Hub : Genes

RIOK3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0210	0.0120	2.8e-02	0.007	0.001	0.002	0.002	0.000	4.2e-02	2.4e-01	1.8e-01	1.8e-01	3.3e-01
2	YFS	Blood	0.0391	0.0132	5.7e-06	0.022	0.017	0.016	0.016	0.021	5.1e-08	2.6e-06	2.8e-06	4.1e-06	1.5e-07
3	TCGA	Prostate Adenocarcinoma	0.0409	0.0249	6.5e-03	0.002	0.003	0.014	NA	-0.001	1.7e-01	1.3e-01	1.2e-02	NA	4.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	1.6	1.2	0.2	0.0
Bipolar Disorder or Schizophrenia	0.5	1.2	1.7	-0.8	-1.2	-1.3
Depressed Affect (Nagel 2018)	0.4	0.8	1.4	-1.0	1.2	-0.3
Depression (Nagel 2018)	0.3	0.5	0.9	-1.0	0.5	0.4
Intelligence (Savage-Jansen 2018)	0.7	2.0	4.7	2.2	0.6	1.0
Neuroticism (Nagel 2018)	1.5	3.6	7.1	-1.9	0.1	-2.7
Schizophrenia (2018)	1.5	3.1	3.8	-1.9	-1.7	-1.7
Schizophrenia vs Biploar Disorder	1.5	2.0	5.8	-2.4	0.0	-0.3
Worry (Nagel 2018)	3.3	6.9	10.9	-3.3	-0.1	-3.2
Alzheimer’s Disease (in mother)	0.8	1.0	1.5	1.2	-0.8	0.9
Alzheimer’s Disease (in father)	1.1	1.2	3.3	-0.2	-1.8	-0.5
Alzheimer’s Disease (including proxy)	1.1	1.5	3.0	1.0	-1.7	0.8
Crohns Disease (2017)	0.0	0.1	0.2	-0.3	-0.4	-0.2
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	0.1	-0.1	-0.5
Ulcerative Colitis (UC)	0.1	0.1	0.2	0.4	0.4	-0.2
Major Depression (MDD)	1.7	2.1	3.7	1.4	0.7	1.9
Reaction Time	0.6	1.2	2.6	-1.6	-0.1	-1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.0	1.7	0.9	0.2
Breast Cancer	0.0	0.1	0.1	-0.4	0.1	-0.3
Ovarian Cancer	0.9	1.1	2.8	0.8	-0.1	1.7
Prostate Cancer	0.7	1.0	1.9	-0.2	-1.4	-1.0
Age at First Birth	0.8	1.2	2.6	1.6	-0.4	1.0
Bipolar Disorder (2011)	2.9	2.8	7.1	2.7	-1.0	-0.5
Body Mass Index (BMI) (2010)	1.1	1.5	4.0	-2.0	0.2	-0.6
Coronary Artery Disease (CAD)	0.2	0.2	0.3	-0.2	0.5	0.5
Crohns Disease (2012)	0.4	0.7	1.6	0.4	-1.3	0.5
Mean Putamen Volume	0.7	0.8	1.5	-0.3	-0.8	1.2
Fasting Glucose	1.0	1.2	2.3	-1.1	-1.5	0.4
HbA1C	0.9	1.1	1.8	-1.3	-0.5	-1.0
HDL Cholesterol	4.3	7.2	12.6	3.6	1.5	2.6
LDL Cholesterol	1.4	2.2	4.4	-2.1	0.3	-1.4
Lupus	0.8	1.3	3.5	-1.9	0.5	0.1
Neuroticism (2016)	0.5	0.7	1.5	-0.7	-0.1	-1.2
Primary Biliary Cirrhosis	1.5	2.2	3.8	0.3	-1.9	1.6
Rheumatoid Arthritis	4.5	6.2	7.3	-2.5	-2.7	-2.3
Schizophrenia (2014)	0.5	1.2	1.9	-1.0	-1.4	-0.9
Triglycerides	2.1	3.4	8.5	-2.9	0.7	-1.0
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.6	-1.6	-0.9	-0.2
Ulcerative Colitis	1.0	1.4	2.5	1.6	-1.3	0.0
Blood Eosinophil Count	0.4	3.2	6.5	-1.6	-2.5	-0.7
Blood Platelet Count	2.7	31.8	49.2	7.0	-6.8	-0.0
Blood Red Count	0.0	0.2	0.4	-0.6	0.2	-0.3
Blood White Count	1.0	7.5	18.7	4.3	-1.8	-0.7
Heel T-Score	0.8	6.5	19.5	4.4	-0.0	0.3
BMI	2.7	15.9	42.8	-6.5	0.3	-2.2
Height	6.9	132.7	295.8	-17.2	-7.1	-7.2
Waist Hip Ratio (WHR)	3.0	13.4	23.0	-4.8	-2.1	-3.6
Systolic Blood Pressure	0.6	3.1	4.8	-2.2	-0.3	-2.1
Smoking Status	0.9	2.1	5.8	0.7	-0.3	-2.4
