[Hub]/) : Traits : Leg fat-free mass (right) : ← →

chr16:19,022,448-21,147,999

Best TWAS P=3.84e-17 · Best GWAS P=4.58e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	GPRC5B	0.07	0.04	lasso	4	0.03	1.3e-03	-7.8	8.4	3.8e-17	-0.96	0.01	0.98	TRUE
43	GTEx	Skin Sun Exposed Lower leg	ACSM5	0.21	0.04	lasso	9	0.07	3.6e-06	1.4	-5.3	1.2e-07	0.16	0.29	0.30	TRUE
65	The Cancer Genome Atlas	Thyroid Carcinoma	GPRC5B	0.06	0.01	blup	38	0.01	2.4e-02	-4.7	-7.1	1.3e-12	0.67	0.01	0.08	FALSE
62	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCK	0.03	0.03	lasso	3	0.02	7.2e-04	-6.4	-6.9	6.1e-12	0.94	0.03	0.94	FALSE
18	GTEx	Breast Mammary Tissue (Male)	AC002550.5	0.37	0.29	lasso	3	0.35	4.8e-09	-6.4	-6.2	4.1e-10	0.90	0.06	0.93	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	KNOP1	0.51	0.44	enet	22	0.56	5.3e-24	-5.4	-6.2	4.2e-10	0.84	0.15	0.85	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	AC002550.5	0.62	0.54	enet	35	0.63	4.4e-29	-4.7	-6.2	4.7e-10	0.77	0.88	0.12	FALSE
28	GTEx	Liver	KNOP1	0.23	0.21	lasso	7	0.25	1.4e-07	-4.7	-6.2	6.6e-10	0.81	0.57	0.32	FALSE
52	GTEx	Whole Blood	KNOP1	0.08	0.04	lasso	3	0.04	1.7e-04	-4.9	-6.1	1.2e-09	0.86	0.36	0.61	FALSE
22	GTEx	Colon Transverse	AC002550.5	0.35	0.36	enet	15	0.41	5.0e-21	-4.9	-6.0	2.1e-09	0.81	0.90	0.10	FALSE
21	GTEx	Colon Transverse	KNOP1	0.22	0.23	enet	19	0.24	9.8e-12	-4.9	-6.0	2.4e-09	0.81	0.55	0.45	FALSE
53	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCK	0.05	0.02	blup	73	0.03	1.0e-03	-6.6	-6.0	2.6e-09	0.84	0.04	0.86	FALSE
36	GTEx	Pancreas	KNOP1	0.42	0.37	lasso	11	0.40	4.2e-18	-4.7	-6.0	2.7e-09	0.84	0.67	0.33	FALSE
2	GTEx	Adipose Subcutaneous	ACSM5	0.14	0.00	lasso	8	0.02	6.4e-03	6.5	-5.9	3.2e-09	0.23	0.08	0.57	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	AC002550.5	0.44	0.43	enet	24	0.43	1.2e-25	-4.7	-5.9	3.7e-09	0.79	0.99	0.01	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCK	0.03	0.03	blup	73	0.03	1.6e-07	-4.7	-5.9	3.8e-09	0.81	0.81	0.19	FALSE
20	GTEx	Colon Sigmoid	KNOP1	0.32	0.35	lasso	6	0.32	4.9e-12	-4.9	-5.9	4.2e-09	0.80	0.23	0.77	FALSE
29	GTEx	Liver	AC002550.5	0.43	0.42	enet	13	0.47	1.1e-14	-4.7	-5.8	5.3e-09	0.85	0.96	0.04	FALSE
6	GTEx	Artery Aorta	KNOP1	0.50	0.48	lasso	8	0.49	4.0e-30	-4.9	-5.8	5.6e-09	0.76	1.00	0.00	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	IQCK	0.04	0.01	blup	73	0.01	1.8e-02	-4.8	-5.8	6.0e-09	0.77	0.08	0.37	FALSE
