TWAS hub - CEP85

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.3010	0.0720	2.0e-04	0.072	NA	0.083	NA	0.053	8.9e-05	NA	2.6e-05	NA	6.9e-04
2	GTEx	Artery Tibial	0.1824	0.0541	7.9e-05	0.017	NA	0.011	NA	0.037	1.7e-02	NA	4.5e-02	NA	6.2e-04
3	GTEx	Brain Caudate basal ganglia	0.3820	0.1120	2.0e-03	0.081	NA	0.280	NA	0.205	2.6e-03	NA	1.1e-08	NA	1.6e-06
4	GTEx	Brain Cerebellum	0.3770	0.0930	8.6e-05	0.154	NA	0.125	NA	0.158	2.7e-05	NA	1.5e-04	NA	2.1e-05
5	GTEx	Esophagus Mucosa	0.2820	0.0630	2.0e-06	0.107	NA	0.145	NA	0.093	1.3e-07	NA	6.3e-10	NA	8.2e-07
6	GTEx	Esophagus Muscularis	0.1690	0.0570	8.6e-04	0.034	NA	0.074	NA	0.062	4.0e-03	NA	2.9e-05	NA	1.3e-04
7	GTEx	Heart Atrial Appendage	0.1670	0.0570	3.8e-04	0.018	NA	0.034	NA	0.016	5.2e-02	NA	1.2e-02	NA	6.4e-02
8	GTEx	Lung	0.1508	0.0441	4.2e-05	0.089	NA	0.070	NA	0.085	2.5e-07	NA	4.7e-06	NA	5.1e-07
9	GTEx	Nerve Tibial	0.1084	0.0461	7.6e-03	0.063	NA	0.039	NA	0.058	3.0e-05	NA	8.8e-04	NA	6.0e-05
10	GTEx	Thyroid	0.3430	0.0530	1.8e-15	0.169	NA	0.250	NA	0.201	6.2e-13	NA	3.9e-19	NA	2.6e-15
11	GTEx	Whole Blood	0.0680	0.0270	1.3e-03	0.009	NA	0.015	NA	0.014	4.1e-02	NA	1.3e-02	NA	1.6e-02
12	METSIM	Adipose	0.0877	0.0261	4.5e-06	0.050	0.053	0.050	0.056	0.043	5.4e-08	1.8e-08	4.5e-08	7.9e-09	4.7e-07
13	ROSMAP	Brain Pre-frontal Cortex	0.0482	0.0227	1.1e-02	0.016	0.014	0.016	0.016	0.017	3.3e-03	5.4e-03	3.6e-03	2.9e-03	2.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.3	5.0	8.5	2.8	2.9	1.6	1.7	1.8	2.0	-2.5	2.1	2.7	1.6	2.4	2.0	2.5
Peak expiratory flow (PEF)	3.8	8.8	15.2	-2.8	-3.9	-1.8	-1.4	-2.2	-3.6	2.7	-3.1	-2.8	-2.7	-3.9	-3.4	-3.0
Medication: Allopurinol	3.5	4.6	13.5	1.1	2.4	1.9	0.2	3.7	1.9	0.9	1.6	2.3	2.0	2.3	2.6	2.7
Migraine (self-reported)	3.2	3.9	7.0	-1.4	-2.4	-1.0	-1.7	-2.0	-2.2	0.2	-2.7	-2.6	-1.8	-0.9	-2.6	-2.4
Forced expiratory volume in 1-second (FEV1)	2.7	9.0	25.5	-2.2	-4.0	-2.0	-1.1	-1.6	-3.2	4.4	-2.4	-2.4	-1.4	-5.0	-3.4	-2.7
Triglycerides	2.6	4.2	9.0	0.8	2.4	2.3	2.1	1.6	1.7	-0.4	2.6	2.1	1.7	3.0	2.1	2.4
Blood clot in the leg (DVT)	2.6	3.4	6.9	-1.2	-2.2	-0.6	-2.3	-2.2	-0.8	1.9	-1.0	-2.1	0.5	-2.6	-2.4	-2.1
Deep venous thrombosis (DVT) (self-reported)	2.6	3.3	7.0	-1.3	-2.1	-0.6	-2.2	-2.3	-0.8	1.6	-1.0	-2.2	0.4	-2.3	-2.6	-2.1
Irritable Bowel Disease (IBD)	2.5	5.9	14.4	1.0	3.8	0.9	2.3	2.3	1.7	-0.5	1.3	3.0	1.3	3.8	3.3	3.0
Supplements: Vitamin C	2.5	2.9	5.3	-1.8	-1.8	-2.2	-0.8	-1.2	-1.2	1.7	-1.8	-1.6	-0.4	-2.3	-2.2	-2.0
Commuting to job workplace: Walk	2.5	2.7	6.5	-0.7	-2.2	-2.2	-1.8	-0.7	-1.7	0.9	-1.8	-1.5	-0.9	-2.5	-1.3	-1.6
Pain experienced in last month	2.5	4.2	16.8	0.4	2.7	0.4	3.5	0.8	0.4	-0.3	1.5	2.0	0.3	4.1	2.6	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.6	25.2	-2.3	-4.1	-1.4	-1.3	-1.6	-2.6	3.7	-1.9	-2.1	-1.2	-5.0	-2.9	-2.5
Eye problems/disorders: None of the above	2.4	2.8	9.1	3.0	1.6	1.4	-0.6	1.6	1.9	1.2	1.6	1.6	1.8	0.4	1.6	1.7
Mouth/teeth dental problems: Mouth ulcers	2.3	3.6	7.0	-2.3	-2.5	-0.4	-2.4	-1.6	-1.1	1.1	-1.5	-2.7	-1.3	-1.9	-2.0	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.8	18.7	-2.5	-2.6	0.2	-1.5	-0.4	-1.3	4.3	-1.8	-1.6	0.0	-3.1	-2.8	-1.8
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	5.5	-1.5	-1.8	-2.1	-1.5	-1.7	-1.2	-0.2	-2.4	-2.1	-1.0	-1.9	-1.2	-2.3
Hayfever, allergic rhinitis or eczema	2.1	4.6	20.1	-0.7	3.2	1.7	4.0	0.6	0.4	-0.6	0.5	1.5	-0.4	4.5	2.4	1.3
Forced vital capacity (FVC)	2.1	8.0	22.9	-1.8	-4.0	-2.3	-1.1	-1.1	-2.8	4.5	-2.1	-2.0	-1.0	-4.8	-3.3	-2.4
Gout (self-reported)	2.1	2.9	7.5	0.6	1.7	1.9	-0.5	2.7	1.9	1.1	1.2	1.3	2.3	1.7	1.9	1.8
Knee pain experienced in last month	2.1	3.3	8.9	-1.2	-2.2	-0.8	-2.7	-1.2	-0.8	-1.0	-1.5	-2.3	-0.8	-3.0	-1.8	-2.2
Ulcerative Colitis	2.0	2.9	9.2	1.2	2.2	0.3	1.8	1.1	0.5	-0.8	1.1	2.0	0.7	3.0	2.6	2.0
Allergy or Eczema	2.0	5.3	16.2	-0.2	3.3	2.1	3.9	1.6	1.2	-1.4	1.2	2.1	0.1	4.0	2.9	1.8
Exposure to tobacco smoke at home	2.0	2.2	4.7	1.1	1.9	0.5	1.5	1.3	1.1	-2.2	1.8	1.7	0.2	1.4	1.8	1.7
Forced vital capacity (FVC), Best measure	2.0	7.3	26.3	-2.0	-4.2	-1.5	-1.6	-0.9	-2.0	4.2	-1.8	-1.9	-0.6	-5.1	-2.8	-2.3
Medication: Omeprazole	2.0	2.3	12.5	-0.6	-0.1	-1.2	1.3	-3.5	-2.0	-0.8	-0.6	-1.4	-1.3	1.4	-1.5	-1.3
HDL Cholesterol	1.9	3.2	7.0	-0.8	-2.2	-1.2	-2.2	-2.1	-0.7	0.3	-1.6	-2.1	-0.1	-2.6	-2.6	-2.1
Time employed in main current job	1.9	2.2	4.5	-0.6	-2.1	-1.9	-2.1	-0.8	-0.7	0.2	-1.2	-1.8	-0.6	-2.0	-1.7	-1.7
Number of children fathered	1.9	2.2	6.7	-2.6	-2.1	-0.3	-1.2	-0.7	-1.1	1.0	-0.8	-1.9	-0.5	-1.9	-1.3	-1.8
