TWAS hub - TRIM63

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.026	0.0160	5.3e-03	0.021	0.023	0.019	NA	0.018	6.6e-03	4.6e-03	9.1e-03	NA	1.1e-02
2	TCGA	Breast Invasive Carcinoma	0.149	0.0518	0.0e+00	0.161	0.149	0.158	NA	0.164	9.7e-32	3.0e-29	3.8e-31	NA	2.3e-32
3	TCGA	Cervical Squamous Cell Carcinoma	0.143	0.0670	8.1e-06	0.148	0.097	0.106	NA	0.140	9.2e-08	1.7e-05	7.0e-06	NA	2.3e-07
4	TCGA	Colon Adenocarcinoma	0.080	0.0450	2.5e-05	0.101	0.092	0.090	NA	0.095	2.0e-06	5.6e-06	6.9e-06	NA	3.7e-06
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.109	0.0452	4.4e-12	0.114	0.116	0.124	NA	0.123	8.7e-13	5.5e-13	9.0e-14	NA	9.5e-14
6	TCGA	Brain Lower Grade Glioma	0.286	0.0887	0.0e+00	0.331	0.326	0.329	NA	0.327	1.5e-38	6.4e-38	2.5e-38	NA	4.1e-38
7	TCGA	Lung Adenocarcinoma	0.139	0.0489	0.0e+00	0.195	0.205	0.207	NA	0.206	2.5e-22	1.5e-23	9.4e-24	NA	1.5e-23
8	TCGA	Lung Squamous Cell Carcinoma	0.159	0.0788	6.2e-11	0.112	0.086	0.089	NA	0.100	1.1e-12	5.9e-10	2.4e-10	NA	2.0e-11
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.138	0.0600	1.4e-10	0.177	0.146	0.146	NA	0.148	4.6e-12	4.3e-10	4.1e-10	NA	3.0e-10
10	TCGA	Pheochromocytoma and Paraganglioma	0.092	0.0620	7.1e-03	0.048	0.036	0.023	NA	0.038	5.5e-03	1.4e-02	4.1e-02	NA	1.2e-02
11	TCGA	Rectum Adenocarcinoma	0.279	0.1120	1.2e-05	0.223	0.178	0.182	NA	0.202	5.8e-06	5.6e-05	4.7e-05	NA	1.7e-05
12	TCGA	Thyroid Carcinoma	0.184	0.0640	0.0e+00	0.263	0.241	0.260	NA	0.257	1.4e-25	2.6e-23	3.0e-25	NA	6.0e-25
13	TCGA	Uterine Corpus Endometrial Carcinoma	0.186	0.0960	2.7e-05	0.068	0.135	0.103	NA	0.095	6.1e-03	1.3e-04	8.3e-04	NA	1.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Chronic bronchitis/emphysema (mother)	12.7	14.8	17.8	-4.2	-3.7	-3.7	-4.0	-3.7	-3.9	-4.0	-3.7	-4.0	-2.7	-4.2	-3.9	-4.1
Forced expiratory volume in 1-second (FEV1), Best measure	12.3	39.2	48.1	6.9	6.4	6.3	6.8	5.7	6.9	6.7	6.4	6.4	2.8	6.1	6.6	6.3
Forced vital capacity (FVC), Best measure	12.3	45.0	55.7	7.3	6.9	6.8	7.2	6.3	7.5	7.1	6.9	6.8	3.5	6.2	7.0	6.7
Forced expiratory volume in 1-second (FEV1)	11.4	38.3	49.2	6.8	6.4	6.3	6.6	5.6	7.0	6.5	6.3	6.3	2.7	6.1	6.5	6.3
Sitting height	11.2	79.2	102.0	8.9	9.5	9.4	9.3	9.0	10.1	9.1	9.4	8.8	6.2	7.2	9.2	9.0
Maternal smoking around birth	10.3	15.0	17.9	-4.2	-3.8	-3.7	-3.9	-3.8	-4.1	-3.9	-3.8	-3.9	-2.7	-4.2	-4.0	-4.1
Trunk fat-free mass	10.2	58.4	69.4	8.0	8.3	8.2	8.0	7.6	8.3	7.8	8.2	7.9	4.2	6.5	8.0	7.3
Trunk predicted mass	10.2	58.1	69.2	8.0	8.3	8.1	8.0	7.5	8.3	7.8	8.2	7.9	4.2	6.5	8.0	7.3
Type 2 Diabetes (T2D) (2018)	9.8	18.4	22.4	-4.4	-4.1	-4.1	-4.7	-4.4	-4.1	-4.7	-4.2	-4.4	-3.7	-3.9	-4.3	-4.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	9.8	20.7	26.9	5.2	4.6	4.6	5.0	4.2	4.7	4.9	4.5	4.8	2.2	4.4	4.8	4.5
Forced vital capacity (FVC)	9.6	37.0	48.3	6.5	6.4	6.4	6.5	5.7	7.0	6.4	6.4	6.2	2.7	5.5	6.4	5.9
Whole body water mass	9.0	51.2	62.7	7.5	7.9	7.7	7.4	7.0	7.9	7.3	7.7	7.4	3.7	6.1	7.5	6.9
Arm fat-free mass (right)	8.7	44.4	55.1	7.0	7.3	7.2	6.9	6.5	7.4	6.7	7.2	6.8	3.2	5.8	7.0	6.4
Whole body fat-free mass	8.7	49.6	60.2	7.4	7.8	7.6	7.3	6.9	7.8	7.2	7.6	7.2	3.6	6.0	7.4	6.7
Arm fat-free mass (left)	8.3	42.2	52.1	6.8	7.2	7.1	6.7	6.4	7.2	6.5	7.1	6.6	3.2	5.5	6.8	6.1
Arm predicted mass (right)	8.2	42.0	52.6	6.9	7.2	7.0	6.7	6.3	7.2	6.5	7.1	6.6	3.1	5.7	6.8	6.2
Alcohol usually taken with meals	8.0	13.0	17.6	3.6	3.3	3.4	3.9	3.6	3.7	3.9	3.4	3.6	3.6	2.8	3.6	4.2
Standing height	7.2	71.3	91.6	8.8	9.0	8.9	8.9	8.2	9.6	8.7	9.0	8.6	4.9	7.1	8.9	8.2
Peak expiratory flow (PEF)	7.2	16.7	21.5	4.6	4.2	4.3	4.3	3.5	4.6	4.3	4.1	4.2	1.1	4.2	4.4	4.2
Basal metabolic rate	7.2	39.9	49.7	6.7	7.0	6.9	6.5	6.2	7.0	6.3	6.8	6.5	3.0	5.6	6.6	6.0
Number of live births	7.1	10.0	11.7	-3.3	-3.3	-3.3	-3.3	-3.3	-3.3	-3.2	-3.4	-3.3	-2.4	-2.6	-3.3	-3.0
Mineral and other dietary supplements	7.0	9.3	14.9	-2.9	-2.8	-2.7	-3.1	-3.4	-2.7	-3.1	-2.9	-2.8	-3.9	-3.1	-2.7	-3.5
Height	6.9	132.5	166.4	12.0	12.3	12.1	12.1	11.3	12.9	11.8	12.3	11.7	6.6	10.3	12.0	10.9
Comparative height size at age 10	6.9	38.1	46.0	6.6	6.4	6.4	6.4	5.8	6.8	6.3	6.3	6.4	3.6	6.0	6.4	6.2
Arm predicted mass (left)	6.9	35.1	44.2	6.2	6.7	6.5	6.2	5.9	6.6	6.0	6.6	6.0	2.8	5.0	6.2	5.5
Supplements: Vitamin C	6.8	8.1	12.1	2.8	2.4	2.4	2.8	2.8	2.6	2.9	2.5	2.7	3.2	3.2	2.7	3.5
Bipolar Disorder (2018)	6.3	10.0	13.7	-3.4	-3.1	-3.0	-3.2	-3.2	-3.1	-3.2	-3.0	-3.0	-2.8	-3.2	-3.1	-3.7
Irritability	6.3	10.7	13.4	-3.3	-3.6	-3.7	-3.2	-3.6	-3.0	-3.2	-3.6	-3.4	-2.6	-2.9	-3.4	-2.8
Leg predicted mass (left)	6.2	32.9	41.3	6.0	6.4	6.3	5.8	5.5	6.4	5.7	6.2	5.9	2.6	5.1	6.0	5.5