Allergy or Eczema	0.3	0.7	0.9	-0.9	0.7	-0.9
Cardiovascular Disease	2.1	7.1	20.5	-4.5	0.8	0.1
Hypothyroidism (self reported)	0.8	1.9	3.6	-1.1	-1.0	-1.9
Respiratory disease	0.3	0.7	1.5	-1.2	0.6	-0.4
Type 2 Diabetes (T2D) (2018)	2.0	3.8	8.8	-3.0	1.0	-1.2
Lung FEV1/FVC ratio	0.2	1.1	3.0	0.1	1.7	0.4
Lung FVC	2.4	12.5	34.3	5.9	1.1	1.3
Neuroticism	0.8	1.8	2.3	-1.0	1.5	-1.5
Chronotype (morning person)	0.8	1.7	4.5	2.1	0.7	0.5
Hair Pigment	0.0	0.6	1.3	-0.3	1.1	0.7
Tanning	0.0	0.6	1.2	1.1	-0.2	-0.7
Hand grip strength (left)	1.9	4.9	10.5	-3.2	-1.1	-1.7
Number of treatments/medications taken	1.5	2.6	6.5	-2.5	-0.9	-0.7
Average weekly spirits intake	1.2	1.5	2.7	1.1	-1.6	0.6
Sensitivity / hurt feelings	0.7	1.3	2.5	-0.6	1.6	-1.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.0	-1.4	-0.3	-0.3
Hearing difficulty/problems: Yes	1.0	1.6	4.4	-0.4	-0.4	-2.1
Relative age of first facial hair	1.9	3.9	8.7	3.0	0.7	1.6
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.0	-1.4	-1.0	-0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	0.0	0.7	0.5
Ever had hysterectomy (womb removed)	0.4	0.5	1.4	-1.2	0.0	-0.2
Systolic blood pressure, automated reading	0.6	1.8	2.6	-0.7	1.5	-1.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	2.8	-1.7	-0.8	-0.7
Angina	0.1	0.1	0.3	-0.5	-0.2	0.3
Medication for hormone replacement therapy	1.4	1.5	3.5	-1.9	-1.0	-0.2
Vitamin and mineral supplements	0.7	0.9	2.7	-0.3	1.6	0.1
Supplements: Zinc	0.9	1.0	1.8	0.9	-1.3	0.7
Medication: Co-codamol	2.3	2.6	6.0	-2.4	-1.2	-0.7
Medication: Metformin	0.9	1.2	2.5	-1.6	-0.1	-1.1
Diabetes (father)	0.1	0.1	0.1	0.2	0.1	0.4
Diabetes (mother)	0.3	0.4	0.6	-0.8	-0.8	0.1
Severe depression (siblings)	0.8	0.9	2.1	-1.4	-0.1	-0.9
Pack years adult smoking proportion	1.3	1.9	5.2	-2.3	-0.1	-0.7
Impedance of leg (right)	0.1	0.7	2.1	0.0	-1.4	0.1
Leg fat-free mass (left)	5.2	27.6	70.9	-8.4	-2.1	-2.8
Trunk fat percentage	3.3	13.3	35.8	-6.0	-1.3	-1.5
Hand grip strength (right)	1.9	5.2	8.7	-3.0	-1.0	-2.4
Townsend deprivation index at recruitment	0.3	0.4	0.8	-0.2	-0.7	0.9
Current tobacco smoking	0.7	1.1	2.4	-0.6	-0.8	-1.5
Average weekly fortified wine intake	0.6	0.7	1.9	1.4	-0.5	0.3
Maternal smoking around birth	0.2	0.3	0.7	-0.5	-0.1	0.8
Fed-up feelings	0.3	0.6	0.7	-0.8	0.6	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.3	-1.8	1.1	0.0
Relative age voice broke	2.0	3.0	7.4	2.7	-1.0	0.8
Taking other prescription medications	2.0	3.0	6.3	-2.5	-1.3	-1.1
Age when periods started (menarche)	0.6	1.5	2.6	1.6	0.8	1.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.0	-1.7	-0.4	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.2	-0.4	-1.8	-0.6
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	4.2	-2.0	-1.4	-0.1
Qualifications: CSEs or equivalent	1.6	2.1	5.8	-2.4	-0.6	-0.3