46	GTEx	Stomach	KNOP1	0.28	0.21	lasso	6	0.21	1.8e-10	-4.3	-5.8	6.8e-09	0.77	0.12	0.87	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IQCK	0.04	0.03	lasso	2	0.04	7.5e-05	-4.9	-5.8	7.0e-09	0.69	0.26	0.21	FALSE
19	GTEx	Breast Mammary Tissue (Female)	AC002550.5	0.36	0.26	enet	19	0.33	1.3e-10	-5.4	-5.8	7.4e-09	0.75	0.45	0.54	FALSE
16	GTEx	Brain Putamen basal ganglia	AC002550.5	0.59	0.48	enet	23	0.58	1.2e-16	-4.9	-5.8	9.0e-09	0.62	1.00	0.00	FALSE
8	GTEx	Artery Coronary	KNOP1	0.28	0.25	lasso	7	0.32	2.5e-11	-4.9	-5.7	9.5e-09	0.82	0.10	0.90	FALSE
7	GTEx	Artery Aorta	AC002550.5	0.52	0.52	lasso	7	0.49	1.9e-30	-4.9	-5.7	1.5e-08	0.75	1.00	0.00	FALSE
51	GTEx	Vagina	KNOP1	0.43	0.35	lasso	5	0.36	4.2e-09	-4.9	-5.7	1.5e-08	0.74	0.52	0.47	FALSE
9	GTEx	Artery Coronary	AC002550.5	0.30	0.34	enet	11	0.37	1.5e-13	-4.9	-5.6	1.7e-08	0.79	0.52	0.48	FALSE
17	GTEx	Breast Mammary Tissue	AC002550.5	0.37	0.49	enet	13	0.50	3.3e-29	-4.9	-5.6	1.7e-08	0.80	1.00	0.00	FALSE
5	GTEx	Adrenal Gland	AC002550.5	0.37	0.39	enet	28	0.40	1.6e-15	-4.9	-5.6	1.9e-08	0.75	0.98	0.02	FALSE
34	GTEx	Ovary	KNOP1	0.61	0.64	lasso	7	0.57	4.4e-17	-4.9	-5.6	2.2e-08	0.77	0.78	0.22	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C16orf88	0.10	0.10	lasso	3	0.13	3.7e-14	-5.4	-5.6	2.5e-08	0.80	0.01	0.99	FALSE
37	GTEx	Pancreas	AC002550.5	0.37	0.36	lasso	12	0.36	3.2e-16	-4.9	-5.5	3.1e-08	0.76	0.94	0.06	FALSE
63	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C16orf88	0.34	0.21	lasso	4	0.17	3.1e-07	-5.4	-5.5	3.1e-08	0.82	0.00	1.00	FALSE
48	GTEx	Testis	AC002550.5	0.49	0.57	lasso	5	0.56	7.7e-30	-4.9	-5.5	4.7e-08	0.77	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C16orf88	0.07	0.05	lasso	2	0.05	7.7e-04	-5.4	-5.5	4.7e-08	0.83	0.00	0.91	FALSE
31	GTEx	Lung	GPRC5B	0.08	0.05	lasso	4	0.06	2.4e-05	-4.7	5.5	4.8e-08	-0.73	0.86	0.06	FALSE
26	GTEx	Esophagus Muscularis	KNOP1	0.47	0.51	lasso	10	0.56	1.9e-40	-4.9	-5.4	5.5e-08	0.74	1.00	0.00	FALSE
12	GTEx	Brain Frontal Cortex BA9	KNOP1	0.43	0.33	lasso	14	0.30	1.0e-08	-4.9	-5.4	5.6e-08	0.76	0.95	0.01	FALSE
4	GTEx	Adrenal Gland	KNOP1	0.40	0.34	lasso	4	0.40	1.1e-15	-5.4	-5.4	6.0e-08	0.79	0.71	0.29	FALSE
13	GTEx	Brain Frontal Cortex BA9	AC002550.5	0.53	0.40	enet	15	0.43	9.0e-13	-4.9	-5.4	6.3e-08	0.71	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C16orf88	0.22	0.08	lasso	3	0.08	2.0e-09	-5.4	-5.4	6.4e-08	0.82	0.00	1.00	FALSE
30	GTEx	Lung	KNOP1	0.34	0.48	lasso	8	0.49	4.0e-42	-4.9	-5.3	8.8e-08	0.76	1.00	0.00	FALSE
