Hub : Genes

RIOK3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0210 0.0120 2.8e-02 0.007 0.001 0.002 0.002 0.000 4.2e-02 2.4e-01 1.8e-01 1.8e-01 3.3e-01
2 YFS Blood 0.0391 0.0132 5.7e-06 0.022 0.017 0.016 0.016 0.021 5.1e-08 2.6e-06 2.8e-06 4.1e-06 1.5e-07
3 TCGA Prostate Adenocarcinoma 0.0409 0.0249 6.5e-03 0.002 0.003 0.014 NA -0.001 1.7e-01 1.3e-01 1.2e-02 NA 4.1e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.5 1.6 1.2 0.2 0.0
Bipolar Disorder or Schizophrenia 0.5 1.2 1.7 -0.8 -1.2 -1.3
Depressed Affect (Nagel 2018) 0.4 0.8 1.4 -1.0 1.2 -0.3
Depression (Nagel 2018) 0.3 0.5 0.9 -1.0 0.5 0.4
Intelligence (Savage-Jansen 2018) 0.7 2.0 4.7 2.2 0.6 1.0
Neuroticism (Nagel 2018) 1.5 3.6 7.1 -1.9 0.1 -2.7
Schizophrenia (2018) 1.5 3.1 3.8 -1.9 -1.7 -1.7
Schizophrenia vs Biploar Disorder 1.5 2.0 5.8 -2.4 0.0 -0.3
Worry (Nagel 2018) 3.3 6.9 10.9 -3.3 -0.1 -3.2
Alzheimer’s Disease (in mother) 0.8 1.0 1.5 1.2 -0.8 0.9
Alzheimer’s Disease (in father) 1.1 1.2 3.3 -0.2 -1.8 -0.5
Alzheimer’s Disease (including proxy) 1.1 1.5 3.0 1.0 -1.7 0.8
Crohns Disease (2017) 0.0 0.1 0.2 -0.3 -0.4 -0.2
Irritable Bowel Disease (IBD) 0.0 0.1 0.3 0.1 -0.1 -0.5
Ulcerative Colitis (UC) 0.1 0.1 0.2 0.4 0.4 -0.2
Major Depression (MDD) 1.7 2.1 3.7 1.4 0.7 1.9
Reaction Time 0.6 1.2 2.6 -1.6 -0.1 -1.0
Verbal and Numeric Reasoning (VNR) 0.5 1.3 3.0 1.7 0.9 0.2
Breast Cancer 0.0 0.1 0.1 -0.4 0.1 -0.3
Ovarian Cancer 0.9 1.1 2.8 0.8 -0.1 1.7
Prostate Cancer 0.7 1.0 1.9 -0.2 -1.4 -1.0
Age at First Birth 0.8 1.2 2.6 1.6 -0.4 1.0
Bipolar Disorder (2011) 2.9 2.8 7.1 2.7 -1.0 -0.5
Body Mass Index (BMI) (2010) 1.1 1.5 4.0 -2.0 0.2 -0.6
Coronary Artery Disease (CAD) 0.2 0.2 0.3 -0.2 0.5 0.5
Crohns Disease (2012) 0.4 0.7 1.6 0.4 -1.3 0.5
Mean Putamen Volume 0.7 0.8 1.5 -0.3 -0.8 1.2
Fasting Glucose 1.0 1.2 2.3 -1.1 -1.5 0.4
HbA1C 0.9 1.1 1.8 -1.3 -0.5 -1.0
HDL Cholesterol 4.3 7.2 12.6 3.6 1.5 2.6
LDL Cholesterol 1.4 2.2 4.4 -2.1 0.3 -1.4
Lupus 0.8 1.3 3.5 -1.9 0.5 0.1
Neuroticism (2016) 0.5 0.7 1.5 -0.7 -0.1 -1.2
Primary Biliary Cirrhosis 1.5 2.2 3.8 0.3 -1.9 1.6
Rheumatoid Arthritis 4.5 6.2 7.3 -2.5 -2.7 -2.3
Schizophrenia (2014) 0.5 1.2 1.9 -1.0 -1.4 -0.9
Triglycerides 2.1 3.4 8.5 -2.9 0.7 -1.0
Type 2 Diabetes (T2D) (2012) 1.0 1.1 2.6 -1.6 -0.9 -0.2
Ulcerative Colitis 1.0 1.4 2.5 1.6 -1.3 0.0
Blood Eosinophil Count 0.4 3.2 6.5 -1.6 -2.5 -0.7
Blood Platelet Count 2.7 31.8 49.2 7.0 -6.8 -0.0