Qualifications: nursing, teaching	1.9	3.0	6.7	-2.1	-1.9	-0.3	-0.4	-1.7	-2.1	-0.2	-2.6	-2.0	-2.5	-0.4	-1.2	-2.1
Cholesterol lowering medication	1.9	2.8	9.6	0.2	2.2	1.1	1.9	1.6	0.2	-1.1	1.1	1.7	0.4	3.1	2.4	1.8
Heel T-Score	1.8	14.5	58.8	-0.2	-2.9	-7.7	-0.8	-3.3	-4.5	-3.4	-4.2	-3.6	-4.5	-1.7	-3.2	-3.8
Glaucoma (self-reported)	1.8	2.1	4.8	-1.2	-1.3	-1.6	0.0	-1.0	-2.2	0.5	-1.9	-1.5	-2.1	-0.2	-1.8	-1.6
Crohns Disease (2017)	1.7	3.7	8.8	1.1	2.8	0.5	0.7	2.1	2.2	-0.0	0.9	2.5	1.5	2.2	3.0	2.5
Ulcerative Colitis (UC)	1.7	3.2	10.2	0.7	2.7	1.0	2.4	1.4	0.6	-0.5	1.0	2.1	0.4	3.2	2.1	2.0
Major Depression (MDD)	1.7	2.1	4.7	-1.5	-1.2	-2.2	-1.5	-0.8	-1.3	0.7	-1.8	-1.7	-0.2	-0.5	-2.1	-1.7
Leg fat-free mass (right)	1.7	8.9	26.8	-2.6	-4.2	-1.7	-3.0	1.1	-2.2	3.6	-2.6	-2.6	-0.8	-5.2	-3.3	-2.7
Leg predicted mass (right)	1.7	9.0	26.7	-2.7	-4.3	-1.9	-3.0	1.1	-2.2	3.5	-2.6	-2.6	-0.9	-5.2	-3.4	-2.7
High cholesterol (Self-reported)	1.7	3.0	8.9	0.5	2.0	0.7	1.2	1.5	0.7	-2.3	1.3	1.4	0.4	3.0	2.9	1.9
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	10.9	-0.4	0.0	-0.8	1.1	-3.3	-2.0	-0.3	-1.1	-1.3	-1.4	1.1	-1.3	-1.2
HbA1C	1.6	1.7	4.5	-1.7	-1.3	-0.4	-0.6	-2.1	-1.6	0.3	-1.3	-2.0	-0.6	-0.1	-0.8	-1.8
Leg fat-free mass (left)	1.6	8.3	25.6	-2.7	-4.1	-1.3	-2.9	1.3	-2.2	3.4	-2.6	-2.6	-1.0	-5.1	-3.0	-2.6
Townsend deprivation index at recruitment	1.6	2.3	4.5	1.8	2.1	1.9	1.1	0.2	1.0	-1.0	0.6	1.9	1.1	2.0	1.6	1.8
Leg predicted mass (left)	1.6	8.3	25.5	-2.7	-4.1	-1.4	-2.8	1.3	-2.2	3.3	-2.6	-2.5	-1.1	-5.0	-3.0	-2.6
Hair/balding pattern: Pattern 2	1.6	2.1	4.3	1.3	2.1	-0.1	1.2	1.4	1.3	-1.1	1.4	2.0	0.9	1.5	1.4	2.0
Allergy	1.6	3.6	19.2	2.1	-2.6	-1.4	-3.4	-0.1	0.2	-0.4	0.2	-0.7	0.1	-4.4	-1.3	-0.5
Arm fat-free mass (right)	1.6	8.4	22.9	-3.1	-3.9	-1.4	-2.4	1.3	-2.3	4.2	-2.8	-2.3	-0.6	-4.8	-3.2	-2.5
Arm predicted mass (right)	1.6	8.2	21.4	-3.2	-3.8	-1.4	-2.2	1.3	-2.5	4.1	-2.8	-2.3	-0.7	-4.6	-3.2	-2.5
Breast cancer (self-reported)	1.6	1.9	4.5	-1.4	-1.4	-0.9	-0.0	-2.1	-1.3	-1.8	-1.2	-1.6	-1.1	-0.7	-1.1	-1.8
Tinnitus: Yes, now most or all of the time	1.6	1.9	4.6	-0.4	-1.1	-2.1	-0.9	-0.9	-1.0	1.7	-1.2	-1.4	-0.7	-1.8	-2.0	-1.4
Commuting to job workplace: Public transport	1.6	2.0	7.2	0.1	-1.0	-1.6	-0.9	-1.2	-1.7	-0.4	-2.7	-1.0	-2.6	0.3	-0.7	-0.9
Ovarian Cancer	1.5	1.9	4.0	1.0	1.7	0.2	1.4	1.4	1.2	-1.3	1.2	1.8	0.4	2.0	1.6	1.7
Blood Eosinophil Count	1.5	11.8	53.3	-0.2	4.9	3.6	5.3	0.6	0.1	-0.5	0.9	2.9	-0.0	7.3	3.9	3.0
Diabetes (mother)	1.5	1.9	5.1	0.9	1.8	1.6	0.3	0.7	1.2	-0.7	0.8	1.5	1.5	2.3	1.5	1.8
Comparative height size at age 10	1.5	8.1	33.9	-1.4	-4.3	-1.9	-1.9	-0.9	-2.9	1.1	-2.8	-2.7	-2.5	-5.8	-1.8	-3.0
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	7.7	-0.9	-1.7	0.1	-0.8	-2.8	-1.7	-0.5	-1.0	-1.9	-0.5	-0.7	-1.0	-1.8
Whole body fat-free mass	1.5	8.7	28.2	-2.7	-4.1	-1.8	-2.6	1.4	-2.4	3.9	-2.6	-2.3	-0.9	-5.3	-3.2	-2.4
Whole body water mass	1.5	8.4	27.6	-2.6	-4.0	-1.6	-2.5	1.5	-2.3	3.8	-2.6	-2.2	-0.9	-5.2	-3.1	-2.3
Ever taken oral contraceptive pill	1.5	1.7	6.1	0.3	-0.4	-1.5	0.4	-1.8	-1.7	-2.5	-1.1	-0.6	-2.1	-0.3	-0.3	-0.7
Financial situation satisfaction	1.5	1.9	4.0	2.0	1.6	-0.3	-0.2	1.8	2.0	-1.2	1.5	1.6	1.3	-0.1	0.6	1.7
Illnesses of father: High blood pressure	1.5	1.8	4.0	0.3	1.6	1.3	1.7	0.4	0.8	-1.8	0.7	1.4	-0.9	2.0	1.8	1.4
Reaction Time	1.4	2.6	8.9	-1.5	-2.3	-1.5	-1.5	-2.0	-0.5	-0.3	-0.9	-1.5	-0.1	-3.0	-1.8	-1.6
Diabetes (father)	1.4	1.7	5.0	-0.9	-1.2	-2.2	-1.4	-1.0	-1.2	0.1	-1.7	-1.5	-1.9	0.2	-0.8	-1.1
Medication: Ramipril	1.4	1.9	7.5	0.0	1.7	-0.4	1.9	0.7	0.3	-2.7	1.2	1.4	-0.2	1.5	1.2	1.5
Trunk fat-free mass	1.4	7.9	26.6	-2.4	-3.8	-1.9	-2.1	1.5	-2.3	4.1	-2.5	-1.9	-0.8	-5.2	-3.0	-2.0
Asthma	1.4	2.8	14.5	-2.9	1.9	0.8	2.7	0.1	-0.7	1.1	-0.6	0.0	-0.1	3.8	0.1	0.0
Breastfed as a baby	1.4	1.8	10.7	0.9	-1.0	-2.0	-1.8	-0.7	0.6	-0.6	0.2	-0.5	1.0	-3.3	-0.6	-0.7
Leg pain on walking	1.4	1.7	5.0	-0.5	-1.6	-0.9	-2.2	-0.8	-0.4	-0.9	-0.9	-1.8	-0.9	-1.9	-1.3	-1.5
Asthma (self-reported)	1.4	2.7	13.4	-3.0	1.8	0.9	2.7	0.2	-0.7	1.0	-0.6	-0.0	-0.2	3.7	-0.0	-0.1
Medication: Gliclazide	1.4	1.6	5.3	-0.4	1.4	1.9	1.4	0.7	0.4	-1.4	1.0	1.1	0.2	2.3	1.2	1.2
Basal metabolic rate	1.4	7.8	23.5	-2.6	-3.9	-1.3	-2.6	1.4	-2.3	3.7	-2.7	-2.3	-1.0	-4.8	-2.9	-2.4
Supplements: Calcium	1.4	1.5	4.1	1.0	1.1	-0.8	1.6	0.5	0.8	-1.9	1.0	1.4	-0.2	1.2	2.0	1.1
Sitting height	1.3	9.4	54.6	-0.5	-4.7	-2.7	-1.7	1.1	-2.8	2.2	-2.2	-1.5	-1.9	-7.4	-2.5	-2.1
Trunk predicted mass	1.3	7.7	25.8	-2.4	-3.7	-1.9	-2.1	1.6	-2.3	4.0	-2.5	-1.8	-0.8	-5.1	-3.0	-1.9
Mean time to correctly identify matches	1.3	2.4	11.5	-0.8	-2.2	-1.1	-2.1	-1.4	-0.2	-0.7	-0.9	-1.3	0.0	-3.4	-1.5	-1.4
