Best TWAS P=2.56e-13 · Best GWAS P=5.24e-13 conditioned to 0.00481
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | MADD | 0.09 | 0.03 | enet | 22 | 0.04 | 1.9e-03 | -7.2 | 7.3 | 2.6e-13 | -0.72 | 0.01 | 0.93 | TRUE |
| 2 | GTEx | Artery Aorta | PACSIN3 | 0.10 | 0.04 | lasso | 4 | 0.03 | 1.1e-02 | 4.5 | 5.9 | 3.6e-09 | -0.27 | 0.36 | 0.06 | FALSE |
| 3 | GTEx | Artery Tibial | MADD | 0.09 | 0.00 | enet | 13 | 0.02 | 1.1e-02 | -2.9 | 5.7 | 9.7e-09 | -0.63 | 0.17 | 0.64 | FALSE |
| 4 | GTEx | Esophagus Mucosa | MADD | 0.27 | 0.04 | enet | 18 | 0.12 | 4.1e-08 | -3.4 | 6.0 | 1.6e-09 | -0.54 | 0.15 | 0.46 | FALSE |
| 5 | GTEx | Esophagus Muscularis | MADD | 0.13 | 0.07 | enet | 8 | 0.11 | 2.0e-07 | -3.4 | 5.8 | 5.3e-09 | -0.62 | 0.45 | 0.40 | FALSE |
| 6 | GTEx | Muscle Skeletal | SLC39A13 | 0.05 | 0.01 | lasso | 3 | 0.01 | 8.5e-02 | 4.8 | -5.3 | 1.4e-07 | 0.41 | 0.05 | 0.53 | FALSE |
| 7 | GTEx | Prostate | PSMC3 | 0.21 | 0.10 | lasso | 6 | 0.20 | 7.9e-06 | 5.1 | -5.5 | 4.1e-08 | 0.12 | 0.14 | 0.13 | FALSE |
| 8 | NTR | Blood | MADD | 0.01 | 0.01 | enet | 8 | 0.01 | 4.7e-03 | 5.5 | 7.1 | 1.7e-12 | -0.40 | 0.16 | 0.10 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | MADD | 0.33 | 0.16 | enet | 23 | 0.23 | 1.9e-29 | -3.4 | 5.6 | 2.4e-08 | -0.46 | 1.00 | 0.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | CELF1 | 0.03 | 0.01 | bslmm | 289 | 0.01 | 2.9e-02 | 5.4 | 5.9 | 2.9e-09 | -0.39 | 0.16 | 0.13 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MADD | 0.16 | 0.05 | blup | 64 | 0.08 | 2.2e-09 | 5.1 | 5.7 | 1.5e-08 | -0.31 | 0.01 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MADD | 0.15 | 0.04 | enet | 10 | 0.06 | 4.5e-07 | -3.4 | 5.5 | 4.1e-08 | -0.36 | 0.15 | 0.25 | FALSE |