[Hub]/) : Traits : Leg fat mass (left) :

chr17:65,123,352-66,885,526

Best TWAS P=4.62e-19 · Best GWAS P=1.73e-19 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous LINC00674 0.12 0.13 enet 6 0.14 9.9e-12 7.5 7.4 1.2e-13 0.79 0.96 0.04 FALSE
2 GTEx Adipose Subcutaneous SH3GL1P3 0.08 0.06 lasso 5 0.04 2.5e-04 7.5 7.4 1.4e-13 0.80 0.06 0.90 FALSE
3 GTEx Adipose Visceral Omentum LINC00674 0.29 0.03 enet 40 0.03 6.9e-03 7.9 5.2 1.8e-07 0.63 0.08 0.50 FALSE
4 GTEx Artery Aorta LINC00674 0.12 0.00 lasso 5 0.01 1.5e-01 4.4 5.5 3.2e-08 0.58 0.08 0.33 FALSE
5 GTEx Brain Cerebellum BPTF 0.22 -0.01 lasso 10 -0.01 6.9e-01 7.4 -7.8 7.8e-15 -0.85 0.04 0.48 FALSE
6 GTEx Brain Cortex C17orf58 0.34 0.09 lasso 6 0.13 2.4e-04 8.9 8.5 2.2e-17 0.95 0.03 0.96 FALSE
7 GTEx Cells Transformed fibroblasts LINC00674 0.30 0.31 enet 10 0.32 1.5e-24 7.5 8.1 7.9e-16 0.86 1.00 0.00 FALSE
8 GTEx Cells Transformed fibroblasts LRRC37A16P 0.50 0.46 lasso 8 0.47 1.1e-38 7.5 7.7 1.5e-14 0.84 1.00 0.00 FALSE
9 GTEx Cells Transformed fibroblasts SH3GL1P3 0.26 0.31 lasso 7 0.31 1.5e-23 7.5 8.2 2.2e-16 0.90 0.99 0.01 FALSE
10 GTEx Colon Sigmoid LINC00674 0.42 0.09 lasso 8 0.12 5.5e-05 7.9 7.4 1.9e-13 0.80 0.15 0.66 FALSE
11 GTEx Esophagus Mucosa LRRC37A16P 0.11 0.06 enet 13 0.08 7.5e-06 6.0 -5.9 3.2e-09 -0.67 0.13 0.80 FALSE
12 GTEx Esophagus Muscularis LINC00674 0.11 0.04 lasso 6 0.07 7.9e-05 4.4 7.1 1.1e-12 0.77 0.18 0.79 FALSE
13 GTEx Esophagus Muscularis LRRC37A16P 0.12 0.03 enet 21 0.02 3.2e-02 8.7 5.4 7.4e-08 0.64 0.02 0.79 FALSE
14 GTEx Heart Atrial Appendage LINC00674 0.14 0.08 lasso 17 0.09 1.1e-04 4.4 6.7 1.9e-11 0.73 0.05 0.87 FALSE
15 GTEx Lung LINC00674 0.14 0.03 enet 22 0.08 2.1e-06 8.7 6.9 7.2e-12 0.80 0.15 0.84 FALSE
16 GTEx Muscle Skeletal LRRC37A16P 0.14 0.04 lasso 5 0.08 3.3e-08 4.4 -5.5 3.0e-08 -0.59 0.99 0.00 FALSE
17 GTEx Nerve Tibial LINC00674 0.09 0.01 enet 13 0.03 2.2e-03 4.4 5.6 1.7e-08 0.65 0.20 0.24 FALSE
18 GTEx Nerve Tibial LRRC37A16P 0.09 0.08 lasso 4 0.06 2.7e-05 7.5 7.6 2.4e-14 0.84 0.10 0.78 FALSE
19 GTEx Skin Sun Exposed Lower leg BPTF 0.10 0.01 enet 14 0.03 2.7e-03 7.3 -6.9 5.4e-12 -0.69 0.05 0.79 FALSE
20 GTEx Spleen C17orf58 0.30 -0.01 lasso 8 -0.01 4.6e-01 4.4 6.8 9.8e-12 0.81 0.03 0.35 FALSE
21 GTEx Stomach RP11-147L13.8 0.23 -0.01 enet 9 0.01 8.1e-02 3.3 6.4 1.4e-10 0.57 0.04 0.18 FALSE
22 GTEx Thyroid LINC00674 0.09 0.10 enet 16 0.12 4.0e-09 4.4 5.2 2.2e-07 0.61 0.57 0.39 FALSE
23 GTEx Thyroid SH3GL1P3 0.08 0.00 lasso 3 0.00 2.8e-01 4.4 5.1 2.7e-07 0.56 0.05 0.44 FALSE
24 YFS Blood KPNA2 0.01 0.01 blup 312 0.01 2.8e-04 7.9 -8.4 3.2e-17 -0.86 0.05 0.93 FALSE
25 The Cancer Genome Atlas Thyroid Carcinoma C17orf58 0.02 0.02 lasso 2 0.01 1.8e-02 8.9 8.9 4.6e-19 1.00 0.00 0.76 TRUE