Serious illness, injury or assault to yourself	2.6	3.1	6.5	-2.6	-1.1	-1.3
High blood pressure	1.0	2.8	7.0	-2.6	0.9	-0.9
Hayfever, allergic rhinitis or eczema	0.5	1.2	1.5	-1.0	1.0	-1.2
Multivitamins +/- minerals	1.4	1.7	4.9	-0.1	-2.2	-0.5
Stomach or abdominal pain in last month	0.8	1.0	1.7	-1.1	-0.3	1.3
Supplements: Glucosamine	0.4	0.5	1.0	1.0	0.3	-0.6
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.9	-1.1	2.0	-0.6
Medication: Atenolol	1.0	1.2	1.6	-0.9	1.3	1.1
Medication: Levothyroxine sodium	1.3	2.3	3.2	-1.4	-1.8	-1.3
Sitting height	2.3	16.1	32.2	-5.7	-2.6	-3.1
Chronic bronchitis/emphysema (father)	0.7	0.8	2.2	-1.5	-0.2	0.4
High blood pressure (mother)	1.5	2.1	5.5	-2.3	0.6	-0.6
Body mass index (BMI)	2.0	8.6	24.6	-5.0	0.3	-1.0
Impedance of leg (left)	0.2	1.1	3.1	-0.2	-1.8	0.3
Leg predicted mass (left)	5.2	27.4	70.7	-8.4	-2.0	-2.8
Trunk fat mass	6.0	25.6	67.7	-8.2	-1.6	-2.5
Waist circumference	7.8	28.6	73.6	-8.6	-1.7	-3.0
Number of incorrect matches in round	0.7	1.2	2.4	-1.5	-1.0	-0.4
Past tobacco smoking	0.8	1.6	2.0	-1.1	-1.4	1.2
Alcohol usually taken with meals	0.2	0.3	0.4	-0.0	0.6	-0.7
Nervous feelings	0.9	1.7	2.9	-1.7	-0.6	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	5.3	-2.3	-0.6	-1.0
Hearing difficulty/problems with background noise	0.7	1.2	2.5	-0.1	-1.0	-1.6
Hair/balding pattern: Pattern 2	2.2	2.8	4.6	-2.0	0.2	-2.2
Had menopause	0.1	0.1	0.2	-0.5	-0.1	0.1
Had other major operations	1.6	1.9	2.8	-1.7	-1.6	-0.6
Forced vital capacity (FVC)	0.2	0.8	2.2	-0.1	-1.5	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	3.1	-0.0	-1.8	-1.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.8	-0.8	0.9	0.7
Qualifications: None of the above	1.0	2.2	5.0	-2.2	1.3	-0.4
Financial difficulties in last 2 years	1.8	2.5	6.6	-0.9	-2.6	-0.2
Mouth/teeth dental problems	1.1	1.7	3.4	1.8	0.3	1.2
Heart attack	1.2	1.6	3.6	-1.9	-0.8	-0.7
Allergy	0.4	1.0	1.8	1.1	0.2	1.3
Pain all over the body in last month	0.7	0.7	1.6	-1.3	-0.8	0.2
Diabetes (self-reported)	1.7	2.7	4.9	-2.2	1.6	-0.8
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.8	-1.7	-0.9	-0.2
Medication: Ramipril	2.3	3.0	5.6	-1.8	2.4	-0.2
Medication: Simvastatin	0.9	1.3	3.4	-0.3	0.7	1.8
Fluid intelligence score	0.1	0.3	0.5	0.7	-0.0	-0.6
Illnesses of siblings	1.9	2.7	5.1	2.3	0.8	1.6
Neuroticism score	0.9	1.8	4.5	-0.9	-0.4	-2.1
Weight	7.5	36.6	96.2	-9.8	-2.0	-3.1
Impedance of arm (right)	1.2	5.8	15.1	3.9	-1.3	0.6
Arm fat percentage (right)	1.5	6.0	16.3	-4.0	-0.2	-1.3
Trunk fat-free mass	7.4	42.6	106.1	-10.3	-2.3	-4.0
Hip circumference	5.2	22.3	61.9	-7.9	-1.9	-1.2
Time employed in main current job	0.4	0.5	1.4	-1.2	0.1	-0.3
Alcohol intake versus 10 years previously	1.8	2.6	2.9	-1.7	1.7	1.5
Father’s age at death	4.4	5.9	12.3	3.5	0.5	2.3