Pack years of smoking	1.3	1.9	3.7	-0.4	-1.6	-0.9	-0.8	-1.6	-1.3	-1.0	-1.0	-1.7	-1.3	-1.9	-1.5	-1.8
Lupus	1.2	1.8	4.6	1.1	0.7	0.2	-0.7	2.1	2.0	0.5	2.1	1.2	1.5	-0.9	0.9	1.5
Height	1.2	23.2	78.0	-3.0	-7.5	-4.6	-2.1	-0.6	-6.2	3.4	-4.9	-3.7	-4.5	-8.8	-2.5	-4.3
Medication for hormone replacement therapy	1.2	1.3	11.0	1.2	-0.3	-0.8	-0.6	-0.2	0.1	-3.3	-0.0	0.1	-1.3	-1.0	0.8	0.2
Serious illness, injury or assault to yourself	1.2	1.4	6.8	-0.9	-0.9	-2.6	0.3	0.1	-1.1	-1.6	-1.0	-0.7	-1.8	-0.5	-1.0	-0.9
Pain all over the body in last month	1.2	1.3	3.3	0.6	1.0	1.6	0.3	0.6	1.8	-0.8	1.3	0.9	1.6	1.0	1.2	0.8
Standing height	1.2	12.3	49.3	-1.8	-5.3	-3.7	-1.5	-0.6	-4.2	2.2	-3.2	-2.6	-3.0	-7.0	-2.2	-3.0
Number of full brothers	1.2	1.6	4.8	1.7	0.8	0.1	-0.5	1.1	1.8	0.4	2.0	1.0	2.2	-0.5	0.9	1.2
Pulse rate, automated reading	1.2	3.8	14.6	2.6	1.9	0.6	1.9	-1.3	0.0	-3.8	1.0	1.4	-1.1	2.8	2.1	1.6
Arm fat-free mass (left)	1.2	6.2	19.0	-2.4	-3.2	-0.8	-2.2	1.9	-1.8	3.9	-2.3	-1.6	-0.6	-4.4	-2.5	-1.7
Number of operations (self-reported)	1.2	1.8	3.6	-1.2	-1.8	-1.9	-0.8	-0.4	-1.3	-0.5	-0.9	-1.7	-1.4	-1.4	-1.5	-1.5
Ever had prostate specific antigen (PSA) test	1.2	1.3	3.3	-0.6	-1.4	-1.0	-1.1	-0.9	-0.6	1.0	-1.4	-1.2	-0.4	-1.4	-1.8	-1.4
Falls in the last year	1.1	1.5	3.0	-1.5	-1.2	-0.3	-0.6	-1.1	-1.4	-1.2	-1.2	-1.4	-1.7	-1.2	-0.2	-1.5
Headache pain in last month	1.1	1.8	3.4	-0.7	-1.5	-0.6	-0.8	-1.6	-1.8	-1.1	-1.8	-1.6	-1.8	-1.0	-1.2	-1.4
Chronic bronchitis/emphysema (mother)	1.1	1.3	5.1	-0.1	1.2	1.1	0.9	0.7	0.9	-1.3	0.8	0.9	0.1	2.3	1.4	1.2
Age started oral contraceptive pill	1.1	1.4	4.9	2.2	0.7	0.3	0.3	1.3	1.2	-1.1	1.2	1.3	0.9	-1.4	1.2	1.2
Arm predicted mass (left)	1.1	5.7	17.6	-2.4	-3.1	-0.8	-2.2	1.8	-1.8	3.6	-2.1	-1.6	-0.7	-4.2	-2.5	-1.6
Body Mass Index (BMI) (2010)	1.0	1.3	4.2	1.0	0.9	0.9	0.1	2.0	1.6	1.1	1.2	1.2	1.5	0.4	0.9	1.1
Respiratory disease	1.0	2.1	8.8	-3.0	1.5	1.2	2.6	0.5	-0.5	0.1	-0.1	0.2	-0.1	2.7	0.4	0.1
Average weekly spirits intake	1.0	1.2	2.8	-0.9	-0.9	0.5	-0.9	-1.4	-0.8	1.1	-1.4	-1.3	0.3	-1.0	-1.7	-1.5
Maternal smoking around birth	1.0	1.5	3.5	-1.2	-0.5	-1.7	-0.1	-1.9	-0.8	-1.1	-0.8	-1.0	-1.8	0.6	-1.8	-0.8
Hair/balding pattern: Pattern 3	1.0	1.5	3.0	-1.7	-1.7	-0.2	-1.2	-0.8	-0.7	0.5	-0.7	-1.7	0.0	-1.6	-1.4	-1.6
Pulse rate	1.0	1.8	8.9	1.5	0.9	-0.9	0.9	-0.9	-0.4	-3.0	0.0	0.9	-1.8	1.2	1.4	0.9
Happiness	1.0	1.2	2.9	1.7	1.6	-1.1	1.0	1.0	0.9	-0.6	0.8	1.4	0.2	1.0	0.9	1.4
Medication: Ventolin 100micrograms inhaler	1.0	1.2	3.2	-0.0	1.4	0.7	0.5	1.2	1.5	0.0	1.3	1.2	1.8	0.6	0.9	1.3
Emphysema/chronic bronchitis	1.0	1.1	2.4	1.1	1.5	-0.7	0.9	0.3	1.3	-0.8	1.3	1.3	1.3	0.5	0.9	1.3
Friendships satisfaction	1.0	1.3	2.9	-0.1	1.7	0.9	1.3	1.7	0.6	1.0	0.6	1.5	0.4	1.4	0.4	1.4
Average weekly champagne plus white wine intake	1.0	1.4	3.7	-0.8	-1.8	-0.5	-1.4	-1.0	-1.3	0.4	-0.6	-1.5	-0.6	-1.1	-1.9	-1.2
Fractured/broken bones in last 5 years	1.0	1.3	3.5	-0.7	1.5	1.9	1.8	-0.4	0.8	-0.3	1.2	0.9	0.6	1.4	1.0	0.8
Basal cell carcinoma (self-reported)	1.0	1.2	3.0	-0.9	-1.3	-0.2	-1.7	-1.2	-0.5	-0.1	-0.4	-1.4	0.0	-1.7	-1.6	-1.1
Bipolar Disorder (2011)	0.9	0.8	3.9	1.0	1.2	0.4	0.7	0.2	0.5	-0.2	1.1	0.8	0.6	2.0	0.5	1.0
Crohns Disease (2012)	0.9	1.5	4.4	0.4	1.6	0.1	0.4	1.6	1.1	-0.3	0.6	1.2	0.5	2.1	2.0	1.5
LDL Cholesterol	0.9	1.4	5.7	1.0	1.4	-1.0	1.1	0.7	0.6	-1.4	1.1	0.9	0.1	2.4	0.9	1.1
Type 2 Diabetes (T2D) (2012)	0.9	1.0	6.9	-0.0	-0.4	-1.3	-0.8	-1.3	-0.5	-2.6	-0.7	-0.7	-0.5	-0.2	-0.7	-0.6
Average weekly fortified wine intake	0.9	1.0	2.5	-1.3	-1.0	0.9	-1.0	-0.5	-0.8	1.6	-1.4	-1.0	-0.1	-0.6	-0.9	-1.1
Age when periods started (menarche)	0.9	2.2	4.9	1.6	0.8	-0.4	-0.1	2.0	1.9	1.6	1.4	1.9	2.2	-1.1	0.6	1.7
Medication: Levothyroxine sodium	0.9	1.5	5.1	-0.8	-1.8	-0.6	-2.3	-0.4	0.1	-0.9	-0.8	-1.6	-0.1	-1.6	-1.0	-1.4
Medication: Simvastatin	0.9	1.3	4.0	0.5	1.1	0.3	0.2	1.4	0.9	-2.0	1.0	1.1	0.8	0.5	1.8	1.4
Fluid intelligence score	0.9	1.9	4.6	-2.1	-0.4	0.9	0.6	-1.6	-2.2	1.2	-2.0	-1.2	-1.2	1.0	-0.9	-1.1
Weight	0.9	4.5	12.4	-1.9	-3.2	-0.1	-2.8	0.9	-1.5	2.4	-2.2	-2.1	-0.9	-3.5	-1.5	-2.0
Alcohol intake versus 10 years previously	0.9	1.4	4.7	-0.6	-1.0	-1.4	-0.5	-0.7	-2.2	0.2	-2.0	-1.3	-1.1	-0.6	-0.6	-1.4
Medication: Paracetamol	0.9	1.6	3.3	-1.4	-1.5	-0.6	-0.9	-1.8	-1.0	0.6	-1.4	-1.5	-0.8	-0.4	-1.7	-1.5
Age at first live birth	0.9	1.6	3.8	-1.6	-1.5	-1.3	0.5	-0.7	-1.6	0.3	-1.3	-1.1	-2.0	-0.1	-1.7	-1.4
Pulse wave peak to peak time	0.9	1.0	2.9	-0.5	-0.8	-0.5	-1.4	0.5	1.1	1.7	1.0	-0.3	1.6	-1.2	-0.8	-0.3
