[Hub]/) : Traits : Leg fat-free mass (right) :

chr5:41,726,855-44,208,409

Best TWAS P=2.93e-18 · Best GWAS P=5.67e-18 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex GHR 0.25 0.07 bslmm 382 0.13 2.6e-15 -5.6 5.8 4.9e-09 0.66 0.07 0.93 FALSE
2 GTEx Adipose Subcutaneous CCDC152 0.09 0.04 lasso 4 0.02 6.4e-03 8.6 8.7 3.9e-18 1.00 0.01 0.99 FALSE
3 GTEx Adipose Visceral Omentum CCDC152 0.09 0.06 lasso 9 0.05 1.9e-03 8.5 8.0 1.1e-15 0.98 0.01 0.92 FALSE
4 GTEx Artery Aorta CCDC152 0.31 0.24 lasso 8 0.24 2.5e-13 8.5 7.9 4.0e-15 0.98 0.01 0.99 FALSE
5 GTEx Artery Coronary CCDC152 0.20 0.13 lasso 2 0.12 7.7e-05 8.5 8.5 1.8e-17 1.00 0.01 0.98 FALSE
6 GTEx Artery Tibial CCDC152 0.22 0.17 enet 35 0.18 1.8e-14 8.5 6.6 4.6e-11 0.88 0.01 0.99 TRUE
7 GTEx Brain Caudate basal ganglia C5orf34 0.14 -0.01 enet 14 0.00 3.3e-01 3.3 5.4 5.7e-08 0.14 0.05 0.50 FALSE
8 GTEx Brain Frontal Cortex BA9 GHR 0.14 0.02 lasso 9 0.06 9.9e-03 6.5 -5.2 2.4e-07 -0.24 0.13 0.05 TRUE
9 GTEx Breast Mammary Tissue (Female) SEPP1 0.15 0.00 enet 29 0.02 1.0e-01 -1.8 -5.3 1.1e-07 -0.37 0.06 0.22 FALSE
10 GTEx Esophagus Muscularis CCDC152 0.13 0.09 lasso 8 0.10 7.9e-07 7.3 7.3 3.9e-13 0.92 0.02 0.98 FALSE
11 GTEx Nerve Tibial CCDC152 0.16 0.06 enet 25 0.06 2.9e-05 8.5 5.7 1.2e-08 0.81 0.02 0.98 TRUE
12 GTEx Stomach SERBP1P6 0.12 0.03 enet 16 0.01 6.7e-02 -4.3 6.7 2.1e-11 0.36 0.08 0.19 TRUE
13 GTEx Thyroid C5orf34 0.08 0.08 lasso 3 0.06 1.4e-05 5.4 5.5 2.9e-08 0.22 0.00 1.00 TRUE
14 GTEx Thyroid CCDC152 0.10 0.07 lasso 4 0.04 4.2e-04 8.5 8.6 1.2e-17 1.00 0.01 0.99 FALSE
15 ROSMAP Brain Pre-frontal Cortex SEPP1 0.18 0.19 lasso 11 0.21 1.3e-26 8.1 -8.6 8.7e-18 -0.98 0.01 0.99 FALSE
16 YFS Blood CCDC152 0.07 0.06 enet 16 0.06 2.0e-19 8.6 8.7 2.9e-18 0.99 0.01 0.99 TRUE
17 The Cancer Genome Atlas Breast Invasive Carcinoma SEPP1 0.01 0.00 enet 7 0.01 1.5e-03 8.0 -6.4 1.7e-10 -0.79 0.02 0.50 TRUE
18 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CCDC152 0.06 0.06 blup 40 0.07 1.6e-08 7.9 -8.4 3.6e-17 -0.95 0.03 0.97 FALSE
19 The Cancer Genome Atlas Prostate Adenocarcinoma CCDC152 0.15 0.12 lasso 6 0.12 1.0e-12 8.0 -8.0 1.3e-15 -0.92 0.46 0.54 TRUE
20 The Cancer Genome Atlas Prostate Adenocarcinoma GHR 0.12 0.11 enet 6 0.13 2.5e-13 -7.2 -7.7 1.2e-14 -0.32 1.00 0.00 TRUE
21 The Cancer Genome Atlas Prostate Adenocarcinoma SEPP1 0.06 0.02 blup 38 0.04 5.2e-05 7.3 -7.5 5.6e-14 -0.79 0.23 0.69 TRUE
22 The Cancer Genome Atlas Thyroid Carcinoma MGC42105 0.04 0.01 blup 63 0.01 4.3e-02 -3.0 -5.1 2.7e-07 -0.11 0.00 0.03 FALSE