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chr11:198,510-1,534,852

Best TWAS P=5.07e-11 · Best GWAS P=8.81e-11 conditioned to 0.0897

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	POLR2L	0.09	0.09	enet	16	0.10	4.6e-12	-4.2	-6.0	2.4e-09	0.85	0.09	0.91	FALSE
2	GTEx	Brain Frontal Cortex BA9	AP006621.5	0.18	0.03	lasso	6	0.04	2.6e-02	-5.0	5.3	1.4e-07	-0.48	0.07	0.48	FALSE
3	GTEx	Brain Hypothalamus	PNPLA2	0.23	-0.01	lasso	9	0.00	4.0e-01	-5.0	-5.2	1.6e-07	0.51	0.05	0.26	FALSE
4	GTEx	Cells Transformed fibroblasts	POLR2L	0.12	0.11	lasso	5	0.12	5.2e-09	-4.3	-5.2	2.3e-07	0.73	0.65	0.35	FALSE
5	GTEx	Colon Transverse	CD151	0.24	0.29	lasso	3	0.27	2.7e-13	-5.3	5.2	1.9e-07	-0.59	0.48	0.52	FALSE
6	GTEx	Heart Left Ventricle	CD151	0.27	0.10	enet	47	0.10	5.5e-06	-5.3	6.4	2.0e-10	-0.49	0.31	0.66	FALSE
7	GTEx	Nerve Tibial	CD151	0.32	0.24	lasso	6	0.21	6.3e-15	-5.3	5.2	2.3e-07	-0.63	0.48	0.52	FALSE
8	GTEx	Pancreas	EFCAB4A	0.23	0.19	enet	8	0.16	4.1e-07	-5.4	5.5	5.1e-08	-0.51	0.44	0.55	FALSE
9	GTEx	Skin Sun Exposed Lower leg	CD151	0.16	0.16	lasso	4	0.15	3.5e-12	-5.3	5.2	2.2e-07	-0.59	0.49	0.51	FALSE
10	GTEx	Testis	CD151	0.39	0.29	lasso	11	0.24	6.0e-11	-5.3	5.3	1.0e-07	-0.62	0.51	0.49	FALSE
11	GTEx	Testis	POLR2L	0.16	0.03	enet	10	0.03	1.9e-02	-6.5	-6.6	5.1e-11	0.85	0.00	0.99	TRUE
12	METSIM	Adipose	POLR2L	0.03	0.02	bslmm	413	0.01	5.0e-03	-4.7	-6.2	5.5e-10	0.57	0.25	0.10	FALSE
13	YFS	Blood	POLR2L	0.26	0.19	bslmm	383	0.30	2.4e-98	-4.2	6.1	1.2e-09	-0.78	0.48	0.47	FALSE
14	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHID1	0.06	0.05	blup	67	0.03	2.0e-02	3.8	-5.6	1.7e-08	0.73	0.04	0.32	FALSE
15	The Cancer Genome Atlas	Glioblastoma Multiforme	CD151	0.13	0.02	blup	50	0.08	1.8e-03	-4.5	5.4	8.2e-08	-0.68	0.05	0.48	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EFCAB4A	0.04	0.05	enet	7	0.05	6.1e-06	-5.3	5.2	2.6e-07	-0.65	0.64	0.33	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PNPLA2	0.07	0.00	blup	51	0.03	1.4e-04	-4.2	6.0	1.9e-09	-0.61	0.02	0.48	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POLR2L	0.02	0.02	blup	46	0.02	4.5e-03	-4.7	5.1	3.1e-07	-0.67	0.08	0.24	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LRDD	0.11	0.03	enet	14	0.04	4.0e-05	4.6	5.2	2.4e-07	-0.61	0.23	0.70	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CHID1	0.07	0.05	blup	68	0.01	8.0e-02	-6.5	-5.5	3.7e-08	0.76	0.01	0.86	FALSE
21	The Cancer Genome Atlas	Soft Tissue Sarcoma	CD151	0.11	0.11	blup	52	0.13	4.2e-08	-3.9	5.3	9.7e-08	-0.76	0.05	0.95	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	CD151	0.03	0.00	blup	50	0.01	3.6e-02	-4.5	5.3	8.9e-08	-0.59	0.04	0.13	FALSE