[Hub]/) : Traits : Leg fat percentage (left) :

chr18:20,082,830-21,863,589

Best TWAS P=4.83e-15 · Best GWAS P=2.07e-14 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C18orf8 0.26 0.35 lasso 6 0.40 1.9e-52 -7.6 -7.8 7.8e-15 0.93 0.02 0.98 FALSE
2 CommonMind Brain Pre-frontal Cortex NPC1 0.08 0.07 lasso 3 0.08 5.2e-10 6.6 -6.2 7.6e-10 0.71 0.74 0.26 FALSE
3 CommonMind Brain Pre-frontal Cortex RIOK3 0.02 0.01 bslmm 348 0.00 1.8e-01 -5.0 -5.8 5.9e-09 0.69 0.12 0.20 FALSE
4 GTEx Adipose Subcutaneous C18orf8 0.17 0.16 enet 13 0.16 2.6e-13 -7.4 -7.8 4.8e-15 0.98 0.02 0.98 TRUE
5 GTEx Adipose Subcutaneous NPC1 0.27 0.27 enet 12 0.30 2.4e-25 -7.4 -7.4 9.6e-14 0.94 0.06 0.94 FALSE
6 GTEx Adipose Visceral Omentum C18orf8 0.18 0.11 enet 10 0.04 4.5e-03 -7.2 -6.3 3.6e-10 0.89 0.02 0.98 FALSE
7 GTEx Adipose Visceral Omentum NPC1 0.20 0.19 lasso 3 0.17 2.9e-09 -7.4 -7.5 5.2e-14 0.92 0.06 0.94 FALSE
8 GTEx Artery Tibial C18orf8 0.18 0.12 lasso 3 0.10 1.5e-08 6.5 -6.4 1.3e-10 0.70 0.94 0.06 FALSE
9 GTEx Artery Tibial NPC1 0.26 0.07 enet 31 0.11 3.7e-09 6.5 -7.2 8.6e-13 0.82 0.06 0.94 FALSE
10 GTEx Brain Caudate basal ganglia C18orf8 0.15 0.16 enet 11 0.11 5.9e-04 -7.6 -7.8 9.1e-15 0.96 0.02 0.95 FALSE
11 GTEx Brain Cerebellar Hemisphere C18orf8 0.27 0.34 enet 19 0.34 1.3e-09 -7.5 -7.8 5.8e-15 0.98 0.02 0.98 FALSE
12 GTEx Brain Cerebellum C18orf8 0.23 0.18 enet 13 0.21 9.9e-07 -7.4 -7.6 2.7e-14 0.91 0.02 0.98 FALSE
13 GTEx Brain Cerebellum NPC1 0.20 0.10 enet 9 0.12 1.9e-04 -7.6 -7.1 1.2e-12 0.93 0.02 0.95 FALSE
14 GTEx Brain Cortex C18orf8 0.19 0.18 lasso 5 0.13 1.8e-04 -7.6 -7.6 2.1e-14 1.00 0.02 0.96 FALSE
15 GTEx Brain Frontal Cortex BA9 C18orf8 0.42 0.30 enet 12 0.08 3.4e-03 -7.5 -7.2 4.2e-13 0.96 0.02 0.98 FALSE
16 GTEx Brain Nucleus accumbens basal ganglia TMEM241 0.17 0.02 lasso 6 -0.01 5.6e-01 -7.4 -5.8 7.9e-09 0.76 0.03 0.68 FALSE
17 GTEx Breast Mammary Tissue NPC1 0.27 0.13 enet 27 0.19 5.0e-10 -7.4 -7.2 8.4e-13 0.88 0.02 0.98 FALSE
18 GTEx Breast Mammary Tissue (Female) NPC1 0.43 0.24 lasso 3 0.27 1.1e-08 -6.9 -7.2 6.3e-13 0.94 0.02 0.98 FALSE
19 GTEx Esophagus Mucosa NPC1 0.09 0.04 lasso 3 0.05 1.5e-04 -7.4 -7.6 4.1e-14 0.93 0.03 0.95 FALSE
20 GTEx Esophagus Muscularis C18orf8 0.14 0.13 lasso 3 0.10 8.0e-07 6.5 -7.1 1.4e-12 0.79 0.09 0.90 FALSE
21 GTEx Esophagus Muscularis NPC1 0.11 0.07 enet 4 0.09 7.3e-06 -7.2 -7.6 2.9e-14 0.97 0.02 0.98 FALSE