42	GTEx	Skin Sun Exposed Lower leg	KNOP1	0.33	0.47	lasso	9	0.48	5.4e-44	-4.9	-5.3	1.0e-07	0.76	1.00	0.00	FALSE
45	GTEx	Spleen	KNOP1	0.45	0.36	lasso	7	0.41	1.2e-11	-4.9	-5.3	1.0e-07	0.74	0.40	0.59	FALSE
39	GTEx	Prostate	AC002550.5	0.49	0.25	lasso	8	0.33	5.7e-09	-4.9	-5.3	1.1e-07	0.74	0.97	0.02	FALSE
47	GTEx	Stomach	AC002550.5	0.36	0.26	lasso	7	0.32	4.8e-16	-4.9	-5.3	1.1e-07	0.73	0.94	0.06	FALSE
10	GTEx	Artery Tibial	AC002550.5	0.31	0.36	lasso	8	0.39	6.8e-32	-4.9	-5.3	1.3e-07	0.73	1.00	0.00	FALSE
38	GTEx	Pituitary	KNOP1	0.40	0.36	lasso	3	0.30	3.1e-08	-4.9	-5.3	1.3e-07	0.76	0.55	0.40	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf88	0.10	0.08	lasso	3	0.08	7.1e-17	-4.9	-5.3	1.5e-07	0.76	0.02	0.97	FALSE
3	GTEx	Adipose Visceral Omentum	KNOP1	0.39	0.52	lasso	3	0.53	9.1e-32	-4.9	-5.2	1.6e-07	0.75	1.00	0.00	FALSE
25	GTEx	Esophagus Mucosa	KNOP1	0.31	0.43	lasso	5	0.43	5.6e-31	-4.9	-5.2	1.7e-07	0.74	1.00	0.00	FALSE
50	GTEx	Uterus	AC002550.5	0.51	0.40	lasso	12	0.36	2.3e-08	-4.9	-5.2	1.8e-07	0.76	0.41	0.52	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	KNOP1	0.37	0.43	lasso	3	0.41	5.0e-24	-4.7	-5.2	1.9e-07	0.74	1.00	0.00	FALSE
27	GTEx	Heart Left Ventricle	KNOP1	0.34	0.48	lasso	2	0.44	2.3e-25	-4.9	-5.2	2.0e-07	0.73	1.00	0.00	FALSE
35	GTEx	Ovary	AC002550.5	0.66	0.56	lasso	4	0.47	3.6e-13	-4.9	-5.2	2.2e-07	0.72	0.89	0.11	FALSE
49	GTEx	Thyroid	KNOP1	0.35	0.41	enet	11	0.43	4.7e-36	-4.9	-5.2	2.2e-07	0.71	1.00	0.00	FALSE
33	GTEx	Muscle Skeletal	AC002550.5	0.35	0.53	lasso	6	0.52	3.2e-59	-4.9	-5.2	2.4e-07	0.73	1.00	0.00	FALSE
44	GTEx	Skin Sun Exposed Lower leg	AC002550.5	0.38	0.56	lasso	6	0.57	8.6e-58	-4.9	-5.2	2.4e-07	0.74	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Glioblastoma Multiforme	C16orf88	0.34	0.07	lasso	3	0.12	1.5e-04	-5.4	-5.2	2.4e-07	0.78	0.00	0.90	FALSE
11	GTEx	Brain Cortex	AC002550.5	0.50	0.46	lasso	6	0.46	3.9e-14	-4.9	-5.2	2.6e-07	0.71	1.00	0.00	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	AC002550.5	0.36	0.41	enet	20	0.42	2.2e-12	-4.9	-5.2	2.6e-07	0.68	0.98	0.02	FALSE
32	GTEx	Lung	AC002550.5	0.43	0.55	lasso	9	0.54	6.4e-48	-4.9	-5.2	2.6e-07	0.73	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C16orf88	0.16	0.09	enet	10	0.14	2.2e-07	-4.7	-5.1	2.8e-07	0.74	0.02	0.97	FALSE
14	GTEx	Brain Hypothalamus	AC002550.5	0.37	0.47	lasso	2	0.46	3.1e-12	-4.9	-5.1	3.0e-07	0.73	0.61	0.38	FALSE