Hub : Genes

SLBP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0814	0.0286	7.8e-04	0.058	NA	0.037	NA	0.042	2.4e-06	NA	1.3e-04	NA	5.0e-05
2	NTR	Blood	0.0363	0.0126	2.5e-05	0.017	0.017	0.022	0.018	0.024	2.6e-06	2.0e-06	9.4e-08	1.1e-06	2.8e-08
3	YFS	Blood	0.0961	0.0196	0.0e+00	0.118	0.105	0.114	0.115	0.115	2.2e-36	1.7e-32	3.4e-35	1.3e-35	1.2e-35

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	1.0	1.4	1.0	-1.2	-0.7
Bipolar Disorder or Schizophrenia	0.3	0.8	1.6	0.5	-1.3	-0.8
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	-0.7	0.6	0.3
Depression (Nagel 2018)	0.3	0.5	1.0	-1.0	0.4	0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.6	0.3	-0.2
Neuroticism (Nagel 2018)	0.6	1.4	2.4	-1.5	1.1	0.8
Schizophrenia (2018)	0.1	0.2	0.5	-0.2	-0.7	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.6	-0.3	0.0
Worry (Nagel 2018)	0.5	1.1	2.4	-1.5	0.6	0.8
Alzheimer’s Disease (in mother)	0.7	0.8	1.9	-1.4	0.5	0.4
Alzheimer’s Disease (in father)	0.4	0.5	0.9	-0.2	1.0	0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	-1.0	0.0	-0.3
Crohns Disease (2017)	0.8	1.7	2.7	1.6	-1.3	-0.8
Irritable Bowel Disease (IBD)	0.8	1.8	3.0	1.7	-1.5	-0.3
Ulcerative Colitis (UC)	0.2	0.3	0.7	0.4	-0.9	0.2
Major Depression (MDD)	3.4	4.1	7.8	2.8	-2.0	-0.8
Reaction Time	0.2	0.4	0.6	-0.1	0.7	0.8
Verbal and Numeric Reasoning (VNR)	0.8	1.8	2.7	-1.6	1.6	0.4
Breast Cancer	1.1	2.7	4.9	0.4	-2.2	-1.7
Ovarian Cancer	0.2	0.2	0.3	0.4	-0.6	-0.5
Prostate Cancer	0.7	1.0	1.8	-0.4	1.0	1.3
Age at First Birth	0.3	0.5	0.8	-0.9	-0.1	-0.7
Bipolar Disorder (2011)	0.2	0.2	0.6	0.0	0.0	-0.8
Body Mass Index (BMI) (2010)	0.5	0.7	0.9	0.7	-0.9	-0.8
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.0	-0.3	0.1
Crohns Disease (2012)	0.9	1.4	3.7	1.9	-0.6	-0.2
Mean Putamen Volume	0.7	0.8	0.9	-0.9	0.7	0.9
Fasting Glucose	1.4	1.7	2.8	-0.0	1.7	1.5
HbA1C	3.2	3.6	5.1	-1.4	2.3	1.9
HDL Cholesterol	0.3	0.5	0.6	0.3	0.8	0.8
LDL Cholesterol	0.2	0.4	0.5	0.5	-0.7	-0.6
Lupus	0.8	1.2	1.8	1.3	-1.1	-0.7
Neuroticism (2016)	0.6	0.9	1.2	-0.8	1.1	0.9
Primary Biliary Cirrhosis	6.4	9.1	9.6	3.1	-3.1	-2.9
Rheumatoid Arthritis	0.1	0.1	0.3	0.3	-0.5	0.1
Schizophrenia (2014)	0.7	1.4	2.4	0.8	-1.5	-1.1
Triglycerides	0.2	0.3	0.6	0.7	0.2	0.6
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.3	-1.2	-0.2	0.3
Ulcerative Colitis	0.2	0.4	0.9	0.2	-0.4	0.9
Blood Eosinophil Count	0.3	2.6	6.2	-0.9	-0.9	-2.5
Blood Platelet Count	0.0	0.1	0.2	0.5	0.3	-0.2
Blood Red Count	1.6	15.1	22.2	2.1	-4.7	-4.3
Blood White Count	0.0	0.3	0.5	-0.7	-0.3	-0.7
Heel T-Score	0.1	1.0	1.5	-0.6	-1.2	-1.1
BMI	0.0	0.2	0.4	0.0	0.6	-0.2
Height	7.4	143.1	204.5	-5.1	14.3	14.1
Waist Hip Ratio (WHR)	0.2	0.8	1.4	-1.2	-0.8	0.6
Systolic Blood Pressure	2.6	13.1	22.5	-1.9	3.6	4.7
