Hub : Genes

C18orf45

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0418	0.0204	0.00038	0.021	0.026	0.022	NA	0.029	0.00170	0.00048	0.00150	NA	0.00027
2	TCGA	Prostate Adenocarcinoma	0.0784	0.0329	0.00036	0.006	0.022	0.012	NA	0.010	0.07700	0.00210	0.01600	NA	0.02600
3	TCGA	Soft Tissue Sarcoma	0.0840	0.0340	0.00022	0.056	0.061	0.052	NA	0.057	0.00032	0.00017	0.00049	NA	0.00028

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.4	2.3	3.5	1.9	0.5	1.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	-0.1	0.9	0.3
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	-0.9	0.5	-0.3
Depression (Nagel 2018)	0.6	0.9	1.4	-1.1	1.2	-0.2
Intelligence (Savage-Jansen 2018)	1.2	3.7	5.7	2.4	0.3	2.3
Neuroticism (Nagel 2018)	1.4	3.4	4.4	-2.1	1.6	-1.8
Schizophrenia (2018)	0.7	1.4	2.6	-1.6	0.7	-1.1
Schizophrenia vs Biploar Disorder	5.5	7.3	12.9	-3.6	-0.8	-2.9
Worry (Nagel 2018)	3.5	7.3	12.2	-3.5	1.5	-2.8
Alzheimer’s Disease (in mother)	0.9	1.0	1.6	1.2	1.2	0.2
Alzheimer’s Disease (in father)	0.9	1.0	2.1	0.0	1.5	-0.9
Alzheimer’s Disease (including proxy)	0.8	1.2	2.4	1.6	0.9	0.5
Crohns Disease (2017)	0.8	1.8	3.8	-0.6	1.9	-1.1
Irritable Bowel Disease (IBD)	1.0	2.4	7.0	-0.0	2.6	-0.4
Ulcerative Colitis (UC)	0.6	1.2	2.9	0.7	1.7	0.5
Major Depression (MDD)	1.6	1.9	3.1	1.8	1.2	1.0
Reaction Time	1.1	2.1	2.8	-1.6	-1.7	-0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.7	1.5	0.4	1.7
Breast Cancer	0.0	0.1	0.2	-0.4	-0.4	0.0
Ovarian Cancer	1.7	2.2	3.3	1.8	0.3	1.8
Prostate Cancer	0.4	0.6	1.5	0.5	1.2	-0.1
Age at First Birth	0.9	1.4	2.8	1.7	-0.2	1.2
Bipolar Disorder (2011)	3.8	3.7	6.4	2.5	0.8	2.0
Body Mass Index (BMI) (2010)	2.3	3.1	5.0	-1.9	0.9	-2.2
Coronary Artery Disease (CAD)	0.2	0.3	0.5	-0.0	-0.7	0.5
Crohns Disease (2012)	0.0	0.0	0.1	0.1	-0.0	-0.3
Mean Putamen Volume	0.2	0.3	0.5	0.5	-0.1	0.7
Fasting Glucose	2.7	3.2	5.7	-0.4	2.4	-1.9
HbA1C	1.2	1.4	1.9	-1.2	0.8	-1.4
HDL Cholesterol	4.7	7.8	10.5	2.3	-3.2	2.7
LDL Cholesterol	0.7	1.1	1.9	-1.4	0.3	-1.2
Lupus	2.0	3.1	4.6	-2.1	0.5	-2.2
Neuroticism (2016)	0.8	1.1	1.5	-1.2	0.8	-1.1
Primary Biliary Cirrhosis	0.2	0.2	0.6	0.8	0.1	0.3
Rheumatoid Arthritis	3.5	4.8	7.6	-2.5	0.6	-2.7
Schizophrenia (2014)	0.2	0.4	0.8	-0.9	0.0	-0.6
Triglycerides	1.7	2.7	6.1	-2.5	0.3	-1.4
Type 2 Diabetes (T2D) (2012)	1.0	1.2	1.5	-1.2	1.0	-1.0
Ulcerative Colitis	0.7	1.0	1.7	1.3	0.5	0.9
Blood Eosinophil Count	0.2	1.6	2.8	-0.6	1.3	-1.7
Blood Platelet Count	1.8	21.1	30.6	4.3	5.5	-3.7
Blood Red Count	0.2	2.2	3.6	-0.3	1.9	-1.7
Blood White Count	0.8	5.6	13.2	3.6	1.8	0.7
Heel T-Score	0.7	5.9	13.7	3.7	1.2	1.6
BMI	4.8	27.8	38.1	-6.0	3.1	-6.2
Height	3.3	62.6	134.6	-11.6	0.3	-7.3
Waist Hip Ratio (WHR)	2.9	13.2	20.4	-4.5	2.2	-3.7
Systolic Blood Pressure	0.6	3.0	6.9	-2.6	-0.2	-1.4