22 GTEx Heart Left Ventricle NPC1 0.19 0.15 enet 12 0.17 1.6e-09 -7.5 -7.4 9.7e-14 0.93 0.03 0.97 FALSE
23 GTEx Lung NPC1 0.11 0.06 enet 11 0.04 2.3e-04 -7.6 -7.1 9.5e-13 0.95 0.02 0.98 FALSE
24 GTEx Nerve Tibial C18orf8 0.16 0.07 enet 21 0.09 3.9e-07 -6.9 -7.5 7.4e-14 0.90 0.02 0.98 FALSE
25 GTEx Nerve Tibial NPC1 0.19 0.12 lasso 6 0.16 1.1e-11 6.5 -7.7 1.9e-14 0.90 0.04 0.96 FALSE
26 GTEx Pancreas NPC1 0.33 0.14 lasso 7 0.12 1.1e-05 -7.6 -7.4 9.8e-14 0.95 0.02 0.98 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic C18orf8 0.21 0.27 enet 6 0.23 6.9e-13 -7.5 -7.6 2.7e-14 0.98 0.02 0.98 FALSE
28 GTEx Skin Not Sun Exposed Suprapubic NPC1 0.15 0.08 lasso 4 0.12 2.3e-07 -7.5 -7.8 5.6e-15 0.94 0.02 0.98 FALSE
29 GTEx Skin Sun Exposed Lower leg C18orf8 0.35 0.33 enet 23 0.36 1.7e-30 -7.6 -7.6 2.4e-14 0.96 0.02 0.98 FALSE
30 GTEx Skin Sun Exposed Lower leg NPC1 0.23 0.18 lasso 3 0.27 1.8e-22 -7.4 -7.7 1.3e-14 0.90 0.07 0.93 FALSE
31 GTEx Testis C18orf8 0.12 0.07 lasso 6 0.08 1.9e-04 -7.5 -7.4 1.2e-13 0.92 0.02 0.92 FALSE
32 GTEx Thyroid NPC1 0.20 0.10 enet 25 0.13 2.3e-10 -7.5 -7.6 3.4e-14 0.90 0.02 0.98 FALSE
33 METSIM Adipose NPC1 0.06 0.05 enet 18 0.05 6.4e-08 -7.6 -6.9 4.2e-12 0.89 0.02 0.98 FALSE
34 The Cancer Genome Atlas Breast Invasive Carcinoma NPC1 0.03 0.03 blup 69 0.04 2.9e-09 -7.6 -7.4 1.1e-13 0.86 0.02 0.98 FALSE
35 The Cancer Genome Atlas Esophageal Carcinoma NPC1 0.16 0.10 lasso 3 0.10 3.7e-04 6.6 -7.3 3.5e-13 0.81 0.05 0.65 FALSE
36 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NPC1 0.05 0.02 blup 66 0.03 1.4e-04 -6.9 -6.3 3.5e-10 0.74 0.13 0.68 FALSE
37 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NPC1 0.03 0.04 lasso 2 0.05 4.2e-06 -6.9 -7.5 8.8e-14 0.93 0.02 0.98 FALSE
38 The Cancer Genome Atlas Brain Lower Grade Glioma C18orf8 0.07 0.05 lasso 5 0.03 9.5e-05 6.5 -6.6 3.6e-11 0.72 0.28 0.70 FALSE
39 The Cancer Genome Atlas Brain Lower Grade Glioma NPC1 0.07 0.08 lasso 3 0.10 1.6e-11 6.5 -7.5 6.3e-14 0.88 0.06 0.94 FALSE
40 The Cancer Genome Atlas Pancreatic Adenocarcinoma NPC1 0.14 0.01 enet 14 0.08 3.3e-04 -6.9 -5.2 2.6e-07 0.70 0.03 0.77 FALSE
41 The Cancer Genome Atlas Prostate Adenocarcinoma NPC1 0.05 0.02 blup 65 0.03 9.9e-04 -6.9 -6.7 2.5e-11 0.73 0.04 0.61 FALSE
42 The Cancer Genome Atlas Thyroid Carcinoma NPC1 0.04 0.03 blup 70 0.05 9.4e-06 -7.5 -7.0 2.1e-12 0.90 0.03 0.97 FALSE