TWAS hub - MGC42105

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Prostate Adenocarcinoma	0.160	0.0575	1.5e-06	0.053	0.075	0.055	NA	0.071	3.1e-06	3.0e-08	2.0e-06	NA	6.2e-08
2	TCGA	Thyroid Carcinoma	0.038	0.0210	6.1e-03	0.011	0.009	0.002	NA	0.007	2.7e-02	4.3e-02	1.9e-01	NA	6.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
High blood pressure (siblings)	9.8	14.2	15.7	-4.0	-3.6
Mouth/teeth dental problems: Mouth ulcers	6.5	10.3	12.5	2.8	3.5
Exposure to tobacco smoke outside home	5.8	7.8	9.0	2.6	3.0
Hip circumference	5.7	24.4	32.4	-4.0	-5.7
Commuting to job workplace: Public transport	5.2	6.2	6.4	-2.4	-2.5
Ulcerative Colitis	5.0	7.3	8.2	-2.5	-2.9
Diabetes (father)	5.0	6.2	8.3	2.9	2.0
Impedance of leg (left)	5.0	24.2	32.5	4.0	5.7
Alzheimer’s Disease (in father)	4.9	5.3	8.2	2.9	1.5
Weight	4.4	21.6	30.2	-3.6	-5.5
Leg predicted mass (left)	4.2	22.3	30.8	-3.7	-5.5
Leg fat-free mass (left)	4.1	21.8	29.8	-3.7	-5.5
Arm fat mass (right)	4.1	16.7	22.2	-3.4	-4.7
Basal metabolic rate	4.0	22.2	30.8	-3.7	-5.5
Impedance of leg (right)	3.9	18.7	25.6	3.4	5.1
Whole body water mass	3.9	22.2	30.1	-3.8	-5.5
Arm fat-free mass (left)	3.9	19.7	26.9	-3.5	-5.2
Medication for cholesterol, blood pressure or diabetes	3.8	6.3	10.2	3.2	1.5
Whole body fat-free mass	3.8	21.6	29.5	-3.7	-5.4
Arm fat mass (left)	3.8	15.4	21.8	-3.0	-4.7
Verbal and Numeric Reasoning (VNR)	3.7	8.8	12.3	-2.3	-3.5
Trunk fat mass	3.7	16.1	20.9	-3.4	-4.6
Fluid intelligence score	3.7	7.6	7.8	-2.7	-2.8
Trunk predicted mass	3.7	21.4	29.2	-3.7	-5.4
Chronotype (morning person)	3.6	8.4	11.8	2.2	3.4
Trunk fat-free mass	3.6	20.8	28.4	-3.6	-5.3
Medication: Cholesterol lowering	3.6	5.6	8.2	-2.9	-1.7
Whole body fat mass	3.6	14.8	19.8	-3.1	-4.5
Body mass index (BMI)	3.5	14.9	21.3	-2.9	-4.6
Number of full brothers	3.5	4.4	6.7	1.5	2.6
Leg fat-free mass (right)	3.5	19.0	26.4	-3.4	-5.1
Arm predicted mass (left)	3.5	17.5	24.0	-3.3	-4.9
Waist circumference	3.4	12.5	16.4	-2.9	-4.0
Leg predicted mass (right)	3.4	18.2	25.3	-3.3	-5.0
Ulcerative Colitis (UC)	3.3	6.2	6.9	-2.3	-2.6
Arm fat-free mass (right)	3.3	16.9	23.7	-3.2	-4.9
Illnesses of father: High blood pressure	3.3	4.1	6.8	-2.6	-1.2
Supplements: Zinc	3.2	3.5	4.0	-1.7	-2.0
Arm predicted mass (right)	3.2	16.1	22.3	-3.2	-4.7
Number of self-reported non-cancer illnesses	3.2	5.5	8.3	-2.9	-1.7
Risk taking	3.2	4.7	8.8	0.8	3.0
Impedance of whole body	3.0	15.0	21.8	2.9	4.7
Medication: Atenolol	2.9	3.7	4.1	-1.8	-2.0
Back pain experienced in last month	2.9	4.2	5.7	-1.6	-2.4
Leg fat mass (left)	2.9	11.5	16.5	-2.6	-4.1
Medication: Blood pressure	2.8	4.9	7.9	-2.8	-1.4
Leg fat mass (right)	2.8	10.9	15.8	-2.4	-4.0
Guilty feelings	2.8	4.2	4.3	-2.0	-2.1
Pain type(s) experienced in last month: Hip pain	2.8	3.5	3.9	-1.7	-2.0
Arm fat percentage (left)	2.7	10.7	15.1	-2.5	-3.9
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	3.9	-2.0	-1.5
Illnesses of siblings	2.6	3.7	3.9	1.9	2.0