Worrier / anxious feelings	2.8	5.4	10.0	-2.2	-1.2	-3.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.2	-0.4	-0.5
Falls in the last year	2.6	3.5	3.9	-2.0	-2.0	-1.7
Hair/balding pattern: Pattern 3	1.1	1.7	3.9	2.0	-0.5	1.0
Number of live births	0.3	0.5	0.6	0.8	0.7	0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.5	0.3	-0.3	0.7
Pulse rate	0.6	0.9	1.8	0.3	-1.0	1.4
Happiness	1.9	2.3	4.7	2.2	-1.5	0.4
Noisy workplace	0.5	0.6	1.4	0.6	-0.5	1.2
Qualifications: A levels/AS levels or equivalent	1.9	4.2	11.0	3.3	1.2	0.1
Serious illness, injury or assault of a close relative in last 2 years	4.4	5.1	7.9	-2.8	-1.8	-2.0
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	-0.5	0.4	-0.5
Asthma	0.4	0.7	1.4	0.2	-1.2	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.5	-0.2	0.4
Medication: Cholesterol lowering	0.9	1.4	2.9	-0.0	1.7	1.1
Depression (self-reported)	0.5	0.6	0.9	1.0	0.7	0.7
Medication: Lansoprazole	0.9	1.0	1.2	-1.1	-1.0	-1.0
Prospective memory result	2.2	2.7	4.3	-2.1	1.7	1.0
Lung cancer (father)	1.0	1.2	2.0	-1.1	0.7	1.4
Illnesses of mother	0.2	0.2	0.7	0.8	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.5	-0.0	-0.7	0.2
Pulse wave Arterial Stiffness index	1.0	1.1	2.5	-0.2	0.9	1.6
Impedance of arm (left)	1.4	6.7	15.9	4.0	-1.6	1.2
Arm fat mass (right)	4.6	18.9	50.1	-7.1	-1.1	-2.3
Trunk predicted mass	7.3	41.8	104.0	-10.2	-2.3	-4.0
Standing height	6.2	61.7	134.6	-11.6	-5.2	-4.9
Length of working week for main job	0.2	0.2	0.4	-0.7	-0.3	0.2
Exposure to tobacco smoke at home	1.6	1.8	3.6	-1.9	1.4	-0.3
Breastfed as a baby	1.7	2.1	3.7	1.6	1.9	-0.5
Tense / ‘highly strung’	1.1	1.9	3.7	-1.9	-0.7	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.5	-1.2	0.4	-0.3
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	0.8	0.5	-0.4
Birth weight of first child	1.1	2.0	4.2	-0.3	2.1	1.3
Peak expiratory flow (PEF)	0.2	0.5	1.3	0.3	1.1	0.2
Pulse wave reflection index	1.6	1.9	3.3	1.3	1.8	1.0
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.5	-0.3	-1.9	-0.6
Loud music exposure frequency	0.0	0.0	0.1	-0.2	-0.2	-0.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	1.5	-0.6	0.9	-1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.0	-1.4	-0.2	-0.6
Blood clot in the leg (DVT)	1.3	1.7	3.1	-1.8	-1.3	-0.6
Medication: Paracetamol	1.0	1.6	3.2	-1.8	-0.8	-1.0
Headache pain in last month	0.6	1.0	2.0	-1.4	-1.0	-0.0
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.4	0.5	-1.8	-1.3
Glaucoma (self-reported)	0.8	0.9	2.0	-1.4	0.9	-0.1
Gout (self-reported)	0.1	0.1	0.4	-0.0	0.6	0.1
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.3	-0.9	-1.3	-1.8
Medication: Amlodipine	0.2	0.2	0.6	-0.0	-0.8	0.2
Medication: Ventolin 100micrograms inhaler	2.1	2.7	4.1	-2.0	-0.9	-1.8
Birth weight	0.7	1.6	3.5	-1.9	0.0	1.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	0.3	0.9	0.4