Blood Red Count 0.0 0.2 0.4 -0.6 0.2 -0.3
Blood White Count 1.0 7.5 18.7 4.3 -1.8 -0.7
Heel T-Score 0.8 6.5 19.5 4.4 -0.0 0.3
BMI 2.7 15.9 42.8 -6.5 0.3 -2.2
Height 6.9 132.7 295.8 -17.2 -7.1 -7.2
Waist Hip Ratio (WHR) 3.0 13.4 23.0 -4.8 -2.1 -3.6
Systolic Blood Pressure 0.6 3.1 4.8 -2.2 -0.3 -2.1
Smoking Status 0.9 2.1 5.8 0.7 -0.3 -2.4
Allergy or Eczema 0.3 0.7 0.9 -0.9 0.7 -0.9
Cardiovascular Disease 2.1 7.1 20.5 -4.5 0.8 0.1
Hypothyroidism (self reported) 0.8 1.9 3.6 -1.1 -1.0 -1.9
Respiratory disease 0.3 0.7 1.5 -1.2 0.6 -0.4
Type 2 Diabetes (T2D) (2018) 2.0 3.8 8.8 -3.0 1.0 -1.2
Lung FEV1/FVC ratio 0.2 1.1 3.0 0.1 1.7 0.4
Lung FVC 2.4 12.5 34.3 5.9 1.1 1.3
Neuroticism 0.8 1.8 2.3 -1.0 1.5 -1.5
Chronotype (morning person) 0.8 1.7 4.5 2.1 0.7 0.5
Hair Pigment 0.0 0.6 1.3 -0.3 1.1 0.7
Tanning 0.0 0.6 1.2 1.1 -0.2 -0.7
Hand grip strength (left) 1.9 4.9 10.5 -3.2 -1.1 -1.7
Number of treatments/medications taken 1.5 2.6 6.5 -2.5 -0.9 -0.7
Average weekly spirits intake 1.2 1.5 2.7 1.1 -1.6 0.6
Sensitivity / hurt feelings 0.7 1.3 2.5 -0.6 1.6 -1.0
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.0 -1.4 -0.3 -0.3
Hearing difficulty/problems: Yes 1.0 1.6 4.4 -0.4 -0.4 -2.1
Relative age of first facial hair 1.9 3.9 8.7 3.0 0.7 1.6
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 2.0 -1.4 -1.0 -0.4
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 0.0 0.7 0.5
Ever had hysterectomy (womb removed) 0.4 0.5 1.4 -1.2 0.0 -0.2
Systolic blood pressure, automated reading 0.6 1.8 2.6 -0.7 1.5 -1.6
Eye problems/disorders: Diabetes related eye disease 1.1 1.3 2.8 -1.7 -0.8 -0.7
Angina 0.1 0.1 0.3 -0.5 -0.2 0.3
Medication for hormone replacement therapy 1.4 1.5 3.5 -1.9 -1.0 -0.2
Vitamin and mineral supplements 0.7 0.9 2.7 -0.3 1.6 0.1
Supplements: Zinc 0.9 1.0 1.8 0.9 -1.3 0.7
Medication: Co-codamol 2.3 2.6 6.0 -2.4 -1.2 -0.7
Medication: Metformin 0.9 1.2 2.5 -1.6 -0.1 -1.1
Diabetes (father) 0.1 0.1 0.1 0.2 0.1 0.4
Diabetes (mother) 0.3 0.4 0.6 -0.8 -0.8 0.1
Severe depression (siblings) 0.8 0.9 2.1 -1.4 -0.1 -0.9
Pack years adult smoking proportion 1.3 1.9 5.2 -2.3 -0.1 -0.7
Impedance of leg (right) 0.1 0.7 2.1 0.0 -1.4 0.1
Leg fat-free mass (left) 5.2 27.6 70.9 -8.4 -2.1 -2.8
Trunk fat percentage 3.3 13.3 35.8 -6.0 -1.3 -1.5
Hand grip strength (right) 1.9 5.2 8.7 -3.0 -1.0 -2.4
Townsend deprivation index at recruitment 0.3 0.4 0.8 -0.2 -0.7 0.9
Current tobacco smoking 0.7 1.1 2.4 -0.6 -0.8 -1.5