Arm fat percentage (right)	2.6	10.2	14.1	-2.5	-3.8
Medication: Lisinopril	2.6	3.3	4.8	-2.2	-1.4
Myopia	2.6	3.8	3.8	-2.0	-1.9
Severe depression (siblings)	2.5	2.9	4.8	-2.2	-0.9
Trunk fat percentage	2.5	9.8	12.9	-2.6	-3.6
Commuting to job workplace: Cycle	2.5	3.0	4.7	-2.2	-1.2
Bipolar Disorder (2011)	2.4	2.3	4.4	-0.5	-2.1
Primary Biliary Cirrhosis	2.4	3.4	6.6	2.6	0.4
Long-standing illness, disability or infirmity	2.4	3.7	4.3	-2.1	-1.8
Prostate Cancer	2.2	3.1	4.3	1.4	2.1
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	3.6	-1.9	-1.4
Age when periods started (menarche)	2.2	5.3	6.3	2.5	2.1
Chronic bronchitis/emphysema (father)	2.2	2.5	3.8	-1.2	-1.9
Number of incorrect matches in round	2.2	3.6	6.3	-2.5	-1.0
Age started oral contraceptive pill	2.2	2.8	3.2	-1.5	-1.8
Frequency of depressed mood in last 2 weeks	2.1	3.0	4.4	-1.3	-2.1
Impedance of arm (right)	2.1	10.0	14.7	2.3	3.8
Medication: Co-codamol	2.0	2.3	3.2	-1.1	-1.8
Body fat percentage	2.0	8.1	11.1	-2.2	-3.3
Intelligence (Savage-Jansen 2018)	1.9	5.9	7.8	-2.0	-2.8
BMI	1.9	11.2	16.8	-2.4	-4.1
Pulse wave reflection index	1.9	2.3	2.6	-1.4	-1.6
Heart disease (mother)	1.9	2.3	3.3	-1.2	-1.8
Commuting to job workplace: Walk	1.9	2.0	4.1	0.1	2.0
Alzheimer’s Disease (including proxy)	1.8	2.6	3.0	1.7	1.5
Illnesses of siblings: Diabetes	1.8	2.2	3.7	1.9	0.9
Maternal smoking around birth	1.7	2.4	3.2	-1.8	-1.3
Lung cancer (father)	1.7	2.0	3.6	0.5	1.9
Deep venous thrombosis (DVT) (self-reported)	1.7	2.1	3.8	1.9	0.7
Irritable Bowel Disease (IBD)	1.6	3.8	5.4	-1.5	-2.3
Number of treatments/medications taken	1.6	2.9	3.4	-1.8	-1.5
High blood pressure	1.6	4.4	6.9	-2.6	-1.4
Nervous feelings	1.6	3.0	3.7	-1.5	-1.9
Hair/balding pattern: Pattern 2	1.6	2.0	2.8	-1.1	-1.7
Number of live births	1.6	2.3	3.5	1.9	1.1
Prospective memory result	1.6	1.9	2.2	-1.5	-1.3
Blood clot in the leg (DVT)	1.6	2.0	3.4	1.9	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	2.7	1.0	1.6
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	2.0	-1.2	-1.4
Mouth/teeth dental problems	1.5	2.3	4.1	-0.7	-2.0
Impedance of arm (left)	1.5	6.9	10.0	1.9	3.2
Shortness of breath walking on level ground	1.5	1.8	3.0	-0.8	-1.7
Illnesses of father: None of the above (group 1)	1.5	1.9	3.3	-0.7	1.8
Medication: Metformin	1.4	1.9	2.4	-1.6	-1.2
Medication: Simvastatin	1.4	2.0	3.8	-1.9	-0.5
Time employed in main current job	1.4	1.7	2.1	-1.4	-1.1
Hypertension (Self-reported)	1.4	3.9	5.6	-2.4	-1.4
Type 2 Diabetes (T2D) (2018)	1.3	2.4	3.1	-1.3	-1.8
Ever had hysterectomy (womb removed)	1.3	1.5	1.9	-1.4	-1.1
Noisy workplace	1.3	1.6	3.1	-0.2	1.8
Breastfed as a baby	1.3	1.7	2.7	-0.8	-1.7
Leg fat percentage (right)	1.3	4.8	7.6	-1.4	-2.8
Breast cancer (self-reported)	1.3	1.6	2.9	0.6	1.7
Body Mass Index (BMI) (2010)	1.2	1.6	2.8	-0.7	-1.7
Medication for hormone replacement therapy	1.2	1.4	2.2	-1.5	-0.7
Depression (self-reported)	1.1	1.3	1.8	-1.4	-0.8
Gout (self-reported)	1.1	1.6	2.3	-1.5	-0.9