Smoking Status	1.2	2.9	7.8	0.9	2.8	-0.3
Allergy or Eczema	0.4	0.9	1.7	-0.6	1.3	-0.9
Cardiovascular Disease	1.2	4.0	9.8	-3.1	0.0	-1.4
Hypothyroidism (self reported)	0.3	0.6	0.9	-0.7	0.7	-1.0
Respiratory disease	0.2	0.4	1.0	-0.4	1.0	-0.4
Type 2 Diabetes (T2D) (2018)	3.2	5.9	9.9	-3.1	1.2	-2.5
Lung FEV1/FVC ratio	0.0	0.2	0.4	-0.3	0.6	-0.2
Lung FVC	1.9	9.5	19.3	4.4	0.8	2.9
Neuroticism	1.2	2.9	5.4	-1.2	2.3	-1.3
Chronotype (morning person)	0.6	1.5	2.9	1.7	0.4	1.2
Hair Pigment	0.0	0.2	0.3	-0.5	0.4	-0.3
Tanning	0.0	0.2	0.3	0.5	0.3	-0.3
Hand grip strength (left)	1.2	3.2	5.0	-2.2	0.9	-1.9
Number of treatments/medications taken	1.1	2.0	3.9	-2.0	-0.1	-1.4
Average weekly spirits intake	1.3	1.6	3.7	1.9	-0.6	1.0
Sensitivity / hurt feelings	1.2	2.0	3.6	-1.2	1.9	-0.9
Frequency of depressed mood in last 2 weeks	2.1	3.0	5.5	-1.4	2.4	-1.2
Hearing difficulty/problems: Yes	0.8	1.2	1.8	-1.1	0.7	-1.4
Relative age of first facial hair	2.1	4.4	6.8	2.4	-0.8	2.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.1	-1.0	-0.1	-1.0
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.2	0.6	-0.4
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	-1.0	0.2	-0.6
Systolic blood pressure, automated reading	0.3	0.8	1.2	-0.9	1.1	-0.6
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.4	-1.5	-0.0	-1.3
Angina	0.3	0.4	1.1	0.1	-1.1	0.2
Medication for hormone replacement therapy	1.6	1.8	2.1	-1.4	1.1	-1.4
Vitamin and mineral supplements	1.3	1.7	4.5	-0.5	2.1	-0.6
Supplements: Zinc	1.1	1.2	2.7	0.6	-1.6	0.8
Medication: Co-codamol	1.0	1.1	2.2	-1.5	0.1	-1.1
Medication: Metformin	1.5	2.2	2.7	-1.6	1.6	-1.2
Diabetes (father)	0.2	0.2	0.6	0.1	0.3	-0.7
Diabetes (mother)	1.3	1.7	3.1	-1.1	-1.8	-0.8
Severe depression (siblings)	1.5	1.6	3.1	-1.8	-0.5	-1.3
Pack years adult smoking proportion	1.5	2.3	4.2	-2.0	0.1	-1.7
Impedance of leg (right)	0.1	0.4	0.8	-0.5	-0.9	0.2
Leg fat-free mass (left)	3.3	17.7	32.8	-5.7	1.1	-4.4
Trunk fat percentage	4.3	17.2	27.1	-5.2	1.1	-4.8
Hand grip strength (right)	0.8	2.2	4.0	-2.0	0.9	-1.3
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.4	0.4	0.6
Current tobacco smoking	1.8	2.9	6.4	-0.8	2.5	-1.3
Average weekly fortified wine intake	1.8	2.1	3.4	1.8	-0.2	1.7
Maternal smoking around birth	0.1	0.1	0.3	-0.0	0.5	-0.1
Fed-up feelings	0.3	0.5	0.9	-0.8	1.0	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	2.1	-1.5	1.3	-0.8
Relative age voice broke	0.7	1.1	2.3	1.5	0.8	0.7
Taking other prescription medications	1.0	1.6	2.9	-1.7	0.8	-1.0
Age when periods started (menarche)	1.4	3.5	5.6	2.4	0.9	2.0
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.3	-1.1	-1.0	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	-0.3	-0.1	-1.0
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.5	-1.4	0.2	-1.9
