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chr15:66,850,204-68,789,191

Best TWAS P=2.22e-15 · Best GWAS P=5.79e-19 conditioned to 5.2e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Muscle Skeletal	MAP2K5	0.08	0.03	lasso	6	0.05	1.9e-05	5.7	7.9	2.2e-15	-0.91	0.01	0.99	TRUE
20	GTEx	Whole Blood	MAP2K5	0.09	0.06	lasso	6	0.06	8.1e-06	-7.3	7.9	2.5e-15	-0.64	0.77	0.09	FALSE
4	GTEx	Artery Aorta	MAP2K5	0.06	0.05	enet	6	0.05	7.7e-04	-7.3	7.5	9.3e-14	-0.65	0.60	0.08	FALSE
19	GTEx	Thyroid	MAP2K5	0.11	0.16	lasso	4	0.15	9.6e-12	-7.3	7.4	1.2e-13	-0.68	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	MAP2K5	0.04	0.04	lasso	3	0.03	8.7e-05	-7.3	7.4	1.2e-13	-0.66	0.75	0.04	FALSE
3	GTEx	Adipose Visceral Omentum	MAP2K5	0.07	0.08	lasso	3	0.05	1.0e-03	-7.2	7.4	1.4e-13	-0.65	0.54	0.12	FALSE
6	GTEx	Artery Tibial	MAP2K5	0.15	0.18	lasso	3	0.18	6.3e-14	-7.3	7.4	1.7e-13	-0.66	1.00	0.00	FALSE
10	GTEx	Esophagus Muscularis	MAP2K5	0.24	0.14	lasso	4	0.13	2.1e-08	-7.3	7.4	1.7e-13	-0.65	1.00	0.00	FALSE
15	GTEx	Nerve Tibial	MAP2K5	0.19	0.21	lasso	2	0.20	3.3e-14	-7.3	7.3	2.1e-13	-0.66	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	MAP2K5	0.14	0.18	lasso	4	0.18	1.0e-14	-7.3	7.3	2.7e-13	-0.66	1.00	0.00	FALSE
12	GTEx	Heart Left Ventricle	MAP2K5	0.10	0.10	lasso	3	0.10	9.4e-06	-7.3	7.3	3.6e-13	-0.66	0.82	0.10	FALSE
16	GTEx	Ovary	MAP2K5	0.19	0.24	lasso	3	0.21	8.3e-06	-7.3	7.2	4.2e-13	-0.65	0.23	0.46	FALSE
11	GTEx	Heart Atrial Appendage	MAP2K5	0.16	0.08	lasso	5	0.16	1.3e-07	-7.3	7.2	5.1e-13	-0.80	0.06	0.94	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	MAP2K5	0.10	0.06	lasso	5	0.04	6.1e-05	-7.3	7.2	5.5e-13	-0.64	0.94	0.01	FALSE
24	YFS	Blood	MAP2K5	0.05	0.07	lasso	4	0.07	1.2e-21	-7.3	7.1	1.1e-12	-0.63	1.00	0.00	FALSE
22	METSIM	Adipose	MAP2K5	0.07	0.05	enet	19	0.06	2.8e-09	-7.8	7.1	1.7e-12	-0.60	0.97	0.03	FALSE
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IQCH	0.35	0.04	blup	112	0.12	1.5e-05	-4.3	7.0	1.9e-12	-0.57	0.37	0.23	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCH	0.04	0.02	enet	6	0.03	1.6e-04	-7.2	7.0	2.5e-12	-0.63	0.01	0.98	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	IQCH	0.04	0.02	enet	8	0.01	1.6e-02	-5.7	6.8	1.4e-11	-0.71	0.13	0.09	FALSE
7	GTEx	Brain Cerebellum	MAP2K5	0.27	0.12	lasso	5	0.14	7.9e-05	-5.2	6.7	1.7e-11	-0.54	0.44	0.13	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCH	0.06	0.05	blup	112	0.06	5.2e-12	-5.3	6.7	1.9e-11	-0.65	0.99	0.01	FALSE
33	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	IQCH	0.10	0.01	blup	111	0.03	1.4e-02	5.1	6.6	3.2e-11	-0.72	0.05	0.18	FALSE
13	GTEx	Lung	MAP2K5	0.12	0.09	enet	11	0.07	3.6e-06	-7.3	6.6	3.4e-11	-0.60	0.97	0.01	FALSE
9	GTEx	Breast Mammary Tissue	MAP2K5	0.14	0.07	lasso	5	0.09	2.8e-05	-7.9	6.5	9.8e-11	-0.62	0.90	0.09	FALSE
40	The Cancer Genome Atlas	Stomach Adenocarcinoma	IQCH	0.08	0.03	blup	111	0.04	9.2e-04	-4.3	6.4	1.6e-10	-0.62	0.10	0.07	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAP2K5	0.03	0.03	blup	142	0.02	1.6e-03	-7.3	6.3	2.9e-10	-0.53	0.56	0.13	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MAP2K5	0.11	0.07	bslmm	474	0.08	1.2e-09	-7.3	6.3	3.2e-10	-0.53	0.99	0.01	FALSE
37	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IQCH	0.11	0.10	blup	112	0.10	2.3e-07	-5.6	6.2	4.5e-10	-0.71	0.07	0.93	FALSE
17	GTEx	Skin Sun Exposed Lower leg	MAP2K5	0.13	0.06	lasso	4	0.09	4.4e-08	3.8	6.2	7.4e-10	-0.73	0.81	0.19	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	IQCH	0.19	0.07	blup	111	0.16	7.4e-17	-2.8	6.1	8.1e-10	-0.70	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	IQCH	0.19	0.14	enet	21	0.12	2.4e-04	-4.3	6.1	1.1e-09	-0.66	0.16	0.70	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IQCH	0.06	0.04	blup	111	0.03	1.0e-04	-4.3	6.0	1.7e-09	-0.67	0.49	0.05	FALSE
18	GTEx	Spleen	MAP2K5	0.25	0.19	lasso	3	0.18	2.1e-05	-7.3	5.9	3.1e-09	-0.45	0.50	0.06	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	IQCH	0.05	0.04	blup	111	0.04	7.7e-06	-4.3	5.9	3.3e-09	-0.69	0.62	0.28	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IQCH	0.12	0.10	enet	22	0.12	4.0e-13	-4.2	5.7	1.2e-08	-0.61	1.00	0.00	FALSE
23	NTR	Blood	MAP2K5	0.02	0.00	enet	13	0.01	5.7e-04	-6.8	5.5	4.0e-08	-0.60	0.69	0.17	FALSE
8	GTEx	Brain Hippocampus	IQCH-AS1	0.20	0.08	enet	11	0.05	2.2e-02	3.8	-5.4	6.1e-08	0.74	0.12	0.36	FALSE
5	GTEx	Artery Coronary	MAP2K5	0.11	0.00	enet	28	0.03	4.5e-02	-5.4	5.4	6.7e-08	-0.33	0.14	0.06	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCH	0.13	0.07	blup	112	0.10	5.2e-09	-4.3	5.4	7.4e-08	-0.58	0.99	0.00	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	IQCH	0.15	0.17	enet	19	0.17	1.3e-16	-4.2	5.4	8.2e-08	-0.67	1.00	0.00	FALSE
21	METSIM	Adipose	IQCH	0.04	0.02	bslmm	593	0.02	3.3e-04	-2.9	5.3	1.4e-07	-0.64	0.30	0.49	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	IQCH	0.08	0.02	blup	111	0.05	4.2e-04	-4.3	5.2	2.1e-07	-0.57	0.39	0.16	FALSE