Leg fat-free mass (left)	6.1	32.3	40.7	6.0	6.3	6.3	5.8	5.5	6.4	5.7	6.1	5.8	2.5	5.1	6.0	5.5
Ever had hysterectomy (womb removed)	6.0	6.8	11.2	-2.0	-2.7	-2.7	-2.5	-3.1	-2.6	-2.6	-2.7	-2.8	-3.4	-1.2	-2.6	-2.4
Pulse rate, automated reading	6.0	19.3	30.2	-5.3	-4.1	-4.0	-4.6	-3.7	-4.4	-4.5	-4.1	-4.5	-1.7	-5.5	-4.6	-4.8
Leg fat-free mass (right)	6.0	32.0	41.1	6.0	6.3	6.2	5.8	5.4	6.4	5.7	6.0	5.8	2.4	5.1	6.0	5.5
Leg predicted mass (right)	6.0	31.9	40.7	6.0	6.3	6.2	5.7	5.3	6.4	5.7	6.0	5.8	2.4	5.1	6.0	5.5
Medication: Metformin	5.9	8.3	11.1	-3.0	-2.7	-2.6	-3.3	-2.9	-2.7	-3.3	-2.7	-2.9	-2.5	-2.8	-2.8	-3.1
Ever had prostate specific antigen (PSA) test	5.9	6.8	10.6	2.3	2.5	2.4	2.8	2.9	2.5	2.8	2.6	2.7	3.2	1.8	2.4	2.8
Fed-up feelings	5.7	10.4	13.2	-3.6	-3.1	-3.1	-3.2	-3.1	-2.7	-3.4	-3.0	-3.6	-2.7	-3.6	-3.5	-3.0
Diabetes diagnosed by doctor	5.4	8.9	11.7	-3.1	-2.6	-2.6	-3.3	-3.0	-2.6	-3.4	-2.6	-3.0	-2.9	-3.0	-3.0	-3.4
Mother’s age at death	5.2	6.5	7.8	2.6	2.5	2.7	2.4	2.6	2.3	2.4	2.5	2.6	2.4	2.8	2.6	2.6
Diabetes (mother)	5.0	6.4	8.2	-2.5	-2.4	-2.4	-2.6	-2.6	-2.4	-2.6	-2.5	-2.6	-2.1	-2.7	-2.5	-2.9
Average weekly beer plus cider intake	4.9	7.1	8.8	-2.7	-2.5	-2.5	-2.7	-2.7	-2.6	-2.8	-2.4	-2.6	-2.7	-2.5	-2.8	-3.0
Tinnitus: Yes, now most or all of the time	4.8	5.6	7.6	2.1	2.3	2.5	2.5	2.6	2.3	2.4	2.4	2.3	2.8	1.9	2.2	2.5
Lung FVC	4.6	23.3	29.9	5.5	4.9	4.9	5.2	4.5	5.1	5.1	4.9	5.0	2.3	4.9	5.1	4.7
Father’s age at death	4.5	6.0	8.6	2.4	2.9	2.9	2.5	2.4	2.9	2.5	2.8	2.5	1.2	1.1	2.8	2.2
Pulse rate	4.5	7.6	10.6	-3.3	-2.7	-2.6	-3.0	-2.6	-2.7	-3.0	-2.7	-2.9	-1.4	-3.1	-2.8	-2.8
Vitamin and mineral supplements	4.4	5.9	10.1	-2.3	-2.1	-2.1	-2.3	-2.6	-2.0	-2.4	-2.0	-2.2	-3.2	-2.8	-2.2	-3.0
Forced expiratory volume in 1-second (FEV1), predicted	4.4	9.1	10.2	3.0	3.2	3.1	3.2	3.2	3.0	3.2	3.1	3.1	2.5	2.2	3.2	3.1
Eye problems/disorders: Diabetes related eye disease	4.3	4.8	7.5	-2.3	-1.9	-1.9	-2.2	-2.1	-1.9	-2.3	-1.9	-2.1	-2.2	-2.3	-2.2	-2.7
Hand grip strength (left)	4.2	11.1	12.8	3.6	3.5	3.4	3.4	3.4	3.3	3.3	3.5	3.3	2.2	3.4	3.5	3.5
Supplements: Fish oil (including cod liver oil)	4.2	5.5	8.1	2.5	2.1	1.9	2.4	2.4	2.2	2.4	2.2	2.1	2.4	2.8	2.2	2.7
High cholesterol (Self-reported)	4.0	7.1	11.5	-2.8	-2.3	-2.3	-2.9	-2.4	-2.8	-2.9	-2.3	-2.7	-1.9	-2.8	-2.7	-3.4
Bipolar Disorder (2011)	3.9	3.8	5.5	-2.2	-2.0	-1.8	-2.0	-1.7	-2.1	-2.0	-1.8	-1.7	-0.9	-2.3	-2.0	-2.4
Rheumatoid Arthritis	3.9	5.4	7.2	-1.9	-2.7	-2.6	-2.6	-2.6	-2.5	-2.5	-2.7	-2.3	-2.1	-0.4	-2.3	-2.0
Hand grip strength (right)	3.9	10.5	13.4	3.7	3.4	3.4	3.3	3.0	3.3	3.2	3.4	3.3	1.3	3.5	3.5	3.2
Schizophrenia vs Biploar Disorder	3.8	4.9	8.5	2.1	2.0	1.9	2.1	2.3	2.1	2.1	2.1	2.1	2.6	2.2	2.1	2.9
Diabetes (father)	3.8	4.7	5.8	-2.4	-2.3	-2.2	-2.3	-2.2	-2.0	-2.4	-2.3	-2.4	-1.3	-1.9	-2.3	-2.1
Birth weight	3.8	8.3	9.9	3.0	3.1	3.0	3.1	2.9	3.0	3.0	3.1	2.9	1.7	2.5	2.9	2.9
Waist Hip Ratio (WHR)	3.7	16.7	21.0	-4.1	-4.3	-4.2	-4.6	-4.2	-4.2	-4.5	-4.3	-4.3	-2.8	-3.2	-4.2	-4.0
Commuting to job workplace: Walk	3.7	4.0	5.5	2.0	2.3	2.1	2.3	2.0	2.3	2.1	2.4	2.1	0.8	1.4	2.0	1.7
Medication: Gliclazide	3.6	4.1	5.7	-2.3	-1.8	-1.8	-2.2	-1.9	-2.0	-2.1	-1.9	-2.0	-1.6	-2.1	-2.1	-2.4
Blood Eosinophil Count	3.5	27.0	31.1	-5.1	-5.3	-5.3	-5.6	-5.4	-5.3	-5.5	-5.3	-5.5	-4.2	-4.4	-5.2	-5.2
Qualifications: College or University degree	3.4	10.7	14.1	3.4	3.1	3.1	3.3	3.1	3.6	3.4	3.1	3.3	2.4	3.8	3.3	3.5
Bipolar Disorder or Schizophrenia	3.3	8.0	11.4	-2.9	-2.8	-2.7	-2.8	-2.9	-3.0	-2.8	-2.8	-2.7	-2.6	-2.6	-2.9	-3.4
Age at first live birth	3.3	5.8	7.2	2.0	2.6	2.7	2.6	2.6	2.6	2.7	2.5	2.7	2.1	1.3	2.5	1.9
Depressed Affect (Nagel 2018)	3.2	6.6	8.6	-2.8	-2.5	-2.6	-2.5	-2.5	-2.1	-2.7	-2.3	-2.9	-2.2	-2.9	-2.9	-2.5
Ever taken oral contraceptive pill	3.2	3.6	4.8	-2.2	-1.8	-1.9	-2.0	-1.9	-1.2	-2.0	-1.6	-2.1	-1.6	-2.0	-2.0	-1.8
Supplements: Glucosamine	3.1	4.1	5.4	2.1	1.9	1.9	2.3	2.0	1.8	2.2	1.9	1.9	1.6	2.2	1.9	2.3
High blood pressure (siblings)	3.1	4.4	6.1	2.3	2.2	2.1	2.1	2.1	2.3	2.0	2.2	1.9	1.2	2.1	2.2	2.5
Number of full brothers	3.1	3.9	5.2	-1.8	-2.0	-1.9	-2.2	-2.0	-2.2	-2.3	-2.0	-2.2	-1.2	-1.7	-1.8	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	6.5	-2.1	-1.6	-1.5	-2.0	-1.7	-1.6	-2.0	-1.6	-1.7	-1.2	-2.6	-1.8	-2.4
Diabetes (self-reported)	2.9	4.4	6.4	-2.2	-1.7	-1.7	-2.4	-2.1	-1.7	-2.5	-1.7	-2.1	-2.3	-2.1	-2.1	-2.5
Illnesses of siblings	2.9	4.0	5.0	-2.2	-2.1	-2.0	-2.0	-2.1	-2.0	-2.0	-2.1	-1.8	-1.7	-1.4	-2.2	-2.2
Multivitamins +/- minerals	2.8	3.6	9.0	1.6	1.7	1.6	1.7	2.2	1.4	1.8	1.6	1.7	3.0	1.7	1.6	2.3
Weight	2.8	13.6	18.3	3.9	4.1	4.0	3.7	3.5	4.3	3.6	4.0	3.7	1.4	3.5	3.9	3.5