Smoking Status	0.8	1.9	1.9	1.4	-1.3	-1.4
Allergy or Eczema	0.2	0.4	1.0	-1.0	-0.0	-0.4
Cardiovascular Disease	1.2	4.1	6.1	-1.2	2.2	2.5
Hypothyroidism (self reported)	0.4	0.8	1.1	0.8	1.1	0.9
Respiratory disease	1.4	3.0	5.2	0.7	-1.8	-2.3
Type 2 Diabetes (T2D) (2018)	4.9	9.1	11.5	2.1	-3.4	-3.4
Lung FEV1/FVC ratio	3.0	15.1	22.6	3.1	-4.8	-3.7
Lung FVC	1.8	9.3	17.9	0.9	-4.2	-3.0
Neuroticism	0.8	2.0	3.7	-1.9	1.2	0.9
Chronotype (morning person)	1.9	4.3	7.0	-2.0	1.4	2.6
Hair Pigment	0.0	1.3	2.9	1.7	-0.6	-0.8
Tanning	0.1	1.5	2.9	-0.3	1.7	1.3
Hand grip strength (left)	1.1	2.9	5.5	-2.4	1.5	0.9
Number of treatments/medications taken	0.4	0.7	1.1	1.0	-0.5	-0.8
Average weekly spirits intake	1.9	2.3	4.6	0.4	-1.5	-2.1
Sensitivity / hurt feelings	0.3	0.5	1.1	-0.6	1.0	0.3
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.6	-0.8	-0.3	-0.1
Hearing difficulty/problems: Yes	0.8	1.2	1.9	1.1	-0.8	-1.4
Relative age of first facial hair	0.0	0.1	0.1	-0.0	0.3	-0.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.0	-1.4	1.2	-0.1
Ever used hormone-replacement therapy (HRT)	0.7	0.8	1.2	1.0	-0.6	-1.1
Ever had hysterectomy (womb removed)	0.1	0.2	0.3	-0.2	-0.6	-0.3
Systolic blood pressure, automated reading	1.4	3.9	7.0	-0.8	2.1	2.6
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	3.7	0.6	-1.9	-1.7
Angina	0.3	0.3	0.7	-0.3	0.8	0.5
Medication for hormone replacement therapy	0.1	0.1	0.1	0.2	0.2	0.3
Vitamin and mineral supplements	0.9	1.2	1.8	-0.5	1.2	1.3
Supplements: Zinc	1.0	1.1	1.8	0.1	-1.2	-1.4
Medication: Co-codamol	0.2	0.3	0.8	0.0	0.9	0.2
Medication: Metformin	1.7	2.4	3.2	1.3	-1.8	-1.6
Diabetes (father)	6.1	7.6	10.6	1.8	-3.3	-3.0
Diabetes (mother)	6.5	8.3	13.0	2.0	-3.6	-2.8
Severe depression (siblings)	0.2	0.2	0.3	-0.2	0.6	0.6
Pack years adult smoking proportion	0.4	0.6	1.7	1.3	0.4	-0.2
Impedance of leg (right)	1.5	7.1	11.1	2.5	-3.3	-2.0
Leg fat-free mass (left)	4.3	23.0	37.7	-2.3	6.1	5.1
Trunk fat percentage	0.3	1.0	2.8	1.7	0.5	0.1
Hand grip strength (right)	0.8	2.2	4.6	-2.1	1.3	0.5
Townsend deprivation index at recruitment	1.3	1.8	3.2	-0.8	1.3	1.8
Current tobacco smoking	2.8	4.6	6.6	2.6	-1.9	-1.9
Average weekly fortified wine intake	0.7	0.8	2.0	-1.4	0.7	-0.1
Maternal smoking around birth	0.1	0.2	0.4	0.6	0.3	-0.0
Fed-up feelings	0.2	0.3	0.7	-0.4	0.8	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	-0.1	0.3	0.8
Relative age voice broke	0.0	0.1	0.1	0.3	0.1	0.3
Taking other prescription medications	0.5	0.8	1.3	1.1	-0.7	-0.8
Age when periods started (menarche)	0.0	0.1	0.2	0.2	0.5	0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.7	0.6	0.4	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.5	0.7	-1.2	-0.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.1	-0.7	-0.1
