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chr4:305,291-2,437,290

Best TWAS P=1.55e-13 · Best GWAS P=2.22e-13 conditioned to 9.84e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
32	NTR	Blood	CRIPAK	0.13	0.09	enet	31	0.15	1.5e-46	-3.60	-7.4	1.5e-13	0.00	1.00	0.00	TRUE
35	NTR	Blood	TACC3	0.05	0.03	lasso	9	0.04	2.7e-13	-5.30	6.5	9.7e-11	0.71	0.50	0.50	TRUE
30	METSIM	Adipose	CRIPAK	0.28	0.16	bslmm	335	0.25	2.7e-37	-3.79	-6.8	9.2e-12	-0.01	1.00	0.00	FALSE
23	GTEx	Lung	CRIPAK	0.61	0.22	enet	46	0.41	1.1e-33	-4.69	-6.8	9.9e-12	0.02	1.00	0.00	FALSE
33	NTR	Blood	KIAA1530	0.19	0.04	blup	345	0.10	9.1e-32	-4.23	-6.8	1.3e-11	0.08	1.00	0.00	FALSE
26	GTEx	Nerve Tibial	CRIPAK	0.50	0.11	enet	76	0.38	1.1e-28	-3.99	-6.6	4.8e-11	-0.08	1.00	0.00	FALSE
9	GTEx	Brain Hippocampus	CRIPAK	0.48	0.22	lasso	4	0.23	4.0e-06	-3.99	-6.4	1.3e-10	0.00	0.18	0.13	FALSE
34	NTR	Blood	SLBP	0.04	0.02	lasso	5	0.02	2.8e-08	-5.49	6.4	1.3e-10	0.82	0.03	0.97	FALSE
8	GTEx	Brain Cortex	CRIPAK	0.34	0.10	lasso	6	0.18	9.5e-06	-4.69	-6.4	1.8e-10	0.03	0.19	0.07	FALSE
14	GTEx	Breast Mammary Tissue (Female)	CRIPAK	0.32	0.17	enet	29	0.26	2.7e-08	-3.61	-6.3	3.9e-10	0.01	0.54	0.03	FALSE
37	YFS	Blood	CRIPAK	0.35	0.27	bslmm	301	0.33	6.0e-112	-3.99	-6.1	1.2e-09	-0.03	1.00	0.00	FALSE
24	GTEx	Muscle Skeletal	FGFRL1	0.14	0.08	lasso	4	0.06	3.7e-06	-6.65	6.1	1.3e-09	0.01	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	CRIPAK	0.22	0.11	blup	28	0.14	5.6e-28	-3.99	-6.1	1.3e-09	0.01	0.02	0.76	FALSE
31	METSIM	Adipose	UVSSA	0.26	0.04	bslmm	366	0.12	9.0e-18	0.83	-6.0	1.7e-09	0.02	0.99	0.01	FALSE
29	GTEx	Whole Blood	CRIPAK	0.38	0.17	lasso	9	0.28	3.4e-26	-3.99	-5.9	3.7e-09	0.02	1.00	0.00	FALSE
25	GTEx	Muscle Skeletal	CRIPAK	0.25	0.11	enet	32	0.18	7.6e-18	-4.69	-5.8	6.0e-09	0.03	1.00	0.00	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	CRIPAK	0.38	0.22	enet	12	0.25	5.4e-24	-3.99	-5.8	8.3e-09	0.01	0.02	0.76	FALSE
27	GTEx	Ovary	CRIPAK	0.43	0.27	enet	19	0.32	9.0e-09	-4.69	-5.8	9.0e-09	0.03	0.47	0.05	FALSE
28	GTEx	Pancreas	CRIPAK	0.34	0.13	lasso	6	0.27	1.0e-11	-3.99	-5.7	9.4e-09	0.01	0.84	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CRIPAK	0.31	0.15	enet	34	0.26	1.2e-31	-3.63	-5.7	1.0e-08	0.04	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	CRIPAK	0.47	0.24	lasso	12	0.31	1.3e-16	-4.69	-5.7	1.1e-08	0.02	1.00	0.00	FALSE
17	GTEx	Colon Transverse	TMEM129	0.23	0.05	lasso	4	0.03	1.8e-02	-5.37	5.7	1.1e-08	0.51	0.09	0.09	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CRIPAK	0.28	0.16	blup	28	0.19	3.2e-21	-3.99	-5.7	1.2e-08	0.03	0.02	0.76	FALSE