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.4	-1.5	-0.4
Medication for pain relief, constipation, heartburn	1.1	2.0	3.4	1.9	0.7
Illnesses of father: Heart disease	1.1	1.5	2.9	-0.2	-1.7
Handedness (chirality/laterality): Left-handed	1.1	1.3	1.8	-1.3	-0.9
Leg fat percentage (left)	1.1	4.0	6.5	-1.2	-2.5
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.6	-1.6	0.0
Vascular/heart problems diagnosed by doctor	1.1	3.0	5.5	2.3	0.8
Smoking Status	1.0	2.3	3.0	-1.7	1.3
Sensitivity / hurt feelings	1.0	1.6	1.9	-1.2	-1.4
Fed-up feelings	1.0	1.8	3.0	-1.7	-0.8
Peak expiratory flow (PEF)	1.0	2.4	4.4	0.6	2.1
Medication: Allopurinol	1.0	1.4	2.0	-1.4	-0.9
Overall health rating	1.0	2.1	2.7	-1.3	-1.6
Eye problems/disorders: Cataract	1.0	1.1	2.2	-0.2	1.5
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.0	-0.9	-1.0
Multivitamins +/- minerals	0.9	1.1	2.1	0.4	-1.5
High blood pressure (mother)	0.9	1.3	1.7	0.9	1.3
Financial difficulties in last 2 years	0.9	1.2	2.4	-1.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.6	-0.4	-1.9
Comparative body size at age 10	0.9	2.5	4.8	-0.5	-2.2
Chest pain or discomfort	0.9	1.3	2.4	-1.6	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.7	0.4	1.3
Ever smoked	0.9	1.6	3.2	0.1	1.8
Rheumatoid Arthritis	0.8	1.2	1.9	1.4	0.7
Cardiovascular Disease	0.8	2.5	4.9	-2.2	-0.2
Townsend deprivation index at recruitment	0.8	1.1	2.0	-1.4	0.5
Diabetes (self-reported)	0.8	1.2	2.4	-0.3	-1.5
Loud music exposure frequency	0.8	0.9	1.1	-0.8	1.1
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.2	1.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.8	1.4	0.1
Comparative height size at age 10	0.8	4.3	5.5	-1.8	-2.3
Number of full sisters	0.8	0.9	1.3	-1.2	-0.7
Diabetes diagnosed by doctor	0.8	1.3	2.4	-0.5	-1.5
Basal cell carcinoma (self-reported)	0.8	0.9	1.8	0.2	1.3
Coronary Artery Disease (CAD)	0.7	0.8	1.5	-1.2	-0.2
Blood Eosinophil Count	0.7	5.4	8.5	-1.5	-2.9
Waist Hip Ratio (WHR)	0.7	3.1	5.4	0.9	2.3
Neuroticism	0.7	1.7	2.7	-1.7	-0.9
Relative age voice broke	0.7	1.0	1.8	-1.4	-0.4
Qualifications: CSEs or equivalent	0.7	1.0	1.8	-1.3	-0.3
Medication: Ramipril	0.7	0.9	1.4	-0.6	-1.2
Falls in the last year	0.7	0.9	1.1	0.9	1.0
Medication: Paracetamol	0.7	1.2	1.9	-1.4	-0.7
Medication: Amlodipine	0.7	1.0	1.5	0.8	1.2
Emphysema/chronic bronchitis	0.7	0.8	1.0	-0.7	-1.0
Migraine (self-reported)	0.7	0.8	1.3	-1.1	0.6
Medication: Ibuprofen	0.7	0.8	1.3	-1.1	0.6
Osteoporosis (self-reported)	0.7	0.9	1.7	-0.3	1.3
Pack years of smoking	0.7	1.0	1.5	-1.2	-0.6
Lung FVC	0.6	3.3	3.5	-1.9	1.8
Diabetes (mother)	0.6	0.8	1.1	-1.0	0.7
Sitting height	0.6	4.3	4.8	-1.9	-2.2
Past tobacco smoking	0.6	1.1	1.9	0.5	-1.4
Alcohol intake versus 10 years previously	0.6	0.9	1.1	-1.1	-0.9
Hair/balding pattern: Pattern 3	0.6	0.8	1.3	-0.6	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.5	-1.2	0.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.4	-1.2	-0.2
Medication: Seretide 50 evohaler	0.6	0.7	0.8	-0.9	-0.8
