[Hub]/) : Traits : Leg fat-free mass (right) :

chr1:752,566-3,191,909

Best TWAS P=4.21e-10 · Best GWAS P=9.41e-09 conditioned to 0.00368

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RER1 0.06 0.00 blup 359 0.01 8.1e-03 1.5 -5.2 2.4e-07 -0.01 0.04 0.11 FALSE
2 CommonMind Brain Pre-frontal Cortex SLC35E2 0.35 0.15 enet 24 0.17 1.0e-20 -5.7 5.2 1.5e-07 0.32 0.01 0.99 FALSE
3 GTEx Adipose Subcutaneous C1orf86 0.15 0.05 enet 10 0.04 2.0e-04 -4.9 -6.0 2.5e-09 -0.11 0.21 0.53 FALSE
4 GTEx Adipose Visceral Omentum RP1-283E3.4 0.26 0.05 enet 25 0.16 1.5e-08 -2.3 -5.2 1.8e-07 -0.27 0.14 0.15 TRUE
5 GTEx Brain Cerebellar Hemisphere NADK 0.18 0.11 lasso 7 0.09 3.1e-03 -5.2 -5.3 9.6e-08 -0.27 0.03 0.63 FALSE
6 GTEx Brain Cerebellar Hemisphere RP5-890O3.9 0.24 0.02 lasso 9 0.02 1.3e-01 -5.7 6.1 1.3e-09 0.28 0.02 0.61 TRUE
7 GTEx Esophagus Gastroesophageal Junction RP11-181G12.2 0.16 0.02 enet 18 0.01 1.1e-01 5.0 5.2 2.3e-07 0.01 0.09 0.23 FALSE
8 GTEx Esophagus Muscularis RP11-181G12.2 0.23 0.14 lasso 4 0.19 1.0e-11 4.6 5.6 2.6e-08 0.00 0.32 0.67 TRUE
9 GTEx Lung NADK 0.07 0.03 lasso 3 0.02 8.5e-03 4.5 -5.2 2.5e-07 -0.27 0.04 0.87 FALSE
10 GTEx Lung AL590822.2 0.09 0.00 lasso 3 0.00 2.0e-01 4.9 5.3 1.1e-07 0.06 0.08 0.17 FALSE
11 GTEx Muscle Skeletal NADK 0.06 0.00 enet 9 0.00 1.3e-01 -5.2 -5.5 4.3e-08 -0.23 0.06 0.80 FALSE
12 GTEx Muscle Skeletal C1orf86 0.20 0.16 lasso 4 0.15 8.0e-15 -4.9 -5.1 3.1e-07 -0.02 0.27 0.73 FALSE
13 GTEx Muscle Skeletal TMEM52 0.11 0.08 lasso 6 0.10 7.2e-10 -5.2 5.3 1.4e-07 0.26 0.13 0.87 FALSE
14 GTEx Nerve Tibial RP11-181G12.2 0.24 0.22 lasso 5 0.21 3.7e-15 -4.9 5.2 2.1e-07 0.02 0.27 0.73 FALSE
15 GTEx Skin Sun Exposed Lower leg TMEM52 0.17 0.14 lasso 7 0.15 2.0e-12 5.1 5.2 2.2e-07 0.26 0.07 0.93 FALSE
16 GTEx Thyroid PRKCZ 0.16 0.03 lasso 4 0.08 1.9e-06 -4.8 -5.2 1.5e-07 0.04 0.24 0.18 FALSE
17 METSIM Adipose TNFRSF14 0.07 0.05 blup 373 0.05 1.9e-07 4.5 6.2 4.2e-10 -0.01 0.34 0.62 TRUE
18 ROSMAP Brain Pre-frontal Cortex C1orf222 0.11 0.14 enet 18 0.14 1.8e-17 -3.8 5.2 2.2e-07 0.22 0.95 0.04 FALSE