Qualifications: CSEs or equivalent	4.3	5.7	8.8	-3.0	-2.2	-1.9
Serious illness, injury or assault to yourself	4.9	6.0	9.4	-2.6	1.3	-3.1
High blood pressure	0.6	1.7	3.5	-1.9	0.4	-1.2
Hayfever, allergic rhinitis or eczema	0.9	1.9	2.8	-1.1	1.7	-1.3
Multivitamins +/- minerals	0.7	0.9	1.9	-0.2	-1.4	-0.8
Stomach or abdominal pain in last month	0.7	0.8	1.5	-1.2	-0.8	-0.5
Supplements: Glucosamine	0.2	0.3	0.7	0.5	-0.0	0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.9	-1.4	-0.6	0.2
Medication: Atenolol	1.5	1.9	4.3	-0.9	-2.1	0.7
Medication: Levothyroxine sodium	0.3	0.4	0.7	-0.8	0.2	-0.8
Sitting height	1.1	7.8	16.5	-4.1	-0.3	-2.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	-0.6	-0.0	-0.5
High blood pressure (mother)	0.6	0.9	1.9	-1.4	-0.9	0.0
Body mass index (BMI)	2.6	11.1	15.2	-3.9	1.8	-3.8
Impedance of leg (left)	0.1	0.3	0.4	-0.6	-0.4	-0.6
Leg predicted mass (left)	3.4	17.8	32.9	-5.7	1.1	-4.4
Trunk fat mass	6.4	27.5	45.3	-6.7	1.4	-5.9
Waist circumference	7.9	28.9	47.4	-6.9	1.9	-6.0
Number of incorrect matches in round	0.9	1.5	1.8	-1.0	1.4	-1.2
Past tobacco smoking	1.1	2.1	5.1	-0.9	-2.3	-0.6
Alcohol usually taken with meals	0.2	0.3	0.5	0.7	0.7	0.2
Nervous feelings	1.2	2.2	3.1	-1.8	1.2	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	3.1	-1.8	1.1	-1.2
Hearing difficulty/problems with background noise	1.2	1.9	4.0	-0.5	2.0	-1.2
Hair/balding pattern: Pattern 2	1.9	2.4	3.7	-1.7	0.8	-1.9
Had menopause	0.6	0.7	1.3	-0.7	-1.2	-0.6
Had other major operations	1.7	2.1	5.0	-0.9	0.7	-2.2
Forced vital capacity (FVC)	0.2	0.7	0.8	0.8	0.8	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	0.1	0.0	-0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.7	-0.9	0.5	-0.5
Qualifications: None of the above	0.4	0.9	1.6	-1.3	0.6	-0.9
Financial difficulties in last 2 years	0.6	0.8	1.8	0.6	1.3	-0.4
Mouth/teeth dental problems	3.0	4.6	7.0	2.4	-0.8	2.7
Heart attack	1.0	1.3	2.8	-1.7	-0.3	-1.0
Allergy	0.6	1.3	2.9	0.5	-1.7	0.9
Pain all over the body in last month	0.9	1.0	1.6	-0.5	1.3	-1.0
Diabetes (self-reported)	2.3	3.5	5.6	-2.4	1.3	-1.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.4	-0.9	0.3	-1.2
Medication: Ramipril	1.0	1.3	2.8	-1.7	-1.1	-0.2
Medication: Simvastatin	0.5	0.8	1.6	0.2	-0.8	1.3
Fluid intelligence score	0.1	0.2	0.4	0.6	0.2	0.5
Illnesses of siblings	2.1	3.0	4.5	2.1	-0.5	2.1
Neuroticism score	1.0	2.1	3.4	-1.2	1.8	-1.2
Weight	6.1	29.9	52.6	-7.2	1.3	-6.0
Impedance of arm (right)	1.0	4.8	5.2	2.2	-2.3	2.1
Arm fat percentage (right)	2.2	8.9	12.7	-3.5	1.4	-3.6
Trunk fat-free mass	4.5	26.0	49.3	-7.0	1.2	-5.2
Hip circumference	4.0	17.2	28.9	-5.4	1.0	-4.7
Time employed in main current job	1.2	1.4	2.5	-1.1	-1.6	-0.5
Alcohol intake versus 10 years previously	1.0	1.5	3.5	-1.0	1.9	0.2
Father’s age at death	3.3	4.5	7.6	2.8	-0.5	2.4