Medication: Aspirin	0.9	1.2	4.3	-0.6	-0.4	-0.4	0.3	-1.2	-1.8	-1.0	-1.3	-1.1	-2.1	0.5	-0.6	-1.0
Eye problems/disorders: Glaucoma	0.9	1.1	2.4	-1.4	-0.8	-0.9	0.4	-0.7	-1.6	0.6	-1.6	-1.1	-1.3	0.3	-1.0	-1.2
Alcohol drinker status: Previous	0.9	1.1	7.1	0.9	1.0	1.3	0.4	-0.3	0.0	-2.7	0.3	0.3	0.1	1.1	1.3	0.4
Verbal and Numeric Reasoning (VNR)	0.8	1.9	6.4	-1.9	-0.2	1.5	0.4	-1.2	-1.5	2.5	-1.7	-1.1	-0.0	1.2	-1.2	-1.2
Coronary Artery Disease (CAD)	0.8	1.0	3.8	1.1	0.3	1.9	0.3	-0.4	0.7	-1.1	1.6	0.6	0.5	0.4	1.3	0.6
Lung FVC	0.8	3.9	24.9	-1.4	-2.0	0.5	-0.5	0.2	-1.4	5.0	-0.8	-0.9	0.3	-2.9	-2.5	-1.2
Pack years adult smoking proportion	0.8	1.3	2.3	-0.3	-1.3	-0.8	-0.7	-1.3	-1.0	-0.7	-0.9	-1.4	-1.0	-1.5	-1.5	-1.5
Impedance of leg (right)	0.8	3.9	10.4	1.6	2.2	1.6	2.2	-1.6	0.5	-2.6	0.9	1.5	-0.5	3.2	3.2	1.4
Hearing difficulty/problems with background noise	0.8	1.4	5.6	2.4	1.0	-1.1	-0.9	0.7	1.1	-1.9	1.1	0.6	0.6	-0.3	0.9	1.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.8	-0.2	1.5	1.5	0.7	1.7	0.9	0.4	0.3	0.9	-0.0	1.5	1.4	0.9
Illnesses of siblings	0.8	1.1	7.3	1.1	0.5	-0.4	0.4	0.1	0.0	-2.7	1.0	0.6	-1.2	1.0	0.7	0.8
Noisy workplace	0.8	1.0	3.1	1.8	0.7	-0.1	-0.5	0.6	1.0	-1.5	0.9	0.7	1.0	-0.9	1.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.4	1.1	1.5	1.2	0.5	0.5	0.5	0.8	0.6	1.0	0.1	1.2	1.3	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.5	0.8	0.7	1.3	-0.2	1.9	1.2	0.7	1.0	0.9	1.3	-0.6	0.1	0.9
Medication: Cholesterol lowering	0.8	1.3	3.6	0.7	0.6	0.2	-0.6	1.6	1.6	-1.6	1.1	0.8	0.7	-0.0	1.9	1.2
Pulse wave Arterial Stiffness index	0.8	1.0	3.2	0.4	0.5	0.4	1.3	-0.4	-1.4	-1.6	-1.2	0.2	-1.8	0.7	0.7	0.1
Length of working week for main job	0.8	0.9	4.1	-2.0	-0.2	0.6	0.7	0.2	-1.1	1.9	-0.5	-0.6	-0.2	0.7	0.2	-0.6
Worry too long after embarrassment	0.8	1.3	3.5	1.1	1.2	0.8	0.5	1.9	1.3	1.6	0.6	1.4	0.8	0.3	0.9	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.7	-0.8	-0.7	-0.1	-1.9	-0.0	0.3	1.4	-0.7	-0.7	0.9	-1.8	-1.3	-0.7
Qualifications: College or University degree	0.8	2.6	10.1	-1.0	-1.6	-2.0	0.0	-0.9	-1.9	-1.0	-2.4	-1.2	-3.2	-0.8	-1.0	-1.4
Chest pain or discomfort	0.8	1.1	2.6	0.9	1.6	0.3	1.0	0.6	0.3	-0.3	0.5	1.3	-1.2	1.5	1.3	1.5
Long-standing illness, disability or infirmity	0.8	1.3	3.9	1.5	1.5	0.6	-0.3	0.8	2.0	-1.5	0.8	1.2	0.8	0.5	0.6	1.2
Hearing aid user	0.8	0.9	2.8	-0.9	-1.3	-1.7	-0.9	-0.6	-1.0	-0.7	-0.9	-0.6	-1.4	-0.7	-0.4	-0.4
Diastolic blood pressure, automated reading	0.8	2.5	6.5	-0.9	-2.5	-1.6	-2.5	-0.5	-1.1	-0.1	-1.5	-2.2	-1.3	-1.0	-1.5	-1.7
Schizophrenia (2014)	0.7	1.6	9.3	-1.0	-0.9	-0.9	0.2	-3.0	-0.4	-0.4	0.1	-1.5	0.7	-0.8	-1.4	-1.6
Medication: Metformin	0.7	1.0	3.5	0.1	1.5	0.8	0.8	0.4	0.1	-1.5	0.4	0.7	0.0	1.9	1.5	1.0
Stomach or abdominal pain in last month	0.7	0.9	4.1	0.7	-0.2	0.8	-1.1	0.3	0.6	2.0	0.0	0.1	1.2	-1.6	-0.9	0.2
Impedance of leg (left)	0.7	3.3	9.5	1.8	1.9	0.9	1.9	-2.0	0.4	-2.4	0.7	1.2	-0.4	3.1	2.9	1.2
Alcohol usually taken with meals	0.7	1.2	9.5	-0.6	-1.1	0.3	-0.9	0.6	0.4	0.6	0.3	-0.5	0.4	-3.1	-1.1	-0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.8	0.7	-0.7	-1.7	-1.2	-0.1	0.3	-1.3	-0.7	-0.7	0.0	-1.4	-1.0	-0.6
Financial difficulties in last 2 years	0.7	0.9	3.9	0.2	1.0	0.1	0.2	2.0	1.2	-0.7	0.8	1.2	-0.3	-0.4	1.1	1.2
Diabetes (self-reported)	0.7	1.0	4.5	-0.4	1.0	-0.1	1.2	0.6	-0.5	-2.1	0.4	0.4	-0.9	1.5	1.5	0.7
Hip circumference	0.7	3.0	7.7	-1.2	-2.8	-0.0	-2.8	0.6	-0.9	1.0	-1.7	-2.0	-0.6	-2.7	-1.3	-1.9
Father’s age at death	0.7	1.0	2.9	-0.7	-1.3	-1.1	0.1	0.2	-0.9	0.1	-1.0	-0.3	-1.2	-1.5	-1.7	-0.7
Mouth/teeth dental problems: Dentures	0.7	1.3	4.5	1.3	1.0	1.6	0.3	0.8	0.7	-0.9	0.8	1.1	0.9	0.9	2.1	1.0
Lung cancer (father)	0.7	0.8	2.2	0.2	1.2	-0.6	0.9	1.5	0.8	-0.3	0.9	0.9	0.6	1.2	0.6	1.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.5	-1.9	-1.2	-1.6	-0.1	0.1	-1.1	1.7	-0.7	-0.6	-0.4	-0.5	-1.2	-0.5
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	6.0	-0.9	1.0	1.4	1.3	0.4	-0.3	-0.3	-0.2	0.2	-1.0	2.5	0.2	0.2
Medication: Amlodipine	0.7	1.0	2.2	-1.1	-1.0	-0.8	-0.6	-0.5	-1.2	-0.4	-1.1	-1.0	-1.1	-1.4	-1.5	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.5	0.1	-0.4	0.7	-1.6	-0.1	1.0	1.9	0.2	-0.4	1.1	-1.1	-0.6	-0.3
Suffer from ‘nerves’	0.7	1.1	3.4	1.8	1.1	-0.7	-0.1	0.3	0.6	-1.2	0.7	1.2	-0.0	0.8	1.5	1.4
Medication: Aspirin	0.7	1.0	3.8	-0.6	-0.6	-0.4	-0.1	-0.9	-1.6	-0.7	-1.3	-1.1	-1.9	0.0	-0.7	-0.9
Mother’s age at death	0.7	0.8	4.0	0.6	-1.0	-0.4	-0.6	0.0	-0.0	1.7	-0.0	-0.1	0.6	-2.0	-1.3	-0.3
Bipolar Disorder (2018)	0.6	1.0	2.2	-1.0	-1.3	-0.7	-1.1	-1.5	-0.8	-0.1	-0.3	-1.2	-0.4	0.7	-1.5	-0.9