Average weekly fortified wine intake 0.6 0.7 1.9 1.4 -0.5 0.3
Maternal smoking around birth 0.2 0.3 0.7 -0.5 -0.1 0.8
Fed-up feelings 0.3 0.6 0.7 -0.8 0.6 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 3.3 -1.8 1.1 0.0
Relative age voice broke 2.0 3.0 7.4 2.7 -1.0 0.8
Taking other prescription medications 2.0 3.0 6.3 -2.5 -1.3 -1.1
Age when periods started (menarche) 0.6 1.5 2.6 1.6 0.8 1.1
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 3.0 -1.7 -0.4 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 3.2 -0.4 -1.8 -0.6
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 4.2 -2.0 -1.4 -0.1
Qualifications: CSEs or equivalent 1.6 2.1 5.8 -2.4 -0.6 -0.3
Serious illness, injury or assault to yourself 2.6 3.1 6.5 -2.6 -1.1 -1.3
High blood pressure 1.0 2.8 7.0 -2.6 0.9 -0.9
Hayfever, allergic rhinitis or eczema 0.5 1.2 1.5 -1.0 1.0 -1.2
Multivitamins +/- minerals 1.4 1.7 4.9 -0.1 -2.2 -0.5
Stomach or abdominal pain in last month 0.8 1.0 1.7 -1.1 -0.3 1.3
Supplements: Glucosamine 0.4 0.5 1.0 1.0 0.3 -0.6
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 3.9 -1.1 2.0 -0.6
Medication: Atenolol 1.0 1.2 1.6 -0.9 1.3 1.1
Medication: Levothyroxine sodium 1.3 2.3 3.2 -1.4 -1.8 -1.3
Sitting height 2.3 16.1 32.2 -5.7 -2.6 -3.1
Chronic bronchitis/emphysema (father) 0.7 0.8 2.2 -1.5 -0.2 0.4
High blood pressure (mother) 1.5 2.1 5.5 -2.3 0.6 -0.6
Body mass index (BMI) 2.0 8.6 24.6 -5.0 0.3 -1.0
Impedance of leg (left) 0.2 1.1 3.1 -0.2 -1.8 0.3
Leg predicted mass (left) 5.2 27.4 70.7 -8.4 -2.0 -2.8
Trunk fat mass 6.0 25.6 67.7 -8.2 -1.6 -2.5
Waist circumference 7.8 28.6 73.6 -8.6 -1.7 -3.0
Number of incorrect matches in round 0.7 1.2 2.4 -1.5 -1.0 -0.4
Past tobacco smoking 0.8 1.6 2.0 -1.1 -1.4 1.2
Alcohol usually taken with meals 0.2 0.3 0.4 -0.0 0.6 -0.7
Nervous feelings 0.9 1.7 2.9 -1.7 -0.6 -1.4
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.2 5.3 -2.3 -0.6 -1.0
Hearing difficulty/problems with background noise 0.7 1.2 2.5 -0.1 -1.0 -1.6
Hair/balding pattern: Pattern 2 2.2 2.8 4.6 -2.0 0.2 -2.2
Had menopause 0.1 0.1 0.2 -0.5 -0.1 0.1
Had other major operations 1.6 1.9 2.8 -1.7 -1.6 -0.6
Forced vital capacity (FVC) 0.2 0.8 2.2 -0.1 -1.5 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 3.1 -0.0 -1.8 -1.1
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.8 -0.8 0.9 0.7
Qualifications: None of the above 1.0 2.2 5.0 -2.2 1.3 -0.4