Worrier / anxious feelings	1.4	2.7	4.8	-2.2	0.4	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	-0.1	0.9	-0.1
Falls in the last year	1.1	1.5	2.7	-1.0	1.6	-0.9
Hair/balding pattern: Pattern 3	0.6	0.9	1.8	1.3	-0.2	0.9
Number of live births	0.2	0.3	0.5	0.7	-0.2	0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	0.9	0.9	0.7	1.0
Pulse rate	0.1	0.1	0.3	-0.2	-0.6	0.1
Happiness	0.4	0.5	1.0	1.0	0.5	0.5
Noisy workplace	1.6	2.0	5.5	0.2	-2.3	0.6
Qualifications: A levels/AS levels or equivalent	1.9	4.2	7.1	2.7	0.8	2.2
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.5	4.0	-2.0	1.7	-1.9
Mouth/teeth dental problems: Dentures	0.9	1.4	2.5	-1.3	0.5	-1.6
Asthma	0.2	0.5	0.8	0.7	0.9	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.7	-0.0	0.4	-0.8
Medication: Cholesterol lowering	0.8	1.3	2.9	0.0	-1.0	1.7
Depression (self-reported)	1.0	1.2	1.9	1.2	1.4	0.6
Medication: Lansoprazole	0.5	0.6	1.7	-1.3	-0.3	-0.1
Prospective memory result	0.6	0.7	1.8	-1.3	0.5	-0.0
Lung cancer (father)	0.0	0.0	0.1	-0.3	0.0	-0.1
Illnesses of mother	0.2	0.3	0.7	0.2	0.9	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.4	0.5	0.6	0.6
Pulse wave Arterial Stiffness index	0.8	1.0	2.4	0.4	1.5	0.6
Impedance of arm (left)	1.2	5.6	5.8	2.4	-2.4	2.3
Arm fat mass (right)	5.0	20.8	30.6	-5.5	2.0	-5.3
Trunk predicted mass	4.4	25.4	47.7	-6.9	1.3	-5.2
Standing height	3.2	32.2	66.9	-8.2	-1.0	-5.3
Length of working week for main job	0.2	0.2	0.4	-0.0	0.6	-0.6
Exposure to tobacco smoke at home	2.6	2.9	5.7	-2.4	0.1	-1.7
Breastfed as a baby	1.3	1.6	2.4	1.6	1.1	1.2
Tense / ‘highly strung’	1.4	2.4	5.6	-2.4	0.1	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.2	-0.6	1.1	-0.1
Hair/balding pattern: Pattern 4	1.2	2.8	6.2	0.5	-2.5	1.4
Birth weight of first child	0.5	0.9	2.0	0.6	-0.6	1.4
Peak expiratory flow (PEF)	0.3	0.7	1.1	0.7	1.0	0.8
Pulse wave reflection index	1.9	2.3	3.5	1.6	0.9	1.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	0.5	1.0	-0.7
Loud music exposure frequency	0.4	0.5	0.9	-0.4	-1.0	-0.6
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	2.4	-1.6	1.3	-1.3
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	2.6	-1.4	1.1	-1.6
Blood clot in the leg (DVT)	1.3	1.6	2.5	-1.6	-0.0	-1.6
Medication: Paracetamol	0.6	1.0	2.1	-0.8	0.6	-1.4
Headache pain in last month	1.1	1.9	2.6	-1.6	-0.7	-1.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.6	0.7	0.8	-0.8
Glaucoma (self-reported)	1.4	1.6	2.5	-1.6	-0.9	-1.2
Gout (self-reported)	0.7	0.9	2.3	-0.7	-1.5	-0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.6	-0.5	0.4	-0.8
Medication: Amlodipine	0.6	0.9	2.1	0.4	-1.4	0.6
Medication: Ventolin 100micrograms inhaler	1.9	2.5	4.3	-2.1	-0.2	-1.8
Birth weight	0.1	0.2	0.5	-0.3	-0.7	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.5	0.3	-0.1