Qualifications: CSEs or equivalent	1.1	1.5	1.7	1.3	-1.3	-1.1
Serious illness, injury or assault to yourself	0.6	0.7	1.0	-0.8	1.0	0.5
High blood pressure	2.7	7.6	12.2	-1.3	3.0	3.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	-1.3	0.2	-0.3
Multivitamins +/- minerals	0.4	0.5	1.0	1.0	-0.5	-0.5
Stomach or abdominal pain in last month	0.5	0.6	1.2	1.1	-0.7	-0.4
Supplements: Glucosamine	0.8	1.0	2.1	-1.5	1.0	-0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	0.3	-0.1	0.8
Medication: Atenolol	0.5	0.6	1.1	1.1	-0.1	0.8
Medication: Levothyroxine sodium	0.4	0.7	1.4	-0.4	1.2	0.8
Sitting height	2.5	17.5	28.8	-0.5	5.4	4.8
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	-0.4	-0.1	0.2
High blood pressure (mother)	0.6	0.8	1.7	0.2	0.9	1.3
Body mass index (BMI)	0.1	0.3	0.7	0.8	0.6	0.0
Impedance of leg (left)	1.3	6.3	10.2	2.1	-3.2	-2.1
Leg predicted mass (left)	4.4	23.2	37.9	-2.3	6.2	5.1
Trunk fat mass	1.0	4.4	8.0	0.2	2.8	2.3
Waist circumference	1.6	6.0	10.2	-0.9	3.2	2.7
Number of incorrect matches in round	0.8	1.4	2.5	-1.6	0.6	1.1
Past tobacco smoking	0.3	0.6	0.6	0.7	-0.8	-0.8
Alcohol usually taken with meals	0.4	0.7	1.2	-0.6	0.7	1.1
Nervous feelings	0.1	0.1	0.2	-0.2	-0.4	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.6	1.3	-1.2	-0.5
Hearing difficulty/problems with background noise	2.0	3.3	5.9	1.0	-1.7	-2.4
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	-0.1	-0.1	-0.2
Had menopause	0.1	0.2	0.3	-0.5	-0.1	-0.4
Had other major operations	0.2	0.3	0.7	0.8	0.2	-0.3
Forced vital capacity (FVC)	0.6	2.3	3.7	-1.4	1.0	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	2.6	1.2	-1.6	-1.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.3	0.1	-0.4
Qualifications: None of the above	0.9	2.0	4.0	1.1	0.9	2.0
Financial difficulties in last 2 years	0.4	0.6	1.0	0.3	1.0	0.9
Mouth/teeth dental problems	0.7	1.1	1.5	-0.8	-1.2	-1.1
Heart attack	1.2	1.5	3.8	1.9	-0.8	-0.1
Allergy	0.2	0.4	0.5	0.7	0.4	0.7
Pain all over the body in last month	1.6	1.7	2.7	-1.6	1.4	0.7
Diabetes (self-reported)	4.1	6.4	8.2	1.9	-2.9	-2.7
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.6	-0.2	-0.2
Medication: Ramipril	0.5	0.6	1.6	-0.2	0.5	1.3
Medication: Simvastatin	0.5	0.7	1.7	-0.1	0.5	1.3
Fluid intelligence score	1.0	2.1	3.6	-1.5	1.9	0.7
Illnesses of siblings	1.2	1.7	3.5	-1.9	1.2	-0.3
Neuroticism score	0.2	0.4	0.7	-0.8	0.5	0.5
Weight	3.1	15.4	25.3	-1.5	5.0	4.3
Impedance of arm (right)	0.7	3.2	4.3	1.8	-2.1	-1.4
Arm fat percentage (right)	0.2	0.9	2.6	1.6	-0.0	-0.3
Trunk fat-free mass	7.9	45.3	64.8	-4.2	8.1	7.3
Hip circumference	2.8	12.1	24.0	-1.0	4.9	3.4
Time employed in main current job	0.8	1.0	2.1	0.3	0.9	1.4
Alcohol intake versus 10 years previously	0.4	0.6	1.0	0.8	-1.0	0.1