Miserableness	2.8	4.9	6.1	-2.1	-2.2	-2.2	-2.3	-2.5	-2.0	-2.3	-2.2	-2.3	-2.4	-2.0	-2.2	-2.1
Medication: Atorvastatin	2.8	3.5	4.6	-2.1	-1.7	-1.8	-2.1	-1.6	-2.0	-2.1	-1.7	-2.0	-1.2	-1.9	-2.0	-1.8
Worry too long after embarrassment	2.7	4.5	6.5	2.0	1.9	1.8	2.1	2.4	2.2	2.1	2.1	1.9	2.5	2.1	1.9	2.6
Mean Putamen Volume	2.6	3.0	4.3	1.7	1.8	1.8	1.9	1.7	2.1	1.8	1.8	1.7	1.1	1.2	1.7	1.8
HbA1C	2.6	2.9	3.5	-1.6	-1.8	-1.8	-1.7	-1.8	-1.2	-1.7	-1.6	-1.8	-1.7	-1.5	-1.9	-1.7
Impedance of arm (right)	2.5	11.6	14.3	-3.6	-3.8	-3.7	-3.6	-3.5	-3.5	-3.5	-3.7	-3.5	-2.1	-2.7	-3.5	-3.4
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	4.1	1.9	1.7	1.6	1.9	1.8	1.8	1.8	1.8	1.7	1.3	1.5	1.8	2.0
Impedance of whole body	2.4	12.3	15.5	-3.7	-3.9	-3.8	-3.7	-3.5	-3.6	-3.7	-3.8	-3.7	-1.8	-2.9	-3.6	-3.4
Average weekly fortified wine intake	2.3	2.6	3.5	1.8	1.4	1.3	1.6	1.6	1.2	1.8	1.4	1.9	1.6	1.8	1.7	1.7
Chronic bronchitis/emphysema (father)	2.3	2.7	4.2	-1.6	-1.8	-1.8	-2.0	-1.6	-1.9	-1.9	-1.9	-1.8	-0.6	-1.0	-1.7	-1.2
Wears glasses or contact lenses	2.3	2.6	3.4	1.4	1.8	1.7	1.8	1.9	1.8	1.8	1.7	1.5	1.5	0.6	1.6	1.5
Townsend deprivation index at recruitment	2.2	3.1	6.1	-1.7	-1.6	-1.5	-1.8	-2.0	-1.4	-1.8	-1.6	-1.5	-2.5	-1.6	-1.6	-2.1
Serious illness, injury or assault to yourself	2.2	2.7	4.1	1.7	1.5	1.4	2.0	1.5	1.8	2.0	1.6	1.8	1.1	1.0	1.7	1.8
Impedance of leg (left)	2.2	10.9	13.5	-3.4	-3.7	-3.7	-3.4	-3.1	-3.5	-3.4	-3.4	-3.5	-1.6	-2.9	-3.4	-3.3
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	4.2	-1.8	-1.4	-1.5	-1.7	-1.6	-1.3	-1.7	-1.4	-1.8	-1.5	-1.9	-1.7	-2.0
Impedance of arm (left)	2.1	9.7	12.6	-3.3	-3.5	-3.4	-3.3	-3.2	-3.2	-3.2	-3.5	-3.2	-1.6	-2.3	-3.2	-2.9
Hair/balding pattern: Pattern 4	2.1	5.2	6.1	-2.2	-2.3	-2.4	-2.5	-2.4	-2.4	-2.4	-2.3	-2.1	-2.0	-2.0	-2.2	-2.3
Qualifications: nursing, teaching	2.1	3.2	4.3	2.1	1.9	1.9	2.0	1.5	1.8	1.9	1.8	2.0	0.1	2.0	1.9	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.0	5.0	-1.7	-1.7	-1.7	-1.7	-1.7	-1.8	-1.7	-1.6	-1.8	-1.5	-2.2	-1.6	-1.7
Medication: Omeprazole	1.9	2.3	3.9	-1.7	-1.4	-1.5	-1.5	-1.3	-1.4	-1.6	-1.3	-1.6	-1.0	-2.0	-1.5	-1.6
Unable to work because of sickness or disability	1.9	2.5	3.3	-1.5	-1.7	-1.7	-1.8	-1.6	-1.7	-1.8	-1.6	-1.5	-1.1	-1.4	-1.5	-1.4
Sensitivity / hurt feelings	1.8	3.0	4.3	-1.6	-2.1	-2.0	-1.7	-1.9	-1.8	-1.8	-2.0	-2.0	-1.2	-0.9	-1.9	-1.5
Impedance of leg (right)	1.8	8.9	10.8	-3.2	-3.3	-3.3	-3.1	-2.7	-3.3	-3.1	-3.0	-3.2	-1.1	-2.8	-3.1	-3.0
Number of full sisters	1.8	2.2	4.0	-1.0	-1.5	-1.4	-1.5	-1.7	-1.6	-1.6	-1.4	-1.6	-2.0	-0.6	-1.2	-1.3
Neuroticism score	1.7	3.6	5.5	-1.9	-2.3	-2.3	-1.9	-2.0	-1.5	-2.0	-2.1	-2.3	-0.9	-1.6	-2.1	-1.1
Birth weight of first child	1.7	3.1	4.6	2.1	1.7	1.8	1.8	1.6	1.5	1.7	1.6	1.8	1.2	2.1	1.8	1.8
Angina (self-reported)	1.7	2.2	3.1	-1.7	-1.4	-1.4	-1.7	-1.5	-1.3	-1.7	-1.4	-1.6	-1.1	-1.3	-1.6	-1.5
Illnesses of siblings: Diabetes	1.7	2.1	3.0	-1.2	-1.4	-1.4	-1.6	-1.6	-1.5	-1.6	-1.4	-1.5	-1.4	-0.8	-1.4	-1.7
Ever had bowel cancer screening	1.7	1.9	3.0	1.4	1.6	1.4	1.7	1.5	1.4	1.7	1.7	1.5	0.8	0.7	1.4	0.9
Coronary Artery Disease (CAD)	1.6	1.9	3.1	-1.8	-1.2	-1.2	-1.3	-1.1	-1.2	-1.3	-1.2	-1.5	-0.9	-1.7	-1.5	-1.5
Primary Biliary Cirrhosis	1.6	2.3	3.2	-1.7	-1.6	-1.7	-1.5	-1.4	-1.3	-1.7	-1.4	-1.5	-1.0	-1.4	-1.8	-1.7
Smoking status: Previous	1.6	2.4	3.7	-1.5	-1.5	-1.5	-1.5	-1.9	-1.1	-1.4	-1.6	-1.4	-1.9	-1.6	-1.5	-1.4
Alcohol drinker status: Previous	1.6	1.8	4.5	-1.3	-1.2	-1.2	-1.4	-1.5	-1.0	-1.4	-1.2	-1.3	-2.1	-0.7	-1.3	-1.5
Number of treatments/medications taken	1.5	2.7	3.6	1.8	1.7	1.6	1.6	1.6	1.8	1.5	1.8	1.5	1.0	1.5	1.7	1.9
Angina	1.5	2.0	2.6	-1.6	-1.3	-1.3	-1.5	-1.5	-1.2	-1.6	-1.3	-1.5	-1.3	-1.2	-1.5	-1.5
Past tobacco smoking	1.5	2.7	4.4	1.7	1.5	1.5	1.5	1.9	1.3	1.5	1.7	1.4	1.9	2.1	1.5	1.6
Hair/balding pattern: Pattern 3	1.5	2.3	3.5	1.2	1.6	1.5	1.9	1.8	1.3	1.8	1.8	1.7	1.8	0.0	1.3	1.1
Basal cell carcinoma (self-reported)	1.5	1.7	2.5	-1.4	-1.4	-1.4	-1.3	-1.4	-1.2	-1.3	-1.4	-1.2	-0.9	-1.6	-1.3	-1.1
Lung FEV1/FVC ratio	1.4	7.2	9.6	3.0	2.7	2.5	2.9	2.4	2.8	2.9	2.6	2.8	1.1	2.6	2.9	3.1
Frequency of depressed mood in last 2 weeks	1.4	2.0	2.4	-1.4	-1.4	-1.3	-1.4	-1.5	-1.3	-1.5	-1.2	-1.5	-1.6	-1.5	-1.3	-1.5
Medication: Co-codamol	1.4	1.6	2.3	1.2	1.3	1.3	1.4	1.1	1.4	1.4	1.2	1.5	0.7	0.7	1.3	1.3
Current tobacco smoking	1.4	2.4	3.3	-1.7	-1.4	-1.4	-1.6	-1.3	-1.8	-1.6	-1.4	-1.6	-0.9	-1.8	-1.5	-1.6
Medication: Amlodipine	1.4	1.9	2.5	1.1	1.5	1.4	1.4	1.6	1.5	1.4	1.6	1.4	1.4	0.5	1.4	1.3
Medication: Seretide 50 evohaler	1.4	1.6	4.0	1.5	0.9	1.0	1.1	1.1	0.6	1.1	1.0	1.3	1.1	2.0	1.3	1.6