High blood pressure (siblings)	0.7	0.9	1.6	-1.2	-0.0	-1.1
Forced vital capacity (FVC), Best measure	0.1	0.3	0.6	0.2	0.8	0.3
Body fat percentage	4.6	18.3	28.1	-5.3	1.6	-4.9
Leg fat percentage (right)	3.8	13.9	21.6	-4.7	2.1	-3.9
Arm fat-free mass (right)	6.2	31.6	56.1	-7.5	1.6	-6.0
Exposure to tobacco smoke outside home	3.8	5.0	9.1	-3.0	-1.4	-2.0
Comparative body size at age 10	1.7	4.8	9.2	-3.0	0.1	-2.3
Number of full brothers	1.0	1.3	2.0	0.0	1.4	-1.4
Worry too long after embarrassment	5.7	9.6	13.0	-2.0	3.6	-3.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.5	-0.6	0.7	0.6
Wheeze or whistling in the chest in last year	1.2	2.1	2.4	-1.5	1.5	-1.2
Number of children fathered	0.0	0.0	0.1	-0.1	-0.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.6	1.6	0.2	0.7
Age at first live birth	1.4	2.5	3.4	1.8	-1.3	1.5
Pulse wave peak to peak time	1.1	1.4	2.4	-0.9	-1.6	-0.9
Health satisfaction	0.2	0.3	0.5	-0.6	-0.1	-0.7
Shortness of breath walking on level ground	1.0	1.2	2.2	-1.5	-0.6	-1.1
Qualifications: College or University degree	2.0	6.2	13.6	3.7	1.3	1.8
Eye problems/disorders: None of the above	0.2	0.3	0.5	0.7	0.4	0.5
Mouth/teeth dental problems: Loose teeth	1.5	1.8	2.4	-1.4	1.0	-1.6
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.4	0.2	0.3
Medication for pain relief, constipation, heartburn	1.3	2.2	3.5	1.9	0.3	1.8
Neck or shoulder pain in last month	0.4	0.6	1.7	-0.4	0.3	-1.3
Medication: Blood pressure	0.5	0.9	1.9	-1.4	-0.8	-0.3
Angina (self-reported)	0.2	0.2	0.6	-0.1	-0.8	-0.1
Migraine (self-reported)	0.2	0.2	0.4	-0.3	0.6	-0.4
Medication: Ibuprofen	0.9	1.1	2.4	-0.7	0.7	-1.5
Medication: Allopurinol	0.7	0.9	2.3	0.0	-1.5	0.6
Medication: Omeprazole	0.3	0.4	1.0	-1.0	0.4	-0.2
Medication: Seretide 50 evohaler	0.3	0.3	0.6	0.2	0.5	0.8
Mean time to correctly identify matches	0.7	1.4	2.5	-1.1	-1.6	-0.6
Heart disease (mother)	1.3	1.6	3.0	-1.7	0.6	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.9	0.9	1.4	0.2
Whole body fat mass	6.8	28.3	44.8	-6.7	2.0	-6.0
Leg fat mass (right)	5.5	21.2	34.1	-5.8	2.2	-5.0
Arm predicted mass (right)	6.1	31.4	55.7	-7.5	1.7	-6.0
Pulse rate, automated reading	1.0	3.2	5.0	-1.7	1.3	-2.2
Alcohol intake frequency.	3.1	7.2	13.9	-3.7	0.9	-2.6
Comparative height size at age 10	5.1	27.9	52.4	-7.2	-0.3	-5.6
Number of full sisters	1.2	1.5	1.9	-1.4	1.1	-1.1
Suffer from ‘nerves’	0.9	1.3	3.1	-1.8	0.0	-0.9
Overall health rating	4.0	8.5	14.6	-3.8	0.1	-3.3
Chest pain or discomfort	1.4	2.0	2.3	-1.5	1.2	-1.5
Had major operations	0.2	0.3	0.5	-0.7	-0.1	-0.6
Age at last live birth	2.4	3.5	6.7	2.6	-0.7	1.8
Family relationship satisfaction	0.4	0.5	1.0	0.6	1.0	0.3