Father’s age at death	2.2	3.0	4.9	-0.3	-2.0	-2.2
Worrier / anxious feelings	0.4	0.7	1.7	-0.6	0.1	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	0.4	0.5	0.5
Falls in the last year	0.4	0.5	0.8	0.6	0.9	0.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.6	-0.3	0.4	1.3
Number of live births	0.1	0.2	0.5	0.7	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	-0.4	-0.8	0.2
Pulse rate	2.4	4.1	4.7	2.2	-1.8	-2.1
Happiness	0.4	0.5	1.4	1.2	-0.1	-0.3
Noisy workplace	0.0	0.0	0.1	0.2	0.1	-0.2
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.5	-0.1	-0.9	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	1.9	1.1	-1.4	-0.7
Mouth/teeth dental problems: Dentures	1.1	1.8	4.5	-0.0	2.1	1.0
Asthma	0.8	1.6	2.3	0.4	-1.5	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.0	-1.0	0.8	0.2
Medication: Cholesterol lowering	0.0	0.1	0.1	0.4	-0.0	0.1
Depression (self-reported)	0.1	0.1	0.4	-0.2	0.2	0.6
Medication: Lansoprazole	1.6	1.8	2.4	-1.0	1.5	1.4
Prospective memory result	0.0	0.0	0.0	0.2	0.0	0.1
Lung cancer (father)	0.3	0.3	0.5	-0.7	0.7	0.2
Illnesses of mother	0.4	0.5	1.0	-1.0	-0.2	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.6	-0.8	-0.6	0.3
Pulse wave Arterial Stiffness index	0.2	0.3	0.4	-0.4	0.6	0.5
Impedance of arm (left)	0.6	3.0	4.1	1.5	-2.0	-1.6
Arm fat mass (right)	0.6	2.4	4.8	0.2	2.2	1.5
Trunk predicted mass	7.9	45.4	64.8	-4.2	8.1	7.3
Standing height	7.0	69.5	95.6	-5.0	9.8	9.4
Length of working week for main job	0.1	0.1	0.1	0.4	0.2	-0.3
Exposure to tobacco smoke at home	2.9	3.3	7.8	0.1	1.4	2.8
Breastfed as a baby	1.0	1.2	3.2	-1.8	0.4	-0.5
Tense / ‘highly strung’	0.1	0.2	0.4	0.3	-0.7	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	0.2	0.6
Hair/balding pattern: Pattern 4	0.3	0.8	1.3	0.8	1.1	0.7
Birth weight of first child	1.8	3.2	3.8	-2.0	1.8	1.6
Peak expiratory flow (PEF)	4.0	9.2	16.2	1.9	-4.0	-2.8
Pulse wave reflection index	1.6	1.9	3.9	0.1	-1.3	-2.0
Ever highly irritable/argumentative for 2 days	2.3	2.8	3.7	1.5	-1.9	-1.5
Loud music exposure frequency	0.6	0.7	1.8	1.3	-0.4	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	-0.6	-0.4	-0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.1	0.6	0.7	1.0
Blood clot in the leg (DVT)	0.6	0.7	1.1	-0.4	0.9	1.1
Medication: Paracetamol	0.7	1.2	2.2	1.5	-0.4	-1.0
Headache pain in last month	1.1	1.8	3.8	2.0	-1.2	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	-0.5	-0.2	-0.7
Glaucoma (self-reported)	0.9	1.1	1.9	1.4	-0.6	-1.0
Gout (self-reported)	0.6	0.8	1.6	0.2	0.9	1.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	1.0	0.5	0.4
Medication: Amlodipine	1.7	2.4	3.7	-1.1	1.9	1.5
Medication: Ventolin 100micrograms inhaler	4.8	6.2	8.3	1.7	-2.7	-2.9
Birth weight	3.3	7.1	11.9	-1.0	2.9	3.5