Age at last live birth	1.4	2.0	2.9	1.0	1.6	1.5	1.6	1.7	1.4	1.7	1.5	1.6	1.6	0.4	1.4	1.0
Family relationship satisfaction	1.4	1.7	4.3	-1.7	-1.0	-1.0	-1.4	-0.8	-1.1	-1.5	-1.0	-1.5	0.2	-2.1	-1.5	-1.3
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.3	-1.2	-1.3	-1.2	-1.4	-1.4	-1.4	-1.4	-1.5	-1.3	-0.9	-1.1	-1.3	-1.1
Mood swings	1.4	2.5	3.1	-1.5	-1.7	-1.7	-1.6	-1.8	-1.3	-1.6	-1.6	-1.7	-1.6	-1.5	-1.6	-1.3
Age started oral contraceptive pill	1.4	1.8	2.9	1.4	1.5	1.4	1.5	1.2	1.7	1.4	1.4	1.3	0.6	1.1	1.3	1.3
Type 2 Diabetes (T2D) (2012)	1.3	1.5	4.4	-1.0	-1.0	-1.3	-1.1	-1.4	-0.5	-1.2	-0.9	-1.6	-2.1	-0.7	-1.2	-1.2
Ulcerative Colitis	1.3	1.9	4.0	-1.1	-1.4	-1.4	-1.3	-1.6	-1.1	-1.4	-1.1	-1.3	-2.0	-0.8	-1.4	-1.7
Qualifications: A levels/AS levels or equivalent	1.3	2.9	4.6	1.8	1.8	1.8	1.9	1.5	2.1	1.8	1.8	1.8	0.3	1.7	1.8	1.6
Exposure to tobacco smoke at home	1.3	1.5	2.1	-1.3	-1.2	-1.1	-1.4	-1.1	-1.2	-1.4	-1.1	-1.1	-0.9	-1.2	-1.2	-1.4
Tense / ‘highly strung’	1.3	2.1	3.0	-1.6	-1.7	-1.6	-1.4	-1.4	-1.4	-1.4	-1.6	-1.7	-0.5	-1.5	-1.6	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.3	1.2	1.4	1.3	1.4	1.6	1.5	1.4	1.4	1.2	1.7	0.5	1.4	1.8
Gout (self-reported)	1.3	1.8	2.6	-1.4	-1.2	-1.2	-1.4	-1.4	-1.3	-1.4	-1.3	-1.3	-1.1	-1.2	-1.4	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.2	1.0	1.4	1.3	1.4	1.3	1.4	1.3	1.5	1.1	0.5	0.9	1.1	1.1
Body Mass Index (BMI) (2010)	1.2	1.6	4.5	1.5	0.9	0.9	1.2	1.2	1.0	1.2	1.0	1.1	1.2	2.1	1.1	1.4
Medication: Ramipril	1.2	1.6	3.6	-1.1	-0.9	-1.0	-1.3	-1.2	-1.1	-1.4	-0.9	-1.2	-1.9	-1.1	-1.1	-1.6
Hip circumference	1.2	5.1	7.0	2.4	2.6	2.5	2.2	2.1	2.6	2.1	2.5	2.2	0.5	2.4	2.3	2.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.5	1.3	1.3	1.3	1.3	1.1	1.6	1.3	1.3	1.1	0.2	1.1	1.3	1.2
Pulse wave peak to peak time	1.2	1.4	3.7	1.0	1.1	1.1	1.1	1.5	0.6	1.2	1.1	1.1	1.9	0.9	1.1	1.1
Emphysema/chronic bronchitis	1.2	1.3	1.7	-1.3	-1.1	-1.1	-1.2	-1.1	-1.1	-1.2	-1.2	-1.1	-0.7	-1.3	-1.2	-1.1
Medication: Allopurinol	1.2	1.6	3.2	-1.1	-1.1	-1.1	-1.2	-1.4	-1.0	-1.3	-1.1	-1.3	-1.8	-0.8	-1.2	-1.5
Suffer from ‘nerves’	1.2	1.9	3.6	-1.6	-1.4	-1.4	-1.3	-1.1	-1.4	-1.4	-1.4	-1.6	-0.5	-1.9	-1.5	-1.2
Cholesterol lowering medication	1.2	1.8	3.3	-1.5	-1.0	-1.0	-1.5	-1.1	-1.4	-1.6	-1.0	-1.4	-0.9	-1.7	-1.3	-1.8
Alzheimer’s Disease (in father)	1.1	1.2	1.7	0.9	1.3	1.2	1.0	1.3	1.1	1.1	1.3	1.1	1.1	0.4	1.1	0.9
Crohns Disease (2017)	1.1	2.3	3.0	1.6	1.5	1.4	1.5	1.7	1.1	1.5	1.5	1.5	1.7	1.4	1.5	1.7
Reaction Time	1.1	2.1	3.2	1.8	1.4	1.5	1.5	0.9	1.5	1.5	1.3	1.6	-0.2	1.6	1.6	1.4
Hearing difficulty/problems with background noise	1.1	1.7	3.1	-1.4	-1.6	-1.6	-1.3	-1.2	-1.3	-1.1	-1.4	-1.1	-0.1	-1.8	-1.3	-1.1
Breastfed as a baby	1.1	1.4	2.0	1.0	1.1	1.1	1.4	1.1	1.4	1.3	1.2	1.3	1.0	0.8	1.0	1.3
Qualifications: CSEs or equivalent	1.0	1.4	2.1	-1.3	-1.1	-1.2	-1.1	-1.0	-1.3	-1.0	-1.1	-1.2	-0.8	-1.5	-1.2	-1.2
Illnesses of mother	1.0	1.3	7.6	1.4	0.7	0.7	0.8	0.7	0.7	0.7	0.8	0.8	0.2	2.8	0.9	1.3
Loud music exposure frequency	1.0	1.1	4.9	-0.7	-0.7	-0.7	-0.9	-1.1	-0.8	-1.1	-0.6	-1.0	-2.2	-0.2	-0.9	-1.4
Medication: Ibuprofen	1.0	1.2	1.8	1.2	1.2	1.3	1.1	0.9	1.4	1.0	1.2	1.0	-0.0	1.0	1.3	1.2
Myopia	1.0	1.4	3.8	1.0	1.0	1.0	1.0	1.2	1.1	1.0	0.9	1.0	2.0	1.1	1.0	1.5
Heart disease (siblings)	1.0	1.3	2.1	0.8	1.3	1.3	1.1	1.3	0.9	1.1	1.2	1.1	1.4	0.0	1.1	1.1
Smoking Status	0.9	2.2	4.7	-1.7	-1.2	-1.3	-1.5	-1.4	-1.4	-1.4	-1.4	-1.3	-1.2	-2.2	-1.4	-1.4
Ever used hormone-replacement therapy (HRT)	0.9	1.2	1.5	-1.1	-1.1	-1.0	-1.2	-1.1	-1.1	-1.2	-1.1	-1.1	-0.8	-0.9	-1.1	-1.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.9	-0.8	-1.1	-1.1	-1.0	-1.3	-0.7	-1.0	-1.2	-1.2	-1.4	-0.3	-1.1	-0.9
Worrier / anxious feelings	0.9	1.7	6.7	1.0	0.8	0.7	1.4	1.5	1.0	1.4	0.9	1.0	2.6	0.6	1.0	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.4	-1.1	-1.1	-1.0	-1.2	-0.9	-1.1	-1.2	-1.1	-1.1	-0.4	-0.6	-1.1	-0.7
Mouth/teeth dental problems: Dentures	0.9	1.5	3.4	-1.1	-0.9	-0.8	-1.2	-1.3	-0.9	-1.3	-0.9	-1.1	-1.8	-1.3	-1.2	-1.7
Exposure to tobacco smoke outside home	0.9	1.2	1.9	-1.1	-0.9	-1.1	-1.3	-1.0	-1.2	-1.2	-1.1	-1.0	-0.8	-1.2	-1.1	-1.4
Smoking status: Current	0.9	1.4	2.5	-1.4	-1.0	-1.1	-1.3	-0.9	-1.4	-1.3	-1.1	-1.2	-0.6	-1.6	-1.2	-1.2
Age at First Birth	0.8	1.1	1.7	1.1	1.3	1.3	1.1	1.1	0.6	1.0	1.1	1.0	0.1	1.2	1.2	0.9
LDL Cholesterol	0.8	1.3	2.2	-1.4	-0.9	-0.8	-1.2	-0.8	-1.2	-1.2	-1.1	-1.1	-0.3	-1.4	-1.2	-1.5
Age when periods started (menarche)	0.8	1.9	2.9	1.5	1.5	1.4	1.7	1.4	1.5	1.5	1.5	1.2	0.6	1.0	1.4	1.1
