[Hub]/) : Traits : Leg fat mass (right) :

chr18:20,082,830-21,863,589

Best TWAS P=3.94e-22 · Best GWAS P=4.39e-20 conditioned to 0.451

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C18orf8 0.26 0.35 lasso 6 0.40 1.9e-52 -9.0 -9.3 2.0e-20 0.93 0.02 0.98 FALSE
2 CommonMind Brain Pre-frontal Cortex NPC1 0.08 0.07 lasso 3 0.08 5.2e-10 7.8 -7.4 1.9e-13 0.71 0.80 0.19 FALSE
3 CommonMind Brain Pre-frontal Cortex RIOK3 0.02 0.01 bslmm 348 0.00 1.8e-01 -6.4 -7.6 3.0e-14 0.69 0.12 0.22 FALSE
4 GTEx Adipose Subcutaneous TMEM241 0.07 0.00 enet 12 0.01 4.1e-02 -6.3 -5.4 5.6e-08 0.58 0.14 0.61 FALSE
5 GTEx Adipose Subcutaneous C18orf8 0.17 0.16 enet 13 0.16 2.6e-13 -8.9 -9.4 6.0e-21 0.98 0.02 0.98 FALSE
6 GTEx Adipose Subcutaneous NPC1 0.27 0.27 enet 12 0.30 2.4e-25 -8.6 -8.7 2.4e-18 0.94 0.45 0.55 FALSE
7 GTEx Adipose Visceral Omentum C18orf8 0.18 0.11 enet 10 0.04 4.5e-03 -9.0 -8.0 9.2e-16 0.89 0.01 0.98 FALSE
8 GTEx Adipose Visceral Omentum NPC1 0.20 0.19 lasso 3 0.17 2.9e-09 -8.6 -8.7 2.4e-18 0.92 0.26 0.74 FALSE
9 GTEx Artery Tibial C18orf8 0.18 0.12 lasso 3 0.10 1.5e-08 7.7 -7.6 2.3e-14 0.70 0.97 0.03 FALSE
10 GTEx Artery Tibial NPC1 0.26 0.07 enet 31 0.11 3.7e-09 7.7 -8.0 1.7e-15 0.82 0.07 0.93 FALSE
11 GTEx Brain Caudate basal ganglia C18orf8 0.15 0.16 enet 11 0.11 5.9e-04 -9.1 -9.3 1.5e-20 0.96 0.02 0.96 FALSE
12 GTEx Brain Cerebellar Hemisphere C18orf8 0.27 0.34 enet 19 0.34 1.3e-09 -9.0 -9.3 1.3e-20 0.98 0.02 0.98 FALSE
13 GTEx Brain Cerebellum C18orf8 0.23 0.18 enet 13 0.21 9.9e-07 -8.9 -9.3 2.1e-20 0.91 0.02 0.98 FALSE
14 GTEx Brain Cerebellum NPC1 0.20 0.10 enet 9 0.12 1.9e-04 -9.0 -8.4 3.7e-17 0.93 0.02 0.94 FALSE
15 GTEx Brain Cortex TMEM241 0.37 0.12 enet 19 0.22 1.3e-06 2.3 -6.1 1.3e-09 0.74 0.05 0.93 FALSE
16 GTEx Brain Cortex C18orf8 0.19 0.18 lasso 5 0.13 1.8e-04 -9.2 -9.2 4.7e-20 0.99 0.02 0.96 FALSE
17 GTEx Brain Frontal Cortex BA9 C18orf8 0.42 0.30 enet 12 0.08 3.4e-03 -8.9 -8.5 1.3e-17 0.96 0.02 0.98 FALSE
18 GTEx Brain Nucleus accumbens basal ganglia TMEM241 0.17 0.02 lasso 6 -0.01 5.6e-01 -8.9 -6.8 8.9e-12 0.76 0.03 0.69 FALSE
19 GTEx Breast Mammary Tissue NPC1 0.27 0.13 enet 27 0.19 5.0e-10 -8.6 -8.6 7.4e-18 0.88 0.03 0.97 FALSE
20 GTEx Breast Mammary Tissue (Male) NPC1 0.15 0.12 lasso 7 0.16 2.0e-04 -1.8 -5.3 1.5e-07 0.53 0.05 0.52 FALSE
21 GTEx Breast Mammary Tissue (Female) NPC1 0.43 0.24 lasso 3 0.27 1.1e-08 -8.3 -8.6 5.2e-18 0.93 0.02 0.98 FALSE
22 GTEx Cells Transformed fibroblasts NPC1 0.26 0.24 lasso 8 0.24 5.7e-18 -4.6 -5.4 6.1e-08 0.69 1.00 0.00 FALSE
23 GTEx Esophagus Gastroesophageal Junction NPC1 0.19 0.13 lasso 5 0.11 1.1e-04 -4.6 -5.8 7.9e-09 0.72 0.07 0.86 FALSE
24 GTEx Esophagus Mucosa NPC1 0.09 0.04 lasso 3 0.05 1.5e-04 -8.6 -9.0 2.8e-19 0.93 0.04 0.94 FALSE
25 GTEx Esophagus Muscularis C18orf8 0.14 0.13 lasso 3 0.10 8.0e-07 7.8 -8.5 1.3e-17 0.79 0.08 0.92 FALSE
26 GTEx Esophagus Muscularis NPC1 0.11 0.07 enet 4 0.09 7.3e-06 -9.0 -9.3 1.6e-20 0.97 0.01 0.98 FALSE
