[Hub]/) : Traits : Leg predicted mass (right) :

chr2:197,660,966-201,571,143

Best TWAS P=1.13e-10 · Best GWAS P=1.7e-12 conditioned to 0.0189

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TYW5 0.08 0.14 lasso 8 0.13 2.2e-15 -5.08 5.3 1.1e-07 -0.05 0.03 0.97 FALSE
2 GTEx Adipose Subcutaneous RFTN2 0.14 0.10 enet 11 0.13 5.3e-11 -5.77 -5.9 4.0e-09 0.86 0.36 0.64 FALSE
3 GTEx Brain Nucleus accumbens basal ganglia C2orf47 0.25 0.01 lasso 3 0.00 2.8e-01 5.02 -5.6 2.6e-08 0.04 0.05 0.45 TRUE
4 GTEx Cells EBV-transformed lymphocytes HSPD1 0.15 0.04 lasso 7 0.04 2.0e-02 -4.38 5.3 9.6e-08 -0.64 0.12 0.52 FALSE
5 GTEx Lung RFTN2 0.06 0.08 lasso 8 0.06 2.7e-05 -6.34 -6.1 9.8e-10 0.86 0.16 0.83 FALSE
6 GTEx Skin Sun Exposed Lower leg MARS2 0.04 0.05 enet 8 0.03 1.2e-03 -6.52 6.4 1.5e-10 -0.86 0.13 0.87 FALSE
7 GTEx Spleen RFTN2 0.11 0.03 enet 26 0.05 2.4e-02 -6.54 -5.9 3.6e-09 0.84 0.09 0.33 FALSE
8 GTEx Spleen MARS2 0.12 0.04 lasso 5 0.00 3.4e-01 -6.49 5.9 3.6e-09 -0.82 0.07 0.31 FALSE
9 GTEx Thyroid PLCL1 0.04 0.01 lasso 4 0.00 2.6e-01 -6.36 -5.4 8.2e-08 0.76 0.20 0.49 FALSE
10 GTEx Thyroid RFTN2 0.04 0.01 enet 11 0.01 9.5e-02 -6.46 -6.0 1.6e-09 0.80 0.10 0.70 FALSE
11 GTEx Whole Blood PLCL1 0.08 0.08 enet 15 0.05 4.1e-05 -6.06 -6.5 1.1e-10 0.92 0.14 0.86 TRUE
12 ROSMAP Brain Pre-frontal Cortex TYW5 0.11 0.12 lasso 5 0.11 5.5e-14 -5.08 5.2 1.7e-07 -0.04 0.03 0.97 FALSE
13 ROSMAP Brain Pre-frontal Cortex C2orf69 0.07 0.04 enet 13 0.06 3.6e-08 -4.89 5.3 1.3e-07 -0.05 0.04 0.96 FALSE
14 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PLCL1 0.04 0.00 blup 130 0.02 4.0e-03 0.75 -5.5 4.0e-08 0.65 0.05 0.38 FALSE
15 The Cancer Genome Atlas Lung Adenocarcinoma C2orf60 0.03 0.03 blup 44 0.03 1.8e-04 -5.06 5.5 4.0e-08 -0.05 0.01 0.97 FALSE
16 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C2orf60 0.04 0.05 lasso 5 0.03 2.1e-03 -5.23 5.2 1.7e-07 -0.04 0.01 0.89 FALSE