Leg pain on walking	0.2	0.2	0.3	-0.6	-0.1	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	0.2	-0.5	-0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.7	-0.5	0.5	-0.8
Illness, injury, bereavement, stress in last 2 years	5.1	6.2	7.9	2.2	-2.4	2.8
Medication: Aspirin	0.4	0.6	1.5	-1.2	-0.1	-0.5
Supplements: Vitamin C	1.8	2.1	3.2	1.1	-1.4	1.8
Knee pain experienced in last month	0.4	0.7	1.8	-0.4	1.4	-0.1
Hypertension (Self-reported)	0.5	1.4	3.1	-1.8	0.4	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.9	-0.3	1.4	-0.9
Illnesses of father: Heart disease	2.5	3.5	6.7	-2.6	0.4	-1.9
Illnesses of siblings: Diabetes	0.0	0.0	0.0	-0.1	0.1	0.0
Smoking status: Previous	0.6	0.9	1.8	0.6	1.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted	4.6	9.5	20.8	-4.6	-0.5	-2.7
Whole body fat-free mass	4.5	25.9	47.8	-6.9	1.3	-5.3
Leg fat-free mass (right)	3.1	16.5	29.2	-5.4	1.1	-4.4
Arm fat percentage (left)	2.2	8.9	12.4	-3.5	1.4	-3.5
Average weekly red wine intake	6.9	10.1	17.7	4.2	0.9	3.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.8	0.7	0.7	0.9
Mood swings	0.0	0.1	0.1	-0.2	-0.3	0.3
Loneliness, isolation	0.1	0.2	0.4	-0.4	-0.6	0.1
Long-standing illness, disability or infirmity	2.6	4.0	6.8	-2.6	0.8	-2.1
Ever had bowel cancer screening	0.1	0.1	0.2	-0.1	0.4	-0.3
Diabetes diagnosed by doctor	2.7	4.5	6.9	-2.6	1.1	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	-0.8	-0.1	-0.5
Friendships satisfaction	1.9	2.4	5.9	2.4	0.3	1.1
Qualifications: nursing, teaching	0.3	0.5	0.9	0.3	0.9	-0.6
Commuting to job workplace: Walk	3.0	3.2	4.8	2.2	-0.3	2.2
Eye problems/disorders: Cataract	0.2	0.2	0.3	-0.1	-0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.3	-0.5	0.5	-0.5
Medication for cholesterol	1.7	2.6	4.0	1.6	-1.1	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.8	-0.7	-0.3	-0.9
Back pain experienced in last month	5.5	8.0	14.1	-3.8	-0.3	-3.1
Mineral and other dietary supplements	1.1	1.5	2.9	-1.7	0.2	-1.3
Breast cancer (self-reported)	0.1	0.2	0.2	0.4	0.3	0.5
Asthma (self-reported)	0.3	0.5	1.0	0.7	1.0	0.2
Osteoporosis (self-reported)	0.3	0.4	0.9	0.4	-1.0	-0.0
Osteoarthritis (self-reported)	3.0	3.9	8.0	-2.8	0.8	-1.7
Medication: Aspirin	0.4	0.6	1.6	-1.3	-0.2	-0.3
Medication: Gliclazide	4.7	5.4	6.1	-2.5	2.0	-2.4
Illnesses of father: None of the above (group 1)	0.7	0.9	2.0	1.4	0.3	0.8
Smoking status: Current	1.5	2.4	5.9	-0.3	2.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	7.6	2.8	0.6	1.9
Whole body water mass	4.5	25.7	47.2	-6.9	1.4	-5.3
Leg predicted mass (right)	3.1	16.8	29.2	-5.4	1.2	-4.4
Arm fat mass (left)	4.5	18.5	28.0	-5.3	1.8	-4.9
Number of self-reported non-cancer illnesses	0.4	0.7	1.0	-0.8	1.0	-0.6
Average weekly champagne plus white wine intake	1.1	1.6	2.9	1.7	1.1	0.8
Miserableness	0.1	0.2	0.6	-0.1	0.8	0.0
Guilty feelings	0.8	1.1	3.0	0.6	1.7	0.2