Bipolar Disorder or Schizophrenia	0.6	1.4	8.2	-1.3	-1.0	-0.2	-0.6	-2.9	-0.4	0.1	0.0	-1.5	0.8	0.6	-1.4	-1.3
Alzheimer’s Disease (in mother)	0.6	0.7	2.8	-0.2	0.1	-1.4	-0.4	0.1	-0.7	0.2	-1.6	-0.4	-1.7	0.1	-1.1	-0.4
Alzheimer’s Disease (in father)	0.6	0.7	2.0	-0.6	-0.3	1.4	0.2	0.0	-1.0	1.0	-1.0	-0.7	-0.9	0.6	-0.8	-0.9
Fasting Glucose	0.6	0.7	2.6	0.9	-0.2	0.4	-1.1	0.5	1.0	-1.1	0.4	0.2	0.9	-1.6	0.9	0.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	5.9	-0.4	1.3	0.1	1.2	0.3	0.0	-1.6	0.5	0.4	0.1	2.4	1.3	0.8
Hearing difficulty/problems: Yes	0.6	0.9	4.0	1.5	0.3	-1.1	-0.6	-0.4	0.0	-2.0	0.6	0.3	-0.5	-0.6	1.7	0.6
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.5	0.7	0.6	0.3	-0.6	0.6	-0.4	-1.9	-0.7	0.5	-1.2	0.8	1.2	0.8
Angina	0.6	0.7	5.3	0.1	-0.0	-1.4	0.5	-0.8	-0.5	-2.3	0.4	-0.6	-0.7	0.0	-0.2	-0.5
Supplements: Glucosamine	0.6	0.7	3.3	0.0	0.7	0.2	1.1	0.9	0.8	0.7	1.2	0.7	1.8	-0.4	0.2	0.5
Number of incorrect matches in round	0.6	1.0	1.7	-0.8	-1.3	-1.3	-1.2	-0.6	-0.2	0.2	-0.7	-1.1	0.3	-1.3	-1.3	-1.3
Had menopause	0.6	0.8	1.6	0.8	1.2	0.5	0.9	0.8	0.3	-0.7	0.7	1.3	-0.6	0.9	1.1	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.8	-1.4	-0.6	-1.7	-0.7	0.5	-0.3	0.1	-1.6	-0.7	-0.3	-0.7	-1.6	-0.9
Loud music exposure frequency	0.6	0.6	2.0	-0.8	0.3	1.2	0.6	-0.6	-0.8	-1.3	-0.1	-0.4	-0.8	1.4	0.2	-0.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.6	-0.8	-0.7	0.1	-0.3	-1.0	-0.9	-1.0	-1.1	-0.9	-1.3	0.1	-0.6	-1.0
Heart disease (mother)	0.6	0.7	2.3	1.5	1.0	0.3	0.8	-0.7	-0.4	-0.9	-0.1	0.6	-0.4	1.3	1.2	0.5
Had major operations	0.6	0.7	3.2	0.2	-0.2	-1.7	0.4	0.8	-0.2	-1.8	-0.3	0.1	-1.3	0.2	0.1	0.2
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.7	0.9	0.7	0.7	-0.0	0.9	1.3	-0.6	1.0	1.2	0.5	-0.1	1.3	1.1
Back pain experienced in last month	0.6	0.9	3.0	-1.2	-1.3	0.3	-1.7	0.4	0.1	0.0	-0.3	-1.1	-0.1	-1.4	-1.4	-0.9
Mineral and other dietary supplements	0.6	0.8	2.4	-0.7	-0.9	1.0	-1.6	-0.8	-0.7	-0.8	-1.2	-0.8	-1.3	0.2	-0.4	-0.5
Pain type(s) experienced in last month: Hip pain	0.6	0.7	3.7	0.2	-0.6	-0.2	-1.9	-0.2	0.1	0.1	-0.6	-0.6	0.3	-1.7	-0.9	-0.5
Myopia	0.6	0.9	3.4	0.0	-0.9	-1.9	-0.6	-1.1	-0.5	-0.2	-1.3	-0.9	-0.6	-1.0	-0.5	-1.2
Alzheimer’s Disease (including proxy)	0.5	0.8	3.1	-0.9	-0.2	-0.6	-0.5	-0.1	-0.8	0.3	-1.3	-0.8	-1.3	0.3	-1.8	-0.8
Age at First Birth	0.5	0.8	2.0	-0.4	-0.0	1.2	-0.4	1.3	1.4	1.0	0.9	0.5	1.2	-0.5	0.3	0.5
Blood Platelet Count	0.5	5.5	28.0	-0.4	2.9	3.1	2.8	-1.3	-1.5	2.5	-0.9	0.0	2.4	5.3	0.9	-0.1
Blood White Count	0.5	3.8	14.2	1.5	2.5	-1.0	-0.5	2.0	3.1	1.5	0.7	2.0	3.8	0.5	1.1	2.1
BMI	0.5	2.7	13.8	-0.0	0.5	3.7	-1.6	2.3	1.8	1.1	1.1	0.5	2.3	-0.3	1.4	0.6
Waist Hip Ratio (WHR)	0.5	2.3	9.9	2.1	1.3	0.4	0.2	-1.7	0.3	-3.1	0.9	0.8	-0.4	1.1	2.5	1.2
Lung FEV1/FVC ratio	0.5	2.6	7.5	-1.5	-1.7	-0.2	-0.3	-1.5	-2.0	1.6	-1.1	-1.6	-1.5	-2.7	-1.9	-1.7
Hand grip strength (left)	0.5	1.3	5.7	0.0	-1.3	-0.8	-0.8	0.7	-0.7	2.4	-1.0	-0.3	-0.9	-2.1	-0.3	-0.4
Relative age of first facial hair	0.5	1.0	3.5	0.4	0.4	-0.8	1.3	-1.2	-1.8	-0.1	-1.0	0.1	-1.9	1.2	0.1	0.0
Ever had hysterectomy (womb removed)	0.5	0.6	2.3	0.6	0.9	0.4	-0.1	0.1	0.6	0.0	0.8	0.7	1.0	0.8	1.5	1.0
Supplements: Zinc	0.5	0.5	2.2	1.1	-0.6	-1.5	-0.3	-0.1	-0.1	-0.5	-0.1	-0.1	-0.5	-1.3	-0.5	-0.2
Medication: Co-codamol	0.5	0.6	1.9	-0.4	-0.9	0.1	-1.4	-0.0	-0.3	1.0	-0.9	-0.5	0.2	-1.2	-1.0	-0.7
Hand grip strength (right)	0.5	1.3	5.5	-0.5	-1.3	-0.9	-0.8	1.7	-0.5	2.0	-0.5	0.0	-0.6	-2.3	0.1	-0.1
Current tobacco smoking	0.5	0.8	4.6	1.5	-0.1	-0.2	-2.1	-0.3	1.0	-0.5	-0.4	-0.1	0.7	-1.3	-0.2	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	6.6	0.2	-0.7	-2.6	-0.9	-0.0	-0.9	-0.5	-1.6	-0.7	-1.4	-0.0	-1.0	-0.8
Trunk fat mass	0.5	2.3	8.6	-0.8	-2.2	0.8	-2.9	0.8	-0.6	0.8	-1.7	-1.6	-0.6	-2.3	0.0	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	4.7	-0.3	-0.7	-2.2	-0.6	0.1	-1.1	0.6	-1.6	-0.8	-1.3	-0.1	-1.0	-0.8
Impedance of arm (right)	0.5	2.4	14.4	2.2	0.6	0.2	0.2	-1.3	0.5	-3.8	0.9	0.5	-1.1	0.9	2.5	0.7
Medication: Lansoprazole	0.5	0.6	1.2	0.9	0.8	0.7	-0.5	1.0	0.6	-0.7	0.5	0.8	0.7	-0.4	1.1	0.9
Arm fat mass (right)	0.5	2.1	9.1	-0.9	-1.8	1.1	-3.0	1.1	-0.2	1.2	-1.3	-1.5	-0.3	-2.0	-0.4	-1.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.6	0.3	1.1	0.1	1.9	-0.8	-0.6	0.8	-0.1	0.7	-0.1	1.9	0.2	0.3
Leg fat percentage (right)	0.5	1.7	12.0	-0.2	0.7	3.5	-1.1	1.0	1.2	0.5	0.1	0.2	0.8	1.5	1.8	0.5
Exposure to tobacco smoke outside home	0.5	0.7	3.1	1.0	0.5	0.8	0.3	0.5	0.4	-1.8	0.7	0.6	-0.8	0.7	1.2	0.7
