[Hub]/) : Traits : Leg fat mass (left) : ← →

chr17:3,371,501-6,068,117

Best TWAS P=3.58e-11 · Best GWAS P=1.24e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	ROSMAP	Brain Pre-frontal Cortex	RPAIN	0.06	0.06	lasso	3	0.06	3.1e-08	6.4	-6.6	3.6e-11	-0.98	0.00	1.00	TRUE
5	GTEx	Brain Putamen basal ganglia	AC012146.7	0.30	0.03	enet	23	0.03	7.6e-02	4.6	-6.3	2.8e-10	-0.45	0.08	0.26	TRUE
3	GTEx	Artery Coronary	RP11-810M2.2	0.30	0.02	lasso	4	0.02	8.5e-02	4.9	5.1	3.0e-07	-0.03	0.02	0.72	TRUE
9	GTEx	Esophagus Gastroesophageal Junction	GP1BA	0.35	0.16	lasso	11	0.18	5.9e-07	4.4	6.3	2.5e-10	0.56	0.26	0.59	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	DHX33	0.12	0.08	lasso	5	0.07	1.8e-03	6.4	-6.3	3.7e-10	-0.96	0.02	0.96	FALSE
22	The Cancer Genome Atlas	Glioblastoma Multiforme	RABEP1	0.23	0.13	blup	79	0.15	3.4e-05	5.1	-6.0	2.0e-09	-0.77	0.06	0.83	FALSE
10	GTEx	Esophagus Muscularis	RABEP1	0.13	0.09	lasso	10	0.10	2.1e-06	6.4	-6.0	2.1e-09	-0.94	0.02	0.98	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	RABEP1	0.04	0.03	enet	5	0.03	1.5e-03	-4.9	-6.0	2.1e-09	-0.67	0.09	0.81	FALSE
2	GTEx	Adrenal Gland	RABEP1	0.13	0.03	lasso	13	0.02	7.2e-02	-4.8	-5.9	4.4e-09	-0.80	0.03	0.84	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	RABEP1	0.19	-0.01	lasso	13	0.00	4.2e-01	5.0	-5.7	1.1e-08	-0.82	0.03	0.81	FALSE
16	GTEx	Thyroid	DHX33	0.09	0.09	enet	13	0.06	1.5e-05	5.6	-5.6	1.7e-08	-0.86	0.16	0.84	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	RABEP1	0.20	0.22	bslmm	546	0.20	7.4e-25	5.0	-5.6	1.8e-08	-0.75	0.91	0.09	FALSE
11	GTEx	Heart Atrial Appendage	RABEP1	0.13	0.10	enet	11	0.12	7.2e-06	5.3	-5.6	2.3e-08	-0.85	0.06	0.93	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	GP1BA	0.02	0.02	blup	49	0.02	9.3e-03	4.6	5.6	2.7e-08	0.33	0.01	0.76	FALSE
24	The Cancer Genome Atlas	Soft Tissue Sarcoma	INCA1	0.06	0.00	enet	11	0.00	1.7e-01	4.4	5.4	7.0e-08	0.30	0.00	0.66	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	C1QBP	0.03	0.03	blup	57	0.04	4.8e-05	4.8	5.4	7.3e-08	0.87	0.24	0.72	FALSE
21	The Cancer Genome Atlas	Glioblastoma Multiforme	NUP88	0.12	0.07	enet	12	0.09	1.2e-03	5.0	-5.4	8.0e-08	-0.78	0.02	0.68	FALSE
14	GTEx	Skin Sun Exposed Lower leg	AC012146.7	0.21	0.07	enet	17	0.18	1.3e-14	2.9	-5.4	8.5e-08	-0.45	1.00	0.00	FALSE
15	GTEx	Testis	RABEP1	0.69	0.60	lasso	12	0.68	4.9e-40	5.1	-5.3	1.3e-07	-0.80	0.89	0.10	FALSE
1	GTEx	Adipose Subcutaneous	RPAIN	0.10	0.08	lasso	5	0.04	2.2e-04	4.4	-5.3	1.5e-07	-0.81	0.39	0.61	FALSE
12	GTEx	Muscle Skeletal	NUP88	0.05	0.01	enet	7	0.00	1.0e-01	3.7	5.2	1.8e-07	0.72	0.09	0.77	FALSE
4	GTEx	Artery Tibial	NUP88	0.10	0.05	lasso	3	0.04	2.5e-04	5.3	-5.2	1.9e-07	-0.82	0.66	0.28	FALSE
25	The Cancer Genome Atlas	Stomach Adenocarcinoma	C17orf107	0.05	0.01	blup	40	0.03	2.0e-03	5.2	5.2	2.4e-07	0.31	0.02	0.82	FALSE
6	GTEx	Cells Transformed fibroblasts	NUP88	0.09	0.10	enet	15	0.10	8.8e-08	5.1	-5.2	2.5e-07	-0.82	0.86	0.13	FALSE
17	GTEx	Thyroid	RABEP1	0.21	0.27	lasso	7	0.26	1.4e-19	5.1	-5.1	2.7e-07	-0.80	0.89	0.10	FALSE
13	GTEx	Nerve Tibial	NUP88	0.08	0.07	lasso	3	0.09	5.0e-07	5.1	-5.1	2.9e-07	-0.87	0.10	0.89	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUP88	0.03	0.02	lasso	2	0.02	6.7e-06	3.8	-5.1	2.9e-07	-0.90	0.01	0.99	FALSE