[Hub]/) : Traits : Leg fat-free mass (right) :

chr7:75,913,086-78,122,616

Best TWAS P=2.07e-15 · Best GWAS P=1.54e-12 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DTX2P1-UPK3BP1-PMS2P11 0.18 0.09 enet 21 0.12 6.1e-15 6.50 7.9 2.1e-15 0.82 0.00 1.00 TRUE
2 GTEx Adipose Subcutaneous RP11-467H10.2 0.12 0.00 lasso 6 0.01 2.1e-02 2.88 5.3 1.2e-07 0.05 0.13 0.04 FALSE
3 GTEx Adipose Visceral Omentum TMEM60 0.20 0.13 lasso 8 0.11 2.3e-06 -5.50 -5.6 2.3e-08 -0.01 0.07 0.93 FALSE
4 GTEx Artery Aorta GSAP 0.19 0.07 lasso 2 0.04 2.8e-03 4.78 -5.3 1.1e-07 -0.03 0.26 0.03 TRUE
5 GTEx Artery Tibial PTPN12 0.25 0.13 lasso 8 0.12 1.8e-09 5.09 -5.2 2.6e-07 0.05 0.13 0.87 FALSE
6 GTEx Artery Tibial TMEM60 0.07 0.05 enet 12 0.02 6.6e-03 -5.33 -5.5 3.7e-08 0.00 0.03 0.94 FALSE
7 GTEx Brain Cerebellum RSBN1L 0.14 0.12 lasso 2 0.13 1.3e-04 4.89 5.2 2.3e-07 0.05 0.06 0.88 FALSE
8 GTEx Brain Frontal Cortex BA9 GSAP 0.38 0.22 lasso 6 0.21 3.0e-06 4.89 -6.0 2.4e-09 -0.13 0.14 0.20 TRUE
9 GTEx Cells Transformed fibroblasts TMEM60 0.25 0.20 lasso 4 0.20 1.5e-14 -5.33 -5.3 1.3e-07 -0.02 0.03 0.97 FALSE
10 GTEx Colon Sigmoid RSBN1L 0.17 0.09 lasso 2 0.05 5.5e-03 -5.01 -5.1 2.7e-07 -0.03 0.07 0.74 FALSE
11 GTEx Esophagus Gastroesophageal Junction RSBN1L-AS1 0.38 0.41 lasso 12 0.44 1.2e-17 -5.50 -5.2 1.9e-07 -0.03 0.06 0.94 FALSE
12 GTEx Esophagus Mucosa TMEM60 0.06 0.04 lasso 2 0.04 1.0e-03 -5.33 -5.2 1.7e-07 -0.02 0.03 0.96 FALSE
13 GTEx Muscle Skeletal TMEM60 0.11 0.12 lasso 4 0.12 4.6e-12 -5.33 5.5 3.2e-08 0.02 0.02 0.98 FALSE
14 GTEx Nerve Tibial TMEM60 0.14 0.14 lasso 8 0.12 1.1e-08 -5.33 -5.3 1.0e-07 -0.02 0.05 0.95 FALSE
15 GTEx Ovary TMEM60 0.23 0.19 enet 7 0.13 5.2e-04 -5.08 -5.2 1.5e-07 0.01 0.07 0.64 FALSE
16 GTEx Pituitary TMEM60 0.19 0.06 lasso 6 0.04 2.8e-02 4.59 -5.1 2.8e-07 -0.02 0.06 0.85 FALSE
17 GTEx Skin Sun Exposed Lower leg TMEM60 0.10 0.10 lasso 3 0.09 1.4e-07 -5.33 -5.3 9.6e-08 -0.01 0.02 0.98 FALSE
18 GTEx Skin Sun Exposed Lower leg DTX2P1 0.16 0.03 enet 22 0.05 4.8e-05 7.07 5.3 9.2e-08 0.70 0.00 0.99 FALSE
19 GTEx Testis RSBN1L-AS1 0.16 0.12 lasso 8 0.16 1.5e-07 -4.94 -5.3 8.7e-08 0.00 0.10 0.89 FALSE
20 GTEx Thyroid AC007000.12 0.13 0.08 enet 24 0.07 2.6e-06 -4.73 -5.5 4.7e-08 -0.18 0.66 0.02 FALSE
21 GTEx Whole Blood TMEM60 0.05 0.04 enet 7 0.03 5.4e-04 -5.18 -5.5 4.5e-08 -0.02 0.04 0.96 FALSE
22 METSIM Adipose TMEM60 0.10 0.07 enet 9 0.08 2.1e-12 5.41 -5.4 6.4e-08 -0.02 0.01 0.99 FALSE
23 ROSMAP Brain Pre-frontal Cortex RSBN1L 0.09 0.07 enet 42 0.08 9.9e-11 -4.37 -6.0 2.7e-09 -0.03 0.09 0.91 TRUE
24 The Cancer Genome Atlas Breast Invasive Carcinoma TMEM60 0.02 0.02 lasso 1 0.02 2.3e-05 5.72 -5.7 1.1e-08 0.00 0.00 1.00 FALSE
25 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PMS2L11 0.05 0.02 enet 3 0.06 2.5e-07 -0.37 5.3 1.1e-07 0.71 0.01 0.97 TRUE
26 The Cancer Genome Atlas Brain Lower Grade Glioma PMS2L11 0.02 0.01 blup 6 0.02 9.7e-04 -0.80 5.2 2.4e-07 0.76 0.00 0.70 FALSE
27 The Cancer Genome Atlas Brain Lower Grade Glioma RSBN1L 0.02 0.02 blup 58 0.02 3.4e-03 -5.33 5.6 2.6e-08 0.01 0.02 0.82 FALSE
28 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TMEM60 0.02 0.03 blup 29 0.02 6.8e-03 5.72 -5.6 2.6e-08 -0.01 0.00 0.92 FALSE
29 The Cancer Genome Atlas Soft Tissue Sarcoma PHTF2 0.06 0.04 blup 72 0.04 2.0e-03 5.16 -5.3 1.4e-07 -0.01 0.04 0.73 FALSE