High blood pressure (mother)	0.8	1.2	2.0	1.3	1.0	1.1	1.0	1.0	0.9	1.2	0.9	1.3	1.1	0.6	1.4	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	3.3	-1.0	-1.0	-0.9	-1.1	-1.3	-0.7	-1.0	-1.0	-1.0	-1.8	-1.1	-0.9	-0.9
Hair/balding pattern: Pattern 2	0.8	1.0	1.4	-1.0	-1.0	-0.9	-1.2	-1.0	-1.0	-1.1	-1.0	-1.0	-1.2	-0.8	-0.9	-1.1
Time employed in main current job	0.8	0.9	1.2	-1.0	-0.9	-0.9	-1.0	-0.8	-1.1	-1.1	-0.8	-0.9	-0.4	-1.0	-1.0	-1.1
Mean time to correctly identify matches	0.8	1.6	2.3	1.5	1.2	1.3	1.4	0.9	1.3	1.3	1.2	1.4	0.1	1.4	1.3	1.2
Heart disease (mother)	0.8	0.9	3.2	-1.2	-0.8	-0.8	-0.9	-0.7	-0.7	-0.9	-0.8	-1.0	0.1	-1.8	-0.9	-0.9
Illnesses of father: None of the above (group 1)	0.8	1.0	1.5	1.0	1.2	1.1	1.1	0.8	1.2	1.0	1.2	1.1	-0.3	0.7	1.0	0.5
Systolic blood pressure, automated reading	0.7	2.0	2.7	1.4	1.4	1.4	1.4	1.5	1.4	1.4	1.3	1.3	1.6	1.6	1.3	1.4
Medication for hormone replacement therapy	0.7	0.8	1.1	-0.9	-1.0	-1.0	-1.1	-1.0	-0.6	-1.1	-1.1	-1.0	-0.5	-0.2	-1.0	-0.4
Prospective memory result	0.7	0.9	2.1	0.8	0.7	0.8	1.0	1.0	0.5	1.0	0.7	1.0	1.4	1.0	0.8	0.9
Lung cancer (father)	0.7	0.8	1.4	-0.8	-1.0	-0.8	-0.9	-1.1	-0.9	-0.9	-1.2	-0.8	-0.9	-0.5	-0.8	-0.7
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.3	0.8	0.7	0.6	1.1	0.9	1.1	1.0	0.8	0.8	1.0	0.8	0.7	1.1
Leg fat percentage (left)	0.7	2.7	3.7	-1.6	-1.5	-1.6	-1.9	-1.6	-1.7	-1.9	-1.5	-1.8	-1.6	-1.1	-1.7	-1.7
Schizophrenia (2018)	0.6	1.2	1.8	-1.0	-1.1	-1.1	-1.0	-1.2	-1.1	-1.0	-1.1	-1.0	-1.1	-0.7	-1.2	-1.4
Pulse wave reflection index	0.6	0.7	2.4	-0.7	-0.7	-0.8	-0.6	-0.9	-0.6	-0.7	-0.6	-0.7	-1.6	-1.0	-0.8	-1.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.3	-1.2	-0.8	-0.7	-0.9	-0.8	-0.7	-0.9	-0.7	-0.9	-0.4	-0.9	-0.9	-0.9
Comparative body size at age 10	0.6	1.6	2.2	1.4	1.3	1.3	1.4	1.2	0.9	1.4	1.1	1.5	0.7	1.3	1.3	1.1
Health satisfaction	0.6	0.8	1.6	0.6	1.1	1.1	0.8	1.0	1.3	0.7	1.1	0.6	0.6	0.1	0.9	0.9
Depression (Nagel 2018)	0.5	0.8	1.2	-0.9	-0.9	-1.0	-0.8	-0.8	-0.7	-1.0	-0.6	-1.1	-0.9	-0.9	-0.9	-0.9
Irritable Bowel Disease (IBD)	0.5	1.2	1.8	1.4	1.1	1.1	1.2	1.1	0.9	1.1	1.3	1.1	0.5	1.2	1.1	0.9
Ovarian Cancer	0.5	0.7	1.6	-0.9	-0.7	-0.8	-0.8	-0.9	-0.6	-0.8	-0.6	-0.7	-1.2	-0.4	-1.0	-1.3
Triglycerides	0.5	0.8	1.9	-0.8	-0.7	-0.5	-0.8	-0.9	-0.6	-0.9	-0.6	-0.9	-1.4	-0.8	-0.8	-1.3
Hearing difficulty/problems: Yes	0.5	0.8	1.1	-0.6	-1.0	-1.0	-0.8	-1.0	-1.0	-0.8	-1.0	-0.6	-0.9	-0.9	-0.7	-0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	-1.0	-0.7	-0.7	-1.0	-0.5	-0.7	-1.0	-0.8	-0.9	0.5	-0.7	-0.9	-0.3
Trunk fat mass	0.5	2.3	4.0	1.7	1.7	1.7	1.3	1.2	2.0	1.2	1.7	1.3	-0.1	1.9	1.6	1.5
Arm fat percentage (right)	0.5	1.9	2.7	-1.3	-1.4	-1.4	-1.7	-1.5	-1.3	-1.6	-1.4	-1.5	-1.5	-0.5	-1.4	-1.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	1.4	1.1	1.0	0.8	1.0	0.7	1.1	1.0	1.0	1.0	-0.5	1.2	0.9	0.6
Blood clot in the leg (DVT)	0.5	0.7	1.6	1.0	0.8	0.8	0.8	0.7	0.7	0.8	0.6	0.8	0.6	1.3	0.8	0.9
Leg fat percentage (right)	0.5	1.9	2.8	-1.3	-1.2	-1.3	-1.6	-1.3	-1.5	-1.7	-1.2	-1.5	-1.2	-0.9	-1.4	-1.5
Wheeze or whistling in the chest in last year	0.5	0.9	2.4	-0.8	-0.8	-0.8	-1.0	-1.1	-0.8	-1.1	-0.7	-0.9	-1.5	-0.7	-0.8	-0.8
Medication: Blood pressure	0.5	0.9	2.3	0.6	1.4	1.3	0.9	1.2	1.1	0.8	1.5	1.0	0.3	-0.0	0.9	0.3
Arm fat percentage (left)	0.5	1.9	2.9	-1.3	-1.4	-1.4	-1.7	-1.6	-1.2	-1.7	-1.4	-1.5	-1.5	-0.4	-1.4	-1.2
Average weekly red wine intake	0.5	0.7	1.0	0.7	0.8	0.8	1.0	0.9	0.9	1.0	0.9	0.9	0.9	0.5	0.7	0.9
Loneliness, isolation	0.5	0.7	1.0	-0.9	-0.8	-0.8	-0.8	-0.9	-0.4	-0.9	-0.7	-0.9	-1.0	-0.9	-0.9	-0.6
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-1.0	-1.0	-1.1	-0.5	-0.9	-0.3	-0.5	-0.9	-0.8	-0.5	-0.9	-1.0	-0.9
Eye problems/disorders: Glaucoma	0.5	0.6	0.9	-0.9	-0.7	-0.7	-0.9	-0.7	-0.7	-1.0	-0.6	-0.8	-0.7	-0.8	-0.8	-0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.2	1.0	0.7	0.6	0.6	0.5	0.9	0.7	0.7	0.7	-0.1	1.0	0.9	1.1
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.0	-1.3	-0.8	-0.9	-1.1	-0.8	-0.9	-1.1	-0.7	-1.0	-0.6	-1.7	-1.1	-1.5
Neuroticism (Nagel 2018)	0.4	0.8	1.6	-1.1	-1.1	-1.1	-0.8	-0.6	-0.9	-0.9	-0.9	-1.3	0.3	-0.9	-1.1	-0.4
Relative age of first facial hair	0.4	0.9	1.3	-1.0	-1.1	-1.1	-1.0	-0.9	-0.9	-1.0	-1.0	-1.1	-0.4	-0.4	-1.0	-0.6
Taking other prescription medications	0.4	0.7	1.7	0.8	0.8	0.7	0.7	0.7	1.3	0.7	0.8	0.5	0.3	0.9	0.9	1.2
Had menopause	0.4	0.5	1.0	-0.6	-0.7	-0.6	-0.6	-0.6	-0.9	-0.7	-0.6	-0.8	-0.7	-0.2	-0.8	-1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.0	0.7	0.6	0.6	0.7	0.9	0.6	0.6	0.8	0.7	1.0	0.6	0.6	1.0
Fluid intelligence score	0.4	0.9	1.6	-0.9	-0.7	-0.8	-0.9	-0.9	-0.6	-0.9	-0.6	-0.9	-1.2	-1.3	-0.8	-1.1