Financial difficulties in last 2 years 1.8 2.5 6.6 -0.9 -2.6 -0.2
Mouth/teeth dental problems 1.1 1.7 3.4 1.8 0.3 1.2
Heart attack 1.2 1.6 3.6 -1.9 -0.8 -0.7
Allergy 0.4 1.0 1.8 1.1 0.2 1.3
Pain all over the body in last month 0.7 0.7 1.6 -1.3 -0.8 0.2
Diabetes (self-reported) 1.7 2.7 4.9 -2.2 1.6 -0.8
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.8 -1.7 -0.9 -0.2
Medication: Ramipril 2.3 3.0 5.6 -1.8 2.4 -0.2
Medication: Simvastatin 0.9 1.3 3.4 -0.3 0.7 1.8
Fluid intelligence score 0.1 0.3 0.5 0.7 -0.0 -0.6
Illnesses of siblings 1.9 2.7 5.1 2.3 0.8 1.6
Neuroticism score 0.9 1.8 4.5 -0.9 -0.4 -2.1
Weight 7.5 36.6 96.2 -9.8 -2.0 -3.1
Impedance of arm (right) 1.2 5.8 15.1 3.9 -1.3 0.6
Arm fat percentage (right) 1.5 6.0 16.3 -4.0 -0.2 -1.3
Trunk fat-free mass 7.4 42.6 106.1 -10.3 -2.3 -4.0
Hip circumference 5.2 22.3 61.9 -7.9 -1.9 -1.2
Time employed in main current job 0.4 0.5 1.4 -1.2 0.1 -0.3
Alcohol intake versus 10 years previously 1.8 2.6 2.9 -1.7 1.7 1.5
Father’s age at death 4.4 5.9 12.3 3.5 0.5 2.3
Worrier / anxious feelings 2.8 5.4 10.0 -2.2 -1.2 -3.2
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 -0.2 -0.4 -0.5
Falls in the last year 2.6 3.5 3.9 -2.0 -2.0 -1.7
Hair/balding pattern: Pattern 3 1.1 1.7 3.9 2.0 -0.5 1.0
Number of live births 0.3 0.5 0.6 0.8 0.7 0.6
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.5 0.3 -0.3 0.7
Pulse rate 0.6 0.9 1.8 0.3 -1.0 1.4
Happiness 1.9 2.3 4.7 2.2 -1.5 0.4
Noisy workplace 0.5 0.6 1.4 0.6 -0.5 1.2
Qualifications: A levels/AS levels or equivalent 1.9 4.2 11.0 3.3 1.2 0.1
Serious illness, injury or assault of a close relative in last 2 years 4.4 5.1 7.9 -2.8 -1.8 -2.0
Mouth/teeth dental problems: Dentures 0.1 0.2 0.3 -0.5 0.4 -0.5
Asthma 0.4 0.7 1.4 0.2 -1.2 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 -0.5 -0.2 0.4
Medication: Cholesterol lowering 0.9 1.4 2.9 -0.0 1.7 1.1
Depression (self-reported) 0.5 0.6 0.9 1.0 0.7 0.7
Medication: Lansoprazole 0.9 1.0 1.2 -1.1 -1.0 -1.0
Prospective memory result 2.2 2.7 4.3 -2.1 1.7 1.0
Lung cancer (father) 1.0 1.2 2.0 -1.1 0.7 1.4
Illnesses of mother 0.2 0.2 0.7 0.8 -0.1 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.5 -0.0 -0.7 0.2
Pulse wave Arterial Stiffness index 1.0 1.1 2.5 -0.2 0.9 1.6
Impedance of arm (left) 1.4 6.7 15.9 4.0 -1.6 1.2
Arm fat mass (right) 4.6 18.9 50.1 -7.1 -1.1 -2.3
Trunk predicted mass 7.3 41.8 104.0 -10.2 -2.3 -4.0
Standing height 6.2 61.7 134.6 -11.6 -5.2 -4.9
