TWAS hub - C18orf45

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0418	0.0204	0.00038	0.021	0.026	0.022	NA	0.029	0.00170	0.00048	0.00150	NA	0.00027
2	TCGA	Prostate Adenocarcinoma	0.0784	0.0329	0.00036	0.006	0.022	0.012	NA	0.010	0.07700	0.00210	0.01600	NA	0.02600
3	TCGA	Soft Tissue Sarcoma	0.0840	0.0340	0.00022	0.056	0.061	0.052	NA	0.057	0.00032	0.00017	0.00049	NA	0.00028

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Waist circumference	7.9	28.9	47.4	-6.9	1.9	-6.0
Average weekly red wine intake	6.9	10.1	17.7	4.2	0.9	3.4
Whole body fat mass	6.8	28.3	44.8	-6.7	2.0	-6.0
Arm fat-free mass (left)	6.7	33.9	57.8	-7.6	1.9	-6.4
Trunk fat mass	6.4	27.5	45.3	-6.7	1.4	-5.9
Arm fat-free mass (right)	6.2	31.6	56.1	-7.5	1.6	-6.0
Weight	6.1	29.9	52.6	-7.2	1.3	-6.0
Arm predicted mass (right)	6.1	31.4	55.7	-7.5	1.7	-6.0
Leg fat mass (left)	5.9	23.2	35.7	-6.0	2.4	-5.3
Worry too long after embarrassment	5.7	9.6	13.0	-2.0	3.6	-3.4
Arm predicted mass (left)	5.7	29.1	51.0	-7.1	1.6	-5.8
Schizophrenia vs Biploar Disorder	5.5	7.3	12.9	-3.6	-0.8	-2.9
Leg fat mass (right)	5.5	21.2	34.1	-5.8	2.2	-5.0
Back pain experienced in last month	5.5	8.0	14.1	-3.8	-0.3	-3.1
Basal metabolic rate	5.2	28.7	51.5	-7.2	1.5	-5.7
Comparative height size at age 10	5.1	27.9	52.4	-7.2	-0.3	-5.6
Illness, injury, bereavement, stress in last 2 years	5.1	6.2	7.9	2.2	-2.4	2.8
Arm fat mass (right)	5.0	20.8	30.6	-5.5	2.0	-5.3
Serious illness, injury or assault to yourself	4.9	6.0	9.4	-2.6	1.3	-3.1
BMI	4.8	27.8	38.1	-6.0	3.1	-6.2
HDL Cholesterol	4.7	7.8	10.5	2.3	-3.2	2.7
Medication: Gliclazide	4.7	5.4	6.1	-2.5	2.0	-2.4
Body fat percentage	4.6	18.3	28.1	-5.3	1.6	-4.9
Forced expiratory volume in 1-second (FEV1), predicted	4.6	9.5	20.8	-4.6	-0.5	-2.7
Trunk fat-free mass	4.5	26.0	49.3	-7.0	1.2	-5.2
Whole body fat-free mass	4.5	25.9	47.8	-6.9	1.3	-5.3
Whole body water mass	4.5	25.7	47.2	-6.9	1.4	-5.3
Arm fat mass (left)	4.5	18.5	28.0	-5.3	1.8	-4.9
Trunk predicted mass	4.4	25.4	47.7	-6.9	1.3	-5.2
Trunk fat percentage	4.3	17.2	27.1	-5.2	1.1	-4.8
Qualifications: CSEs or equivalent	4.3	5.7	8.8	-3.0	-2.2	-1.9
Leg fat percentage (left)	4.2	15.2	21.1	-4.6	2.4	-4.3
Hip circumference	4.0	17.2	28.9	-5.4	1.0	-4.7
Overall health rating	4.0	8.5	14.6	-3.8	0.1	-3.3
Bipolar Disorder (2011)	3.8	3.7	6.4	2.5	0.8	2.0
Leg fat percentage (right)	3.8	13.9	21.6	-4.7	2.1	-3.9
Exposure to tobacco smoke outside home	3.8	5.0	9.1	-3.0	-1.4	-2.0
Basal cell carcinoma (self-reported)	3.6	4.2	8.5	1.8	-1.0	2.9
Worry (Nagel 2018)	3.5	7.3	12.2	-3.5	1.5	-2.8
Rheumatoid Arthritis	3.5	4.8	7.6	-2.5	0.6	-2.7
Leg predicted mass (left)	3.4	17.8	32.9	-5.7	1.1	-4.4
Height	3.3	62.6	134.6	-11.6	0.3	-7.3
Leg fat-free mass (left)	3.3	17.7	32.8	-5.7	1.1	-4.4
Father’s age at death	3.3	4.5	7.6	2.8	-0.5	2.4