Asthma	0.4	0.8	1.7	-0.2	-0.8	-0.7	-0.9	-0.9	-1.3	-1.0	-0.8	-0.8	-1.3	0.9	-0.6	-0.5
Pulse wave Arterial Stiffness index	0.4	0.5	2.6	-0.5	-0.5	-0.5	-0.5	-0.9	0.0	-0.6	-0.5	-0.6	-1.6	-0.4	-0.6	-0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.5	-0.6	-1.2	-1.1	-0.8	-1.0	-0.9	-0.7	-1.2	-0.8	-0.2	-0.3	-0.8	-0.4
Eye problems/disorders: Cataract	0.4	0.4	1.3	-0.6	-0.4	-0.3	-0.6	-0.6	-0.6	-0.6	-0.5	-0.4	-0.5	-1.2	-0.5	-1.1
Back pain experienced in last month	0.4	0.6	0.9	-0.8	-0.7	-0.7	-0.7	-0.8	-0.6	-0.7	-0.8	-0.7	-0.7	-1.0	-0.8	-0.6
Hearing aid user	0.4	0.5	1.2	-0.7	-0.4	-0.5	-0.5	-0.6	-0.8	-0.4	-0.5	-0.2	-0.9	-1.1	-0.6	-1.1
Medication: Lisinopril	0.4	0.5	0.9	0.7	0.8	0.7	0.9	0.7	0.7	0.9	0.7	0.9	0.2	0.6	0.7	0.4
Illnesses of father: High blood pressure	0.4	0.5	1.0	-0.4	-1.0	-0.9	-0.8	-0.7	-1.0	-0.7	-0.9	-0.8	-0.2	0.0	-0.5	-0.1
Pain experienced in last month	0.4	0.6	1.6	-0.6	-0.7	-0.7	-0.8	-0.7	-1.0	-0.9	-0.6	-0.6	-0.9	0.2	-0.9	-1.3
Crohns Disease (2012)	0.3	0.5	1.5	0.7	0.5	0.4	0.5	0.9	-0.2	0.6	0.6	0.9	1.2	0.4	0.6	0.5
Hypothyroidism (self reported)	0.3	0.6	1.9	-0.7	-0.4	-0.4	-0.6	-0.7	-0.4	-0.8	-0.3	-0.8	-1.4	-1.3	-0.6	-1.1
Neuroticism	0.3	0.6	1.4	-0.9	-1.0	-1.1	-0.7	-0.7	-0.3	-0.8	-0.9	-1.2	0.3	-0.7	-1.0	0.0
Tanning	0.3	3.2	5.2	-1.3	-1.9	-2.0	-1.8	-2.3	-1.5	-1.7	-2.0	-1.6	-2.3	-1.0	-1.6	-1.5
Severe depression (siblings)	0.3	0.3	0.9	-0.4	-0.5	-0.5	-0.6	-0.7	-0.3	-0.6	-0.5	-0.6	-0.9	-0.2	-0.5	-0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.9	0.3	0.5	0.5	0.5	0.7	0.8	0.5	0.6	0.4	0.9	0.5	0.5	0.9
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.3	-0.8	-1.0	-0.9	-0.9	-0.8	-1.1	-1.0	-0.9	-1.0	-0.3	-0.8	-0.9	-0.6
Stomach or abdominal pain in last month	0.3	0.3	0.6	0.7	0.6	0.4	0.6	0.4	0.6	0.6	0.6	0.5	-0.3	0.5	0.6	0.7
Nervous feelings	0.3	0.6	6.0	-0.1	-0.2	-0.1	0.1	0.6	-0.1	0.2	-0.2	-0.1	2.5	-0.1	0.0	0.9
Qualifications: None of the above	0.3	0.7	1.4	-0.9	-0.8	-0.7	-1.0	-0.6	-1.2	-1.0	-0.7	-0.8	-0.1	-1.1	-0.8	-0.9
Mouth/teeth dental problems	0.3	0.4	1.0	0.6	0.4	0.3	0.6	0.6	0.4	0.7	0.4	0.5	1.0	1.0	0.5	1.0
Alcohol intake versus 10 years previously	0.3	0.5	1.3	0.6	0.7	0.7	0.4	0.3	1.1	0.3	0.8	0.4	-0.8	1.0	0.5	0.5
Happiness	0.3	0.4	0.9	0.4	0.7	0.7	0.6	0.9	0.5	0.4	0.8	0.4	0.9	-0.2	0.4	0.4
Arm fat mass (right)	0.3	1.0	2.3	1.1	1.1	1.1	0.8	0.8	1.3	0.7	1.1	0.9	-0.1	1.5	1.0	1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.6	-0.3	-0.4	-0.4	-0.7	-0.7	-0.7	-0.7	-0.5	-0.6	-1.3	0.0	-0.4	-0.6
Body fat percentage	0.3	1.0	2.1	-0.8	-0.9	-0.9	-1.2	-1.1	-0.7	-1.3	-0.9	-1.1	-1.5	-0.2	-1.0	-1.0
Shortness of breath walking on level ground	0.3	0.4	0.9	0.4	0.8	1.0	0.4	0.6	0.8	0.4	0.7	0.7	0.3	0.0	0.9	0.5
Whole body fat mass	0.3	1.1	2.1	1.2	1.3	1.2	0.8	0.7	1.4	0.7	1.2	0.8	-0.5	1.4	1.1	0.9
Alcohol intake frequency.	0.3	0.7	1.5	1.0	0.8	0.8	0.5	0.7	0.8	0.6	0.8	0.9	0.0	1.2	0.9	0.9
Hypertension (Self-reported)	0.3	0.7	1.2	0.8	1.0	0.9	0.8	1.1	0.8	0.8	1.1	0.8	0.6	0.5	0.8	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	-0.6	-1.0	-1.0	-0.8	-0.8	-0.6	-0.8	-0.9	-0.7	-0.3	-0.1	-0.8	-0.2
Osteoporosis (self-reported)	0.3	0.4	1.0	-0.6	-0.8	-0.8	-0.6	-0.5	-1.0	-0.5	-0.7	-0.5	0.2	-0.4	-0.7	-0.6
Commuting to job workplace: Public transport	0.3	0.3	0.6	0.5	0.4	0.5	0.3	0.6	0.5	0.4	0.5	0.5	0.8	0.7	0.7	0.7
Supplements: Calcium	0.3	0.4	0.7	0.6	0.6	0.6	0.8	0.7	0.4	0.7	0.5	0.5	0.7	0.8	0.4	0.5
Worry (Nagel 2018)	0.2	0.5	4.3	-0.2	-0.2	-0.2	0.2	0.7	0.1	0.1	0.0	-0.3	2.1	-0.1	-0.2	0.9
Fasting Glucose	0.2	0.2	1.2	0.1	0.3	0.3	0.5	0.6	-0.1	0.3	0.6	-0.0	1.1	0.1	0.1	0.5
Blood Platelet Count	0.2	1.9	2.6	-1.3	-1.4	-1.4	-1.6	-1.5	-1.2	-1.4	-1.4	-1.4	-1.0	-1.3	-1.3	-1.5
Blood Red Count	0.2	1.5	4.5	-0.8	-0.9	-0.8	-1.3	-1.5	-1.2	-1.3	-1.1	-1.3	-2.1	-0.9	-0.8	-1.2
Blood White Count	0.2	1.2	2.4	1.1	0.8	0.9	0.8	0.9	1.3	1.1	0.7	1.1	1.5	0.8	1.2	1.6
Hair Pigment	0.2	6.2	8.8	-2.6	-2.6	-2.4	-2.7	-2.5	-3.0	-2.5	-2.8	-2.4	-1.5	-1.9	-2.5	-2.6
Pack years adult smoking proportion	0.2	0.3	1.4	-0.9	-0.1	-0.2	-0.4	-0.0	-0.5	-0.4	-0.1	-0.2	0.2	-1.2	-0.5	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	-0.5	-0.5	-0.6	-0.6	-0.4	-0.7	-0.6	-0.4	-0.5	-0.3	-0.6	-0.5	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	-0.4	-0.8	-0.8	-0.9	-0.8	-0.5	-0.9	-0.7	-0.7	-0.6	0.4	-0.5	0.1
Number of incorrect matches in round	0.2	0.3	1.2	0.8	0.3	0.2	0.4	0.3	0.1	0.4	0.3	0.4	0.2	1.1	0.5	0.6
Financial difficulties in last 2 years	0.2	0.3	0.7	0.3	0.8	0.8	0.4	0.6	0.3	0.3	0.8	0.5	-0.2	0.3	0.5	0.4
Allergy	0.2	0.5	0.9	0.3	0.8	0.7	0.6	0.8	0.8	0.8	0.7	0.8	1.0	0.0	0.7	0.4
Pain all over the body in last month	0.2	0.2	0.5	-0.2	-0.6	-0.7	-0.5	-0.4	-0.7	-0.4	-0.6	-0.4	0.3	-0.5	-0.3	-0.1