Friendships satisfaction	0.6	0.7	1.1	-1.0	-0.6
Smoking status: Current	0.6	0.9	1.4	-1.2	0.6
Medication: Paracetamol	0.6	1.0	1.6	-1.3	-0.5
Height	0.5	9.3	15.1	-1.9	-3.9
Hypothyroidism (self reported)	0.5	1.1	2.1	0.4	-1.4
Lung FEV1/FVC ratio	0.5	2.3	3.1	-1.8	1.2
Hearing difficulty/problems: Yes	0.5	0.8	1.2	0.6	1.1
Relative age of first facial hair	0.5	1.1	2.1	-1.4	0.1
Vitamin and mineral supplements	0.5	0.7	1.4	-1.2	0.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.1	1.5	0.5
Had other major operations	0.5	0.6	1.1	0.2	1.1
Neuroticism score	0.5	1.1	2.0	-1.4	-0.5
Asthma	0.5	1.0	1.4	0.8	-1.2
Standing height	0.5	5.1	6.4	-2.0	-2.5
Health satisfaction	0.5	0.7	1.3	-1.1	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.9	-0.9	-0.6
Ovarian Cancer	0.4	0.5	0.6	-0.6	0.8
HbA1C	0.4	0.4	0.7	-0.8	-0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.6	-0.6	-0.8
Average weekly spirits intake	0.4	0.5	0.8	-0.5	-0.9
Angina	0.4	0.5	0.6	-0.8	-0.6
Pack years adult smoking proportion	0.4	0.7	1.3	-1.1	-0.1
Current tobacco smoking	0.4	0.6	0.6	-0.8	0.8
Average weekly fortified wine intake	0.4	0.5	0.8	0.9	0.5
Taking other prescription medications	0.4	0.6	0.8	-0.6	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.0	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	1.7	-1.0	1.3
Exposure to tobacco smoke at home	0.4	0.4	0.7	-0.5	0.8
Hair/balding pattern: Pattern 4	0.4	1.0	1.6	-0.6	-1.3
Glaucoma (self-reported)	0.4	0.5	0.6	-0.6	-0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	-0.2	-1.0
Worry too long after embarrassment	0.4	0.7	1.3	-0.4	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.7	0.6	0.8
Smoking status: Previous	0.4	0.5	0.6	-0.8	0.7
Medication: Gliclazide	0.4	0.4	0.8	-0.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.5	-0.2	1.2
Ever taken oral contraceptive pill	0.4	0.4	0.7	-0.8	-0.3
Fractured/broken bones in last 5 years	0.4	0.5	0.8	-0.9	0.3
Supplements: Calcium	0.4	0.4	0.6	-0.8	-0.5
Alcohol drinker status: Previous	0.4	0.4	0.6	-0.8	-0.5
Depressed Affect (Nagel 2018)	0.3	0.7	1.3	-1.1	0.3
Neuroticism (Nagel 2018)	0.3	0.8	1.3	-1.1	-0.6
Alzheimer’s Disease (in mother)	0.3	0.4	0.6	0.4	0.8
Crohns Disease (2017)	0.3	0.6	1.0	-0.3	-1.0
Breast Cancer	0.3	0.7	1.1	0.6	1.0
Neuroticism (2016)	0.3	0.5	0.9	-1.0	-0.1
Allergy or Eczema	0.3	0.9	1.5	1.2	-0.5
Respiratory disease	0.3	0.6	1.0	0.4	-1.0
Tanning	0.3	3.9	6.3	1.2	2.5
Medication: Levothyroxine sodium	0.3	0.4	0.5	0.7	-0.6
Had menopause	0.3	0.4	0.4	-0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.0	-0.5	-1.0
Qualifications: None of the above	0.3	0.7	1.3	-0.0	1.2
Allergy	0.3	0.6	1.1	-1.0	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.5	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.6	-0.8	1.3
Pulse rate	0.3	0.6	0.8	0.6	0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	0.8	0.6	-0.9
Pulse wave Arterial Stiffness index	0.3	0.4	0.4	-0.6	-0.6
Tense / ‘highly strung’	0.3	0.5	0.9	-1.0	-0.1