Wears glasses or contact lenses	1.4	1.6	2.4	1.5	0.3	1.5
Ever taken oral contraceptive pill	0.9	1.0	2.8	-0.1	-1.7	-0.5
Hearing aid user	2.1	2.4	4.7	1.1	-1.2	2.2
Mother’s age at death	0.1	0.1	0.2	0.1	-0.5	-0.1
Financial situation satisfaction	0.7	0.9	2.3	0.1	1.5	-0.5
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.9	-0.2	1.7	-0.6
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.0	-0.5	-0.1
Eye problems/disorders: Glaucoma	1.2	1.4	1.9	-1.1	-1.4	-1.0
Medication: Blood pressure	1.6	3.1	4.5	-2.1	1.1	-1.9
Pain type(s) experienced in last month: Hip pain	2.0	2.5	4.9	-2.2	-0.6	-1.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	0.4	0.2	0.7
High cholesterol (Self-reported)	0.0	0.1	0.2	-0.3	0.4	0.1
Medication: Bendroflumethiazide	0.2	0.4	0.7	-0.9	-0.4	0.4
Medication: Paracetamol	0.3	0.5	1.0	-0.5	0.5	-1.0
Medication: Lisinopril	0.4	0.6	1.5	-0.1	-0.4	1.2
Medication: Atorvastatin	1.1	1.4	2.0	-0.5	1.4	-1.3
Illnesses of father: High blood pressure	1.5	1.9	3.8	-2.0	-0.5	-1.3
Alcohol drinker status: Never	0.9	1.1	2.0	-1.4	0.3	-1.1
Ever smoked	1.4	2.4	5.3	1.2	2.3	0.6
Basal metabolic rate	5.2	28.7	51.5	-7.2	1.5	-5.7
Leg fat percentage (left)	4.2	15.2	21.1	-4.6	2.4	-4.3
Arm fat-free mass (left)	6.7	33.9	57.8	-7.6	1.9	-6.4
Number of operations (self-reported)	0.6	0.8	1.7	-0.6	0.7	-1.3
Average weekly beer plus cider intake	0.1	0.1	0.3	-0.2	0.2	0.6
Irritability	0.1	0.2	0.4	0.5	0.0	0.6
Risk taking	1.4	2.0	5.6	0.7	2.4	0.2
Ever had prostate specific antigen (PSA) test	2.2	2.5	4.3	2.1	1.8	-0.0
Fractured/broken bones in last 5 years	1.6	2.0	2.7	-1.4	1.6	-1.2
Age started oral contraceptive pill	2.8	3.5	5.0	2.2	-0.7	2.2
Diastolic blood pressure, automated reading	3.3	10.3	13.8	-3.7	1.9	-3.7
Ever depressed for a whole week	0.5	0.6	0.9	-0.4	0.8	-1.0
Unable to work because of sickness or disability	0.8	1.1	2.0	-1.4	-0.3	-1.1
Commuting to job workplace: Cycle	1.6	2.0	3.6	1.9	1.4	0.6
Myopia	1.9	2.7	6.0	1.5	2.4	0.2
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.1	1.8	0.3	0.4
Cholesterol lowering medication	0.3	0.4	0.9	-0.3	0.6	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	-1.1	0.8	-0.4
Pain experienced in last month	1.3	2.1	3.5	1.6	-0.4	1.9
Supplements: Calcium	1.0	1.1	1.6	-0.6	-1.2	-1.3
Basal cell carcinoma (self-reported)	3.6	4.2	8.5	1.8	-1.0	2.9
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.2	-1.5	-0.4	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.4	-1.5	0.2	-1.5
Heart disease (siblings)	2.1	2.6	3.7	-1.9	0.6	-1.9
Alcohol drinker status: Previous	1.7	1.9	4.8	-2.2	-0.3	-0.9
Pack years of smoking	1.0	1.5	3.0	-1.7	0.0	-1.3
Impedance of whole body	0.3	1.7	3.3	0.9	-1.8	0.9
Leg fat mass (left)	5.9	23.2	35.7	-6.0	2.4	-5.3
Arm predicted mass (left)	5.7	29.1	51.0	-7.1	1.6	-5.8