Length of working week for main job 0.2 0.2 0.4 -0.7 -0.3 0.2
Exposure to tobacco smoke at home 1.6 1.8 3.6 -1.9 1.4 -0.3
Breastfed as a baby 1.7 2.1 3.7 1.6 1.9 -0.5
Tense / ‘highly strung’ 1.1 1.9 3.7 -1.9 -0.7 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.5 -1.2 0.4 -0.3
Hair/balding pattern: Pattern 4 0.2 0.4 0.7 0.8 0.5 -0.4
Birth weight of first child 1.1 2.0 4.2 -0.3 2.1 1.3
Peak expiratory flow (PEF) 0.2 0.5 1.3 0.3 1.1 0.2
Pulse wave reflection index 1.6 1.9 3.3 1.3 1.8 1.0
Ever highly irritable/argumentative for 2 days 1.1 1.3 3.5 -0.3 -1.9 -0.6
Loud music exposure frequency 0.0 0.0 0.1 -0.2 -0.2 -0.0
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 1.5 -0.6 0.9 -1.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.0 -1.4 -0.2 -0.6
Blood clot in the leg (DVT) 1.3 1.7 3.1 -1.8 -1.3 -0.6
Medication: Paracetamol 1.0 1.6 3.2 -1.8 -0.8 -1.0
Headache pain in last month 0.6 1.0 2.0 -1.4 -1.0 -0.0
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 3.4 0.5 -1.8 -1.3
Glaucoma (self-reported) 0.8 0.9 2.0 -1.4 0.9 -0.1
Gout (self-reported) 0.1 0.1 0.4 -0.0 0.6 0.1
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 3.3 -0.9 -1.3 -1.8
Medication: Amlodipine 0.2 0.2 0.6 -0.0 -0.8 0.2
Medication: Ventolin 100micrograms inhaler 2.1 2.7 4.1 -2.0 -0.9 -1.8
Birth weight 0.7 1.6 3.5 -1.9 0.0 1.2
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.8 0.3 0.9 0.4
High blood pressure (siblings) 0.9 1.3 2.8 -1.7 0.2 -0.9
Forced vital capacity (FVC), Best measure 0.3 1.2 3.4 -0.6 -1.8 -0.2
Body fat percentage 3.4 13.6 37.2 -6.1 -0.9 -1.6
Leg fat percentage (right) 3.2 11.4 33.5 -5.8 0.2 -0.9
Arm fat-free mass (right) 8.4 43.3 114.5 -10.7 -2.2 -3.2
Exposure to tobacco smoke outside home 2.2 3.0 8.4 -2.9 0.7 -0.2
Comparative body size at age 10 1.2 3.2 7.3 -2.7 1.3 -0.8
Number of full brothers 1.3 1.7 3.8 -1.1 -2.0 0.2
Worry too long after embarrassment 5.4 9.0 22.1 -1.2 -1.9 -4.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 3.0 -0.4 1.7 1.6
Wheeze or whistling in the chest in last year 2.0 3.5 4.5 -2.1 -1.8 -1.7
Number of children fathered 1.3 1.5 3.3 -0.2 1.0 -1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 0.9 0.5 -1.0 -0.6
Age at first live birth 1.4 2.4 5.8 2.4 -1.0 0.7
Pulse wave peak to peak time 1.8 2.1 4.0 -0.7 -1.3 -2.0
Health satisfaction 0.5 0.6 1.6 0.3 -0.4 1.3
Shortness of breath walking on level ground 1.9 2.3 4.4 -2.1 0.7 1.4