Neck or shoulder pain in last month	0.5	0.7	2.8	0.8	-0.6	-0.1	-1.4	-1.0	-0.3	0.5	-0.6	-0.4	-0.1	-1.7	-0.9	-0.5
Angina (self-reported)	0.5	0.7	5.7	0.2	0.0	-1.3	0.4	-0.6	-0.3	-2.4	0.5	-0.5	-0.6	0.1	0.1	-0.4
Whole body fat mass	0.5	2.2	8.3	-1.0	-2.1	0.9	-2.9	0.6	-0.7	1.0	-1.7	-1.7	-0.5	-2.0	-0.3	-1.5
Illnesses of siblings: Diabetes	0.5	0.6	1.9	0.3	0.9	0.5	0.3	-0.5	0.4	1.4	0.2	0.5	1.1	1.4	0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.8	-0.2	-1.8	-0.8	0.8	0.0	-1.2	-0.0	-0.3	-0.6	-1.8	-2.0	-0.2	-0.8
Diabetes diagnosed by doctor	0.5	0.9	4.1	-0.3	0.8	-0.5	0.6	0.5	-0.3	-2.0	0.4	0.2	-0.7	1.5	1.4	0.6
Medication for cholesterol	0.5	0.7	3.0	-0.5	-1.0	-0.4	0.2	-1.7	-0.2	1.0	-0.1	-0.7	0.0	-0.8	-1.2	-0.9
Osteoarthritis (self-reported)	0.5	0.6	2.8	0.0	-0.6	0.6	-1.1	-0.3	0.3	-1.7	-0.1	-0.7	-0.4	-1.1	-0.8	-0.8
Arm fat mass (left)	0.5	2.1	9.1	-1.1	-1.9	1.1	-3.0	1.0	-0.2	1.0	-1.5	-1.6	-0.3	-2.0	-0.5	-1.3
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.6	0.2	0.9	-0.8	1.6	1.1	0.1	1.0	1.0	0.6	1.0	0.3	0.2	0.5
Medication: Lisinopril	0.5	0.7	2.4	-1.0	-0.4	0.9	-0.5	1.6	-0.3	1.0	-0.7	-0.2	-1.0	1.2	0.2	0.1
Irritability	0.5	0.9	2.7	0.9	0.5	-1.3	-0.6	-1.7	-1.1	-1.3	-0.4	-0.7	-1.3	-0.3	0.0	-0.5
Unable to work because of sickness or disability	0.5	0.7	3.8	-0.4	-0.4	0.3	-1.9	-1.1	0.7	-0.7	-1.2	-0.7	0.2	0.1	-0.5	-0.5
Impedance of whole body	0.5	2.5	11.0	1.8	1.1	0.4	1.3	-1.9	0.2	-3.3	0.7	0.7	-0.9	1.8	2.6	0.6
Schizophrenia (2018)	0.4	0.8	6.0	-0.9	-0.2	0.3	0.1	-2.4	0.1	0.1	0.2	-0.9	1.4	0.2	-0.6	-0.9
Breast Cancer	0.4	0.9	2.6	-1.2	-1.5	0.0	-1.6	0.1	-0.7	-0.6	-0.9	-1.1	-1.0	-1.1	-0.2	-0.9
Primary Biliary Cirrhosis	0.4	0.6	2.4	0.6	0.3	0.6	0.7	-1.4	0.1	-1.6	0.2	0.1	-0.2	1.2	0.1	-0.0
Blood Red Count	0.4	4.2	15.4	-1.8	-0.4	1.2	0.7	-2.4	-2.2	-3.9	-1.5	-1.4	-3.0	1.8	2.1	-1.4
Cardiovascular Disease	0.4	1.2	4.1	-0.2	1.1	1.3	0.7	1.4	0.1	-1.3	0.1	0.7	-0.3	2.0	1.6	1.0
Chronotype (morning person)	0.4	0.9	6.4	0.3	-0.1	-2.5	0.7	0.2	-0.6	-0.4	-0.2	-0.5	-0.2	-0.3	-1.7	-0.4
Number of treatments/medications taken	0.4	0.7	2.8	-0.5	-0.7	-0.8	-1.5	0.4	-0.2	-0.8	-1.0	-0.8	-0.0	-1.7	0.0	-0.6
Sensitivity / hurt feelings	0.4	0.7	1.4	-0.2	1.2	0.8	-0.4	0.8	0.7	1.2	-0.0	0.5	0.9	1.0	1.1	0.8
Vitamin and mineral supplements	0.4	0.6	2.2	0.2	0.2	1.5	-0.7	0.9	0.1	-1.2	0.4	0.4	-0.9	0.4	0.6	0.8
Severe depression (siblings)	0.4	0.4	1.2	-0.7	0.1	-0.6	0.6	-1.1	-1.0	-0.4	-0.8	-0.2	-0.3	0.4	-1.0	-0.4
Taking other prescription medications	0.4	0.7	3.0	0.5	0.7	0.7	-0.9	0.8	1.5	0.2	0.5	0.3	1.7	-0.6	-0.2	0.3
Medication: Atenolol	0.4	0.5	3.7	-0.3	-0.3	0.2	-0.3	0.3	0.0	-1.9	0.7	-0.5	-0.2	-0.9	-0.1	-0.4
Heart attack	0.4	0.5	2.7	-0.5	0.2	-0.4	1.2	-0.3	-0.6	-1.6	-0.0	-0.1	-1.0	0.6	-0.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.3	0.2	1.0	0.3	-0.3	0.7	-0.1	-1.1	-0.8	0.4	-1.0	1.5	0.2	0.7
Impedance of arm (left)	0.4	1.7	11.4	1.7	0.1	-0.4	0.3	-1.6	0.1	-3.4	0.4	0.0	-1.0	0.5	1.9	0.0
Tense / ‘highly strung’	0.4	0.7	2.3	1.4	1.3	-0.5	-0.2	0.8	0.5	-0.3	0.2	0.8	-0.2	1.5	0.4	1.1
Hair/balding pattern: Pattern 4	0.4	1.0	2.2	1.3	0.1	-1.2	-1.5	-0.4	0.9	-1.4	0.9	-0.3	1.3	-1.3	-0.8	0.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	3.8	0.1	-0.7	0.3	-1.9	0.3	1.2	-0.6	0.0	-0.4	1.1	-1.2	-0.5	-0.3
Birth weight	0.4	0.8	4.9	-0.0	-1.3	0.6	-1.2	0.4	0.1	0.8	-0.5	-0.4	0.5	-2.2	-0.1	-0.7
High blood pressure (siblings)	0.4	0.5	1.5	0.2	0.7	1.0	0.8	1.1	0.2	1.0	-0.3	0.6	0.2	0.5	1.2	0.5
Comparative body size at age 10	0.4	1.1	4.6	1.2	-0.4	0.2	-1.4	1.6	0.5	2.1	0.4	0.4	0.5	-1.5	0.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	3.8	0.2	0.3	-0.2	0.1	-0.5	-0.6	1.9	-0.7	0.0	-0.2	0.6	-0.7	0.0
Medication for pain relief, constipation, heartburn	0.4	0.6	1.2	0.1	0.6	0.1	0.8	1.1	0.8	0.4	0.9	0.9	1.0	0.9	1.1	0.7
Leg fat mass (right)	0.4	1.6	4.9	-1.3	-1.2	2.2	-2.2	0.9	0.0	1.7	-1.1	-1.0	0.2	-0.8	0.0	-0.8
Overall health rating	0.4	0.9	2.5	1.4	1.0	1.1	-1.6	1.2	0.8	-0.7	-0.9	0.4	0.4	0.5	0.3	0.6
Family relationship satisfaction	0.4	0.5	1.9	0.5	1.4	-0.6	1.2	0.6	-0.2	-0.4	0.0	0.7	-0.6	1.2	0.0	0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.1	-1.0	-0.2	1.4	0.4	-0.7	0.2	0.3	0.6	-0.8	0.4	0.0	-0.5	-0.9
Hypertension (Self-reported)	0.4	1.2	4.0	-0.9	-0.8	0.0	-1.6	0.1	-1.5	0.7	-2.0	-1.4	-0.9	-0.1	-1.1	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	0.6	1.0	0.5	0.9	0.6	0.4	-0.7	0.6	0.9	0.4	0.0	1.0	0.7
Ever had bowel cancer screening	0.4	0.5	2.7	0.1	-0.4	-0.4	-0.7	0.4	-0.2	1.6	-0.7	0.0	-0.2	-0.4	-1.3	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	2.3	0.2	-0.6	-0.7	-0.8	0.1	0.4	-1.2	0.5	-0.2	0.1	-1.5	-0.5	-0.1
