Best TWAS P=5.22e-13 · Best GWAS P=1.87e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARFRP1 | 0.07 | 0.07 | lasso | 3 | 0.06 | 5.3e-08 | -6.5 | 6.4 | 2.0e-10 | -0.95 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Brain Cortex | STMN3 | 0.25 | 0.09 | lasso | 7 | 0.11 | 6.8e-04 | -4.3 | -5.2 | 2.3e-07 | 0.71 | 0.10 | 0.65 | FALSE |
| 3 | GTEx | Testis | RTEL1 | 0.19 | 0.06 | lasso | 5 | 0.14 | 8.0e-07 | -4.3 | -5.6 | 2.7e-08 | 0.61 | 0.16 | 0.68 | FALSE |
| 4 | METSIM | Adipose | TPD52L2 | 0.03 | 0.00 | bslmm | 207 | 0.02 | 1.5e-03 | 4.6 | 5.8 | 7.3e-09 | -0.68 | 0.02 | 0.71 | FALSE |
| 5 | YFS | Blood | LIME1 | 0.12 | 0.19 | enet | 15 | 0.19 | 5.3e-59 | -7.0 | -7.2 | 5.2e-13 | 0.99 | 0.00 | 1.00 | TRUE |
| 6 | The Cancer Genome Atlas | Esophageal Carcinoma | GMEB2 | 0.16 | 0.04 | blup | 64 | 0.05 | 1.0e-02 | 2.9 | 5.7 | 1.0e-08 | -0.49 | 0.02 | 0.11 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIME1 | 0.02 | 0.03 | blup | 47 | 0.02 | 6.2e-03 | -4.3 | -6.1 | 1.3e-09 | 0.82 | 0.03 | 0.61 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | TNFRSF6B | 0.02 | 0.01 | enet | 7 | 0.01 | 6.9e-03 | -4.8 | -6.1 | 1.1e-09 | 0.92 | 0.02 | 0.87 | FALSE |
| 9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TNFRSF6B | 0.05 | 0.02 | blup | 44 | 0.03 | 2.9e-03 | -6.7 | -6.3 | 3.2e-10 | 0.92 | 0.01 | 0.70 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARFRP1 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.2e-03 | -6.5 | 6.6 | 5.3e-11 | -0.96 | 0.01 | 0.96 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LIME1 | 0.04 | 0.05 | blup | 47 | 0.05 | 9.0e-06 | -7.0 | -7.1 | 1.4e-12 | 0.97 | 0.00 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC2A4RG | 0.05 | 0.01 | blup | 48 | 0.02 | 2.0e-03 | -6.7 | 5.4 | 8.2e-08 | -0.83 | 0.01 | 0.94 | FALSE |
| 13 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LIME1 | 0.10 | 0.02 | blup | 47 | 0.04 | 1.5e-02 | -6.7 | -5.9 | 2.7e-09 | 0.90 | 0.01 | 0.63 | FALSE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | ARFRP1 | 0.04 | 0.00 | blup | 51 | 0.00 | 1.3e-01 | -7.0 | 5.5 | 3.3e-08 | -0.80 | 0.01 | 0.67 | FALSE |