Noisy workplace	0.2	0.3	0.9	0.3	0.8	0.7	0.4	0.5	1.0	0.3	0.8	0.5	0.0	0.1	0.5	0.3
Medication: Lansoprazole	0.2	0.2	0.6	0.4	0.4	0.3	0.4	0.2	0.8	0.3	0.4	0.2	-0.5	0.8	0.2	0.6
Length of working week for main job	0.2	0.2	0.4	0.1	-0.5	-0.3	-0.4	-0.6	-0.6	-0.4	-0.5	-0.1	-0.6	0.6	-0.1	-0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	2.1	-0.5	-0.2	-0.2	-0.2	-0.3	-0.2	-0.2	-0.2	-0.2	-0.7	-1.4	-0.3	-1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	2.2	-0.3	0.0	-0.0	-0.1	-0.4	0.3	-0.3	0.2	-0.4	-1.5	-0.9	-0.2	-0.5
Number of children fathered	0.2	0.2	0.7	0.6	0.4	0.3	0.4	0.2	0.3	0.4	0.4	0.6	-0.4	0.9	0.5	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.1	0.4	0.3	0.6	0.5	0.6	0.6	0.5	0.4	0.6	-0.1	0.1	-0.0
Overall health rating	0.2	0.4	1.7	-0.8	-0.4	-0.3	-0.7	-0.3	-0.3	-0.7	-0.4	-0.6	-0.2	-1.3	-0.5	-0.6
Chest pain or discomfort	0.2	0.3	0.7	-0.6	-0.5	-0.5	-0.6	-0.4	-0.7	-0.6	-0.4	-0.5	-0.7	-0.6	-0.5	-0.8
Had major operations	0.2	0.3	0.7	-0.6	-0.4	-0.4	-0.4	-0.5	-0.2	-0.4	-0.4	-0.4	-0.7	-0.8	-0.5	-0.5
Long-standing illness, disability or infirmity	0.2	0.3	1.5	-0.7	-0.2	-0.2	-0.5	-0.1	-0.4	-0.5	-0.2	-0.3	0.4	-1.2	-0.3	-0.3
Asthma (self-reported)	0.2	0.4	2.3	0.4	-0.3	-0.2	-0.5	-0.5	-0.8	-0.5	-0.4	-0.3	-1.0	1.5	-0.1	-0.1
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.8	-0.5	-0.5	-0.5	-0.4	-0.7	-0.4	-0.6	-0.4	0.2	-0.9	-0.6	-0.5
Medication: Aspirin	0.2	0.2	0.7	-0.7	-0.1	-0.1	-0.5	-0.3	-0.4	-0.6	-0.2	-0.3	-0.7	-0.6	-0.5	-0.8
Arm fat mass (left)	0.2	1.0	2.1	1.1	1.2	1.1	0.8	0.8	1.3	0.7	1.1	0.9	-0.2	1.4	1.0	1.0
Number of self-reported non-cancer illnesses	0.2	0.4	0.7	0.4	0.8	0.7	0.5	0.7	0.9	0.5	0.8	0.6	0.5	-0.0	0.6	0.5
Guilty feelings	0.2	0.3	1.0	0.7	0.2	0.3	0.6	0.3	0.7	0.6	0.3	0.5	0.5	0.5	0.5	1.0
Medication: Blood pressure	0.2	0.3	0.6	0.5	0.6	0.6	0.6	0.8	0.3	0.6	0.6	0.7	0.6	0.3	0.5	0.1
Number of operations (self-reported)	0.2	0.3	0.8	0.3	0.4	0.4	0.7	0.5	0.9	0.7	0.6	0.5	0.3	-0.1	0.4	0.5
Risk taking	0.2	0.2	1.8	0.5	0.1	0.2	0.2	0.0	0.2	0.3	0.1	0.4	-0.2	1.4	0.4	0.4
Diastolic blood pressure, automated reading	0.2	0.7	1.5	-1.2	-0.6	-0.6	-0.8	-0.5	-0.9	-0.9	-0.6	-0.9	-0.1	-1.1	-1.0	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	-0.6	-0.4	-0.5	-0.6	-0.4	-0.4	-0.6	-0.3	-0.7	-0.3	-0.8	-0.4	-0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	-0.0	0.1	0.2	0.3	0.2	0.4	0.3	0.0	0.3	0.5	-0.1	0.1	0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	-0.4	-0.0	-0.2	-0.2	-0.3	-0.1	-0.1	-0.2	-0.2	-0.5	-0.7	-0.3	-0.3
Ulcerative Colitis (UC)	0.1	0.1	0.3	0.5	0.2	0.2	0.3	0.2	0.3	0.2	0.5	0.2	-0.4	0.4	0.3	-0.1
Major Depression (MDD)	0.1	0.1	0.5	-0.2	0.2	0.2	0.3	0.0	0.7	0.2	0.3	0.1	-0.4	-0.2	-0.2	-0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.1	1.1	-0.5	-0.0	-0.1	-0.1	-0.1	0.1	-0.2	0.1	-0.2	-0.3	-1.1	-0.3	-0.5
Breast Cancer	0.1	0.2	1.4	-0.2	-0.3	-0.2	-0.1	-0.5	-0.0	-0.2	-0.1	-0.1	-1.2	-0.2	-0.2	-0.4
Prostate Cancer	0.1	0.2	0.9	-0.5	-0.4	-0.4	-0.4	-0.3	-0.4	-0.3	-0.4	-0.3	0.2	-1.0	-0.3	0.0
HDL Cholesterol	0.1	0.2	0.8	0.6	0.2	0.1	0.3	0.1	0.4	0.4	0.1	0.3	0.0	0.8	0.4	0.9
Lupus	0.1	0.1	0.5	-0.2	-0.3	-0.3	-0.2	-0.3	-0.6	-0.1	-0.3	0.1	-0.4	-0.3	-0.2	-0.7
Heel T-Score	0.1	0.5	2.5	0.1	-0.5	-0.5	-0.2	-0.1	-0.0	0.0	-0.6	0.2	1.1	1.2	0.1	1.6
BMI	0.1	0.5	2.3	0.9	0.3	0.3	0.1	-0.2	0.4	0.1	0.3	0.3	-1.5	1.5	0.5	0.4
Systolic Blood Pressure	0.1	0.4	1.5	0.2	0.7	0.7	0.7	0.9	0.6	0.5	0.7	0.3	1.2	0.2	0.3	0.5
Allergy or Eczema	0.1	0.1	0.3	0.4	0.4	0.5	0.3	0.5	-0.0	0.2	0.4	0.3	0.5	0.1	0.4	0.5
Respiratory disease	0.1	0.2	1.3	0.4	0.1	0.2	-0.1	-0.1	-0.4	-0.2	0.1	0.0	-0.7	1.1	0.1	-0.0
Average weekly spirits intake	0.1	0.2	0.4	-0.6	-0.4	-0.4	-0.4	-0.5	-0.0	-0.4	-0.4	-0.4	-0.3	-0.3	-0.5	-0.4
Supplements: Zinc	0.1	0.1	0.5	-0.5	-0.4	-0.3	-0.2	-0.1	-0.4	-0.3	-0.3	-0.3	0.7	-0.3	-0.5	-0.3
Trunk fat percentage	0.1	0.4	1.5	-0.3	-0.4	-0.4	-0.8	-0.8	-0.1	-0.8	-0.4	-0.7	-1.2	0.3	-0.5	-0.5
Relative age voice broke	0.1	0.1	0.4	-0.5	-0.2	-0.2	-0.2	-0.1	0.1	-0.1	-0.2	-0.2	0.2	-0.7	-0.2	0.0
High blood pressure	0.1	0.3	0.7	0.4	0.7	0.5	0.6	0.8	0.6	0.6	0.8	0.5	0.4	0.2	0.5	0.3
Medication: Levothyroxine sodium	0.1	0.2	1.7	-0.1	-0.1	-0.2	-0.2	-0.5	0.1	-0.3	-0.0	-0.5	-1.3	-0.5	-0.2	-0.4
Waist circumference	0.1	0.3	1.1	-0.3	-0.3	-0.4	-0.8	-0.6	-0.3	-0.8	-0.3	-0.6	-1.0	0.2	-0.4	-0.4
Had other major operations	0.1	0.2	0.7	-0.2	0.3	0.3	0.3	0.3	0.6	0.3	0.4	0.3	0.4	-0.8	0.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	2.0	0.6	-0.0	-0.1	0.0	-0.0	0.2	0.1	-0.0	0.2	0.1	1.4	0.3	1.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.7	-0.2	0.0	0.1	0.1	0.2	0.4	0.1	0.1	-0.2	0.9	-0.4	-0.0	0.4
