[Hub]/) : Traits : Leg fat percentage (left) :

chr8:86,841,229-88,271,452

Best TWAS P=2.86e-10 · Best GWAS P=3.24e-10 conditioned to 0.0889

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CPNE3 0.17 0.07 blup 453 0.10 7.9e-12 4.2 -5.6 2.9e-08 0.59 0.20 0.80 FALSE
2 GTEx Artery Tibial RMDN1 0.18 0.08 lasso 9 0.10 1.8e-08 -6.0 5.9 3.1e-09 -0.95 0.01 0.99 FALSE
3 GTEx Brain Cerebellum NTAN1P2 0.19 0.14 enet 11 0.10 6.0e-04 -5.8 -5.8 6.5e-09 0.90 0.02 0.95 FALSE
4 GTEx Cells Transformed fibroblasts WWP1 0.06 0.00 lasso 6 0.00 1.5e-01 5.5 -5.3 1.1e-07 0.71 0.13 0.14 FALSE
5 GTEx Cells Transformed fibroblasts RMDN1 0.27 0.15 enet 30 0.23 1.5e-17 3.0 5.3 9.7e-08 -0.81 0.17 0.83 FALSE
6 GTEx Cells Transformed fibroblasts NTAN1P2 0.07 0.02 lasso 6 0.03 2.0e-03 -6.0 5.9 3.4e-09 -0.84 0.01 0.98 FALSE
7 GTEx Skin Not Sun Exposed Suprapubic RMDN1 0.22 0.07 lasso 7 0.11 1.9e-06 5.1 5.4 7.3e-08 -0.82 0.05 0.93 FALSE
8 GTEx Skin Sun Exposed Lower leg RMDN1 0.05 0.04 lasso 2 0.01 1.1e-01 5.5 5.5 4.7e-08 -0.80 0.07 0.87 FALSE
9 GTEx Spleen RMDN1 0.46 0.20 enet 29 0.18 2.2e-05 -6.3 5.4 5.1e-08 -0.83 0.02 0.97 FALSE
10 GTEx Stomach RMDN1 0.15 0.05 lasso 6 0.06 1.2e-03 -6.3 5.7 1.2e-08 -0.88 0.01 0.97 FALSE
11 NTR Blood CPNE3 0.02 0.01 blup 451 0.01 2.1e-03 1.6 -5.1 2.9e-07 0.48 0.27 0.22 FALSE
12 YFS Blood WWP1 0.09 0.06 blup 457 0.09 1.3e-26 5.1 -5.2 2.1e-07 0.77 0.08 0.92 FALSE
13 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CPNE3 0.07 0.03 lasso 4 0.05 2.3e-06 -6.0 -5.7 1.5e-08 0.82 0.00 0.99 FALSE
14 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma WWP1 0.03 0.01 blup 63 0.02 1.8e-03 -5.7 -6.0 1.5e-09 0.92 0.03 0.91 FALSE
15 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma WWP1 0.05 0.01 enet 8 0.02 2.0e-02 5.5 -5.7 1.3e-08 0.80 0.02 0.60 FALSE
16 The Cancer Genome Atlas Soft Tissue Sarcoma FAM82B 0.07 0.00 blup 45 0.01 1.1e-01 -6.3 6.3 2.9e-10 -0.86 0.00 0.66 TRUE