0.06	0.00	blup	79	0.00	2.1e-01	4.9	-5.2	2.3e-07	-0.89	0.02	0.53	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	GP1BA	0.02	0.02	blup	49	0.02	9.3e-03	4.8	5.7	1.2e-08	0.33	0.01	0.79	FALSE
32	The Cancer Genome Atlas	Soft Tissue Sarcoma	INCA1	0.06	0.00	enet	11	0.00	1.7e-01	4.5	5.5	3.4e-08	0.30	0.00	0.71	FALSE
33	The Cancer Genome Atlas	Stomach Adenocarcinoma	C17orf107	0.05	0.01	blup	40	0.03	2.0e-03	5.3	5.3	1.1e-07	0.31	0.02	0.87	TRUE
34	The Cancer Genome Atlas	Thyroid Carcinoma	C1QBP	0.03	0.03	blup	57	0.04	4.8e-05	4.9	5.5	2.9e-08	0.87	0.24	0.72	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	RABEP1	0.04	0.03	enet	5	0.03	1.5e-03	-4.9	-5.9	3.1e-09	-0.67	0.09	0.82	TRUE