Diastolic blood pressure, automated reading	3.3	10.3	13.8	-3.7	1.9	-3.7
Type 2 Diabetes (T2D) (2018)	3.2	5.9	9.9	-3.1	1.2	-2.5
Standing height	3.2	32.2	66.9	-8.2	-1.0	-5.3
Alcohol intake frequency.	3.1	7.2	13.9	-3.7	0.9	-2.6
Leg fat-free mass (right)	3.1	16.5	29.2	-5.4	1.1	-4.4
Leg predicted mass (right)	3.1	16.8	29.2	-5.4	1.2	-4.4
Mouth/teeth dental problems	3.0	4.6	7.0	2.4	-0.8	2.7
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.5	4.0	-2.0	1.7	-1.9
Commuting to job workplace: Walk	3.0	3.2	4.8	2.2	-0.3	2.2
Osteoarthritis (self-reported)	3.0	3.9	8.0	-2.8	0.8	-1.7
Waist Hip Ratio (WHR)	2.9	13.2	20.4	-4.5	2.2	-3.7
Age started oral contraceptive pill	2.8	3.5	5.0	2.2	-0.7	2.2
Fasting Glucose	2.7	3.2	5.7	-0.4	2.4	-1.9
Diabetes diagnosed by doctor	2.7	4.5	6.9	-2.6	1.1	-2.3
Body mass index (BMI)	2.6	11.1	15.2	-3.9	1.8	-3.8
Exposure to tobacco smoke at home	2.6	2.9	5.7	-2.4	0.1	-1.7
Long-standing illness, disability or infirmity	2.6	4.0	6.8	-2.6	0.8	-2.1
Illnesses of father: Heart disease	2.5	3.5	6.7	-2.6	0.4	-1.9
Age at last live birth	2.4	3.5	6.7	2.6	-0.7	1.8
Body Mass Index (BMI) (2010)	2.3	3.1	5.0	-1.9	0.9	-2.2
Diabetes (self-reported)	2.3	3.5	5.6	-2.4	1.3	-1.8
Arm fat percentage (right)	2.2	8.9	12.7	-3.5	1.4	-3.6
Arm fat percentage (left)	2.2	8.9	12.4	-3.5	1.4	-3.5
Ever had prostate specific antigen (PSA) test	2.2	2.5	4.3	2.1	1.8	-0.0
Frequency of depressed mood in last 2 weeks	2.1	3.0	5.5	-1.4	2.4	-1.2
Relative age of first facial hair	2.1	4.4	6.8	2.4	-0.8	2.6
Illnesses of siblings	2.1	3.0	4.5	2.1	-0.5	2.1
Hearing aid user	2.1	2.4	4.7	1.1	-1.2	2.2
Heart disease (siblings)	2.1	2.6	3.7	-1.9	0.6	-1.9
Lupus	2.0	3.1	4.6	-2.1	0.5	-2.2
Qualifications: College or University degree	2.0	6.2	13.6	3.7	1.3	1.8
Pain type(s) experienced in last month: Hip pain	2.0	2.5	4.9	-2.2	-0.6	-1.4
Lung FVC	1.9	9.5	19.3	4.4	0.8	2.9
Hair/balding pattern: Pattern 2	1.9	2.4	3.7	-1.7	0.8	-1.9
Qualifications: A levels/AS levels or equivalent	1.9	4.2	7.1	2.7	0.8	2.2
Pulse wave reflection index	1.9	2.3	3.5	1.6	0.9	1.9
Medication: Ventolin 100micrograms inhaler	1.9	2.5	4.3	-2.1	-0.2	-1.8
Friendships satisfaction	1.9	2.4	5.9	2.4	0.3	1.1
Myopia	1.9	2.7	6.0	1.5	2.4	0.2
Blood Platelet Count	1.8	21.1	30.6	4.3	5.5	-3.7
Current tobacco smoking	1.8	2.9	6.4	-0.8	2.5	-1.3
Average weekly fortified wine intake	1.8	2.1	3.4	1.8	-0.2	1.7
Supplements: Vitamin C	1.8	2.1	3.2	1.1	-1.4	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	7.6	2.8	0.6	1.9
Ovarian Cancer	1.7	2.2	3.3	1.8	0.3	1.8
Triglycerides	1.7	2.7	6.1	-2.5	0.3	-1.4
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.5	-1.4	0.2	-1.9
Had other major operations	1.7	2.1	5.0	-0.9	0.7	-2.2
Comparative body size at age 10	1.7	4.8	9.2	-3.0	0.1	-2.3
