[Hub]/) : Traits : Leg predicted mass (right) :

chr1:76,862,305-79,699,821

Best TWAS P=4.05e-18 · Best GWAS P=9.89e-40 conditioned to 6.29e-23

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Coronary PIGK 0.22 0.00 lasso 8 -0.01 9.0e-01 4.7 -5.3 1.1e-07 -0.10 0.08 0.06 TRUE
2 GTEx Cells EBV-transformed lymphocytes NEXN 0.23 0.10 lasso 3 0.08 1.4e-03 -5.7 -6.1 8.6e-10 -0.13 0.21 0.04 FALSE
3 GTEx Cells Transformed fibroblasts PTGFR 0.12 0.04 enet 17 0.04 4.7e-04 4.3 -6.3 2.2e-10 -0.26 0.97 0.00 FALSE
4 GTEx Lung GIPC2 0.15 0.09 enet 17 0.12 2.5e-09 -5.9 6.2 4.0e-10 0.19 1.00 0.00 FALSE
5 GTEx Nerve Tibial DNAJB4 0.08 0.07 lasso 3 0.07 1.3e-05 -5.7 -5.7 1.0e-08 -0.14 0.82 0.01 FALSE
6 GTEx Pancreas GIPC2 0.41 0.13 enet 29 0.14 1.1e-06 -5.3 6.2 5.8e-10 0.31 0.65 0.10 FALSE
7 GTEx Skin Sun Exposed Lower leg DNAJB4 0.07 0.05 lasso 5 0.05 6.5e-05 -5.7 -5.4 7.0e-08 -0.11 0.60 0.01 FALSE
8 GTEx Spleen GIPC2 0.43 0.07 enet 19 0.22 2.9e-06 -6.0 6.5 1.0e-10 0.22 0.83 0.02 FALSE
9 METSIM Adipose DNAJB4 0.04 0.04 lasso 4 0.03 2.1e-05 -5.9 -6.3 2.4e-10 -0.26 0.70 0.01 FALSE
10 ROSMAP Brain Pre-frontal Cortex DNAJB4 0.08 0.09 lasso 2 0.09 1.3e-11 -5.5 -5.5 2.9e-08 -0.18 1.00 0.00 FALSE
11 ROSMAP Brain Pre-frontal Cortex FAM73A 0.09 0.04 enet 19 0.06 9.6e-09 -3.6 7.6 4.0e-14 0.33 0.99 0.01 FALSE
12 The Cancer Genome Atlas Bladder Urothelial Carcinoma DNAJB4 0.05 0.03 lasso 3 0.02 3.3e-03 -5.3 -6.1 9.0e-10 -0.20 0.30 0.09 FALSE
13 The Cancer Genome Atlas Breast Invasive Carcinoma GIPC2 0.02 0.02 lasso 2 0.02 8.3e-05 -5.3 5.4 6.8e-08 0.24 0.56 0.02 FALSE
14 The Cancer Genome Atlas Colon Adenocarcinoma GIPC2 0.04 0.01 blup 65 0.00 2.5e-01 -5.3 7.3 3.8e-13 0.28 0.07 0.06 FALSE
15 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma USP33 0.07 0.02 blup 42 0.01 7.7e-03 -2.9 -5.8 5.9e-09 -0.21 0.06 0.03 FALSE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GIPC2 0.10 0.06 enet 13 0.06 1.5e-07 -6.4 7.1 1.7e-12 0.37 0.96 0.00 FALSE
17 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NEXN 0.03 0.01 blup 44 0.01 1.3e-02 -3.5 5.5 3.9e-08 0.23 0.02 0.07 FALSE
18 The Cancer Genome Atlas Brain Lower Grade Glioma DNAJB4 0.08 0.07 lasso 1 0.06 9.3e-08 -5.3 -5.3 1.4e-07 -0.19 0.97 0.00 FALSE
19 The Cancer Genome Atlas Brain Lower Grade Glioma GIPC2 0.02 0.02 lasso 3 0.02 1.0e-03 -6.0 6.1 1.4e-09 0.22 0.37 0.02 FALSE
20 The Cancer Genome Atlas Lung Adenocarcinoma DNAJB4 0.04 0.04 lasso 2 0.04 1.2e-05 8.7 -8.7 4.1e-18 -0.45 0.00 1.00 TRUE
21 The Cancer Genome Atlas Testicular Germ Cell Tumors DNAJB4 0.24 0.14 lasso 1 0.11 1.1e-04 -5.3 -5.3 1.4e-07 -0.19 0.10 0.20 FALSE
22 The Cancer Genome Atlas Thyroid Carcinoma GIPC2 0.07 0.05 blup 64 0.06 1.5e-06 -6.7 6.8 1.1e-11 0.28 0.67 0.02 FALSE