Birth weight of first child	0.3	0.6	1.1	1.1	-0.2
Forced vital capacity (FVC), Best measure	0.3	1.0	1.9	-1.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.6	-0.8	-0.2
Number of children fathered	0.3	0.3	0.6	0.3	-0.8
Pulse wave peak to peak time	0.3	0.3	0.4	0.6	0.5
Angina (self-reported)	0.3	0.4	0.5	-0.7	-0.5
Medication: Omeprazole	0.3	0.4	0.8	-0.9	-0.2
Asthma (self-reported)	0.3	0.5	0.8	0.5	-0.9
Osteoarthritis (self-reported)	0.3	0.4	0.4	-0.7	-0.6
Miserableness	0.3	0.6	1.1	-1.1	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	-0.0	-0.8
Unable to work because of sickness or disability	0.3	0.4	0.4	-0.6	0.7
Depression (Nagel 2018)	0.2	0.3	0.6	-0.2	-0.8
Age at First Birth	0.2	0.3	0.5	-0.2	-0.7
Triglycerides	0.2	0.4	0.4	-0.6	-0.6
Heel T-Score	0.2	1.3	2.5	0.4	1.6
Systolic Blood Pressure	0.2	1.1	2.0	-0.4	1.4
Systolic blood pressure, automated reading	0.2	0.6	1.0	0.4	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.4	-0.6	-0.6
Stomach or abdominal pain in last month	0.2	0.3	0.4	-0.6	-0.3
Alcohol usually taken with meals	0.2	0.4	0.5	0.5	0.7
Forced vital capacity (FVC)	0.2	0.9	1.3	-1.1	0.7
Pain all over the body in last month	0.2	0.2	0.5	0.2	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.2	0.5	0.4
Mouth/teeth dental problems: Dentures	0.2	0.4	0.8	-0.9	-0.0
Illnesses of mother	0.2	0.2	0.2	0.4	0.5
Length of working week for main job	0.2	0.2	0.5	-0.7	-0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.4	-0.6	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	0.1	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.7	0.2
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.1	-0.6
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.1	0.7
Pulse rate, automated reading	0.2	0.7	1.1	1.0	0.6
Had major operations	0.2	0.2	0.3	-0.6	-0.4
Family relationship satisfaction	0.2	0.2	0.2	-0.5	-0.4
Leg pain on walking	0.2	0.3	0.3	-0.5	-0.5
Medication: Aspirin	0.2	0.2	0.3	-0.6	-0.4
Supplements: Vitamin C	0.2	0.3	0.3	0.4	0.6
Loneliness, isolation	0.2	0.2	0.4	-0.6	0.3
Ever had bowel cancer screening	0.2	0.2	0.2	-0.4	-0.5
Qualifications: nursing, teaching	0.2	0.3	0.6	0.2	-0.8
Medication: Aspirin	0.2	0.2	0.4	-0.2	-0.6
Financial situation satisfaction	0.2	0.2	0.4	-0.6	0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	0.6	-0.3
Medication: Bendroflumethiazide	0.2	0.3	0.3	0.5	0.6
Medication: Atorvastatin	0.2	0.3	0.6	0.8	-0.1
Alcohol drinker status: Never	0.2	0.2	0.2	0.5	-0.5
Cholesterol lowering medication	0.2	0.4	0.5	0.7	0.4
Worry (Nagel 2018)	0.1	0.2	0.4	-0.6	-0.2
Major Depression (MDD)	0.1	0.2	0.3	0.6	-0.1
Reaction Time	0.1	0.1	0.2	0.5	0.2
Crohns Disease (2012)	0.1	0.2	0.3	-0.3	-0.5
Mean Putamen Volume	0.1	0.1	0.1	-0.3	0.3
Fasting Glucose	0.1	0.1	0.2	-0.3	0.4
HDL Cholesterol	0.1	0.2	0.3	-0.5	-0.5
LDL Cholesterol	0.1	0.2	0.3	-0.1	-0.6
Lupus	0.1	0.2	0.2	0.5	0.5
Schizophrenia (2014)	0.1	0.2	0.4	0.6	0.1
Hair Pigment	0.1	1.7	2.3	1.5	1.0
