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chr7:75,913,086-78,122,616

Best TWAS P=2.07e-15 · Best GWAS P=1.54e-12 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DTX2P1-UPK3BP1-PMS2P11	0.18	0.09	enet	21	0.12	6.1e-15	6.50	7.9	2.1e-15	0.82	0.00	1.00	TRUE
8	GTEx	Brain Frontal Cortex BA9	GSAP	0.38	0.22	lasso	6	0.21	3.0e-06	4.89	-6.0	2.4e-09	-0.13	0.14	0.20	TRUE
23	ROSMAP	Brain Pre-frontal Cortex	RSBN1L	0.09	0.07	enet	42	0.08	9.9e-11	-4.37	-6.0	2.7e-09	-0.03	0.09	0.91	TRUE
4	GTEx	Artery Aorta	GSAP	0.19	0.07	lasso	2	0.04	2.8e-03	4.78	-5.3	1.1e-07	-0.03	0.26	0.03	TRUE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PMS2L11	0.05	0.02	enet	3	0.06	2.5e-07	-0.37	5.3	1.1e-07	0.71	0.01	0.97	TRUE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM60	0.02	0.02	lasso	1	0.02	2.3e-05	5.72	-5.7	1.1e-08	0.00	0.00	1.00	FALSE
3	GTEx	Adipose Visceral Omentum	TMEM60	0.20	0.13	lasso	8	0.11	2.3e-06	-5.50	-5.6	2.3e-08	-0.01	0.07	0.93	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSBN1L	0.02	0.02	blup	58	0.02	3.4e-03	-5.33	5.6	2.6e-08	0.01	0.02	0.82	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM60	0.02	0.03	blup	29	0.02	6.8e-03	5.72	-5.6	2.6e-08	-0.01	0.00	0.92	FALSE
13	GTEx	Muscle Skeletal	TMEM60	0.11	0.12	lasso	4	0.12	4.6e-12	-5.33	5.5	3.2e-08	0.02	0.02	0.98	FALSE
6	GTEx	Artery Tibial	TMEM60	0.07	0.05	enet	12	0.02	6.6e-03	-5.33	-5.5	3.7e-08	0.00	0.03	0.94	FALSE
21	GTEx	Whole Blood	TMEM60	0.05	0.04	enet	7	0.03	5.4e-04	-5.18	-5.5	4.5e-08	-0.02	0.04	0.96	FALSE
20	GTEx	Thyroid	AC007000.12	0.13	0.08	enet	24	0.07	2.6e-06	-4.73	-5.5	4.7e-08	-0.18	0.66	0.02	FALSE
22	METSIM	Adipose	TMEM60	0.10	0.07	enet	9	0.08	2.1e-12	5.41	-5.4	6.4e-08	-0.02	0.01	0.99	FALSE
19	GTEx	Testis	RSBN1L-AS1	0.16	0.12	lasso	8	0.16	1.5e-07	-4.94	-5.3	8.7e-08	0.00	0.10	0.89	FALSE
18	GTEx	Skin Sun Exposed Lower leg	DTX2P1	0.16	0.03	enet	22	0.05	4.8e-05	7.07	5.3	9.2e-08	0.70	0.00	0.99	FALSE
17	GTEx	Skin Sun Exposed Lower leg	TMEM60	0.10	0.10	lasso	3	0.09	1.4e-07	-5.33	-5.3	9.6e-08	-0.01	0.02	0.98	FALSE
14	GTEx	Nerve Tibial	TMEM60	0.14	0.14	lasso	8	0.12	1.1e-08	-5.33	-5.3	1.0e-07	-0.02	0.05	0.95	FALSE
2	GTEx	Adipose Subcutaneous	RP11-467H10.2	0.12	0.00	lasso	6	0.01	2.1e-02	2.88	5.3	1.2e-07	0.05	0.13	0.04	FALSE
9	GTEx	Cells Transformed fibroblasts	TMEM60	0.25	0.20	lasso	4	0.20	1.5e-14	-5.33	-5.3	1.3e-07	-0.02	0.03	0.97	FALSE
29	The Cancer Genome Atlas	Soft Tissue Sarcoma	PHTF2	0.06	0.04	blup	72	0.04	2.0e-03	5.16	-5.3	1.4e-07	-0.01	0.04	0.73	FALSE
15	GTEx	Ovary	TMEM60	0.23	0.19	enet	7	0.13	5.2e-04	-5.08	-5.2	1.5e-07	0.01	0.07	0.64	FALSE
12	GTEx	Esophagus Mucosa	TMEM60	0.06	0.04	lasso	2	0.04	1.0e-03	-5.33	-5.2	1.7e-07	-0.02	0.03	0.96	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	RSBN1L-AS1	0.38	0.41	lasso	12	0.44	1.2e-17	-5.50	-5.2	1.9e-07	-0.03	0.06	0.94	FALSE
7	GTEx	Brain Cerebellum	RSBN1L	0.14	0.12	lasso	2	0.13	1.3e-04	4.89	5.2	2.3e-07	0.05	0.06	0.88	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	PMS2L11	0.02	0.01	blup	6	0.02	9.7e-04	-0.80	5.2	2.4e-07	0.76	0.00	0.70	FALSE
5	GTEx	Artery Tibial	PTPN12	0.25	0.13	lasso	8	0.12	1.8e-09	5.09	-5.2	2.6e-07	0.05	0.13	0.87	FALSE
10	GTEx	Colon Sigmoid	RSBN1L	0.17	0.09	lasso	2	0.05	5.5e-03	-5.01	-5.1	2.7e-07	-0.03	0.07	0.74	FALSE
16	GTEx	Pituitary	TMEM60	0.19	0.06	lasso	6	0.04	2.8e-02	4.59	-5.1	2.8e-07	-0.02	0.06	0.85	FALSE