Medication for cholesterol	1.7	2.6	4.0	1.6	-1.1	2.0
Alcohol drinker status: Previous	1.7	1.9	4.8	-2.2	-0.3	-0.9
Major Depression (MDD)	1.6	1.9	3.1	1.8	1.2	1.0
Medication for hormone replacement therapy	1.6	1.8	2.1	-1.4	1.1	-1.4
Noisy workplace	1.6	2.0	5.5	0.2	-2.3	0.6
Medication: Blood pressure	1.6	3.1	4.5	-2.1	1.1	-1.9
Fractured/broken bones in last 5 years	1.6	2.0	2.7	-1.4	1.6	-1.2
Commuting to job workplace: Cycle	1.6	2.0	3.6	1.9	1.4	0.6
Medication: Metformin	1.5	2.2	2.7	-1.6	1.6	-1.2
Severe depression (siblings)	1.5	1.6	3.1	-1.8	-0.5	-1.3
Pack years adult smoking proportion	1.5	2.3	4.2	-2.0	0.1	-1.7
Medication: Atenolol	1.5	1.9	4.3	-0.9	-2.1	0.7
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	2.6	-1.4	1.1	-1.6
Mouth/teeth dental problems: Loose teeth	1.5	1.8	2.4	-1.4	1.0	-1.6
Smoking status: Current	1.5	2.4	5.9	-0.3	2.4	-1.1
Illnesses of father: High blood pressure	1.5	1.9	3.8	-2.0	-0.5	-1.3
Bipolar Disorder (2018)	1.4	2.3	3.5	1.9	0.5	1.7
Neuroticism (Nagel 2018)	1.4	3.4	4.4	-2.1	1.6	-1.8
Age when periods started (menarche)	1.4	3.5	5.6	2.4	0.9	2.0
Worrier / anxious feelings	1.4	2.7	4.8	-2.2	0.4	-1.8
Tense / ‘highly strung’	1.4	2.4	5.6	-2.4	0.1	-1.2
Glaucoma (self-reported)	1.4	1.6	2.5	-1.6	-0.9	-1.2
Age at first live birth	1.4	2.5	3.4	1.8	-1.3	1.5
Chest pain or discomfort	1.4	2.0	2.3	-1.5	1.2	-1.5
Wears glasses or contact lenses	1.4	1.6	2.4	1.5	0.3	1.5
Ever smoked	1.4	2.4	5.3	1.2	2.3	0.6
Risk taking	1.4	2.0	5.6	0.7	2.4	0.2
Average weekly spirits intake	1.3	1.6	3.7	1.9	-0.6	1.0
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.4	-1.5	-0.0	-1.3
Vitamin and mineral supplements	1.3	1.7	4.5	-0.5	2.1	-0.6
Diabetes (mother)	1.3	1.7	3.1	-1.1	-1.8	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	3.1	-1.8	1.1	-1.2
Breastfed as a baby	1.3	1.6	2.4	1.6	1.1	1.2
Blood clot in the leg (DVT)	1.3	1.6	2.5	-1.6	-0.0	-1.6
Medication for pain relief, constipation, heartburn	1.3	2.2	3.5	1.9	0.3	1.8
Heart disease (mother)	1.3	1.6	3.0	-1.7	0.6	-1.2
Pain experienced in last month	1.3	2.1	3.5	1.6	-0.4	1.9
Intelligence (Savage-Jansen 2018)	1.2	3.7	5.7	2.4	0.3	2.3
HbA1C	1.2	1.4	1.9	-1.2	0.8	-1.4
Smoking Status	1.2	2.9	7.8	0.9	2.8	-0.3
Cardiovascular Disease	1.2	4.0	9.8	-3.1	0.0	-1.4
Neuroticism	1.2	2.9	5.4	-1.2	2.3	-1.3
Hand grip strength (left)	1.2	3.2	5.0	-2.2	0.9	-1.9
Sensitivity / hurt feelings	1.2	2.0	3.6	-1.2	1.9	-0.9
Nervous feelings	1.2	2.2	3.1	-1.8	1.2	-1.4
Hearing difficulty/problems with background noise	1.2	1.9	4.0	-0.5	2.0	-1.2
Time employed in main current job	1.2	1.4	2.5	-1.1	-1.6	-0.5
Impedance of arm (left)	1.2	5.6	5.8	2.4	-2.4	2.3
Hair/balding pattern: Pattern 4	1.2	2.8	6.2	0.5	-2.5	1.4
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	2.4	-1.6	1.3	-1.3
