[Hub]/) : Traits : Leg fat mass (left) : ← →

chr17:45,029,294-47,718,188

Best TWAS P=2.76e-11 · Best GWAS P=9.12e-14 conditioned to 0.000436

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDK5RAP3	0.06	0.00	blup	62	0.03	1.0e-03	-4.57	-6.7	2.8e-11	-0.35	0.01	0.79	TRUE
8	GTEx	Brain Nucleus accumbens basal ganglia	RP11-6N17.9	0.47	0.05	lasso	17	0.11	8.3e-04	5.43	-5.7	1.0e-08	-0.65	0.11	0.38	TRUE
2	CommonMind	Brain Pre-frontal Cortex	SNF8	0.08	0.07	lasso	5	0.08	9.3e-10	-4.45	5.3	1.0e-07	0.07	0.13	0.87	TRUE
14	GTEx	Stomach	RP11-6N17.9	0.13	0.02	lasso	6	0.04	8.0e-03	5.46	-6.3	3.6e-10	-0.70	0.12	0.69	FALSE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	CBX1	0.03	0.04	lasso	4	0.04	3.7e-05	6.27	-6.2	6.3e-10	-0.84	0.01	0.99	FALSE
15	GTEx	Testis	RP11-6N17.4	0.14	0.02	lasso	10	0.02	4.8e-02	6.21	6.1	1.3e-09	0.78	0.18	0.66	FALSE
11	GTEx	Muscle Skeletal	AC003665.1	0.05	0.03	enet	8	0.03	1.4e-03	5.10	6.0	1.5e-09	0.63	0.12	0.72	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	CDK5RAP3	0.21	0.04	lasso	4	0.02	7.2e-02	6.21	-5.9	4.1e-09	-0.78	0.08	0.36	FALSE
4	GTEx	Brain Cerebellar Hemisphere	CDK5RAP3	0.22	0.10	lasso	6	0.09	2.6e-03	4.88	-5.8	6.2e-09	-0.74	0.08	0.40	FALSE
3	GTEx	Brain Caudate basal ganglia	RP11-6N17.9	0.45	-0.01	enet	28	0.16	3.3e-05	-0.88	-5.8	7.5e-09	-0.48	0.06	0.13	FALSE
12	GTEx	Pancreas	CDK5RAP3	0.11	-0.01	lasso	4	0.02	5.1e-02	4.88	-5.7	1.2e-08	-0.48	0.09	0.18	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CDK5RAP3	0.15	0.12	bslmm	392	0.14	3.6e-16	5.97	-5.7	1.3e-08	-0.78	0.89	0.11	FALSE
13	GTEx	Pancreas	RP11-6N17.9	0.15	0.04	lasso	5	0.04	9.3e-03	-1.68	-5.5	4.4e-08	-0.47	0.13	0.17	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDK5RAP3	0.05	0.03	lasso	2	0.02	1.8e-05	5.46	-5.5	4.6e-08	-0.76	0.00	1.00	FALSE
9	GTEx	Heart Atrial Appendage	CDK5RAP3	0.13	0.00	enet	18	0.04	5.1e-03	2.02	-5.4	5.8e-08	-0.42	0.09	0.05	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CBX1	0.03	0.01	lasso	3	0.01	8.7e-03	6.21	-5.4	7.8e-08	-0.80	0.01	0.82	FALSE
5	GTEx	Brain Cerebellar Hemisphere	RP11-6N17.10	0.21	0.16	lasso	5	0.13	3.8e-04	4.88	-5.4	8.1e-08	-0.73	0.09	0.43	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	KPNB1	0.24	0.00	lasso	9	0.01	2.1e-01	1.07	-5.3	1.3e-07	-0.80	0.02	0.79	FALSE
16	GTEx	Thyroid	RP11-6N17.10	0.19	0.12	lasso	5	0.13	3.0e-10	-3.48	-5.3	1.3e-07	-0.47	1.00	0.00	FALSE
10	GTEx	Heart Left Ventricle	ATP5G1	0.24	0.22	lasso	4	0.22	9.3e-12	-4.60	5.1	2.9e-07	0.12	0.86	0.14	FALSE