High blood pressure (siblings)	0.9	1.3	2.8	-1.7	0.2	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.2	3.4	-0.6	-1.8	-0.2
Body fat percentage	3.4	13.6	37.2	-6.1	-0.9	-1.6
Leg fat percentage (right)	3.2	11.4	33.5	-5.8	0.2	-0.9
Arm fat-free mass (right)	8.4	43.3	114.5	-10.7	-2.2	-3.2
Exposure to tobacco smoke outside home	2.2	3.0	8.4	-2.9	0.7	-0.2
Comparative body size at age 10	1.2	3.2	7.3	-2.7	1.3	-0.8
Number of full brothers	1.3	1.7	3.8	-1.1	-2.0	0.2
Worry too long after embarrassment	5.4	9.0	22.1	-1.2	-1.9	-4.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.0	-0.4	1.7	1.6
Wheeze or whistling in the chest in last year	2.0	3.5	4.5	-2.1	-1.8	-1.7
Number of children fathered	1.3	1.5	3.3	-0.2	1.0	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	0.5	-1.0	-0.6
Age at first live birth	1.4	2.4	5.8	2.4	-1.0	0.7
Pulse wave peak to peak time	1.8	2.1	4.0	-0.7	-1.3	-2.0
Health satisfaction	0.5	0.6	1.6	0.3	-0.4	1.3
Shortness of breath walking on level ground	1.9	2.3	4.4	-2.1	0.7	1.4
Qualifications: College or University degree	2.0	6.2	17.0	4.1	-1.2	-0.1
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.2	-0.4	-0.5
Mouth/teeth dental problems: Loose teeth	1.9	2.2	3.6	-1.9	-1.2	-1.2
Emphysema/chronic bronchitis	1.1	1.2	2.8	-1.7	-0.9	0.2
Medication for pain relief, constipation, heartburn	2.2	3.8	6.9	2.6	1.6	1.4
Neck or shoulder pain in last month	1.4	2.0	4.9	-0.8	-2.2	-0.6
Medication: Blood pressure	0.4	0.6	1.1	-0.9	1.0	0.2
Angina (self-reported)	0.2	0.3	0.6	-0.8	-0.5	0.1
Migraine (self-reported)	0.2	0.2	0.4	-0.4	-0.2	-0.7
Medication: Ibuprofen	0.6	0.7	1.7	-1.3	-0.5	-0.5
Medication: Allopurinol	0.3	0.4	1.0	-0.3	1.0	0.0
Medication: Omeprazole	1.9	2.3	5.5	-2.4	-1.0	-0.6
Medication: Seretide 50 evohaler	0.6	0.7	1.9	-0.1	0.2	-1.4
Mean time to correctly identify matches	0.5	0.9	1.6	-1.3	0.8	-0.8
Heart disease (mother)	1.6	1.9	3.0	-1.7	0.4	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.2	0.3	0.4	-0.5
Whole body fat mass	6.3	26.2	69.5	-8.3	-1.4	-2.7
Leg fat mass (right)	5.3	20.5	57.8	-7.6	-0.6	-1.9
Arm predicted mass (right)	8.2	42.1	111.6	-10.6	-2.1	-3.2
Pulse rate, automated reading	0.4	1.4	2.0	-1.4	-1.4	-0.6
Alcohol intake frequency.	3.3	7.6	21.8	-4.7	-1.1	-0.0
Comparative height size at age 10	9.7	53.5	114.5	-10.7	-4.3	-5.2
Number of full sisters	1.2	1.5	3.1	-1.8	-0.4	-1.1
Suffer from ‘nerves’	1.5	2.3	3.6	-1.7	-0.6	-1.9
Overall health rating	2.4	5.2	14.3	-3.8	-1.0	-0.5
Chest pain or discomfort	1.5	2.2	4.4	-2.1	-1.4	-0.5
Had major operations	0.2	0.2	0.5	-0.7	0.3	0.3
Age at last live birth	3.8	5.5	12.3	3.5	-0.5	1.9
Family relationship satisfaction	0.4	0.5	1.1	1.1	-0.6	0.3
Leg pain on walking	0.1	0.1	0.1	-0.3	0.3	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	0.5	-1.1	0.2
