TWAS
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Genes
Traits
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Traits
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Leg fat percentage (left)
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chr21:45,583,922-47,343,320
Best TWAS P=3.24e-08 · Best GWAS P=1e-11 conditioned to 0.00391
45.6M
45.8M
46M
46.2M
46.4M
46.6M
46.8M
47M
47.2M
47.4M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Pancreatic Adenocarcinoma
C21orf122
0.20
0.04
lasso
6
0.08
0.00026
5.7
-5.5
3.2e-08
0.57
0.00
0.99
TRUE
1
CommonMind
Brain Pre-frontal Cortex
ADARB1
0.12
0.03
blup
656
0.03
0.00036
-4.2
-5.5
4.0e-08
0.51
0.31
0.64
TRUE
2
GTEx
Muscle Skeletal
PTTG1IP
0.07
0.01
enet
6
0.00
0.09740
-6.4
5.4
6.6e-08
-0.71
0.01
0.89
FALSE
3
The Cancer Genome Atlas
Cervical Squamous Cell Carcinoma
ADARB1
0.07
0.01
blup
139
0.04
0.00451
4.8
-5.1
2.9e-07
0.83
0.01
0.90
FALSE