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.2	1.1	0.2	-0.1
High blood pressure (siblings)	0.5	0.7	1.8	0.5	-0.1	1.3
Forced vital capacity (FVC), Best measure	0.9	3.3	4.3	-1.9	1.4	2.1
Body fat percentage	0.3	1.1	3.2	1.8	0.1	-0.2
Leg fat percentage (right)	0.2	0.7	1.7	1.3	-0.4	-0.3
Arm fat-free mass (right)	5.2	26.7	41.0	-3.0	6.4	5.5
Exposure to tobacco smoke outside home	2.6	3.5	7.0	-0.5	1.8	2.6
Comparative body size at age 10	0.3	0.9	1.7	1.3	-1.0	-0.2
Number of full brothers	0.7	0.8	1.5	1.2	-0.5	0.9
Worry too long after embarrassment	1.1	1.8	5.2	-2.3	0.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.8	-0.9	0.4	0.2
Wheeze or whistling in the chest in last year	1.1	2.0	2.2	1.5	-1.5	-1.2
Number of children fathered	1.9	2.1	3.9	-0.3	2.0	1.5
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	7.7	-2.8	0.4	-0.3
Age at first live birth	0.5	0.9	1.9	-1.4	0.7	0.3
Pulse wave peak to peak time	0.0	0.1	0.1	-0.0	0.2	0.4
Health satisfaction	0.8	1.0	1.7	0.4	1.1	1.3
Shortness of breath walking on level ground	0.6	0.7	1.0	1.0	-0.8	-0.8
Qualifications: College or University degree	0.3	1.0	1.9	-0.8	-0.7	-1.4
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.1	-0.3	-0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	0.9	-0.1	-0.6
Emphysema/chronic bronchitis	0.5	0.5	1.6	1.3	0.0	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	-0.9	0.1	0.2
Neck or shoulder pain in last month	1.4	2.0	3.5	0.2	1.6	1.9
Medication: Blood pressure	0.4	0.7	1.1	1.0	0.2	1.0
Angina (self-reported)	0.2	0.2	0.5	-0.2	0.7	0.3
Migraine (self-reported)	1.1	1.3	2.4	1.0	-1.6	-0.7
Medication: Ibuprofen	0.3	0.3	0.7	-0.8	0.5	-0.0
Medication: Allopurinol	0.4	0.5	1.1	1.0	-0.3	0.6
Medication: Omeprazole	2.5	3.0	4.0	2.0	-1.4	-1.7
Medication: Seretide 50 evohaler	4.0	4.6	7.5	1.3	-2.1	-2.7
Mean time to correctly identify matches	0.8	1.5	2.0	-0.6	1.4	1.4
Heart disease (mother)	1.8	2.2	3.9	-1.0	1.3	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	-0.6	0.6	0.2
Whole body fat mass	0.9	3.7	6.6	0.3	2.6	2.1
Leg fat mass (right)	0.6	2.2	3.6	0.6	1.9	1.6
Arm predicted mass (right)	5.3	27.2	41.9	-2.9	6.5	5.6
Pulse rate, automated reading	3.4	11.1	11.5	3.4	-3.2	-3.4
Alcohol intake frequency.	0.5	1.3	3.0	1.7	-0.6	0.7
Comparative height size at age 10	12.8	70.2	94.1	-7.2	9.7	8.1
Number of full sisters	0.3	0.3	0.6	-0.8	0.2	0.6
Suffer from ‘nerves’	0.8	1.3	2.0	-0.1	1.4	1.4
Overall health rating	2.0	4.4	6.8	-0.1	2.6	2.5
Chest pain or discomfort	1.7	2.5	3.5	1.9	-1.7	-0.9
Had major operations	0.2	0.3	0.8	0.9	0.0	0.1
Age at last live birth	0.8	1.2	2.9	-1.7	0.8	0.0
Family relationship satisfaction	0.3	0.3	0.9	1.0	0.2	0.2
Leg pain on walking	0.6	0.7	2.0	1.4	0.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	-1.1	0.7	0.6