Wheeze or whistling in the chest in last year	1.2	2.1	2.4	-1.5	1.5	-1.2
Number of full sisters	1.2	1.5	1.9	-1.4	1.1	-1.1
Eye problems/disorders: Glaucoma	1.2	1.4	1.9	-1.1	-1.4	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.4	-1.5	0.2	-1.5
Reaction Time	1.1	2.1	2.8	-1.6	-1.7	-0.9
Number of treatments/medications taken	1.1	2.0	3.9	-2.0	-0.1	-1.4
Supplements: Zinc	1.1	1.2	2.7	0.6	-1.6	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	2.1	-1.5	1.3	-0.8
Sitting height	1.1	7.8	16.5	-4.1	-0.3	-2.6
Past tobacco smoking	1.1	2.1	5.1	-0.9	-2.3	-0.6
Falls in the last year	1.1	1.5	2.7	-1.0	1.6	-0.9
Headache pain in last month	1.1	1.9	2.6	-1.6	-0.7	-1.6
Pulse wave peak to peak time	1.1	1.4	2.4	-0.9	-1.6	-0.9
Mineral and other dietary supplements	1.1	1.5	2.9	-1.7	0.2	-1.3
Average weekly champagne plus white wine intake	1.1	1.6	2.9	1.7	1.1	0.8
Medication: Atorvastatin	1.1	1.4	2.0	-0.5	1.4	-1.3
Irritable Bowel Disease (IBD)	1.0	2.4	7.0	-0.0	2.6	-0.4
Type 2 Diabetes (T2D) (2012)	1.0	1.2	1.5	-1.2	1.0	-1.0
Medication: Co-codamol	1.0	1.1	2.2	-1.5	0.1	-1.1
Taking other prescription medications	1.0	1.6	2.9	-1.7	0.8	-1.0
Heart attack	1.0	1.3	2.8	-1.7	-0.3	-1.0
Medication: Ramipril	1.0	1.3	2.8	-1.7	-1.1	-0.2
Neuroticism score	1.0	2.1	3.4	-1.2	1.8	-1.2
Impedance of arm (right)	1.0	4.8	5.2	2.2	-2.3	2.1
Alcohol intake versus 10 years previously	1.0	1.5	3.5	-1.0	1.9	0.2
Depression (self-reported)	1.0	1.2	1.9	1.2	1.4	0.6
Number of full brothers	1.0	1.3	2.0	0.0	1.4	-1.4
Shortness of breath walking on level ground	1.0	1.2	2.2	-1.5	-0.6	-1.1
Pulse rate, automated reading	1.0	3.2	5.0	-1.7	1.3	-2.2
Supplements: Calcium	1.0	1.1	1.6	-0.6	-1.2	-1.3
Pack years of smoking	1.0	1.5	3.0	-1.7	0.0	-1.3
Alzheimer’s Disease (in mother)	0.9	1.0	1.6	1.2	1.2	0.2
Alzheimer’s Disease (in father)	0.9	1.0	2.1	0.0	1.5	-0.9
Age at First Birth	0.9	1.4	2.8	1.7	-0.2	1.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.3	-1.1	-1.0	-1.0
Hayfever, allergic rhinitis or eczema	0.9	1.9	2.8	-1.1	1.7	-1.3
Number of incorrect matches in round	0.9	1.5	1.8	-1.0	1.4	-1.2
Pain all over the body in last month	0.9	1.0	1.6	-0.5	1.3	-1.0
Mouth/teeth dental problems: Dentures	0.9	1.4	2.5	-1.3	0.5	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.6	1.6	0.2	0.7
Medication: Ibuprofen	0.9	1.1	2.4	-0.7	0.7	-1.5
Suffer from ‘nerves’	0.9	1.3	3.1	-1.8	0.0	-0.9
Ever taken oral contraceptive pill	0.9	1.0	2.8	-0.1	-1.7	-0.5
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.9	-0.2	1.7	-0.6
Alcohol drinker status: Never	0.9	1.1	2.0	-1.4	0.3	-1.1
Alzheimer’s Disease (including proxy)	0.8	1.2	2.4	1.6	0.9	0.5
Crohns Disease (2017)	0.8	1.8	3.8	-0.6	1.9	-1.1
Neuroticism (2016)	0.8	1.1	1.5	-1.2	0.8	-1.1
Blood White Count	0.8	5.6	13.2	3.6	1.8	0.7
Hearing difficulty/problems: Yes	0.8	1.2	1.8	-1.1	0.7	-1.4