13	GTEx	Breast Mammary Tissue	CRIPAK	0.42	0.12	enet	35	0.39	5.2e-21	-4.69	-5.5	3.6e-08	0.02	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	UVSSA	0.46	0.05	lasso	11	0.24	1.1e-12	-4.23	-5.5	4.7e-08	0.01	0.87	0.02	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	CRIPAK	0.34	0.13	lasso	6	0.25	2.7e-07	-4.69	-5.4	5.9e-08	0.05	0.21	0.05	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	CRIPAK	0.49	0.27	lasso	8	0.35	2.9e-12	-4.69	-5.4	6.1e-08	0.05	0.84	0.01	FALSE
41	The Cancer Genome Atlas	Colon Adenocarcinoma	CRIPAK	0.38	0.16	blup	28	0.21	2.8e-12	-3.99	-5.4	6.3e-08	0.01	0.01	0.89	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIAA1530	0.13	0.01	blup	48	0.03	4.9e-07	-3.69	-5.4	6.6e-08	-0.05	0.03	0.56	FALSE
20	GTEx	Esophagus Mucosa	CRIPAK	0.49	0.14	enet	28	0.40	6.8e-29	-4.69	-5.4	6.7e-08	0.00	1.00	0.00	FALSE
12	GTEx	Brain Putamen basal ganglia	CRIPAK	0.30	0.00	enet	25	0.10	1.9e-03	-3.45	-5.4	7.8e-08	0.11	0.06	0.09	FALSE
10	GTEx	Brain Hypothalamus	CRIPAK	0.22	0.00	lasso	5	0.01	2.1e-01	-4.23	-5.4	8.2e-08	0.02	0.06	0.08	FALSE
5	GTEx	Artery Aorta	UVSSA	0.33	0.06	enet	30	0.28	7.2e-16	-4.23	-5.4	8.3e-08	0.01	0.58	0.38	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	CRIPAK	0.31	0.11	enet	10	0.18	1.5e-19	-3.99	-5.3	9.8e-08	-0.03	0.02	0.76	FALSE
7	GTEx	Brain Cerebellum	CRIPAK	0.37	0.09	enet	24	0.31	8.8e-10	-3.69	-5.3	1.0e-07	-0.01	0.40	0.04	FALSE
22	GTEx	Heart Atrial Appendage	CRIPAK	0.31	0.26	enet	23	0.33	2.1e-15	-4.69	-5.3	1.2e-07	0.03	1.00	0.00	FALSE
38	YFS	Blood	SLBP	0.10	0.12	lasso	3	0.12	1.2e-35	-5.30	5.3	1.3e-07	0.60	1.00	0.00	FALSE
18	GTEx	Colon Transverse	CRIPAK	0.33	0.10	enet	22	0.24	5.8e-12	-3.99	-5.2	1.5e-07	0.03	0.97	0.00	FALSE
16	GTEx	Colon Sigmoid	CRIPAK	0.40	0.21	lasso	7	0.30	4.7e-11	-4.45	-5.2	1.7e-07	0.06	0.72	0.01	FALSE
6	GTEx	Artery Aorta	CRIPAK	0.31	0.20	enet	34	0.30	2.8e-17	-4.69	-5.2	2.0e-07	0.01	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	CRIPAK	0.42	0.11	enet	42	0.34	9.0e-29	-3.65	-5.2	2.1e-07	0.04	1.00	0.00	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	UVSSA	0.31	0.05	blup	350	0.23	7.1e-29	0.83	-5.2	2.1e-07	-0.05	0.88	0.12	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	CRIPAK	0.33	0.20	lasso	5	0.30	1.4e-11	-4.69	-5.1	2.7e-07	0.02	0.99	0.00	FALSE
21	GTEx	Esophagus Muscularis	CRIPAK	0.38	0.14	enet	34	0.30	2.6e-18	-4.69	-5.1	3.0e-07	0.05	1.00	0.00	FALSE