Commuting to job workplace: Car/motor vehicle	2.8	3.2	4.3	1.9	-1.4	-2.1
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.7	-0.8	1.3	0.7
Medication: Aspirin	0.4	0.5	0.6	-0.6	0.7	0.8
Supplements: Vitamin C	0.4	0.5	1.4	-1.2	-0.0	-0.1
Knee pain experienced in last month	2.8	4.4	9.4	-1.0	3.1	1.7
Hypertension (Self-reported)	2.7	7.4	12.5	-1.1	2.9	3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.0	-0.2	0.0	0.2
Illnesses of father: Heart disease	0.7	1.0	1.5	-0.6	1.1	1.2
Illnesses of siblings: Diabetes	5.0	6.2	9.9	2.3	-3.1	-1.8
Smoking status: Previous	0.8	1.1	2.5	-1.6	0.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.7	8.8	-2.5	3.0	2.3
Whole body fat-free mass	6.5	36.9	55.7	-3.5	7.5	6.5
Leg fat-free mass (right)	4.8	25.7	41.3	-2.8	6.4	5.3
Arm fat percentage (left)	0.2	0.9	2.5	1.6	0.1	-0.3
Average weekly red wine intake	0.0	0.0	0.0	-0.2	0.1	0.1
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.4	0.5	1.2	1.0
Mood swings	0.4	0.8	1.3	-0.2	1.0	1.1
Loneliness, isolation	0.0	0.1	0.1	0.4	0.1	0.2
Long-standing illness, disability or infirmity	0.3	0.5	0.7	0.6	0.9	0.7
Ever had bowel cancer screening	3.4	4.0	6.0	-1.5	1.9	2.4
Diabetes diagnosed by doctor	5.6	9.2	12.6	2.5	-3.5	-3.0
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.2	-0.4	1.2	1.5
Friendships satisfaction	0.5	0.7	1.5	1.2	-0.3	-0.6
Qualifications: nursing, teaching	0.4	0.6	0.9	-0.8	-0.4	-0.9
Commuting to job workplace: Walk	0.9	1.0	2.3	-1.5	0.8	0.4
Eye problems/disorders: Cataract	0.4	0.5	0.8	-0.8	0.9	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.6	-0.2	0.4
Medication for cholesterol	1.2	1.8	3.9	0.1	-1.3	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.4	0.8	0.8	1.2
Back pain experienced in last month	0.9	1.2	3.0	-0.8	1.7	0.3
Mineral and other dietary supplements	0.6	0.8	1.5	-0.6	0.8	1.2
Breast cancer (self-reported)	0.1	0.2	0.4	0.4	0.6	0.1
Asthma (self-reported)	0.9	1.8	2.5	0.8	-1.5	-1.6
Osteoporosis (self-reported)	0.1	0.1	0.1	0.3	0.3	0.2
Osteoarthritis (self-reported)	5.8	7.5	13.5	-2.2	3.7	2.0
Medication: Aspirin	0.1	0.2	0.3	-0.3	0.4	0.6
Medication: Gliclazide	0.5	0.6	1.2	0.2	-1.1	-0.8
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	0.4	-0.3	-1.2
Smoking status: Current	2.4	3.7	6.5	2.5	-1.6	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.5	7.5	11.4	1.8	-3.4	-2.8
Whole body water mass	6.3	36.1	54.5	-3.5	7.4	6.5
Leg predicted mass (right)	4.9	26.3	42.1	-2.9	6.5	5.3
Arm fat mass (left)	0.5	2.1	4.1	0.4	2.0	1.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.7	-0.1	-0.1
Average weekly champagne plus white wine intake	0.5	0.7	1.1	-0.8	1.0	0.7
Miserableness	0.2	0.3	0.6	-0.8	-0.4	-0.3
Guilty feelings	0.1	0.1	0.2	-0.4	0.3	-0.1