Qualifications: College or University degree 2.0 6.2 17.0 4.1 -1.2 -0.1
Eye problems/disorders: None of the above 0.1 0.1 0.3 0.2 -0.4 -0.5
Mouth/teeth dental problems: Loose teeth 1.9 2.2 3.6 -1.9 -1.2 -1.2
Emphysema/chronic bronchitis 1.1 1.2 2.8 -1.7 -0.9 0.2
Medication for pain relief, constipation, heartburn 2.2 3.8 6.9 2.6 1.6 1.4
Neck or shoulder pain in last month 1.4 2.0 4.9 -0.8 -2.2 -0.6
Medication: Blood pressure 0.4 0.6 1.1 -0.9 1.0 0.2
Angina (self-reported) 0.2 0.3 0.6 -0.8 -0.5 0.1
Migraine (self-reported) 0.2 0.2 0.4 -0.4 -0.2 -0.7
Medication: Ibuprofen 0.6 0.7 1.7 -1.3 -0.5 -0.5
Medication: Allopurinol 0.3 0.4 1.0 -0.3 1.0 0.0
Medication: Omeprazole 1.9 2.3 5.5 -2.4 -1.0 -0.6
Medication: Seretide 50 evohaler 0.6 0.7 1.9 -0.1 0.2 -1.4
Mean time to correctly identify matches 0.5 0.9 1.6 -1.3 0.8 -0.8
Heart disease (mother) 1.6 1.9 3.0 -1.7 0.4 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.2 0.3 0.4 -0.5
Whole body fat mass 6.3 26.2 69.5 -8.3 -1.4 -2.7
Leg fat mass (right) 5.3 20.5 57.8 -7.6 -0.6 -1.9
Arm predicted mass (right) 8.2 42.1 111.6 -10.6 -2.1 -3.2
Pulse rate, automated reading 0.4 1.4 2.0 -1.4 -1.4 -0.6
Alcohol intake frequency. 3.3 7.6 21.8 -4.7 -1.1 -0.0
Comparative height size at age 10 9.7 53.5 114.5 -10.7 -4.3 -5.2
Number of full sisters 1.2 1.5 3.1 -1.8 -0.4 -1.1
Suffer from ‘nerves’ 1.5 2.3 3.6 -1.7 -0.6 -1.9
Overall health rating 2.4 5.2 14.3 -3.8 -1.0 -0.5
Chest pain or discomfort 1.5 2.2 4.4 -2.1 -1.4 -0.5
Had major operations 0.2 0.2 0.5 -0.7 0.3 0.3
Age at last live birth 3.8 5.5 12.3 3.5 -0.5 1.9
Family relationship satisfaction 0.4 0.5 1.1 1.1 -0.6 0.3
Leg pain on walking 0.1 0.1 0.1 -0.3 0.3 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.2 0.5 -1.1 0.2
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.4 -0.2 1.1 -1.2
Illness, injury, bereavement, stress in last 2 years 2.2 2.7 6.7 2.6 0.8 0.9
Medication: Aspirin 1.4 1.8 2.2 -1.4 -1.2 -1.5
Supplements: Vitamin C 0.8 1.0 1.4 1.2 0.9 0.9
Knee pain experienced in last month 0.3 0.5 1.4 -1.2 0.2 0.3
Hypertension (Self-reported) 1.3 3.5 8.1 -2.8 1.4 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 2.4 -0.5 -1.5 -1.3
Illnesses of father: Heart disease 3.8 5.3 8.0 -2.7 -0.6 -2.8
Illnesses of siblings: Diabetes 0.2 0.2 0.5 -0.3 -0.1 0.7
Smoking status: Previous 0.9 1.4 2.0 1.0 1.4 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 8.5 17.6 41.4 -6.4 -2.5 -2.3
