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chr1:31,402,148-34,592,020

Best TWAS P=2.66e-18 · Best GWAS P=1.85e-18 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PEF1	0.04	0.04	lasso	4	0.03	2.8e-04	-5.2	5.2	1.8e-07	-0.01	0.57	0.35	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMEM54	0.05	0.00	blup	281	0.02	4.5e-03	1.7	-7.6	2.7e-14	0.50	0.11	0.23	FALSE
3	CommonMind	Brain Pre-frontal Cortex	ZNF362	0.05	0.06	lasso	1	0.06	2.2e-07	-8.7	-8.7	2.7e-18	0.98	0.01	0.99	TRUE
4	GTEx	Artery Aorta	PEF1	0.15	0.05	lasso	5	0.04	2.2e-03	-5.8	6.4	1.8e-10	-0.05	0.23	0.55	TRUE
5	GTEx	Cells EBV-transformed lymphocytes	KPNA6	0.19	0.14	enet	18	0.10	4.9e-04	4.9	5.5	2.9e-08	-0.03	0.19	0.18	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	PHC2	0.58	0.34	lasso	7	0.28	7.3e-10	-8.6	8.4	6.0e-17	-0.99	0.02	0.98	FALSE
7	GTEx	Colon Sigmoid	PEF1	0.16	0.09	lasso	3	0.09	4.3e-04	-5.6	6.0	2.7e-09	-0.04	0.17	0.26	FALSE
8	GTEx	Muscle Skeletal	ZNF362	0.04	0.01	enet	7	0.02	4.9e-03	3.2	-5.4	6.7e-08	0.68	0.06	0.82	FALSE
9	METSIM	Adipose	ZNF362	0.09	0.02	enet	32	0.03	1.5e-05	-8.7	-6.2	7.0e-10	0.70	0.01	0.98	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	PHC2	0.11	0.07	lasso	3	0.05	2.2e-07	-8.6	-8.2	3.7e-16	0.99	0.01	0.99	FALSE
11	YFS	Blood	KPNA6	0.03	0.03	bslmm	236	0.04	1.1e-11	5.1	5.4	8.4e-08	0.01	0.93	0.07	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF362	0.03	0.01	blup	49	0.01	1.3e-03	3.7	-6.5	8.1e-11	0.72	0.01	0.32	FALSE
13	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	S100PBP	0.06	0.03	blup	48	0.06	6.8e-04	-4.8	5.7	1.2e-08	-0.06	0.01	0.75	TRUE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	S100PBP	0.06	0.06	blup	47	0.05	5.2e-06	-5.1	5.2	1.7e-07	-0.07	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PTP4A2	0.09	-0.01	blup	26	0.00	4.1e-01	6.2	7.3	3.6e-13	0.00	0.01	0.60	TRUE