Hand grip strength (right)	0.8	2.2	4.0	-2.0	0.9	-1.3
Medication: Cholesterol lowering	0.8	1.3	2.9	0.0	-1.0	1.7
Pulse wave Arterial Stiffness index	0.8	1.0	2.4	0.4	1.5	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.9	0.9	1.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.9	-0.3	1.4	-0.9
Guilty feelings	0.8	1.1	3.0	0.6	1.7	0.2
Unable to work because of sickness or disability	0.8	1.1	2.0	-1.4	-0.3	-1.1
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.2	-1.5	-0.4	-0.8
Schizophrenia (2018)	0.7	1.4	2.6	-1.6	0.7	-1.1
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.7	1.5	0.4	1.7
LDL Cholesterol	0.7	1.1	1.9	-1.4	0.3	-1.2
Ulcerative Colitis	0.7	1.0	1.7	1.3	0.5	0.9
Heel T-Score	0.7	5.9	13.7	3.7	1.2	1.6
Relative age voice broke	0.7	1.1	2.3	1.5	0.8	0.7
Multivitamins +/- minerals	0.7	0.9	1.9	-0.2	-1.4	-0.8
Stomach or abdominal pain in last month	0.7	0.8	1.5	-1.2	-0.8	-0.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.9	-1.4	-0.6	0.2
Gout (self-reported)	0.7	0.9	2.3	-0.7	-1.5	-0.0
High blood pressure (siblings)	0.7	0.9	1.6	-1.2	-0.0	-1.1
Medication: Allopurinol	0.7	0.9	2.3	0.0	-1.5	0.6
Mean time to correctly identify matches	0.7	1.4	2.5	-1.1	-1.6	-0.6
Illnesses of father: None of the above (group 1)	0.7	0.9	2.0	1.4	0.3	0.8
Financial situation satisfaction	0.7	0.9	2.3	0.1	1.5	-0.5
Depression (Nagel 2018)	0.6	0.9	1.4	-1.1	1.2	-0.2
Ulcerative Colitis (UC)	0.6	1.2	2.9	0.7	1.7	0.5
Systolic Blood Pressure	0.6	3.0	6.9	-2.6	-0.2	-1.4
Chronotype (morning person)	0.6	1.5	2.9	1.7	0.4	1.2
High blood pressure	0.6	1.7	3.5	-1.9	0.4	-1.2
High blood pressure (mother)	0.6	0.9	1.9	-1.4	-0.9	0.0
Had menopause	0.6	0.7	1.3	-0.7	-1.2	-0.6
Financial difficulties in last 2 years	0.6	0.8	1.8	0.6	1.3	-0.4
Allergy	0.6	1.3	2.9	0.5	-1.7	0.9
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.4	-0.9	0.3	-1.2
Hair/balding pattern: Pattern 3	0.6	0.9	1.8	1.3	-0.2	0.9
Prospective memory result	0.6	0.7	1.8	-1.3	0.5	-0.0
Medication: Paracetamol	0.6	1.0	2.1	-0.8	0.6	-1.4
Medication: Amlodipine	0.6	0.9	2.1	0.4	-1.4	0.6
Smoking status: Previous	0.6	0.9	1.8	0.6	1.3	0.7
Number of operations (self-reported)	0.6	0.8	1.7	-0.6	0.7	-1.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.1	-1.0	-0.1	-1.0
Medication: Simvastatin	0.5	0.8	1.6	0.2	-0.8	1.3
Medication: Lansoprazole	0.5	0.6	1.7	-1.3	-0.3	-0.1
Birth weight of first child	0.5	0.9	2.0	0.6	-0.6	1.4
Medication: Blood pressure	0.5	0.9	1.9	-1.4	-0.8	-0.3
Hypertension (Self-reported)	0.5	1.4	3.1	-1.8	0.4	-1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.8	0.7	0.7	0.9
Ever depressed for a whole week	0.5	0.6	0.9	-0.4	0.8	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	-1.1	0.8	-0.4
Prostate Cancer	0.4	0.6	1.5	0.5	1.2	-0.1