Whole body fat-free mass 7.1 40.3 101.6 -10.1 -2.4 -3.7
Leg fat-free mass (right) 4.8 25.8 65.3 -8.1 -2.2 -2.7
Arm fat percentage (left) 1.5 5.8 16.6 -4.1 -0.3 -0.9
Average weekly red wine intake 5.0 7.4 19.1 4.4 1.5 0.9
Handedness (chirality/laterality): Left-handed 0.9 1.1 2.3 0.1 0.9 1.5
Mood swings 0.3 0.5 1.1 -0.7 -1.0 0.1
Loneliness, isolation 0.2 0.2 0.6 0.3 0.1 0.8
Long-standing illness, disability or infirmity 1.9 2.8 6.3 -2.5 -0.7 -1.3
Ever had bowel cancer screening 0.2 0.2 0.5 0.3 -0.5 -0.7
Diabetes diagnosed by doctor 1.9 3.1 6.6 -2.6 0.9 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 3.4 -0.7 -1.3 -1.9
Friendships satisfaction 3.7 4.6 9.1 3.0 -1.7 1.4
Qualifications: nursing, teaching 0.6 1.0 1.3 1.1 -1.0 0.7
Commuting to job workplace: Walk 2.2 2.4 3.4 1.8 -0.6 1.9
Eye problems/disorders: Cataract 1.7 1.9 3.5 0.7 1.9 1.3
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.4 -0.3 0.3 -0.7
Medication for cholesterol 1.0 1.5 4.2 2.0 0.2 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.9 4.8 -2.2 -1.9 -0.5
Back pain experienced in last month 1.8 2.6 5.2 -2.3 -1.0 -1.2
Mineral and other dietary supplements 0.7 1.0 2.7 -1.6 -0.4 -0.2
Breast cancer (self-reported) 0.8 0.9 2.7 0.1 0.1 1.6
Asthma (self-reported) 0.4 0.8 1.7 0.1 -1.3 -0.8
Osteoporosis (self-reported) 0.9 1.1 2.9 0.6 -1.7 -0.2
Osteoarthritis (self-reported) 4.2 5.4 13.5 -3.7 -0.2 -1.6
Medication: Aspirin 1.2 1.6 2.2 -1.4 -0.8 -1.5
Medication: Gliclazide 2.2 2.4 5.7 -2.4 0.8 -1.0
Illnesses of father: None of the above (group 1) 1.1 1.3 3.5 1.9 0.1 0.6
Smoking status: Current 0.5 0.8 1.7 -0.3 -0.7 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.6 8.9 3.0 1.1 0.8
Whole body water mass 6.9 39.5 99.6 -10.0 -2.4 -3.6
Leg predicted mass (right) 4.8 25.8 65.1 -8.1 -2.3 -2.7
Arm fat mass (left) 4.2 17.3 46.6 -6.8 -1.0 -2.0
Number of self-reported non-cancer illnesses 1.5 2.6 7.5 -2.7 -0.6 -0.3
Average weekly champagne plus white wine intake 0.7 1.0 2.6 0.2 -1.6 -0.5
Miserableness 0.0 0.1 0.2 0.4 0.2 -0.1
Guilty feelings 1.3 2.0 2.7 1.1 -1.4 -1.6
Wears glasses or contact lenses 0.5 0.5 1.3 1.1 -0.2 -0.5
Ever taken oral contraceptive pill 0.2 0.3 0.5 -0.0 -0.5 0.7
Hearing aid user 1.0 1.1 3.1 0.4 0.3 1.8
Mother’s age at death 1.2 1.5 3.6 0.8 0.6 1.9
Financial situation satisfaction 1.3 1.6 3.3 0.9 0.8 1.8
Tinnitus: Yes, now most or all of the time 1.1 1.3 2.9 0.1 -1.0 -1.7