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.4	-0.2	1.1	-1.2
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	6.7	2.6	0.8	0.9
Medication: Aspirin	1.4	1.8	2.2	-1.4	-1.2	-1.5
Supplements: Vitamin C	0.8	1.0	1.4	1.2	0.9	0.9
Knee pain experienced in last month	0.3	0.5	1.4	-1.2	0.2	0.3
Hypertension (Self-reported)	1.3	3.5	8.1	-2.8	1.4	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.4	-0.5	-1.5	-1.3
Illnesses of father: Heart disease	3.8	5.3	8.0	-2.7	-0.6	-2.8
Illnesses of siblings: Diabetes	0.2	0.2	0.5	-0.3	-0.1	0.7
Smoking status: Previous	0.9	1.4	2.0	1.0	1.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	8.5	17.6	41.4	-6.4	-2.5	-2.3
Whole body fat-free mass	7.1	40.3	101.6	-10.1	-2.4	-3.7
Leg fat-free mass (right)	4.8	25.8	65.3	-8.1	-2.2	-2.7
Arm fat percentage (left)	1.5	5.8	16.6	-4.1	-0.3	-0.9
Average weekly red wine intake	5.0	7.4	19.1	4.4	1.5	0.9
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.3	0.1	0.9	1.5
Mood swings	0.3	0.5	1.1	-0.7	-1.0	0.1
Loneliness, isolation	0.2	0.2	0.6	0.3	0.1	0.8
Long-standing illness, disability or infirmity	1.9	2.8	6.3	-2.5	-0.7	-1.3
Ever had bowel cancer screening	0.2	0.2	0.5	0.3	-0.5	-0.7
Diabetes diagnosed by doctor	1.9	3.1	6.6	-2.6	0.9	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	3.4	-0.7	-1.3	-1.9
Friendships satisfaction	3.7	4.6	9.1	3.0	-1.7	1.4
Qualifications: nursing, teaching	0.6	1.0	1.3	1.1	-1.0	0.7
Commuting to job workplace: Walk	2.2	2.4	3.4	1.8	-0.6	1.9
Eye problems/disorders: Cataract	1.7	1.9	3.5	0.7	1.9	1.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	-0.3	0.3	-0.7
Medication for cholesterol	1.0	1.5	4.2	2.0	0.2	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	4.8	-2.2	-1.9	-0.5
Back pain experienced in last month	1.8	2.6	5.2	-2.3	-1.0	-1.2
Mineral and other dietary supplements	0.7	1.0	2.7	-1.6	-0.4	-0.2
Breast cancer (self-reported)	0.8	0.9	2.7	0.1	0.1	1.6
Asthma (self-reported)	0.4	0.8	1.7	0.1	-1.3	-0.8
Osteoporosis (self-reported)	0.9	1.1	2.9	0.6	-1.7	-0.2
Osteoarthritis (self-reported)	4.2	5.4	13.5	-3.7	-0.2	-1.6
Medication: Aspirin	1.2	1.6	2.2	-1.4	-0.8	-1.5
Medication: Gliclazide	2.2	2.4	5.7	-2.4	0.8	-1.0
Illnesses of father: None of the above (group 1)	1.1	1.3	3.5	1.9	0.1	0.6
Smoking status: Current	0.5	0.8	1.7	-0.3	-0.7	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	8.9	3.0	1.1	0.8
Whole body water mass	6.9	39.5	99.6	-10.0	-2.4	-3.6
Leg predicted mass (right)	4.8	25.8	65.1	-8.1	-2.3	-2.7
Arm fat mass (left)	4.2	17.3	46.6	-6.8	-1.0	-2.0
Number of self-reported non-cancer illnesses	1.5	2.6	7.5	-2.7	-0.6	-0.3
Average weekly champagne plus white wine intake	0.7	1.0	2.6	0.2	-1.6	-0.5
Miserableness	0.0	0.1	0.2	0.4	0.2	-0.1
Guilty feelings	1.3	2.0	2.7	1.1	-1.4	-1.6