Smoking status: Current	0.4	0.7	3.2	1.5	-0.0	-0.1	-1.8	-0.1	1.1	-0.6	-0.2	0.1	0.5	-1.3	-0.3	0.2
Medication: Bendroflumethiazide	0.4	0.6	1.9	-1.1	0.5	1.4	0.5	1.4	-0.6	0.2	-0.2	-0.0	0.1	1.3	0.7	0.2
Medication: Atorvastatin	0.4	0.5	2.2	0.0	0.6	0.2	0.8	0.2	-0.3	-0.7	0.4	0.0	-0.8	1.5	1.2	0.3
Leg fat percentage (left)	0.4	1.3	8.2	-0.2	0.4	2.9	-1.4	0.7	1.1	0.6	-0.1	-0.1	0.7	1.4	1.4	0.2
Average weekly beer plus cider intake	0.4	0.6	1.6	-1.0	-0.4	0.6	-0.6	-0.1	-0.7	-0.4	-0.8	-0.8	-1.2	1.1	-0.2	-0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.9	-0.4	0.4	-0.2	1.3	-0.3	-0.7	-1.7	0.0	0.0	-1.0	0.8	0.1	-0.1
Heart disease (siblings)	0.4	0.5	2.1	-0.6	-0.8	-0.5	-0.2	0.1	0.2	1.1	0.1	-0.3	0.6	-1.4	-1.1	-0.5
Leg fat mass (left)	0.4	1.5	5.3	-1.2	-1.4	1.8	-2.3	0.8	-0.1	1.6	-1.2	-1.1	0.1	-0.9	-0.2	-1.0
Intelligence (Savage-Jansen 2018)	0.3	0.8	3.5	-1.0	0.5	1.9	1.2	-0.4	-0.9	0.8	-0.7	0.2	-0.4	1.5	0.3	0.1
Worry (Nagel 2018)	0.3	0.7	2.4	1.6	0.7	-1.5	-0.1	0.5	0.2	0.0	-0.6	0.6	-0.8	1.2	0.6	0.7
Prostate Cancer	0.3	0.5	1.1	-0.3	-0.0	0.6	0.8	-0.6	-0.9	-0.8	-1.0	-0.4	-0.9	0.7	0.1	-0.6
Mean Putamen Volume	0.3	0.3	1.4	-0.1	-0.1	0.8	1.2	1.2	-0.5	-0.3	0.0	0.1	-0.3	0.4	0.6	-0.2
Systolic Blood Pressure	0.3	1.3	6.1	0.9	1.7	-0.0	0.9	1.2	0.5	0.7	0.5	1.1	0.3	2.5	1.0	1.4
Smoking Status	0.3	0.7	2.3	1.5	0.4	0.2	-1.4	0.6	1.0	-1.0	0.2	0.6	0.3	-1.3	-0.3	0.7
Hypothyroidism (self reported)	0.3	0.6	2.5	0.1	0.2	0.3	-1.4	0.7	1.4	-0.5	0.6	0.1	1.6	-0.4	0.3	0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.5	-0.8	-0.1	-0.4	-0.2	-1.2	-0.3	-0.7	0.1	-0.5	-0.3	-0.2	-0.6	-0.3
Trunk fat percentage	0.3	1.3	7.1	-0.2	-1.3	1.4	-2.7	0.5	0.0	-0.3	-1.2	-1.2	-0.5	-1.1	0.9	-1.0
Fed-up feelings	0.3	0.5	1.2	0.5	1.1	-0.5	-0.3	0.7	0.9	-0.4	0.9	0.7	0.6	0.3	0.7	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	0.4	1.0	0.4	0.1	0.3	0.8	0.1	0.6	0.9	0.6	0.2	0.5	1.0
Relative age voice broke	0.3	0.4	1.8	0.7	0.2	-1.3	0.5	-0.8	-0.7	0.1	-0.5	0.4	-1.0	-0.2	-0.2	0.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.5	-0.2	-0.1	-0.2	0.6	-0.5	-1.2	0.3	-0.9	-0.5	-0.7	0.6	0.2	-0.7
High blood pressure	0.3	0.7	2.5	-0.6	-0.3	0.7	-1.4	0.5	-1.0	0.9	-1.6	-0.9	-0.3	0.4	-0.8	-0.5
Multivitamins +/- minerals	0.3	0.4	1.2	0.3	0.3	-0.9	1.1	-0.6	-0.2	1.0	-0.2	-0.2	1.0	0.2	-0.4	-0.5
Body mass index (BMI)	0.3	1.3	5.2	-1.1	-0.9	1.7	-2.3	1.3	0.4	1.4	-0.7	-1.0	0.5	-0.6	-0.6	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.5	0.6	1.2	0.8	0.5	0.5	0.6	-0.8	0.4	1.1	0.2	0.3	0.4	1.1
Had other major operations	0.3	0.4	1.3	-0.4	-0.4	-0.1	-0.3	-0.6	0.4	-1.1	0.8	-0.5	0.6	-1.1	-0.7	-0.4
Mouth/teeth dental problems	0.3	0.4	1.5	-0.1	0.0	-1.2	0.1	-0.0	-0.2	1.1	-0.3	-0.1	0.8	-0.8	-1.2	-0.1
Arm fat percentage (right)	0.3	1.2	7.6	0.1	-0.6	1.9	-2.8	1.1	0.9	-0.2	-0.4	-0.8	0.2	-0.4	0.8	-0.3
Worrier / anxious feelings	0.3	0.6	2.4	0.7	-0.1	-1.6	-0.7	0.5	0.3	1.4	-0.5	0.0	0.5	-0.1	-1.0	0.2
Number of live births	0.3	0.4	1.6	1.3	0.4	0.1	0.1	-1.0	0.3	-0.4	1.0	0.4	0.5	-0.0	0.3	0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.6	-0.4	-1.1	-1.1	-0.4	0.3	-0.9	1.3	-0.9	-0.5	-1.1	-1.0	-1.0	-0.5
Prospective memory result	0.3	0.4	1.3	-0.5	-0.0	-0.7	0.5	1.0	-0.2	0.0	-0.5	-0.3	-1.0	1.1	-0.1	-0.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.3	-0.4	-0.1	-0.2	0.2	-0.7	-0.6	-1.1	-0.4	-0.8	-0.6	0.3	-0.5	-0.9
Body fat percentage	0.3	1.0	5.0	-0.1	-0.7	2.1	-2.2	0.7	0.4	-0.1	-0.8	-0.8	-0.0	-0.2	1.2	-0.6
Shortness of breath walking on level ground	0.3	0.4	0.9	-0.4	0.2	-0.9	0.7	-0.5	-0.8	-0.2	-0.7	-0.4	-1.0	0.8	-0.6	-0.5
Medication: Ibuprofen	0.3	0.3	2.0	0.4	0.5	0.3	-0.2	1.4	0.4	0.2	0.1	0.7	0.4	-0.4	0.3	0.6
Number of full sisters	0.3	0.4	1.6	0.2	0.5	-0.5	-0.7	0.2	-0.4	-1.3	-1.0	0.2	-0.7	0.2	0.5	0.3
Age at last live birth	0.3	0.4	0.9	-0.1	-0.6	-0.9	0.6	-0.9	-0.6	0.6	-0.0	-0.2	-0.9	-0.4	-0.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.9	-0.3	0.1	-0.8	0.1	1.4	0.0	-0.3	0.1	0.6	-0.7	0.4	0.5	0.6
Illnesses of father: Heart disease	0.3	0.4	1.2	0.7	-0.1	-0.3	-0.8	-0.2	0.9	-1.1	0.1	-0.1	0.0	-1.1	-0.7	0.0
Smoking status: Previous	0.3	0.4	1.8	0.8	0.6	0.6	0.2	0.1	0.2	-1.3	0.8	0.5	-0.2	-0.2	0.6	0.6
Arm fat percentage (left)	0.3	1.2	7.8	-0.4	-1.0	1.6	-2.8	0.8	0.6	-0.1	-0.8	-1.2	0.2	-0.6	0.4	-0.8
Loneliness, isolation	0.3	0.4	2.4	0.7	-0.1	-1.6	-0.6	0.1	-0.1	-0.8	-0.3	-0.1	0.0	-0.6	-0.4	-0.1
Osteoporosis (self-reported)	0.3	0.3	2.1	-0.6	0.2	0.1	0.1	-0.8	0.6	-1.5	0.1	0.0	0.4	0.1	0.7	-0.2
Wears glasses or contact lenses	0.3	0.3	1.1	0.7	0.2	0.2	-0.1	-0.9	-0.8	0.9	-1.1	-0.3	-0.0	-0.2	0.1	-0.4