Heart attack	0.1	0.2	1.2	-0.2	0.4	0.5	0.1	0.2	0.0	0.0	0.4	0.3	-0.2	-1.1	0.1	-0.6
Falls in the last year	0.1	0.2	0.4	0.5	0.5	0.6	0.3	0.2	0.5	0.4	0.3	0.5	-0.1	0.4	0.6	0.5
Medication: Cholesterol lowering	0.1	0.2	0.5	-0.4	-0.3	-0.3	-0.6	-0.4	-0.5	-0.6	-0.3	-0.4	-0.5	-0.3	-0.4	-0.7
Depression (self-reported)	0.1	0.2	1.4	-0.4	-0.3	-0.1	-0.1	-0.1	-0.0	-0.1	-0.3	-0.1	0.7	-1.2	-0.1	0.1
Medication: Paracetamol	0.1	0.2	0.4	-0.6	-0.5	-0.6	-0.3	-0.2	0.2	-0.3	-0.4	-0.7	0.6	-0.3	-0.5	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.2	0.2	0.1	0.2	0.2	0.4	0.2	0.3	0.0	0.2	-0.6	0.2	0.4
Eye problems/disorders: None of the above	0.1	0.1	0.5	0.2	-0.0	-0.1	0.3	0.3	-0.1	0.3	-0.0	0.1	0.7	0.7	0.1	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.8	-0.2	0.3	0.2	0.0	0.1	0.3	-0.1	0.4	-0.1	-0.4	-0.9	-0.1	-0.5
Migraine (self-reported)	0.1	0.1	0.5	-0.2	-0.0	0.0	-0.2	-0.3	0.1	-0.2	-0.1	-0.3	-0.7	-0.3	-0.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	0.2	-0.1	-0.1	0.2	0.2	-0.2	0.2	-0.1	0.1	0.7	0.2	0.1	0.6
Leg fat mass (right)	0.1	0.6	1.0	0.8	1.0	0.9	0.5	0.6	1.0	0.4	1.0	0.5	-0.6	0.9	0.7	0.5
Leg pain on walking	0.1	0.1	0.5	0.1	0.3	0.4	0.3	0.3	0.7	0.3	0.3	0.3	0.3	-0.4	0.4	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.8	0.5	0.3	0.3	0.1	0.3	-0.0	0.2	0.2	0.5	-0.0	0.9	0.5	0.5
Medication: Aspirin	0.1	0.2	0.5	-0.7	-0.0	0.0	-0.4	-0.2	-0.2	-0.4	-0.1	-0.2	-0.4	-0.4	-0.4	-0.7
Knee pain experienced in last month	0.1	0.2	0.6	-0.5	-0.4	-0.5	-0.3	-0.3	-0.0	-0.3	-0.4	-0.5	0.2	-0.7	-0.4	0.0
Illnesses of father: Heart disease	0.1	0.1	0.6	-0.5	-0.3	-0.4	-0.3	-0.1	-0.2	-0.2	-0.4	-0.4	0.8	-0.3	-0.3	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.5	-0.3	0.0	-0.0	0.1	0.1	0.2	0.1	-0.1	-0.1	0.6	-0.7	-0.1	0.0
Friendships satisfaction	0.1	0.1	0.3	0.1	0.5	0.4	0.1	0.3	-0.0	-0.1	0.6	0.1	-0.1	-0.2	0.0	-0.2
Breast cancer (self-reported)	0.1	0.1	0.2	-0.0	-0.4	-0.3	-0.1	-0.1	-0.2	-0.0	-0.4	-0.0	0.5	0.2	0.0	0.3
Financial situation satisfaction	0.1	0.1	0.2	-0.3	0.3	0.4	-0.2	0.3	-0.0	-0.2	0.3	0.1	0.4	-0.4	0.1	-0.2
Medication: Bendroflumethiazide	0.1	0.1	1.3	0.2	0.1	-0.0	-0.2	-0.1	-0.3	-0.2	0.2	0.2	-1.1	-0.1	0.1	-0.6
Medication: Paracetamol	0.1	0.1	0.6	-0.0	-0.1	-0.1	0.1	0.1	0.6	0.1	0.0	-0.2	0.6	0.1	0.0	0.8
Alcohol drinker status: Never	0.1	0.1	0.2	0.3	0.4	0.3	0.1	0.4	0.3	0.1	0.5	0.2	0.3	0.4	0.3	0.3
Ever smoked	0.1	0.1	0.6	-0.1	-0.1	-0.1	-0.1	-0.5	0.1	-0.1	-0.2	-0.1	-0.8	-0.6	-0.0	-0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.2	0.2	0.3	0.0	0.3	-0.5	0.1	0.2	0.3	0.0	-0.5	0.1	-0.5
Ever depressed for a whole week	0.1	0.1	0.7	-0.1	0.4	0.3	0.2	0.3	0.8	0.2	0.4	-0.0	0.1	-0.6	0.1	0.0
Commuting to job workplace: Cycle	0.1	0.1	1.3	0.1	0.1	0.2	0.2	-0.3	0.6	0.1	0.1	-0.1	-1.1	0.1	0.0	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	-0.3	-0.6	-0.5	-0.5	-0.7	-0.5	-0.5	-0.7	-0.5	-0.4	0.1	-0.4	-0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	1.4	-0.4	0.2	0.3	0.0	0.1	-0.2	-0.1	0.3	0.2	-0.2	-1.2	-0.1	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.9	0.5	0.3	0.3	0.3	0.3	0.2	0.4	0.1	0.4	0.2	1.0	0.3	0.5
Pack years of smoking	0.1	0.2	1.1	-0.4	0.4	0.3	0.1	0.5	-0.0	0.1	0.4	0.4	0.6	-1.0	0.0	-0.2
Leg fat mass (left)	0.1	0.4	0.7	0.6	0.8	0.7	0.3	0.4	0.8	0.2	0.8	0.4	-0.8	0.7	0.6	0.3
Neuroticism (2016)	0.0	0.0	0.1	0.3	0.2	0.2	0.1	-0.2	0.1	0.1	-0.1	0.3	-0.4	0.3	0.1	0.2
Schizophrenia (2014)	0.0	0.1	0.2	-0.3	-0.4	-0.5	-0.2	-0.2	-0.4	-0.1	-0.4	-0.1	0.3	0.2	-0.3	-0.1
Cardiovascular Disease	0.0	0.1	0.2	0.1	0.3	0.3	-0.1	0.2	0.2	-0.1	0.3	0.0	-0.5	0.2	0.2	-0.2
Chronotype (morning person)	0.0	0.1	0.7	-0.3	-0.1	-0.1	0.0	0.1	0.2	0.1	-0.1	0.1	0.8	-0.6	-0.0	0.5
Medication: Atenolol	0.0	0.1	0.1	-0.4	0.2	0.2	-0.2	0.0	0.1	-0.3	0.2	0.1	-0.3	-0.4	-0.2	-0.2
Body mass index (BMI)	0.0	0.1	0.7	0.1	0.2	0.1	-0.2	-0.1	0.1	-0.2	0.1	-0.1	-0.9	0.5	-0.0	-0.1
Medication: Simvastatin	0.0	0.0	0.1	-0.0	0.1	0.1	-0.1	0.1	-0.1	-0.1	0.1	-0.0	0.1	-0.3	0.0	-0.3
Headache pain in last month	0.0	0.0	0.2	0.2	0.2	0.2	0.1	0.0	0.2	0.1	0.1	0.2	-0.2	-0.1	0.3	0.4
Glaucoma (self-reported)	0.0	0.0	0.2	-0.4	0.1	0.1	-0.0	0.2	0.1	-0.1	0.2	-0.0	0.3	-0.4	-0.1	-0.2
Medication for pain relief, constipation, heartburn	0.0	0.0	0.3	0.2	-0.1	-0.1	-0.1	-0.0	-0.5	0.0	-0.2	0.1	0.3	0.2	0.1	-0.2
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.0	-0.2	-0.1	0.0	-0.3	-0.0	0.0	-0.2	-0.1	-0.2	-0.2	-0.0	0.1
Medication for cholesterol	0.0	0.1	0.5	-0.1	-0.1	-0.1	0.1	-0.3	-0.0	0.0	-0.1	-0.1	-0.7	-0.3	-0.1	0.0

Hub : Genes

TRIM63

Models

Trait associations