Wears glasses or contact lenses	0.5	0.5	1.3	1.1	-0.2	-0.5
Ever taken oral contraceptive pill	0.2	0.3	0.5	-0.0	-0.5	0.7
Hearing aid user	1.0	1.1	3.1	0.4	0.3	1.8
Mother’s age at death	1.2	1.5	3.6	0.8	0.6	1.9
Financial situation satisfaction	1.3	1.6	3.3	0.9	0.8	1.8
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.9	0.1	-1.0	-1.7
Commuting to job workplace: Public transport	0.1	0.2	0.3	0.1	-0.4	-0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	-0.6	0.1	-0.7
Medication: Blood pressure	1.9	3.6	8.1	-2.8	1.3	-1.0
Pain type(s) experienced in last month: Hip pain	1.4	1.8	4.8	-2.2	-0.4	-0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	0.0	1.2	-0.3
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.8	-0.1	-0.1
Medication: Bendroflumethiazide	2.4	3.7	8.1	-1.6	2.8	0.7
Medication: Paracetamol	1.7	2.7	4.2	-2.1	-1.6	-1.2
Medication: Lisinopril	1.6	2.0	5.2	-0.2	2.3	0.9
Medication: Atorvastatin	0.8	1.0	1.9	-1.0	-0.6	-1.4
Illnesses of father: High blood pressure	1.5	1.8	4.3	-2.1	-0.9	-0.6
Alcohol drinker status: Never	0.5	0.6	1.6	-1.3	0.2	-0.6
Ever smoked	0.6	1.0	1.5	1.1	0.6	-1.2
Basal metabolic rate	7.6	42.1	106.4	-10.3	-2.5	-3.7
Leg fat percentage (left)	3.2	11.5	33.9	-5.8	0.0	-0.8
Arm fat-free mass (left)	9.1	46.4	116.6	-10.8	-2.6	-4.0
Number of operations (self-reported)	0.7	1.0	1.4	-1.2	-1.1	-0.6
Average weekly beer plus cider intake	0.5	0.7	1.4	-0.4	-1.2	0.8
Irritability	0.5	0.8	1.4	1.2	-1.0	-0.4
Risk taking	0.6	0.9	1.6	0.7	1.3	-0.7
Ever had prostate specific antigen (PSA) test	1.1	1.2	3.2	1.8	-0.7	-0.1
Fractured/broken bones in last 5 years	0.9	1.1	3.2	-1.8	-0.3	-0.1
Age started oral contraceptive pill	1.2	1.5	2.2	1.5	1.3	0.7
Diastolic blood pressure, automated reading	1.7	5.3	10.6	-3.3	-0.2	-2.3
Ever depressed for a whole week	0.0	0.0	0.1	-0.1	0.2	-0.3
Unable to work because of sickness or disability	2.6	3.4	6.0	-2.5	-1.6	1.2
Commuting to job workplace: Cycle	0.6	0.7	1.6	1.3	0.2	0.8
Myopia	0.2	0.4	0.9	1.0	0.2	0.4
Vascular/heart problems diagnosed by doctor	1.1	2.9	6.2	2.5	-1.6	0.2
Cholesterol lowering medication	0.2	0.2	0.6	-0.8	-0.3	0.0
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.3	-1.8	-0.9	-0.9
Pain experienced in last month	1.3	2.1	3.5	1.6	1.9	-0.6
Supplements: Calcium	1.7	1.9	4.3	-0.3	-2.1	-1.1
Basal cell carcinoma (self-reported)	1.1	1.4	1.8	0.9	1.2	1.4
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.1	-1.8	-0.9	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	3.2	-1.8	-1.5	-1.0
Heart disease (siblings)	2.8	3.5	6.4	-1.9	-2.5	-0.7
Alcohol drinker status: Previous	1.6	1.9	5.0	-2.2	-0.5	-0.6
Pack years of smoking	1.1	1.6	4.6	-2.1	-0.1	-0.5
Impedance of whole body	0.6	3.2	5.3	2.3	-1.9	0.7
Leg fat mass (left)	5.5	21.3	59.7	-7.7	-0.7	-1.9
Arm predicted mass (left)	8.2	41.5	106.0	-10.3	-2.4	-3.6