Medication: Blood pressure	0.3	0.5	1.6	-0.7	0.4	1.3	-0.4	0.8	-0.8	0.7	-1.1	-0.3	-0.0	1.1	-0.0	-0.2
Risk taking	0.3	0.4	1.0	0.0	-0.5	-1.0	-0.9	0.4	-0.0	-0.7	-0.2	-0.4	-0.8	-1.0	-0.4	-0.2
Commuting to job workplace: Cycle	0.3	0.4	1.4	-0.5	0.7	-0.4	1.2	0.8	-0.4	0.0	0.1	0.7	-0.7	0.8	0.3	0.8
Depression (Nagel 2018)	0.2	0.3	1.0	-0.1	0.4	0.0	0.5	-0.4	-0.5	-0.9	-0.5	0.2	-1.0	0.9	0.4	0.2
Neuroticism (Nagel 2018)	0.2	0.5	1.7	1.3	1.1	-0.8	-0.1	0.8	0.2	0.3	-0.2	0.7	-0.2	0.6	0.8	0.7
Schizophrenia vs Biploar Disorder	0.2	0.3	1.2	-0.3	0.0	-0.6	0.6	-0.6	0.2	0.2	-0.2	-0.4	0.6	-1.1	-0.6	-0.7
Rheumatoid Arthritis	0.2	0.3	2.5	0.3	0.4	-1.6	-0.1	-0.3	-0.0	-0.4	-0.2	0.1	0.1	0.5	-0.1	0.2
Neuroticism	0.2	0.5	2.3	1.5	1.0	-1.0	-0.3	0.4	0.3	0.0	-0.4	0.6	0.2	0.5	0.6	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	0.4	1.0	-0.6	0.3	-0.0	0.1	-0.5	-0.1	0.6	-0.4	0.8	0.1	0.8
Systolic blood pressure, automated reading	0.2	0.6	3.3	0.9	0.4	0.3	-0.3	1.1	0.4	1.8	0.2	0.3	0.8	0.5	0.5	0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.7	0.2	-0.2	-0.7	-0.6	-0.1	-0.3	-0.1	0.2	0.4	-0.2	0.6	0.4
Qualifications: CSEs or equivalent	0.2	0.2	0.9	-0.8	0.2	-0.3	0.2	-0.2	-0.0	0.7	0.3	-0.2	0.3	0.7	-0.9	0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.5	0.8	0.1	-1.2	-0.2	0.5	0.1	0.3	-0.6	0.1	-0.0	0.0	-0.2	0.1
Chronic bronchitis/emphysema (father)	0.2	0.3	1.4	0.2	0.7	-0.5	-0.3	0.3	-0.1	0.1	-0.6	0.1	-0.6	1.2	0.5	0.2
High blood pressure (mother)	0.2	0.3	0.9	-0.8	-0.3	0.8	0.4	-0.4	-0.4	0.9	-0.6	-0.2	-0.2	0.6	-0.3	-0.2
Waist circumference	0.2	0.7	3.9	0.1	-1.0	0.9	-2.0	0.0	-0.2	-0.2	-0.6	-1.1	-0.3	-1.2	0.2	-0.7
Past tobacco smoking	0.2	0.4	1.9	-0.9	-0.7	-0.7	-0.2	0.4	-0.2	1.4	-0.6	-0.4	0.2	0.1	-0.5	-0.5
Nervous feelings	0.2	0.3	2.0	1.4	0.7	-0.8	-0.2	0.2	0.8	0.2	-0.1	0.4	0.2	0.4	0.2	0.6
Neuroticism score	0.2	0.4	1.3	1.0	1.1	-1.0	-0.2	-0.2	-0.1	0.3	-0.5	0.3	0.2	0.8	0.3	0.5
Depression (self-reported)	0.2	0.3	1.4	0.6	-0.0	0.0	-1.2	0.4	0.8	-0.3	0.3	0.2	0.3	-1.0	-0.0	0.2
Illnesses of mother	0.2	0.3	0.8	-0.6	-0.5	-0.9	-0.2	-0.4	-0.4	-0.1	-0.0	-0.7	-0.1	-0.7	-0.2	-0.7
Birth weight of first child	0.2	0.3	2.0	0.3	-0.4	0.2	-0.1	1.1	0.0	-0.2	0.6	0.0	0.3	-1.4	0.6	0.1
Pulse wave reflection index	0.2	0.3	1.2	-0.8	-0.0	1.1	0.8	-0.2	-0.4	0.0	-0.0	-0.1	-0.5	0.5	-0.6	-0.1
Wheeze or whistling in the chest in last year	0.2	0.3	1.1	-0.3	1.0	-0.1	0.1	0.4	0.5	-0.8	0.3	0.2	1.1	0.6	0.4	0.2
Health satisfaction	0.2	0.3	0.8	-0.0	-0.3	0.6	-0.5	0.1	-0.4	-0.3	-0.9	-0.5	-0.6	-0.4	-0.6	-0.7
Medication: Blood pressure	0.2	0.3	1.1	-0.5	-0.5	-0.5	-0.8	1.0	-0.3	-0.6	-0.3	-0.4	-0.4	-0.9	-0.6	-0.0
Average weekly red wine intake	0.2	0.3	1.6	0.2	-0.4	0.8	-0.0	0.1	0.4	-1.0	0.5	0.3	-0.2	-1.3	0.3	0.0
Eye problems/disorders: Cataract	0.2	0.2	1.9	-1.4	-0.4	0.0	-0.2	-0.4	0.2	-0.7	0.1	-0.1	0.4	0.0	-0.5	0.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	-0.8	-0.0	0.1	0.9	0.7	-0.6	0.5	-0.2	0.1	-0.0	0.6	-0.1	-0.0
Miserableness	0.2	0.4	1.7	0.1	0.0	-0.2	-1.2	0.2	-0.0	1.3	-0.0	-0.2	0.8	-0.6	-0.7	0.2
Medication: Paracetamol	0.2	0.4	1.3	-0.2	-0.7	-0.3	-0.5	-1.1	-0.6	-0.0	-1.0	-0.6	-0.7	-0.1	-0.6	-0.6
Alcohol drinker status: Never	0.2	0.3	0.7	0.2	-0.5	-0.9	-0.2	0.6	0.7	-0.4	0.7	0.3	0.3	-0.8	0.3	0.3
Ever smoked	0.2	0.4	2.1	0.3	0.2	-0.1	0.1	-1.5	-0.9	-0.7	-0.7	-0.5	-0.7	-0.1	-0.3	-0.5
Depressed Affect (Nagel 2018)	0.1	0.3	1.1	0.5	1.0	-0.1	0.4	0.5	-0.1	-0.4	0.2	0.4	0.5	0.9	0.7	0.5
Neuroticism (2016)	0.1	0.1	0.5	0.0	0.6	0.7	-0.4	-0.2	0.1	0.4	-0.3	0.0	0.7	-0.0	0.0	0.2
Hair Pigment	0.1	2.7	10.4	-0.1	-1.3	-3.0	-0.6	-1.5	-1.1	-3.2	-0.2	-1.2	-2.8	0.6	0.7	-0.7
Tanning	0.1	0.9	4.2	-0.7	-0.3	-1.0	1.1	-2.0	-0.8	-1.3	0.5	-0.4	0.2	-0.6	-1.0	-0.5
Qualifications: None of the above	0.1	0.3	1.2	0.4	0.4	0.4	0.2	-0.2	0.7	-0.0	0.8	0.2	1.1	0.0	0.6	0.2
Medication: Seretide 50 evohaler	0.1	0.1	0.5	0.1	0.5	-0.2	0.4	0.4	0.5	-0.2	0.0	0.3	0.2	-0.4	0.7	0.2
Alcohol intake frequency.	0.1	0.2	1.3	0.5	-0.2	-0.1	-0.6	0.2	0.1	0.5	-0.2	-0.2	1.1	-0.1	0.1	-0.2
Mood swings	0.1	0.2	1.4	0.3	0.9	0.2	0.0	0.4	-0.1	-0.0	-0.4	0.2	-0.2	1.2	0.6	0.2
Number of self-reported non-cancer illnesses	0.1	0.2	1.0	-0.2	0.2	-0.2	-1.0	0.4	0.2	-0.4	-0.3	-0.3	0.4	-0.8	-0.2	-0.0
Guilty feelings	0.1	0.2	0.8	0.5	0.4	-0.4	-0.0	-0.0	-0.3	0.2	-0.9	0.2	-0.9	0.2	0.4	0.1
Ever depressed for a whole week	0.1	0.2	1.0	-0.0	0.2	0.0	-0.0	0.4	-0.2	-1.0	-0.8	-0.3	-0.1	0.3	-0.5	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.4	0.4	0.2	-0.7	1.2	-0.6	0.8	0.1	1.1	0.7	0.3	-0.1	0.5	0.4

Hub : Genes

CEP85

Models

Trait associations