Allergy or Eczema	0.4	0.9	1.7	-0.6	1.3	-0.9
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	-1.0	0.2	-0.6
Qualifications: None of the above	0.4	0.9	1.6	-1.3	0.6	-0.9
Happiness	0.4	0.5	1.0	1.0	0.5	0.5
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	0.5	1.0	-0.7
Loud music exposure frequency	0.4	0.5	0.9	-0.4	-1.0	-0.6
Neck or shoulder pain in last month	0.4	0.6	1.7	-0.4	0.3	-1.3
Family relationship satisfaction	0.4	0.5	1.0	0.6	1.0	0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.7	-0.5	0.5	-0.8
Medication: Aspirin	0.4	0.6	1.5	-1.2	-0.1	-0.5
Knee pain experienced in last month	0.4	0.7	1.8	-0.4	1.4	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.8	-0.7	-0.3	-0.9
Medication: Aspirin	0.4	0.6	1.6	-1.3	-0.2	-0.3
Number of self-reported non-cancer illnesses	0.4	0.7	1.0	-0.8	1.0	-0.6
Medication: Lisinopril	0.4	0.6	1.5	-0.1	-0.4	1.2
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.1	1.8	0.3	0.4
Hypothyroidism (self reported)	0.3	0.6	0.9	-0.7	0.7	-1.0
Systolic blood pressure, automated reading	0.3	0.8	1.2	-0.9	1.1	-0.6
Angina	0.3	0.4	1.1	0.1	-1.1	0.2
Fed-up feelings	0.3	0.5	0.9	-0.8	1.0	0.2
Medication: Levothyroxine sodium	0.3	0.4	0.7	-0.8	0.2	-0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.7	-0.9	0.5	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.2	-0.6	1.1	-0.1
Peak expiratory flow (PEF)	0.3	0.7	1.1	0.7	1.0	0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.6	0.7	0.8	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.5	-0.6	0.7	0.6
Medication: Omeprazole	0.3	0.4	1.0	-1.0	0.4	-0.2
Medication: Seretide 50 evohaler	0.3	0.3	0.6	0.2	0.5	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	-0.8	-0.1	-0.5
Qualifications: nursing, teaching	0.3	0.5	0.9	0.3	0.9	-0.6
Asthma (self-reported)	0.3	0.5	1.0	0.7	1.0	0.2
Osteoporosis (self-reported)	0.3	0.4	0.9	0.4	-1.0	-0.0
Medication: Paracetamol	0.3	0.5	1.0	-0.5	0.5	-1.0
Cholesterol lowering medication	0.3	0.4	0.9	-0.3	0.6	-1.0
Impedance of whole body	0.3	1.7	3.3	0.9	-1.8	0.9
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	-0.9	0.5	-0.3
Coronary Artery Disease (CAD)	0.2	0.3	0.5	-0.0	-0.7	0.5
Mean Putamen Volume	0.2	0.3	0.5	0.5	-0.1	0.7
Primary Biliary Cirrhosis	0.2	0.2	0.6	0.8	0.1	0.3
Schizophrenia (2014)	0.2	0.4	0.8	-0.9	0.0	-0.6
Blood Eosinophil Count	0.2	1.6	2.8	-0.6	1.3	-1.7
Blood Red Count	0.2	2.2	3.6	-0.3	1.9	-1.7
Respiratory disease	0.2	0.4	1.0	-0.4	1.0	-0.4
Diabetes (father)	0.2	0.2	0.6	0.1	0.3	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	-0.3	-0.1	-1.0
Supplements: Glucosamine	0.2	0.3	0.7	0.5	-0.0	0.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	-0.6	-0.0	-0.5
Alcohol usually taken with meals	0.2	0.3	0.5	0.7	0.7	0.2
Forced vital capacity (FVC)	0.2	0.7	0.8	0.8	0.8	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	-0.1	0.9	-0.1