Hand grip strength (left)	0.1	0.2	0.2	-0.5	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.2	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	0.2	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.6	-0.0
Hearing difficulty/problems with background noise	0.1	0.1	0.1	-0.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	0.3	-0.2
Father’s age at death	0.1	0.1	0.1	0.3	0.3
Worrier / anxious feelings	0.1	0.2	0.3	-0.1	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.5	-0.0
Headache pain in last month	0.1	0.2	0.3	0.5	0.5
Qualifications: College or University degree	0.1	0.2	0.3	0.5	-0.3
Mean time to correctly identify matches	0.1	0.3	0.5	-0.0	-0.7
Alcohol intake frequency.	0.1	0.2	0.5	-0.1	-0.7
Suffer from ‘nerves’	0.1	0.1	0.1	0.4	-0.3
Age at last live birth	0.1	0.1	0.1	0.2	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.5	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	0.1	-0.5
Knee pain experienced in last month	0.1	0.1	0.2	0.5	0.2
Mood swings	0.1	0.2	0.3	-0.6	0.1
Medication for cholesterol	0.1	0.1	0.3	0.1	0.5
Mineral and other dietary supplements	0.1	0.1	0.2	-0.4	0.3
Wears glasses or contact lenses	0.1	0.1	0.2	-0.5	0.2
High cholesterol (Self-reported)	0.1	0.3	0.4	-0.4	0.6
Number of operations (self-reported)	0.1	0.1	0.3	0.1	0.5
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.2	-0.4
Diastolic blood pressure, automated reading	0.1	0.2	0.2	-0.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.3	0.4
Heart disease (siblings)	0.1	0.1	0.1	0.4	0.1
Bipolar Disorder (2018)	0.0	0.1	0.1	0.3	-0.2
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	0.3	-0.3
Schizophrenia (2018)	0.0	0.0	0.0	0.1	0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	0.3	-0.1
Blood Platelet Count	0.0	0.4	0.8	-0.2	0.9
Blood Red Count	0.0	0.3	0.4	0.6	0.4
Blood White Count	0.0	0.3	0.4	-0.4	-0.6
Hand grip strength (right)	0.0	0.0	0.0	0.2	0.1
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.0	-0.1
Supplements: Glucosamine	0.0	0.1	0.1	0.3	-0.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	0.2	0.0
Heart attack	0.0	0.1	0.1	0.0	-0.3
Happiness	0.0	0.0	0.1	0.3	0.0
Medication: Lansoprazole	0.0	0.1	0.1	0.2	-0.2
Birth weight	0.0	0.0	0.0	-0.1	0.1
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	0.2	-0.3
Age at first live birth	0.0	0.1	0.2	0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	-0.4	0.1
Average weekly red wine intake	0.0	0.0	0.0	-0.2	-0.2
Average weekly champagne plus white wine intake	0.0	0.0	0.0	0.1	-0.0
Hearing aid user	0.0	0.0	0.1	-0.2	0.1
Mother’s age at death	0.0	0.0	0.1	-0.1	-0.3
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	0.0	0.1
Medication: Blood pressure	0.0	0.1	0.2	0.4	-0.1
Irritability	0.0	0.1	0.1	0.2	0.3
Ever depressed for a whole week	0.0	0.0	0.0	0.2	0.1
Pain experienced in last month	0.0	0.0	0.1	0.2	-0.0
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.1	-0.2	-0.3

Hub : Genes

MGC42105

Models

Trait associations