Wears glasses or contact lenses	0.6	0.7	1.4	0.5	-0.7	-1.2
Ever taken oral contraceptive pill	0.1	0.2	0.3	-0.5	0.1	-0.4
Hearing aid user	0.6	0.6	1.3	-1.2	0.7	0.0
Mother’s age at death	0.1	0.1	0.3	-0.4	-0.2	-0.5
Financial situation satisfaction	0.5	0.6	0.7	0.6	-0.8	-0.8
Tinnitus: Yes, now most or all of the time	3.2	3.8	4.3	-1.9	1.8	2.1
Commuting to job workplace: Public transport	0.8	1.0	1.3	-1.0	0.9	1.1
Eye problems/disorders: Glaucoma	0.9	1.1	2.3	1.5	-0.4	-0.8
Medication: Blood pressure	4.7	9.0	13.6	-0.9	3.5	3.7
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	1.2	0.5	0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	0.9	0.8	-0.7	-0.9
High cholesterol (Self-reported)	0.6	1.1	2.2	-0.2	1.0	1.5
Medication: Bendroflumethiazide	3.7	5.6	8.2	-1.1	2.7	2.9
Medication: Paracetamol	0.6	0.9	2.1	1.4	-0.2	-0.7
Medication: Lisinopril	1.4	1.8	2.9	0.6	1.7	1.5
Medication: Atorvastatin	0.5	0.7	1.4	-1.2	0.7	-0.3
Illnesses of father: High blood pressure	2.4	2.9	4.6	-1.0	1.8	2.1
Alcohol drinker status: Never	0.7	0.8	1.2	0.7	-1.1	-0.8
Ever smoked	0.0	0.1	0.1	0.0	0.3	-0.3
Basal metabolic rate	5.7	31.6	48.9	-3.0	7.0	6.1
Leg fat percentage (left)	0.1	0.4	1.1	1.1	-0.2	-0.2
Arm fat-free mass (left)	5.1	25.9	38.6	-3.0	6.2	5.5
Number of operations (self-reported)	0.2	0.2	0.4	0.6	0.5	0.3
Average weekly beer plus cider intake	0.4	0.5	0.7	0.8	-0.6	-0.8
Irritability	0.0	0.1	0.2	0.5	-0.0	0.1
Risk taking	0.1	0.2	0.4	0.1	0.6	0.4
Ever had prostate specific antigen (PSA) test	2.1	2.4	4.8	-2.2	1.5	0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.6	0.8	0.4	0.2
Age started oral contraceptive pill	0.1	0.1	0.2	0.4	-0.2	0.0
Diastolic blood pressure, automated reading	0.2	0.7	1.1	0.4	0.8	1.1
Ever depressed for a whole week	0.1	0.1	0.2	0.2	-0.1	-0.5
Unable to work because of sickness or disability	0.1	0.2	0.3	0.1	0.6	0.5
Commuting to job workplace: Cycle	0.1	0.1	0.1	0.2	-0.3	-0.3
Myopia	0.3	0.4	1.1	-0.1	0.4	1.0
Vascular/heart problems diagnosed by doctor	3.0	8.3	12.4	1.6	-3.2	-3.5
Cholesterol lowering medication	0.2	0.3	0.6	-0.4	0.3	0.8
Medication: Omeprazole (e.g. Zanprol)	4.0	4.9	7.0	2.6	-2.0	-2.0
Pain experienced in last month	1.4	2.3	4.7	0.5	-2.2	-1.4
Supplements: Calcium	0.3	0.3	0.8	0.9	0.3	0.2
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	-0.5	-0.4	-0.9
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.3	1.8	-0.7	0.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.3	-0.3	0.8	1.1
Heart disease (siblings)	0.5	0.6	1.5	1.2	0.1	0.5
Alcohol drinker status: Previous	0.3	0.3	0.6	0.6	-0.3	0.7
Pack years of smoking	0.2	0.4	0.6	0.8	0.7	0.0
Impedance of whole body	1.5	7.4	10.7	2.5	-3.3	-2.3
Leg fat mass (left)	0.6	2.4	4.3	0.3	2.1	1.7
Arm predicted mass (left)	5.1	26.2	39.1	-2.8	6.2	5.6