Number of live births	0.2	0.3	0.5	0.7	-0.2	0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	0.9	0.9	0.7	1.0
Asthma	0.2	0.5	0.8	0.7	0.9	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.7	-0.0	0.4	-0.8
Illnesses of mother	0.2	0.3	0.7	0.2	0.9	0.2
Length of working week for main job	0.2	0.2	0.4	-0.0	0.6	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.6	-0.5	0.4	-0.8
Health satisfaction	0.2	0.3	0.5	-0.6	-0.1	-0.7
Eye problems/disorders: None of the above	0.2	0.3	0.5	0.7	0.4	0.5
Angina (self-reported)	0.2	0.2	0.6	-0.1	-0.8	-0.1
Migraine (self-reported)	0.2	0.2	0.4	-0.3	0.6	-0.4
Had major operations	0.2	0.3	0.5	-0.7	-0.1	-0.6
Leg pain on walking	0.2	0.2	0.3	-0.6	-0.1	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	0.2	-0.5	-0.5
Eye problems/disorders: Cataract	0.2	0.2	0.3	-0.1	-0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.3	-0.5	0.5	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	0.4	0.2	0.7
Medication: Bendroflumethiazide	0.2	0.4	0.7	-0.9	-0.4	0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	-0.1	0.9	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.2	0.6	-0.4
Impedance of leg (right)	0.1	0.4	0.8	-0.5	-0.9	0.2
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.4	0.4	0.6
Maternal smoking around birth	0.1	0.1	0.3	-0.0	0.5	-0.1
Impedance of leg (left)	0.1	0.3	0.4	-0.6	-0.4	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	0.1	0.0	-0.9
Fluid intelligence score	0.1	0.2	0.4	0.6	0.2	0.5
Pulse rate	0.1	0.1	0.3	-0.2	-0.6	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.4	0.5	0.6	0.6
Birth weight	0.1	0.2	0.5	-0.3	-0.7	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.5	0.3	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	0.6	0.2	0.8	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.4	0.2	0.3
Loneliness, isolation	0.1	0.2	0.4	-0.4	-0.6	0.1
Ever had bowel cancer screening	0.1	0.1	0.2	-0.1	0.4	-0.3
Breast cancer (self-reported)	0.1	0.2	0.2	0.4	0.3	0.5
Miserableness	0.1	0.2	0.6	-0.1	0.8	0.0
Mother’s age at death	0.1	0.1	0.2	0.1	-0.5	-0.1
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.0	-0.5	-0.1
Average weekly beer plus cider intake	0.1	0.1	0.3	-0.2	0.2	0.6
Irritability	0.1	0.2	0.4	0.5	0.0	0.6
Breast Cancer	0.0	0.1	0.2	-0.4	-0.4	0.0
Crohns Disease (2012)	0.0	0.0	0.1	0.1	-0.0	-0.3
Lung FEV1/FVC ratio	0.0	0.2	0.4	-0.3	0.6	-0.2
Hair Pigment	0.0	0.2	0.3	-0.5	0.4	-0.3
Tanning	0.0	0.2	0.3	0.5	0.3	-0.3
Lung cancer (father)	0.0	0.0	0.1	-0.3	0.0	-0.1
Number of children fathered	0.0	0.0	0.1	-0.1	-0.1	-0.3
Illnesses of siblings: Diabetes	0.0	0.0	0.0	-0.1	0.1	0.0
Mood swings	0.0	0.1	0.1	-0.2	-0.3	0.3
High cholesterol (Self-reported)	0.0	0.1	0.2	-0.3	0.4	0.1

Hub : Genes

C18orf45

Models

Trait associations