Commuting to job workplace: Public transport 0.1 0.2 0.3 0.1 -0.4 -0.6
Eye problems/disorders: Glaucoma 0.2 0.3 0.5 -0.6 0.1 -0.7
Medication: Blood pressure 1.9 3.6 8.1 -2.8 1.3 -1.0
Pain type(s) experienced in last month: Hip pain 1.4 1.8 4.8 -2.2 -0.4 -0.7
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.5 0.0 1.2 -0.3
High cholesterol (Self-reported) 0.1 0.2 0.6 -0.8 -0.1 -0.1
Medication: Bendroflumethiazide 2.4 3.7 8.1 -1.6 2.8 0.7
Medication: Paracetamol 1.7 2.7 4.2 -2.1 -1.6 -1.2
Medication: Lisinopril 1.6 2.0 5.2 -0.2 2.3 0.9
Medication: Atorvastatin 0.8 1.0 1.9 -1.0 -0.6 -1.4
Illnesses of father: High blood pressure 1.5 1.8 4.3 -2.1 -0.9 -0.6
Alcohol drinker status: Never 0.5 0.6 1.6 -1.3 0.2 -0.6
Ever smoked 0.6 1.0 1.5 1.1 0.6 -1.2
Basal metabolic rate 7.6 42.1 106.4 -10.3 -2.5 -3.7
Leg fat percentage (left) 3.2 11.5 33.9 -5.8 0.0 -0.8
Arm fat-free mass (left) 9.1 46.4 116.6 -10.8 -2.6 -4.0
Number of operations (self-reported) 0.7 1.0 1.4 -1.2 -1.1 -0.6
Average weekly beer plus cider intake 0.5 0.7 1.4 -0.4 -1.2 0.8
Irritability 0.5 0.8 1.4 1.2 -1.0 -0.4
Risk taking 0.6 0.9 1.6 0.7 1.3 -0.7
Ever had prostate specific antigen (PSA) test 1.1 1.2 3.2 1.8 -0.7 -0.1
Fractured/broken bones in last 5 years 0.9 1.1 3.2 -1.8 -0.3 -0.1
Age started oral contraceptive pill 1.2 1.5 2.2 1.5 1.3 0.7
Diastolic blood pressure, automated reading 1.7 5.3 10.6 -3.3 -0.2 -2.3
Ever depressed for a whole week 0.0 0.0 0.1 -0.1 0.2 -0.3
Unable to work because of sickness or disability 2.6 3.4 6.0 -2.5 -1.6 1.2
Commuting to job workplace: Cycle 0.6 0.7 1.6 1.3 0.2 0.8
Myopia 0.2 0.4 0.9 1.0 0.2 0.4
Vascular/heart problems diagnosed by doctor 1.1 2.9 6.2 2.5 -1.6 0.2
Cholesterol lowering medication 0.2 0.2 0.6 -0.8 -0.3 0.0
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 3.3 -1.8 -0.9 -0.9
Pain experienced in last month 1.3 2.1 3.5 1.6 1.9 -0.6
Supplements: Calcium 1.7 1.9 4.3 -0.3 -2.1 -1.1
Basal cell carcinoma (self-reported) 1.1 1.4 1.8 0.9 1.2 1.4
Heart attack/myocardial infarction (self-reported) 1.1 1.4 3.1 -1.8 -0.9 -0.7
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 3.2 -1.8 -1.5 -1.0
Heart disease (siblings) 2.8 3.5 6.4 -1.9 -2.5 -0.7
Alcohol drinker status: Previous 1.6 1.9 5.0 -2.2 -0.5 -0.6
Pack years of smoking 1.1 1.6 4.6 -2.1 -0.1 -0.5
Impedance of whole body 0.6 3.2 5.3 2.3 -1.9 0.7
Leg fat mass (left) 5.5 21.3 59.7 -7.7 -0.7 -1.9
Arm predicted mass (left) 8.2 41.5 106.0 -10.3 -2.4 -3.6