27 GTEx Heart Left Ventricle NPC1 0.19 0.15 enet 12 0.17 1.6e-09 -8.9 -9.0 3.3e-19 0.93 0.04 0.96 FALSE
28 GTEx Lung NPC1 0.11 0.06 enet 11 0.04 2.3e-04 -9.1 -8.6 9.6e-18 0.95 0.02 0.98 FALSE
29 GTEx Nerve Tibial TMEM241 0.16 0.04 enet 10 0.07 1.8e-05 -6.4 -6.5 7.4e-11 0.50 0.60 0.16 FALSE
30 GTEx Nerve Tibial C18orf8 0.16 0.07 enet 21 0.09 3.9e-07 -8.3 -8.6 5.4e-18 0.89 0.02 0.98 FALSE
31 GTEx Nerve Tibial NPC1 0.19 0.12 lasso 6 0.16 1.1e-11 7.8 -9.1 1.1e-19 0.90 0.04 0.96 FALSE
32 GTEx Pancreas NPC1 0.33 0.14 lasso 7 0.12 1.1e-05 -9.0 -8.8 1.6e-18 0.95 0.02 0.97 FALSE
33 GTEx Skin Not Sun Exposed Suprapubic C18orf8 0.21 0.27 enet 6 0.23 6.9e-13 -8.9 -9.1 8.2e-20 0.98 0.03 0.97 FALSE
34 GTEx Skin Not Sun Exposed Suprapubic NPC1 0.15 0.08 lasso 4 0.12 2.3e-07 -9.0 -9.2 2.3e-20 0.94 0.04 0.96 FALSE
35 GTEx Skin Sun Exposed Lower leg C18orf8 0.35 0.33 enet 23 0.36 1.7e-30 -9.1 -9.1 6.9e-20 0.96 0.02 0.98 FALSE
36 GTEx Skin Sun Exposed Lower leg NPC1 0.23 0.18 lasso 3 0.27 1.8e-22 -8.6 -9.0 2.1e-19 0.90 0.24 0.76 FALSE
37 GTEx Testis C18orf8 0.12 0.07 lasso 6 0.08 1.9e-04 -9.0 -9.7 3.9e-22 0.92 0.03 0.90 TRUE
38 GTEx Thyroid NPC1 0.20 0.10 enet 25 0.13 2.3e-10 -9.0 -8.4 3.0e-17 0.90 0.02 0.98 FALSE
39 GTEx Vagina NPC1 0.27 0.09 lasso 7 0.14 4.9e-04 -5.7 -6.3 3.3e-10 0.58 0.11 0.57 FALSE
40 METSIM Adipose C18orf8 0.08 0.02 enet 23 0.04 1.0e-06 7.7 -6.2 5.0e-10 0.56 0.22 0.73 FALSE
41 METSIM Adipose NPC1 0.06 0.05 enet 18 0.05 6.4e-08 -9.2 -8.1 5.5e-16 0.89 0.02 0.98 FALSE
42 The Cancer Genome Atlas Breast Invasive Carcinoma NPC1 0.03 0.03 blup 69 0.04 2.9e-09 -9.0 -8.8 1.7e-18 0.86 0.03 0.97 FALSE
43 The Cancer Genome Atlas Esophageal Carcinoma NPC1 0.16 0.10 lasso 3 0.10 3.7e-04 7.8 -8.7 5.1e-18 0.81 0.05 0.64 FALSE
44 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NPC1 0.05 0.02 blup 66 0.03 1.4e-04 -8.4 -7.2 7.5e-13 0.74 0.22 0.48 FALSE
45 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NPC1 0.03 0.04 lasso 2 0.05 4.2e-06 -8.4 -9.0 2.4e-19 0.92 0.03 0.97 FALSE
46 The Cancer Genome Atlas Brain Lower Grade Glioma C18orf45 0.04 0.02 lasso 3 0.03 2.7e-04 5.5 -5.8 5.3e-09 0.60 0.02 0.97 FALSE
47 The Cancer Genome Atlas Brain Lower Grade Glioma C18orf8 0.07 0.05 lasso 5 0.03 9.5e-05 7.7 -7.8 5.6e-15 0.72 0.27 0.71 FALSE
48 The Cancer Genome Atlas Brain Lower Grade Glioma NPC1 0.07 0.08 lasso 3 0.10 1.6e-11 7.7 -9.1 9.2e-20 0.88 0.05 0.95 FALSE
49 The Cancer Genome Atlas Pancreatic Adenocarcinoma NPC1 0.14 0.01 enet 14 0.08 3.3e-04 -8.4 -6.1 1.1e-09 0.69 0.03 0.78 FALSE
50 The Cancer Genome Atlas Prostate Adenocarcinoma NPC1 0.05 0.02 blup 65 0.03 9.9e-04 -8.4 -8.0 1.0e-15 0.73 0.04 0.60 FALSE
51 The Cancer Genome Atlas Stomach Adenocarcinoma NPC1 0.06 0.01 enet 6 0.05 2.2e-04 -5.6 -5.4 7.1e-08 0.63 0.07 0.37 FALSE
52 The Cancer Genome Atlas Thyroid Carcinoma NPC1 0.04 0.03 blup 70 0.05 9.4e-06 -9.0 -8.2 1.9e-16 0.90 0.03 0.97 FALSE